Search Results - "LAWSON, John A"

Adjunctive everolimus therapy for treatment-resistant focal-onset seizures associated with tuberous sclerosis (EXIST-3): a phase 3, randomised, double-blind, placebo-controlled study by French, Jacqueline A, Dr Prof, Lawson, John A, MD, Yapici, Zuhal, Prof, Ikeda, Hiroko, MD, Polster, Tilman, MD, Nabbout, Rima, PhD, Curatolo, Paolo, Prof, de Vries, Petrus J, Prof, Dlugos, Dennis J, MD, Berkowitz, Noah, PhD, Voi, Maurizio, MD, Peyrard, Severine, MS, Pelov, Diana, MS, Franz, David N, Prof

“…Summary Background Everolimus, a mammalian target of rapamycin (mTOR) inhibitor, has been used for various benign tumours associated with tuberous sclerosis…”
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Mammalian Target of Rapamycin Inhibitors for Intractable Epilepsy and Subependymal Giant Cell Astrocytomas in Tuberous Sclerosis Complex by Cardamone, Michael, BSc (Hons), PhD, MBBS, FRACP, Flanagan, Danny, BSc (DipSci), PhD, Mowat, David, MBBS, DRACOG, MRCGP, FRACP, Kennedy, Sean E., MBBS, PhD, FRACP, Chopra, Maya, BSc (Med), MBBS, FRACP, Lawson, John A., BMed, FRACP, PhD

“…Objectives To evaluate the efficacy and side effects of oral mammalian target of rapamycin (mTOR) inhibitors in children and adolescents with tuberous…”
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Differential impairment of aspirin-dependent platelet cyclooxygenase acetylation by nonsteroidal antiinflammatory drugs by Li, Xuanwen, Fries, Susanne, Li, Ruizhi, Lawson, John A., Propert, Kathleen J., Diamond, Scott L., Blair, Ian A., FitzGerald, Garret A., Grosser, Tilo, Coller, Barry S.

“…Significance Painkillers classified as nonsteroidal antiinflammatory drugs (NSAIDs) are among the most commonly consumed drugs. Although they ameliorate pain…”
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Methotrexate-related central neurotoxicity: clinical characteristics, risk factors and genome-wide association study in children treated for acute lymphoblastic leukemia by Mateos, Marion K, Marshall, Glenn M, Barbaro, Pasquale M, Quinn, Michael C J, George, Carly, Mayoh, Chelsea, Sutton, Rosemary, Revesz, Tamas, Giles, Jodie E, Barbaric, Draga, Alvaro, Frank, Mechinaud, Françoise, Catchpoole, Daniel, Lawson, John A, Chenevix-Trench, Georgia, MacGregor, Stuart, Kotecha, Rishi S, Dalla-Pozza, Luciano, Trahair, Toby N

“…Symptomatic methotrexate-related central neurotoxicity (MTX neurotoxicity) is a severe toxicity experienced during acute lymphoblastic leukemia (ALL) therapy…”
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Ten-Year Single-Center Experience of the Ketogenic Diet: Factors Influencing Efficacy, Tolerability, and Compliance by Wibisono, Cinthya, B. Nutrition & Dietetics (Hons). B Comm, Rowe, Natalie, BSc (Nutrition) Masters (Dietetics), Beavis, Erin, RN, Kepreotes, Helen, BSc Master Nutr & Diet, Mackie, Fiona E., MBBS, PhD, FRACP, Lawson, John A., B.Med., FRACP, PhD, Cardamone, Michael, BSc (Hons), PhD, MBBS, FRACP

“…Objectives To evaluate the efficacy, tolerability, and compliance of 3 ketogenic diets, the classical ketogenic diet, medium-chain triglyceride (MCT), and…”
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Management strategies for CLN2 disease by Williams, Ruth E., DM, FRCPCH, Adams, Heather R., PhD, Blohm, Martin, MD, Cohen-Pfeffer, Jessica L., MD, de los Reyes, Emily, MD, Denecke, Jonas, MD, Drago, Kristen, RN, CHPPN, Fairhurst, Charlie, MBBS, FRCPCH, Frazier, Margie, PhD, Guelbert, Norberto, MD, PhD, Kiss, Szilárd, MD, Kofler, Annamaria, PT, Lawson, John A., BMed, FRACP, PhD, Lehwald, Lenora, MD, Leung, Mary-Anne, SRD, Mikhailova, Svetlana, MD, Mink, Jonathan W., MD, PhD, Nickel, Miriam, MD, Shediac, Renée, PhD, Sims, Katherine, MD, Specchio, Nicola, MD, PhD, Topcu, Meral, MD, von Löbbecke, Ina, PT, West, Andrea, MSc, Zernikow, Boris, MD, PhD, Schulz, Angela, MD, PhD

“…Abstract CLN2 disease (neuronal ceroid lipofuscinosis type 2) is a rare, autosomal recessive, pediatric-onset, rapidly progressive neurodegenerative lysosomal…”
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Prostaglandin D2 Inhibits Wound-Induced Hair Follicle Neogenesis through the Receptor, Gpr44 by Nelson, Amanda M., Loy, Dorothy E., Lawson, John A., Katseff, Adiya S., FitzGerald, Garret A., Garza, Luis A.

“…Prostaglandins (PGs) are key inflammatory mediators involved in wound healing and regulating hair growth; however, their role in skin regeneration after injury…”
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COX-2-Derived Prostacyclin Confers Atheroprotection on Female Mice by Egan, Karine M., Lawson, John A., Fries, Susanne, Koller, Beverley, Rader, Daniel J., Smyth, Emer M., FitzGerald, Garret A.

“…Female gender affords relative protection from cardiovascular disease until the menopause. We report that estrogen acts on estrogen receptor subtype alpha to…”
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Cell Selective Cardiovascular Biology of Microsomal Prostaglandin E Synthase-1 by LIHONG CHEN, GUANGRUI YANG, XIUFENG XU, GRANT, Gregory, LAWSON, John A, BOHLOOLY-Y, Mohammad, FITZGERALD, Garret A

“…Global deletion of microsomal prostaglandin E synthase 1 (mPGES-1) in mice attenuates the response to vascular injury without a predisposition to…”
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Role of Prostacyclin in the Cardiovascular Response to Thromboxane A2 by Cheng, Yan, Austin, Sandra C., Rocca, Bianca, Koller, Beverly H., Coffman, Thomas M., Grosser, Tilo, Lawson, John A., FitzGerald, Garret A.

“…Thromboxane (Tx) A2is a vasoconstrictor and platelet agonist. Aspirin affords cardioprotection through inhibition of TxA2formation by platelet cyclooxygenase…”
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Microsomal Prostaglandin E Synthase-1 Deletion Suppresses Oxidative Stress and Angiotensin II-Induced Abdominal Aortic Aneurysm Formation by MIAO WANG, LEE, Eric, WENLIANG SONG, RICCIOTTI, Emanuela, RADER, Daniel J, LAWSON, John A, PURE, Ellen, FITZGERALD, Garret A

“…Microsomal prostaglandin (PG) E(2) synthase-1 (mPGES-1) catalyzes isomerization of the cyclooxygenase product PGH(2) into PGE(2). Deletion of mPGES-1 modulates…”
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Myeloid cell microsomal prostaglandin E synthase-1 fosters atherogenesis in mice by Chen, Lihong, Yang, Guangrui, Monslow, James, Todd, Leslie, Cormode, David P., Tang, Jun, Grant, Gregory R., DeLong, Jonathan H., Tang, Soon Yew, Lawson, John A., Pure, Ellen, FitzGerald, Garret A.

“…Microsomal prostaglandin E synthase-1 (mPGES-1) in myeloid and vascular cells differentially regulates the response to vascular injury, reflecting distinct…”
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Measuring Health-Related Quality of Life in Tuberous Sclerosis Complex - Psychometric Evaluation of Three Instruments in Individuals With Refractory Epilepsy by de Vries, Petrus J, Franz, David N, Curatolo, Paolo, Nabbout, Rima, Neary, Maureen, Herbst, Fabian, Sully, Kate, Brohan, Elaine, Bennett, Bryan, Lawson, John A

“…Tuberous sclerosis complex (TSC) is a rare genetic disease associated with significant disease burden and considerable impact on health-related quality of life…”
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Disruption of the 5-lipoxygenase pathway attenuates atherogenesis consequent to COX-2 deletion in mice by Yu, Zhou, Crichton, Irene, Tang, Soon Yew, Hui, Yiqun, Ricciotti, Emanuela, Levin, Mark D, Lawson, John A, Puré, Ellen, FitzGerald, Garret A

“…Suppression of cyclooxygenase 2 (COX-2)–derived prostacyclin (PGI2) is sufficient to explain most elements of the cardiovascular hazard from nonsteroidal…”
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Quantification of Lipid Mediator Metabolites in Human Urine from Asthma Patients by Electrospray Ionization Mass Spectrometry: Controlling Matrix Effects by Balgoma, David, Larsson, Johan, Rokach, Joshua, Lawson, John A, Daham, Kameran, Dahlén, Barbro, Dahlén, Sven-Erik, Wheelock, Craig E

“…Eicosanoids (e.g., prostaglandins and leukotrienes) are inflammatory signaling molecules that are metabolized and excreted in urine. The quantification of…”
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Tetranor PGDM, an Abundant Urinary Metabolite Reflects Biosynthesis of Prostaglandin D2 in Mice and Humans by Song, Wen-Liang, Wang, Miao, Ricciotti, Emanuela, Fries, Susanne, Yu, Ying, Grosser, Tilo, Reilly, Muredach, Lawson, John A., FitzGerald, Garret A.

“…Prostaglandin D2 (PGD2) is a cyclooxygenase (COX) product of arachidonic acid that activates D prostanoid receptors to modulate vascular, platelet, and…”
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Marked Interindividual Variability in the Response to Selective Inhibitors of Cyclooxygenase-2 by Fries, Susanne, Grosser, Tilo, Price, Thomas S., Lawson, John A., Kapoor, Shiv, DeMarco, Susan, Pletcher, Mathew T., Wiltshire, Tim, FitzGerald, Garret A.

“…Background & Aims: Variability in response to drugs may influence both efficacy and safety. Cyclooxygenase (COX)-2 inhibitors pose a cardiovascular risk by…”
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Neurofurans, Novel Indices of Oxidant Stress Derived from Docosahexaenoic Acid by Song, Wen-Liang, Lawson, John A., Reilly, Dermot, Rokach, Joshua, Chang, Chih-Tsung, Giasson, Benoit, FitzGerald, Garret A.

“…Isoeicosanoids are free radical-catalyzed isomers of the enzymatic products of arachidonic acid. They are formed in situ in cell membranes, are cleaved,…”
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Novel Eicosapentaenoic Acid-derived F3-isoprostanes as Biomarkers of Lipid Peroxidation by Song, Wen-Liang, Paschos, Georgios, Fries, Susanne, Reilly, Muredach P., Yu, Ying, Rokach, Joshua, Chang, Chih-Tsung, Patel, Pranav, Lawson, John A., FitzGerald, Garret A.

“…Isoprostanes (iPs) are prostaglandin (PG) isomers generated by free radical-catalyzed peroxidation of polyunsaturated fatty acids (PUFAs). Urinary F2-iPs,…”
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Effects of celecoxib on prostanoid biosynthesis and circulating angiogenesis proteins in familial adenomatous polyposis by Dovizio, Melania, Tacconelli, Stefania, Ricciotti, Emanuela, Bruno, Annalisa, Maier, Thorsten Jürgen, Anzellotti, Paola, Di Francesco, Luigia, Sala, Paola, Signoroni, Stefano, Bertario, Lucio, Dixon, Dan A, Lawson, John A, Steinhilber, Dieter, FitzGerald, Garret A, Patrignani, Paola

“…Vascular cyclooxygenase (COX)-2-dependent prostacyclin (PGI(2)) may affect angiogenesis by preventing endothelial activation and platelet release of angiogenic…”
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