Search Results - "LAWSON, C. F"

Single-dose aprepitant vs ondansetron for the prevention of postoperative nausea and vomiting: a randomized, double-blind Phase III trial in patients undergoing open abdominal surgery by Diemunsch, P., Gan, T.J., Philip, B.K., Girao, M.J., Eberhart, L., Irwin, M.G., Pueyo, J., Chelly, J.E., Carides, A.D., Reiss, T., Evans, J.K., Lawson, F.C.

“…The neurokinin1 antagonist aprepitant is effective for prevention of chemotherapy-induced nausea and vomiting. We compared aprepitant with ondansetron for…”
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Isochroman-6-carboxamides as Highly Selective 5-HT1D Agonists:  Potential New Treatment for Migraine without Cardiovascular Side Effects by Ennis, Michael D, Ghazal, Nabil B, Hoffman, Robert L, Smith, Martin W, Schlachter, Siusaidh K, Lawson, Charles F, Im, Wha Bin, Pregenzer, Jeffrey F, Svensson, Kjell A, Lewis, Richard A, Hall, Edward D, Sutter, Dorothy M, Harris, Lorri T, McCall, Robert B

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Long-acting CRF2 receptor agonist COR-1389 improves cardiopulmonary function parameters in monocrotaline-induced pulmonary hypertension and right heart failure rat model by Kowala, M C, Guignabert, C, Thuillet, R, Ottaviani, M, Tu, L, Ozoux, M L, Lawson, F C, Janiak, P

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Myotropic activity of leukotriene B4 on lung parenchyma strips is not necessarily attributable to thromboxane A2 release by Fitzpatrick, F A, Lawson, C F

“…Leukotriene B4 contracts guinea pig lung parenchymal strips by an indirect mechanism dependent upon formation of myotropic cyclooxygenase metabolites. In…”
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(S)-(−)-4-[4-[2-(Isochroman-1-yl)ethyl]piperazin-1-yl]benzenesulfonamide, a Selective Dopamine D4 Antagonist by TenBrink, Ruth E, Bergh, Carol L, Duncan, J. Neil, Harris, Douglas W, Huff, R. M, Lahti, Robert A, Lawson, Charles F, Lutzke, Barry S, Martin, Iain J, Rees, Susan A, Schlachter, Siusaidh K, Sih, John C, Smith, Martin W

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Pharmacology of a human dopamine D4 receptor expressed in HEK293 cells by Lawson, C F, Mortimore, R A, Schlachter, S K, Smith, M W

“…Dopamine receptors play an important role in neurotransmission within the central nervous system, as evidenced by their affinity to and apparent site of action…”
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Novel indolodioxanes with antihypertensive effects: potent ligands for the 5-HT1A receptor by Ennis, Michael D, Baze, Mark E, Smith, Martin W, Lawson, Charles F, McCall, Robert B, Lahti, Robert A, Piercey, Montford F

“…The synthesis and biological evaluation of a new family of tricyclic indolodioxanes is described. These compounds all contain the…”
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Medicinal chemistry of imidazoquinolinone dopamine receptor agonists by Moon, M W, Morris, J K, Heier, R F, Hsi, R S, Manis, M O, Royer, M E, Walters, R R, Lawson, C F, Smith, M W, Lahti, R A

“…(R)-5-(Dipropylamino)-5,6-dihydro-4H-imidazo[4,5,1-ij]-quinolin-2( 1H)-on e (1a, U-86170), a potent high intrinsic activity dopamine (D2) agonist, has been…”
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Substituted 4-aminopiperidines having high in vitro affinity and selectivity for the cloned human dopamine D4 receptor by SCHLACHTER, S. K, POEL, T. J, LAWSON, C. F, DINH, D. M, LAJINESS, M. E, ROMERO, A. G, REES, S. A, DUNCAN, J. N, SMITH, M. W

“…We have discovered two substituted 4-aminopiperidine compounds having high in vitro affinity and selectivity for the human dopamine D1 receptor. Both…”
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Lixisenatide in Patients with Type 2 Diabetes and Acute Coronary Syndrome by Pfeffer, Marc A, Claggett, Brian, Diaz, Rafael, Dickstein, Kenneth, Gerstein, Hertzel C, Køber, Lars V, Lawson, Francesca C, Ping, Lin, Wei, Xiaodan, Lewis, Eldrin F, Maggioni, Aldo P, McMurray, John J.V, Probstfield, Jeffrey L, Riddle, Matthew C, Solomon, Scott D, Tardif, Jean-Claude

“…In this randomized study, the addition of lixisenatide, a glucagon-like peptide 1–receptor agonist, to usual care in patients with type 2 diabetes and a recent…”
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Effect of Piriprost, a 5-lipoxygenase inhibitor, on leukocyte accumulation during thioglycollate-induced acute inflammation by Lawson, C F, Smith, H W, Fitzpatrick, F A

“…We evaluated the effect of a prototype 5-lipoxygenase enzyme inhibitor, Piriprost [6,9-deepoxy-6,9-(phenylimino-)delta 6,8-prostaglandin I1], on the leukocyte…”
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Receptor antagonism of leukotriene B4 myotropic activity by the 2,6 disubstituted pyridine analog U-75302: characterization on lung parenchyma strips by Lawson, C F, Wishka, D G, Morris, J, Fitzpatrick, F A

“…Leukotriene B4 constricts guinea pig lung parenchyma strips in a concentration-dependent manner. The LTB4 structural analog U-75302, 6-(6-[3-hydroxy-1E,5…”
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Effects of Caffeine-and Sugar-Free Beverages on Psychomotor Performance by Meliska, Charles J., Lawson, Christopher F.

“…Two cola beverages containing caffeine stimulated rope jumping more than beverages without caffeine; sugar content of the beverages did not appear to affect…”
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Naphtho and benzo analogs of the .kappa. opioid agonist trans-(.+-.)-3,4-dichloro-N-methyl-N-[2-(1-pyrrolidinyl)cyclohexyl]benzeneacetamide by Freeman, Jeremiah P, Michalson, Eric T, D'Andrea, Stan V, Baczynskyj, Lubomir, VonVoigtlander, Philip F, Lahti, R. A, Smith, Martin W, Lawson, Charles F, Scahill, Terrence A

“…Further elaboration on the structure-activity relationships in our U-50,488 series has revealed that benzologation of this cyclohexane-1,2-diamine derivative…”
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Prevention of postoperative nausea and vomiting (PONV) following open abdominal surgery: A double-blind, multicenter comparison of the NK1 receptor antagonist aprepitant with ondansetron: A-612 by Diemunsch, P., Gan, T. J., Philip, B., Girao, M., Eberhart, L., Irwin, M., Pueyo, J., Lawson, F. C.

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Prostaglandin prodrugs III: Synthesis and biological properties of C9- and C15-monoesters of dinoprost (prostaglandin F2 alpha) by Morozowich, W, Oesterling, T O, Miller, W L, Lawson, C F, Cornette, J C, Weeks, J R, Douglas, S L

“…Methods are described for the synthesis of dinoprost C9- and C15-monoesters using protective groups. Esters at C9 were synthesized by acylation of dinoprost…”
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Prostaglandin prodrugs. I: Stabilization of dinoprostone (prostaglandin E2) in solid state through formation of crystalline C1-phenyl esters by Morozowich, W, Oesterling, T O, Miller, W L, Lawson, C F, Weeks, J R, Stehle, R G, Douglas, S L

“…Dinoprostone para-substituted phenyl esters were synthesized in attempt to improve the solid-state stability of the parent prostaglandin. A phenol series…”
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( S )-(−)-4-[4-[2-(Isochroman-1-yl)ethyl]piperazin-1-yl]benzenesulfonamide, a Selective Dopamine D 4 Antagonist by TenBrink, Ruth E., Bergh, Carol L., Duncan, J. Neil, Harris, Douglas W., Huff, R. M., Lahti, Robert A., Lawson, Charles F., Lutzke, Barry S., Martin, Iain J., Rees, Susan A., Schlachter, Siusaidh K., Sih, John C., Smith, Martin W.

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Substituted 4-aminopiperidines having high in vitro affinity and selectivity for the cloned human dopamine D sub(4) receptor by Schlachter, S K, Poel, T J, Lawson, C F, Dinh, D M, Lajiness, ME, Romero, A G, Rees, SA, Duncan, J N, Smith, M W

“…We have discovered two substituted 4-aminopiperidine compounds having high in vitro affinity and selectivity for the human dopamine D sub(4) receptor. Both…”
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Substituted 4-aminopiperidines having high in vitro affinity and selectivity for the cloned human dopamine D 4 receptor by Schlachter, Siusaidh K, Poel, Toni J, Lawson, Charles F, Dinh, Dac M, Lajiness, Mary E, Romero, Arthur G, Rees, Susan A, Duncan, J.Neil, Smith, Martin W

“…We have discovered two substituted 4-aminopiperidine compounds having high in vitro affinity and selectivity for the human dopamine D 4 receptor. Both…”
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