Search Results - "LAWS, Susan C"

High-throughput screening and chemotype-enrichment analysis of ToxCast phase II chemicals evaluated for human sodium-iodide symporter (NIS) inhibition by Wang, Jun, Hallinger, Daniel R., Murr, Ashley S., Buckalew, Angela R., Lougee, Ryan R., Richard, Ann M., Laws, Susan C., Stoker, Tammy E.

“…In support of the Endocrine Disruptor Screening Program (EDSP), the U.S.EPA's Office of Research and Development (ORD) is developing high-throughput screening…”
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The use of purified rat Leydig cells complements the H295R screen to detect chemical-induced alterations in testosterone production by Principato, Nicole L. Botteri, Suarez, Juan D, Laws, Susan C, Klinefelter, Gary R

“…Exposure to endocrine disrupting chemicals has been associated with compromised testosterone production leading to abnormal male reproductive development and…”
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Characterization of the Hypothalamic-Pituitary-Adrenal Axis Response to Atrazine and Metabolites in the Female Rat by Fraites, Melanie J. P., Cooper, Ralph L., Buckalew, Angela, Jayaraman, Saro, Mills, Lesley, Laws, Susan C.

“…Atrazine (ATR) has recently been shown to activate the hypothalamic-pituitary-adrenal (HPA) axis in rodents. The current study investigated the effect of ATR…”
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Atrazine and reproductive function: mode and mechanism of action studies by Cooper, Ralph L., Laws, Susan C., Das, Parikshit C., Narotsky, Michael G., Goldman, Jerome M., Lee Tyrey, E., Stoker, Tammy E.

“…Atrazine, a chlorotriazine herbicide, is used to control annual grasses and broadleaf weeds. In this review, we summarize our laboratory's work evaluating the…”
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Understanding the effects of atrazine on steroidogenesis in rat granulosa and H295R adrenal cortical carcinoma cells by Tinfo, Nicole S., Hotchkiss, Michelle G., Buckalew, Angela R., Zorrilla, Leah M., Cooper, Ralph L., Laws, Susan C.

“…Atrazine (2-chloro-4-ethylamino-6-isopropylamino-s-triazine) was introduced in the 1950s as a broad spectrum herbicide, and remains one of the most widely used…”
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Evaluating Chemicals for Thyroid Disruption: Opportunities and Challenges with in Vitro Testing and Adverse Outcome Pathway Approaches by Noyes, Pamela D, Friedman, Katie Paul, Browne, Patience, Haselman, Jonathan T, Gilbert, Mary E, Hornung, Michael W, Barone, Jr, Stan, Crofton, Kevin M, Laws, Susan C, Stoker, Tammy E, Simmons, Steven O, Tietge, Joseph E, Degitz, Sigmund J

“…Extensive clinical and experimental research documents the potential for chemical disruption of thyroid hormone (TH) signaling through multiple molecular…”
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The Impact of Gender and Estrogen on Striatal Dopaminergic Neurotoxicity by MILLER, DIANE B., ALI, SYED F., O'CALLAGHAN, JAMES P., LAWS, SUSAN C.

“…The reproductive properties of estrogen are well established, but it is now evident that this steroid hormone has substantial modulatory capabilities in…”
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High-Throughput Screening and Quantitative Chemical Ranking for Sodium-Iodide Symporter Inhibitors in ToxCast Phase I Chemical Library by Wang, Jun, Hallinger, Daniel R, Murr, Ashley S, Buckalew, Angela R, Simmons, Steven O, Laws, Susan C, Stoker, Tammy E

“…Thyroid uptake of iodide via the sodium-iodide symporter (NIS) is the first step in the biosynthesis of thyroid hormones that are critical for health and…”
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Evaluation of potential sodium-iodide symporter (NIS) inhibitors using a secondary Fischer rat thyroid follicular cell (FRTL-5) radioactive iodide uptake (RAIU) assay by Buckalew, Angela R., Wang, Jun, Murr, Ashley S., Deisenroth, Chad, Stewart, Wendy M., Stoker, Tammy E., Laws, Susan C.

“…The Fischer rat thyroid follicular cell line (FRTL-5) endogenously expresses the sodium-iodide symporter (NIS) and has been used to identify environmental…”
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Development of a screening approach to detect thyroid disrupting chemicals that inhibit the human sodium iodide symporter (NIS) by Hallinger, Daniel R., Murr, Ashley S., Buckalew, Angela R., Simmons, Steven O., Stoker, Tammy E., Laws, Susan C.

“…The U.S. EPA's Endocrine Disruptor Screening Program aims to use high-throughput assays and computational toxicology models to screen and prioritize chemicals…”
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Expanded high-throughput screening and chemotype-enrichment analysis of the phase II: e1k ToxCast library for human sodium-iodide symporter (NIS) inhibition by Wang, Jun, Richard, Ann M., Murr, Ashley S., Buckalew, Angela R., Lougee, Ryan R., Shobair, Mahmoud, Hallinger, Daniel R., Laws, Susan C., Stoker, Tammy E.

“…The sodium-iodide symporter (NIS) mediates the uptake of iodide into the thyroid. Inhibition of NIS function by xenobiotics has been demonstrated to suppress…”
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Endocrine-Disrupting Chemicals: Prepubertal Exposures and Effects on Sexual Maturation and Thyroid Activity in the Female Rat. A Focus on the EDSTAC Recommendations by Goldman, Jerome M., Laws, Susan C., Balchak, Sharon K., Cooper, Ralph L., Kavlock, Robert J.

“…In 1996, the US Environmental Protection Agency was given a mandate by Congress to develop a screening program that would evaluate whether variously identified…”
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Chlorotriazine Herbicides and Metabolites Activate an ACTH-dependent Release of Corticosterone in Male Wistar Rats by Laws, Susan C., Hotchkiss, Michelle, Ferrell, Janet, Jayaraman, Saro, Mills, Lesley, Modic, Walker, Tinfo, Nicole, Fraites, Melanie, Stoker, Tammy, Cooper, Ralph

“…Previously, we reported that atrazine (ATR) alters steroidogenesis in male Wistar rats resulting in elevated serum corticosterone (CORT), progesterone, and…”
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Modulation of aromatase activity as a mode of action for endocrine disrupting chemicals in a marine fish by Mills, Lesley J., Gutjahr-Gobell, Ruth E., Zaroogian, Gerald E., Horowitz, Doranne Borsay, Laws, Susan C.

“…•Effects of four EDCs on reproduction and aromatase in a marine fish were studied.•Aromatase activity in brain and ovary were affected differently by the four…”
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Assessment of DE-71, a Commercial Polybrominated Diphenyl Ether (PBDE) Mixture, in the EDSP Male and Female Pubertal Protocols by Stoker, Tammy E., Laws, Susan C., Crofton, Kevin M., Hedge, Joan M., Ferrell, Janet M., Cooper, Ralph L.

“…DE-71, a commercial mixture, was used to test the sensitivity of the female and male pubertal protocol to detect thyroid active chemicals. These protocols are…”
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In vitro metabolism and bioavailability tests for endocrine active substances: what is needed next for regulatory purposes? by Jacobs, Miriam N, Laws, Susan C, Willett, Kate, Schmieder, Pat, Odum, Jenny, Bovee, Toine F

“…Legislation and prospective legislative proposals internationally (may) require that chemicals be tested for their ability to disrupt the hormonal systems of…”
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Novel molecular events associated with altered steroidogenesis induced by exposure to atrazine in the intact and castrate male rat by Riffle, Brandy W., Klinefelter, Gary R., Cooper, Ralph L., Winnik, Witold M., Swank, Adam, Jayaraman, Saro, Suarez, Juan, Best, Deborah, Laws, Susan C.

“…•Atrazine increases serum progesterone and corticosterone in both intact and castrate male rats.•Luteinizing hormone, androstenedione and testosterone were…”
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Approaches for predicting effects of unintended environmental exposure to an endocrine active pharmaceutical, tamoxifen by Mills, Lesley J., Henderson, W. Matthew, Jayaraman, Saro, Gutjahr-Gobell, Ruth E., Zaroogian, Gerald E., Horowitz, Doranne Borsay, Laws, Susan C.

“…ABSTRACT Tamoxifen is an endocrine‐active pharmaceutical (EAP) that is used world‐wide. Because tamoxifen is a ubiquitous pharmaceutical and interacts with…”
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Measurement of steroids in rats after exposure to an endocrine disruptor: Mass spectrometry and radioimmunoassay demonstrate similar results by Riffle, Brandy W., Henderson, W. Matthew, Laws, Susan C.

“…Commercially available radioimmunoassays (RIAs) are frequently used to evaluate the effects of endocrine disrupting chemicals (EDCs) on steroidogenesis in…”
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Atrazine does not induce pica behavior at doses that increase hypothalamic–pituitary–adrenal axis activation and cause conditioned taste avoidance by Hotchkiss, Michelle Gatien, Best, Deborah S, Cooper, Ralph L, Laws, Susan C

“…Abstract Previous work has shown that a single oral administration of atrazine (ATR), a chlorotriazine herbicide, causes rapid increases in plasma…”
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