Search Results - "LAWRIE, Allan"

The role of chemokines and chemokine receptors in pulmonary arterial hypertension by Mamazhakypov, Argen, Viswanathan, Gayathri, Lawrie, Allan, Schermuly, Ralph Theo, Rajagopal, Sudarshan

“…Pulmonary arterial hypertension (PAH) is characterized by progressive pulmonary artery remodelling leading to increased right ventricular pressure overload,…”
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Discovery of Distinct Immune Phenotypes Using Machine Learning in Pulmonary Arterial Hypertension by Sweatt, Andrew J, Hedlin, Haley K, Balasubramanian, Vidhya, Hsi, Andrew, Blum, Lisa K, Robinson, William H, Haddad, Francois, Hickey, Peter M, Condliffe, Robin, Lawrie, Allan, Nicolls, Mark R, Rabinovitch, Marlene, Khatri, Purvesh, Zamanian, Roham T

“…RATIONALE:Accumulating evidence implicates inflammation in pulmonary arterial hypertension (PAH) and therapies targeting immunity are under investigation,…”
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Identifying early pulmonary arterial hypertension biomarkers in systemic sclerosis: Machine learning on proteomics from the DETECT cohort by Bauer, Yasmina, de Bernard, Simon, Hickey, Peter, Ballard, Karri, Cruz, Jeremy, Cornelisse, Peter, Chadha-Boreham, Harbajan, Distler, Oliver, Rosenberg, Daniel, Doelberg, Martin, Roux, Sebastien, Nayler, Oliver, Lawrie, Allan

“…Pulmonary arterial hypertension (PAH) is a devastating complication of Systemic Sclerosis (SSc). Screening for PAH in SSc has increased detection, allowed…”
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Plasma Metabolomics Implicates Modified Transfer RNAs and Altered Bioenergetics in the Outcomes of Pulmonary Arterial Hypertension by Rhodes, Christopher J, Ghataorhe, Pavandeep, Wharton, John, Rue-Albrecht, Kevin C, Hadinnapola, Charaka, Watson, Geoffrey, Bleda, Marta, Haimel, Matthias, Coghlan, Gerry, Corris, Paul A, Howard, Luke S, Kiely, David G, Peacock, Andrew J, Pepke-Zaba, Joanna, Toshner, Mark R, Wort, S John, Gibbs, J Simon R, Lawrie, Allan, Gräf, Stefan, Morrell, Nicholas W, Wilkins, Martin R

“…Pulmonary arterial hypertension (PAH) is a heterogeneous disorder with high mortality. We conducted a comprehensive study of plasma metabolites using…”
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Pulmonary hypertension in COPD: results from the ASPIRE registry by HURDMAN, Judith, CONDLIFFE, Robin, POLLARD, Lauren, WILD, Jim M, LAWRIE, Allan, LAWSON, Rod, SABROE, Ian, KIELY, David G, ELLIOT, Charlie A, SWIFT, Andrew, RAJARAM, Smitha, DAVIES, Christine, HILL, Catherine, HAMILTON, Neil, ARMSTRONG, Lain J, BILLINGS, Catherine

“…The phenotype and outcome of severe pulmonary hypertension in chronic obstructive pulmonary disease (COPD) is described in small numbers, and predictors of…”
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Loss of Endothelial Endoglin Promotes High-Output Heart Failure Through Peripheral Arteriovenous Shunting Driven by VEGF Signaling by Tual-Chalot, Simon, Garcia-Collado, Maria, Redgrave, Rachael E., Singh, Esha, Davison, Benjamin, Park, Catherine, Lin, Hua, Luli, Saimir, Jin, Yi, Wang, Yixin, Lawrie, Allan, Jakobsson, Lars, Arthur, Helen M.

“…ENG (endoglin) is a coreceptor for BMP (bone morphogenetic protein) 9/10 and is strongly expressed in endothelial cells. Mutations in lead to the inherited…”
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Low-Dose FK506 (Tacrolimus) in End-Stage Pulmonary Arterial Hypertension by Spiekerkoetter, Edda, Sung, Yon K, Sudheendra, Deepti, Bill, Matthew, Aldred, Micheala A, van de Veerdonk, Mariëlle C, Vonk Noordegraaf, Anton, Long-Boyle, Janel, Dash, Rajesh, Yang, Phillip C, Lawrie, Allan, Swift, Andrew J, Rabinovitch, Marlene, Zamanian, Roham T

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Plasma proteome analysis in patients with pulmonary arterial hypertension: an observational cohort study by Rhodes, Christopher J, PhD, Wharton, John, PhD, Ghataorhe, Pavandeep, MD, Watson, Geoffrey, MD, Girerd, Barbara, PhD, Howard, Luke S, DPhil, Gibbs, J Simon R, MD, Condliffe, Robin, MD, Elliot, Charles A, MD, Kiely, David G, Prof, Simonneau, Gerald, Prof, Montani, David, Prof, Sitbon, Olivier, Prof, Gall, Henning, MD, Schermuly, Ralph T, Prof, Ghofrani, H Ardeschir, Prof, Lawrie, Allan, PhD, Humbert, Marc, Prof, Wilkins, Martin R, Prof

“…Summary Background Idiopathic and heritable pulmonary arterial hypertension form a rare but molecularly heterogeneous disease group. We aimed to measure and…”
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Blood DNA methylation profiling identifies cathepsin Z dysregulation in pulmonary arterial hypertension by Ulrich, Anna, Wu, Yukyee, Draisma, Harmen, Wharton, John, Swietlik, Emilia M., Cebola, Inês, Vasilaki, Eleni, Balkhiyarova, Zhanna, Jarvelin, Marjo-Riitta, Auvinen, Juha, Herzig, Karl-Heinz, Coghlan, J. Gerry, Lordan, James, Church, Colin, Howard, Luke S., Pepke-Zaba, Joanna, Toshner, Mark, Wort, Stephen J., Kiely, David G., Condliffe, Robin, Lawrie, Allan, Gräf, Stefan, Morrell, Nicholas W., Wilkins, Martin R., Prokopenko, Inga, Rhodes, Christopher J.

“…Pulmonary arterial hypertension (PAH) is characterised by pulmonary vascular remodelling causing premature death from right heart failure. Established DNA…”
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Bosutinib therapy resulting in severe deterioration of pre-existing pulmonary arterial hypertension by Hickey, Peter M, Thompson, Alfred A R, Charalampopoulos, Athanasios, Elliot, Charles A, Hamilton, Neil, Kiely, David G, Lawrie, Allan, Sabroe, Ian, Condliffe, Robin

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The Hepcidin/Ferroportin axis modulates proliferation of pulmonary artery smooth muscle cells by Ramakrishnan, Latha, Pedersen, Sofia L., Toe, Quezia K., West, Laura E., Mumby, Sharon, Casbolt, Helen, Issitt, Theo, Garfield, Benjamin, Lawrie, Allan, Wort, S. John, Quinlan, Gregory J.

“…Studies were undertaken to examine any role for the hepcidin/ferroportin axis in proliferative responses of human pulmonary artery smooth muscle cells…”
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Mendelian Randomization Study With Clinical Follow-Up Links Metabolites to Risk and Severity of Pulmonary Arterial Hypertension by Alhathli, Elham, Julian, Thomas, Girach, Zain Ul Abideen, Thompson, A A Roger, Rhodes, Christopher, Gräf, Stefan, Errington, Niamh, Wilkins, Martin R, Lawrie, Allan, Wang, Dennis, Cooper-Knock, Johnathan

“…Pulmonary arterial hypertension (PAH) exhibits phenotypic heterogeneity and variable response to therapy. The metabolome has been implicated in the…”
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TNF-related apoptosis-inducing ligand (TRAIL) regulates inflammatory neutrophil apoptosis and enhances resolution of inflammation by McGrath, Emmet E., Marriott, Helen M., Lawrie, Allan, Francis, Sheila E., Sabroe, Ian, Renshaw, Stephen A., Dockrell, David H., Whyte, Moira K. B.

“…The death ligand TRAIL plays a role in physiologic resolution of inflammation and exogenous TRAIL has potential therapeutic benefits in neutrophil‐dominant…”
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A diagnostic miRNA signature for pulmonary arterial hypertension using a consensus machine learning approach by Errington, Niamh, Iremonger, James, Pickworth, Josephine A., Kariotis, Sokratis, Rhodes, Christopher J., Rothman, Alexander MK, Condliffe, Robin, Elliot, Charles A., Kiely, David G., Howard, Luke S., Wharton, John, Thompson, A. A. Roger, Morrell, Nicholas W, Wilkins, Martin R., Wang, Dennis, Lawrie, Allan

“…Pulmonary arterial hypertension (PAH) is a rare but life shortening disease, the diagnosis of which is often delayed, and requires an invasive right heart…”
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Pulmonary Artery Denervation Reduces Pulmonary Artery Pressure and Induces Histological Changes in an Acute Porcine Model of Pulmonary Hypertension by Rothman, Alexander M.K, Arnold, Nadine D, Chang, William, Watson, Oliver, Swift, Andrew J, Condliffe, Robin, Elliot, Charlie A, Kiely, David G, Suvarna, S Kim, Gunn, Julian, Lawrie, Allan

“…BACKGROUND—Pulmonary arterial hypertension is a devastating disease with high morbidity and mortality and limited treatment options. Recent studies have shown…”
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Pulmonary Artery Denervation Attenuates Pulmonary Arterial Remodeling in Dogs With Pulmonary Arterial Hypertension Induced by Dehydrogenized Monocrotaline by Zhou, Ling, MD, Zhang, Juan, MD, Jiang, Xiao-Min, MD, Xie, Du-Jiang, MD, Wang, Jin-Song, MD, Li, Li, MD, Li, Bin, PhD, Wang, Zhi-Mei, MD, Rothman, Alexander M.K., MD, Lawrie, Allan, PhD, Chen, Shao-Liang, MD

“…Abstract Objectives This study aimed to investigate sympathetic nerve (SN) ultrastructural changes and hemodynamic and pulmonary artery (PA) pathological…”
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Eplerenone attenuates pathological pulmonary vascular rather than right ventricular remodeling in pulmonary arterial hypertension by Boehm, Mario, Arnold, Nadine, Braithwaite, Adam, Pickworth, Josephine, Lu, Changwu, Novoyatleva, Tatyana, Kiely, David G, Grimminger, Friedrich, Ghofrani, Hossein A, Weissmann, Norbert, Seeger, Werner, Lawrie, Allan, Schermuly, Ralph T, Kojonazarov, Baktybek

“…Aldosterone is a mineralocorticoid hormone critically involved in arterial blood pressure regulation. Although pharmacological aldosterone antagonism reduces…”
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Inhibition of tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) reverses experimental pulmonary hypertension by Hameed, Abdul G, Arnold, Nadine D, Chamberlain, Janet, Pickworth, Josephine A, Paiva, Claudia, Dawson, Sarah, Cross, Simon, Long, Lu, Zhao, Lan, Morrell, Nicholas W, Crossman, David C, Newman, Christopher M H, Kiely, David G, Francis, Sheila E, Lawrie, Allan

“…Pulmonary arterial hypertension (PAH) is a life-threatening disease characterized by the progressive narrowing and occlusion of small pulmonary arteries…”
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Training and clinical testing of artificial intelligence derived right atrial cardiovascular magnetic resonance measurements by Alandejani, Faisal, Alabed, Samer, Garg, Pankaj, Goh, Ze Ming, Karunasaagarar, Kavita, Sharkey, Michael, Salehi, Mahan, Aldabbagh, Ziad, Dwivedi, Krit, Mamalakis, Michail, Metherall, Pete, Uthoff, Johanna, Johns, Chris, Rothman, Alexander, Condliffe, Robin, Hameed, Abdul, Charalampoplous, Athanasios, Lu, Haiping, Plein, Sven, Greenwood, John P, Lawrie, Allan, Wild, Jim M, de Koning, Patrick J H, Kiely, David G, Van Der Geest, Rob, Swift, Andrew J

“…Right atrial (RA) area predicts mortality in patients with pulmonary hypertension, and is recommended by the European Society…”
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Soluble P-Selectin and von Willebrand Factor Rise in Healthy Volunteers Following Non-exertional Ascent to High Altitude by Turton, Helena A, Pickworth, Josephine, Paterson, Gordon G, Lawrie, Allan, Baillie, J Kenneth, Thompson, A A Roger

“…Reduced oxygen tensions experienced at high altitudes are thought to predispose to thrombosis, yet there are few studies linking hypoxia, platelet activation,…”
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