Search Results - "LAWRENCE, K. M"

Chondroprotection by urocortin involves blockade of the mechanosensitive ion channel Piezo1 by Lawrence, K. M., Jones, R. C., Jackson, T. R., Baylie, R. L., Abbott, B., Bruhn-Olszewska, B., Board, T. N., Locke, I. C., Richardson, S. M., Townsend, P. A.

“…Osteoarthritis (OA) is characterised by progressive destruction of articular cartilage and chondrocyte cell death. Here, we show the expression of the…”
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Locally advanced rectal cancer : histopathological correlation and predictive accuracy of serial MRI after neoadjuvant chemotherapy by JOHNSTON, D. F, LAWRENCE, K. M, SIZER, B. F, ARULAMPALAM, T. H. A, MOTSON, R. W, DOVE, E, LACEY, N

“…The accuracy of MRI after long-course chemoradiotherapy (CRT) in locally advanced rectal cancer (LARC) has been questioned. We have evaluated our experience of…”
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The Urocortins: mechanisms of cardioprotection and therapeutic potential by Lawrence, K M, Latchman, D S

“…The study of the Urocortin family of peptides is becoming increasingly important clinically, as new discoveries have revealed that their roles in the body are…”
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Protective effects of the urocortin homologues stresscopin (SCP) and stresscopin-related peptide (SRP) against hypoxia/reoxygenation injury in rat neonatal cardiomyocytes by Chanalaris, A., Lawrence, K.M., Stephanou, A., Knight, R.D., Hsu, S.Y., Hsueh, A.J.W., Latchman, D.S.

“…Urocortin (UCN), a member of the Corticotropin-Releasing Factor (CRF) family of peptides is a well described cardioprotective agent. UCN is able to bind to two…”
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Quantitative assessment of cardiac myocyte apoptosis in tissue sections using the fluorescence-based tunel technique enhanced with counterstains by Scarabelli, T.M, Knight, R.A, Rayment, N.B, Cooper, T.J, Stephanou, A, Brar, B.K, Lawrence, K.M, Santilli, G, Latchman, D.S, Baxter, G.F, Yellon, D.M

“…Apoptosis is a distinct form of cell death, induced, for example, by ischaemia/reperfusion injury, that results in characteristic alterations in cell…”
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Urocortin – From Parkinson's disease to the skeleton by Lawrence, K.M., Jackson, T.R., Jamieson, D., Stevens, A., Owens, G., Sayan, B.S., Locke, I.C., Townsend, P.A.

“…Urocortin (Ucn 1), a 40 amino acid long peptide related to corticotropin releasing factor (CRF) was discovered 19 years ago, based on its sequence homology to…”
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Urocortin protects chondrocytes from NO-induced apoptosis: a future therapy for osteoarthritis? by Intekhab-Alam, N Y, White, O B, Getting, S J, Petsa, A, Knight, R A, Chowdrey, H S, Townsend, P A, Lawrence, K M, Locke, I C

“…Osteoarthritis (OA) is characterized by a loss of joint mobility and pain resulting from progressive destruction and loss of articular cartilage secondary to…”
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Characterisation of C101248: A novel selective THIK-1 channel inhibitor for the modulation of microglial NLRP3-inflammasome by Ossola, Bernardino, Rifat, Ali, Rowland, Anna, Hunter, Helen, Drinkall, Samuel, Bender, Clare, Hamlischer, Mayida, Teall, Martin, Burley, Russell, Barker, Daneil F., Cadwalladr, David, Dickson, Louise, Lawrence, Jason M.K., Harvey, Jenna R.M., Lizio, Marina, Xu, Xiao, Kavanagh, Edel, Cheung, Toni, Sheardown, Steve, Lawrence, Catherine B., Harte, Michael, Brough, David, Madry, Christian, Matthews, Kim, Doyle, Kevin, Page, Keith, Powell, Justin, Brice, Nicola L., Bürli, Roland W., Carlton, Mark B., Dawson, Lee A.

“…Neuroinflammation, specifically the NLRP3 inflammasome cascade, is a common underlying pathological feature of many neurodegenerative diseases. Evidence…”
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KATP channel gene expression is induced by urocortin and mediates its cardioprotective effect by LAWRENCE, K. M, CHANALARIS, A, KNIGHT, R. A, LATCHMAN, D. S, SCARABELLI, T, HUBANK, M, PASINI, E, TOWNSEND, P. A, COMINI, L, FERRARI, R, TINKER, A, STEPHANOU, A

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Urocortin protects cardiac myocytes from ischemia/reperfusion injury by attenuating calcium insensitive phospholipase A2 gene expression by Lawrence, Kevin M., Scarabelli, Tiziano M., Turtle, Lance, Chanalaris, Anastasios, Townsend, Paul A., Carroll, Christopher J., Hubank, Mike, Stephanou, Anastasis, Knight, Richard A., Latchman, David S.

“…ABSTRACT We have used Affymetrix gene chip technology to look for changes in gene expression caused by a 24 h exposure of rat primary neonatal cardiac myocytes…”
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Alpha-1-acid glycoprotein in major depressive and eating disorders by Healy, D, Calvin, J, Whitehouse, A M, White, W, Wilton-Cox, H, Theodorou, A E, Lawrence, K M, Horton, R W, Paykel, E S

“…Plasma alpha 1-acid glycoprotein (AGP) levels were measured in 49 subjects with major depressive disorder, 15 subjects with anorexia nervosa and 18 subjects…”
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[ 3H] Imipramine binding in brain samples from depressed suicides and controls: 5-HT uptake sites compared with sites defined by desmethylimipramine by Lawrence, Kevin M., Kanagasundaram, Mohan, Lowther, Sandra, Katona, Cornelius L.E., Crompton, M.Rufus, Horton, Roger W.

“…Using desmethylimipramine (DMI) defined and Na + dependent [ 3H]imipramine binding, we have examined both 5-HT uptake sites and sites unrelated to 5-HT uptake,…”
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K(ATP) channel gene expression is induced by urocortin and mediates its cardioprotective effect by Lawrence, K M, Chanalaris, A, Scarabelli, T, Hubank, M, Pasini, E, Townsend, P A, Comini, L, Ferrari, R, Tinker, A, Stephanou, A, Knight, R A, Latchman, D S

“…Urocortin is a novel cardioprotective agent that can protect cardiac myocytes from the damaging effects of ischemia/reperfusion both in culture and in the…”
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BAG-1 Proteins Protect Cardiac Myocytes from Simulated Ischemia/Reperfusion-induced Apoptosis via an Alternate Mechanism of Cell Survival Independent of the Proteasome by Townsend, Paul A, Cutress, Ramsey I, Carroll, Christopher J, Lawrence, Kevin M, Scarabelli, Tiziano M, Packham, Graham, Stephanou, Anastasis, Latchman, David S

“…BAG-1 ( B cl-2-associated a thano g ene- 1 ) proteins interact with the HSC70 and HSP70 heat shock proteins and have been proposed to promote cell survival by…”
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Enhanced displacement of [ [formula omitted]]imipramine, but not [ [formula omitted]]paroxetine binding by plasma from depressed patients by Lawrence, Kevin M, Lowther, Sandra, Falkowski, Jan, Jacobson, Robin R, Horton, Roger W

“…Plasma from healthy subjects inhibited the binding of [ 3 H ]imipramine competitively and [ 3 H ]paroxetine non-competitively to platelet membranes in a…”
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Brain 5-hydroxytryptamine uptake sites labeled with [3H]paroxetine in antidepressant drug-treated depressed suicide victims and controls by LAWRENCE, K. M, DE PAERMENTIER, F, LOWTHER, S, CROMPTON, M. R, KATONA, C. L. E, HORTON, R. W

“…Saturation binding of [3H]paroxetine was performed in 10 brain regions from a group of suicide victims who had a firm, retrospective diagnosis of depression…”
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CRH-like peptides protect cardiac myocytes from lethal ischaemic injury by Brar, Bhawanjit K, Stephanou, Anastasis, Okosi, Anne, Lawrence, Kevin M, Knight, Richard A, Marber, Michael S, Latchman, David S

“…Simulated ischaemia causes both necrotic and apoptotic death of primary cultures of neonatal rat cardiac myocytes. Simulated ischaemia is associated with…”
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Platelet 5-HT uptake sites, labelled with [3H] paroxetine, in controls and depressed patients before and after treatment with fluoxetine or lofepramine by LAWRENCE, K. M, KATONA, C. L. E, ABOU-SALEH, M. T, ROBERTSON, M. M, NAIRAC, B. L, EDWARDS, D. R. L, BURNS, R. A, HARRISON, D. A, HORTON, R. W

“…Platelet [3H] paroxetine binding was measured in 73 depressed patients and in 64 healthy volunteers. No differences were found in Bmax or Kd either overall, or…”
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Investigating the endothelin receptor antagonist aprocitentan in resistant hypertension: design and baseline characteristics of the PRECISION study by Danaietash, P, Verweij, P, Wang, J, Dresser, G, Kantola, I, Lawrence, M K, Narkiewicz, K, Schlaich, M, Bellet, M

“…Abstract   The endothelin (ET) system plays an important role in hypertension, especially in volume and salt-dependent forms, which are common in patients with…”
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Growth hormone and physiological responses to clonidine in depression by Katona, C L, Healy, D, Paykel, E S, Theodorou, A E, Lawrence, K M, Whitehouse, A, White, B, Horton, R W

“…Clonidine (1.3 micrograms/kg) was administered to 62 control and 55 depressed patients free of psychoactive drugs for at least 7 days and fasted overnight…”
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