Search Results - "LAW, Debbie"

PDL241, a novel humanized monoclonal antibody, reveals CD319 as a therapeutic target for rheumatoid arthritis by Woo, Jacky, Vierboom, Michel P M, Kwon, Hakju, Chao, Debra, Ye, Shiming, Li, Jianmin, Lin, Karen, Tang, Irene, Belmar, Nicole A, Hartman, Taymar, Breedveld, Elia, Vexler, Vladimir, 't Hart, Bert A, Law, Debbie A, Starling, Gary C

“…Targeting the CD20 antigen has been a successful therapeutic intervention in the treatment of rheumatoid arthritis (RA). However, in some patients with an…”
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Integrin cytoplasmic tyrosine motif is required for outside-in αIIbβ3 signalling and platelet function by Phillips, David R, Law, Debbie A, DeGuzman, Francis R, Heiser, Patrick, Ministri-Madrid, Kathleen, Killeen, Nigel

“…Integrins not only bind adhesive ligands, they also act as signalling receptors. Both functions allow the integrin αIIbβ3 to mediate platelet aggregation…”
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Functional Characterization of N297A, A Murine Surrogate for low-Fc Binding Anti-Human CD3 Antibodies by Chao, Debra T., Ma, Xiaohong, Li, Olga, Park, Hyunjoo, Law, Debbie

“…Several low- or non-FcR binding anti-human CD3 monoclonal antibodies have been under investigation for the treatment of autoimmune diseases. To model the…”
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E-selectin up-regulation allows for targeted drug delivery in prostate cancer by BHASKAR, Vinay, LAW, Debbie A, PONG, Melody, POWERS, Rick, SENTER, Peter, STOCKETT, David, SUTHERLAND, Robert L, VON FREEDEN-JEFFRY, Ursula, WILLHITE, Dorian, MURRAY, Richard, AFAR, Daniel E. H, RAMAKRISHNAN, Vanitha, IBSEN, Eric, BREINBERG, Danna, CASS, Kellie M, DUBRIDGE, Robert B, EVANGELISTA, Ferdinand, HENSHALL, Susan M, HEVEZI, Peter, MILLER, Jennifer C

“…We have used the Eos Hu03 GeneChip array, which represents over 92% of the transcribed human genome, to measure gene expression in a panel of normal and…”
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Dissociation of efficacy and cytokine release mediated by an Fc-modified anti-CD3 mAb in a chronic experimental autoimmune encephalomyelitis model by Belmar, Nicole A, Lombardo, John R, Chao, Debra T, Li, Olga, Ma, Xiaohong, Pong-Afar, Melody, Law, Debbie A, Starling, Gary C

“…Abstract Humanization and modification of the Fc region of anti-human CD3 mAbs have greatly expanded their potential use in chronic T cell mediated diseases…”
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Stimulation of protein tyrosine phosphorylation by the B-lymphocyte antigen receptor by Gold, Michael R, Law, Debbie A, DeFranco, Anthony L

“…Signalling by membrane immunoglobulin, the B-lymphocyte antigen receptor, regulates B-cell maturation and activation. Crosslinking of membrane immunoglobulin…”
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Anti-CS1 humanized monoclonal antibody HuLuc63 inhibits myeloma cell adhesion and induces antibody-dependent cellular cytotoxicity in the bone marrow milieu by Tai, Yu-Tzu, Dillon, Myles, Song, Weihua, Leiba, Merav, Li, Xian-Feng, Burger, Peter, Lee, Alfred I., Podar, Klaus, Hideshima, Teru, Rice, Audie G., van Abbema, Anne, Jesaitis, Lynne, Caras, Ingrid, Law, Debbie, Weller, Edie, Xie, Wanling, Richardson, Paul, Munshi, Nikhil C., Mathiot, Claire, Avet-Loiseau, Hervé, Afar, Daniel E.H., Anderson, Kenneth C.

“…Currently, no approved monoclonal antibody (mAb) therapies exist for human multiple myeloma (MM). Here we characterized cell surface CS1 as a novel MM antigen…”
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Preclinical validation of anti-TMEFF2-auristatin E–conjugated antibodies in the treatment of prostate cancer by Afar, Daniel E H, Bhaskar, Vinay, Ibsen, Eric, Breinberg, Danna, Henshall, Susan M, Kench, James G, Drobnjak, Marija, Powers, Rick, Wong, Melanie, Evangelista, Ferdinand, O'Hara, Chris, Powers, David, DuBridge, Robert B, Caras, Ingrid, Winter, Ruth, Anderson, Terri, Solvason, Nanette, Stricker, Phillip D, Cordon-Cardo, Carlos, Scher, Howard I, Grygiel, John J, Sutherland, Robert L, Murray, Richard, Ramakrishnan, Vanitha, Law, Debbie A

“…Current treatments for advanced stage, hormone-resistant prostate cancer are largely ineffective, leading to high patient mortality and morbidity. To fulfill…”
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Nanobodies – from llamas to therapeutic proteins by Kolkman, Joost A., Law, Debbie A.

“…Antibodies have been a focus of drug development since the approval of Orthoclone ® OKT3 in 1986. However these large biologics are not without limitations…”
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Tyrosine Phosphorylation of the β3 Cytoplasmic Domain Mediates Integrin-Cytoskeletal Interactions by Jenkins, Alison L., Nannizzi-Alaimo, Lisa, Silver, Debra, Sellers, James R., Ginsberg, Mark H., Law, Debbie A., Phillips, David R.

“…Tyrosine phosphorylation of the β3 subunit of the major platelet integrin αIIbβ3 has been shown to occur during thrombin-induced platelet aggregation (1). We…”
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Anti-CSl humanized monoclonal antibody HuLuc63 inhibits myeloma cell adhesion and induces antibody-dependent cellular cytotoxicity in the bone marrow milieu by TAI, Yu-Tzu, DILLON, Myles, VAN ABBEMA, Anne, JESAITIS, Lynne, CARAS, Ingrid, LAW, Debbie, WELLER, Edie, WANLING XIE, RICHARDSON, Paul, MUNSHI, Nikhil C, MATHIOT, Claire, AVET-LOISEAU, Hervé, WEIHUA SONG, AFAR, Daniel E. H, ANDERSON, Kenneth C, LEIBA, Merav, LI, Xian-Feng, BURGER, Peter, LEE, Alfred I, PODAR, Klaus, HIDESHIMA, Teru, RICE, Audie G

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Signal transduction pathways for mouse platelet membrane adhesion receptors by Law, D A, Nannizzi-Alaimo, L, Cowan, K J, Prasad, K S, Ramakrishnan, V, Phillips, D R

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Abstract 586: Discovery of a novel TIM3 binding partner and a key role for TIM3 on macrophages: Identification of specific antibodies capable of converting immune-suppressive macrophages to immune-enhancing by Wong, Jamie, Phennicie, Ryan, Feldman, Igor, Sathyanarayanan, Sriram, Shaffer, Don, Zafari, Mohammad, Sazinsky, Steve, Crook, Kenneth, Law, Debbie

“…Abstract Our Translational Science Platform uses an unbiased bioinformatics-based approach to interrogate particular cell types within the tumor…”
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Tyrosine Phosphatases and the Antibody Response by DeFranco, Anthony L., Law, Debbie A.

“…Research indicates that SH2-containing protein tyrosine phosphatases (PTP1C) play a major role in the regulation of signaling by receptors that use tyrosine…”
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Outside-in Integrin Signal Transduction by Law, Debbie A., Nannizzi-Alaimo, Lisa, Phillips, David R.

“…α β -(GPIIb-IIIa) is the most abundant integrin expressed on platelets and plays a critical role in platelet aggregation and normal hemostasis. In response…”
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A Consideration of the Retention Ratio and the Impact on Selected Management and Investment Performance Metrics by Law, Debbie

“…They would possibly be less contentious if there was conclusive proof that managers were better allocators of capital generated through income retained than…”
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Eradication of Tumors in Pre-Clinical Models of Multiple Myeloma by Anti-CS1 Monoclonal Antibody HuLuc63: Mechanism of Action Studies by Rice, Audie, Dillon, Myles, van Abbema, Anne, Jesaitis, Lynne, Wong, Melanie, Lawson, Stacey, Liu, Gao, Zhang, Yin, Powers, David, Rhodes, Susan, Caras, Ingrid, Law, Debbie, Afar, Daniel

“…Introduction: We have recently shown that CS1 (CD2 subset 1, CRACC, SLAMF7), a cell surface glycoprotein of the CD2 family, is uniformly expressed on myeloma…”
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In Vivo Validation of Antibodies Against Ov1, a Novel Ovarian Cancer Target by Bhaskar, Vinay, Law, Debbie, Ibsen, Eric, Liu, Gao, Seto, Pui

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Sa.3. Efficacy of an Anti-Mouse Cd3 Fc Modified Antibody On Experimental Autoimmune Encephalomyelitis(EAE) by Belmar, Nicole, Chao, Debra, Li, Olga, Ibsen, Eric, Gish, Kurt, Tanlimco, Sonia, Pong, Melody, Law, Debbie

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Sa.138. Characterization of An Fc Modified Anti-Mouse CD3 Antibody in a Murine Inflammatory Bowel Disease (IBD) Model by Chao, Debra, Ma, Shirley, Li, Olga, Park, Summer, Irrinki, Alivelu, Emek, Tina, Law, Debbie

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