Search Results - "LAUFER, D"

Disease modeling of a mutation in α‐actinin 2 guides clinical therapy in hypertrophic cardiomyopathy by Prondzynski, Maksymilian, Lemoine, Marc D, Zech, Antonia TL, Horváth, András, Di Mauro, Vittoria, Koivumäki, Jussi T, Kresin, Nico, Busch, Josefine, Krause, Tobias, Krämer, Elisabeth, Schlossarek, Saskia, Spohn, Michael, Friedrich, Felix W, Münch, Julia, Laufer, Sandra D, Redwood, Charles, Volk, Alexander E, Hansen, Arne, Mearini, Giulia, Catalucci, Daniele, Meyer, Christian, Christ, Torsten, Patten, Monica, Eschenhagen, Thomas, Carrier, Lucie

“…Hypertrophic cardiomyopathy (HCM) is a cardiac genetic disease accompanied by structural and contractile alterations. We identified a rare c.740C>T (p.T247M)…”
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Cellular delivery of small interfering RNA by a non-covalently attached cell-penetrating peptide: quantitative analysis of uptake and biological effect by Veldhoen, Sandra, Laufer, Sandra D, Trampe, Alexander, Restle, Tobias

“…Cell-penetrating peptides (CPPs) have evolved as promising new tools to deliver nucleic acids into cells. So far, the majority of these delivery systems…”
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MicroRNA-mediated regulation of gene expression is affected by disease-associated SNPs within the 3′-UTR via altered RNA structure by Haas, Ulrike, Sczakiel, Georg, Laufer, Sandra

“…Single nucleotide polymorphisms (SNPs) in microRNAs (miRNAs) or their target sites (miR-SNPs) within the 3′-UTR of mRNAs are increasingly thought to play a…”
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Generation of a patient-specific hiPS cell line with heterozygous GNB2 mutation (UKMi003-A) causative for human sinus node dysfunction and a corresponding CRISPR/Cas9-corrected isogenic control (UKMi004-A) by Kayser, Anne, Dittmann, Sven, Hamidi, Jassin, Laufer, Sandra D., Krampe, Ramona, Mearini, Giulia, Hansen, Arne, Schulze-Bahr, Eric

“…The heterozygous mutation c.155G > T in GNB2 clinically leads to sinus bradycardia and sinus node dysfunction. Here, patient-specific skin fibroblasts of the…”
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Evaluation of MYBPC3 trans-Splicing and Gene Replacement as Therapeutic Options in Human iPSC-Derived Cardiomyocytes by Prondzynski, Maksymilian, Krämer, Elisabeth, Laufer, Sandra D., Shibamiya, Aya, Pless, Ole, Flenner, Frederik, Müller, Oliver J., Münch, Julia, Redwood, Charles, Hansen, Arne, Patten, Monica, Eschenhagen, Thomas, Mearini, Giulia, Carrier, Lucie

“…Gene therapy is a promising option for severe forms of genetic diseases. We previously provided evidence for the feasibility of trans-splicing, exon skipping,…”
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Recent developments in peptide-based nucleic acid delivery by Veldhoen, Sandra, Laufer, Sandra D, Restle, Tobias

“…Despite the fact that non-viral nucleic acid delivery systems are generally considered to be less efficient than viral vectors, they have gained much interest…”
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Oxytocin response to an experimental psychosocial challenge in adults exposed to traumatic experiences during childhood or adolescence by Pierrehumbert, B, Torrisi, R, Laufer, D, Halfon, O, Ansermet, F, Beck Popovic, M

“…Abstract Long-term implications of the exposure to traumatizing experiences during childhood or adolescence, such as sexual abuse, or cancer, have been…”
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Physioxia rewires mitochondrial complex composition to protect stem cell viability by Raabe, Janice, Wittig, Ilka, Laurette, Patrick, Stathopoulou, Konstantina, Brand, Theresa, Schulze, Thomas, Klampe, Birgit, Orthey, Ellen, Cabrera-Orefice, Alfredo, Meisterknecht, Jana, Thiemann, Ellen, Laufer, Sandra D., Shibamiya, Aya, Reinsch, Marina, Fuchs, Sigrid, Kaiser, Jennifer, Yang, Jiaqi, Zehr, Simonida, Wrona, Kinga M., Lorenz, Kristina, Lukowski, Robert, Hansen, Arne, Gilsbach, Ralf, Brandes, Ralf P., Ulmer, Bärbel M., Eschenhagen, Thomas, Cuello, Friederike

“…Human induced pluripotent stem cells (hiPSCs) are an invaluable tool to study molecular mechanisms on a human background. Culturing stem cells at an oxygen…”
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Disease modeling of a mutation in α‐actinin 2 guides clinical therapy in hypertrophic cardiomyopathy by Prondzynski, Maksymilian, Lemoine, Marc D, Zech, Antonia TL, Horváth, András, Di Mauro, Vittoria, Koivumäki, Jussi T, Kresin, Nico, Busch, Josefine, Krause, Tobias, Krämer, Elisabeth, Schlossarek, Saskia, Spohn, Michael, Friedrich, Felix W, Münch, Julia, Laufer, Sandra D, Redwood, Charles, Volk, Alexander E, Hansen, Arne, Mearini, Giulia, Catalucci, Daniele, Meyer, Christian, Christ, Torsten, Patten, Monica, Eschenhagen, Thomas, Carrier, Lucie

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Low-threshold SARS-CoV-2 testing facility for hospital staff: Prevention of COVID-19 outbreaks? by Menting, T., Krause, K., Benz-Tettey, F., Boehringer, R., Laufer, D., Gruber, B., Crump, M., Schieferdecker, R., Reuhl, S., Kaeferstein, A., Engelhart, S., Streeck, H., Marx, B., Aldabbagh, S., Eis-Hübinger, A., Rockstroh, J.K., Schwarze-Zander, C.

“…The ongoing global SARS-CoV-2 pandemic has caused over 4.7 million infections greatly challenging healthcare workers (HCW) and medical institutions worldwide…”
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Yield and nitrogen use efficiency of fodder and sugar beet (Beta vulgaris L.) in contrasting environments of northwestern Europe by Laufer, D., Nielsen, O., Wilting, P., Koch, H.-J., Märländer, B.

“…•Yield and nitrogen utilization efficiency is higher for sugar beet than fodder beet.•Increased yield is caused by a higher sucrose concentration in taproot…”
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Generation of bi-allelic MYBPC3 truncating mutant and isogenic control from an iPSC line of a patient with hypertrophic cardiomyopathy by Warnecke, Nele, Ulmer, Bärbel M., Laufer, Sandra D., Shibamiya, Aya, Krämer, Elisabeth, Neuber, Christiane, Hanke, Sophia, Behrens, Charlotta, Loos, Malte, Münch, Julia, Kühnisch, Jirko, Klaassen, Sabine, Eschenhagen, Thomas, Patten-Hamel, Monica, Carrier, Lucie, Mearini, Giulia

“…MYBPC3 is the most frequently affected gene in hypertrophic cardiomyopathy (HCM), which is an autosomal-dominant cardiac disease caused by mutations in…”
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Activity of comets at large heliocentric distances pre-perihelion by Meech, K.J., Pittichová, J., Bar-Nun, A., Notesco, G., Laufer, D., Hainaut, O.R., Lowry, S.C., Yeomans, D.K., Pitts, M.

“…We present observational data for two long-period and three dynamically new comets observed at heliocentric distances between 5.8 to 14.0 AU. All of the comets…”
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016 Case report: Turner syndrome by Laufer, D.

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Postlicensure evaluation of the effectiveness of seven valent pneumococcal conjugate vaccine by BLACK, STEVEN B, SHINEFIELD, HENRY R, HANSEN, JOHN, ELVIN, LAURA, LAUFER, DAGNA, MALINOSKI, FRANK

“…OBJECTIVE.To evaluate the impact of the introduction and routine use of seven valent pneumococcal conjugate vaccine on the epidemiology of invasive…”
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Chemical composition of simulated Titan's midatmospheric aerosols by Jacovi, R., Laufer, D., Dimitrov, V., Bar-Nun, A.

“…A large fraction of the major unsaturated species (C2H2 C2H4, HCN, and HC3N) with mixing ratios of about 3 × 10−6, 10−7–10−8, 3 × 10−7, and 10−9–10−10 reside…”
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Can Simulators Replace Traditional Multiple-Choice Exams in Assessment of Novice Trainees’ Understanding of Hemodynamics Concepts? by Mukdad, L, Laufer, D, Frank, P, Sareh, S, Toppen, W, Huang, Y, Melega, W, Napolitano, J, Benharash, P

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Small Molecule Inhibitors Targeting HIV-1 Reverse Transcriptase Dimerization by Grohmann, Dina, Corradi, Valentina, Elbasyouny, Mira, Baude, Annika, Horenkamp, Florian, Laufer, Sandra D, Manetti, Fabrizio, Botta, Maurizio, Restle, Tobias

“…The enzymatic activities of human immunodeficiency virus type 1 (HIV-1) reverse transcriptase (RT) are strictly correlated with the dimeric forms of this vital…”
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Comparison between the findings of Deep Impact and our experimental results on large samples of gas-laden amorphous ice by Bar-Nun, A., Pat-El, I., Laufer, D.

“…The findings of Deep Impact on the structure and composition of Tempel-1 are compared with our experimental results on large (20 cm diameter and up to 10 cm…”
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An experimental study of the formation of an ice crust and migration of water vapor in a comet's upper layers by Pat-El, I., Laufer, D., Notesco, G., Bar-Nun, A.

“…From recent close encounters with Comets Wild-2 and Tempel 1 we learned that their surfaces are very rugged and no simple uniform layers model can be applied…”
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