Search Results - "LAUER, Georg"

Omics studies in gastroenterological and hepatological patient populations: current impact and future promise exemplified by a large study of HCV-infected livers by Lauer, Georg M

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CD39 Expression Identifies Terminally Exhausted CD8+ T Cells by Gupta, Prakash K, Godec, Jernej, Wolski, David, Adland, Emily, Yates, Kathleen, Pauken, Kristen E, Cosgrove, Cormac, Ledderose, Carola, Junger, Wolfgang G, Robson, Simon C, Wherry, E John, Alter, Galit, Goulder, Philip J R, Klenerman, Paul, Sharpe, Arlene H, Lauer, Georg M, Haining, W Nicholas

“…Exhausted T cells express multiple co-inhibitory molecules that impair their function and limit immunity to chronic viral infection. Defining novel markers of…”
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Immune Responses to Hepatitis C Virus (HCV) Infection and the Prospects for an Effective HCV Vaccine or Immunotherapies by Lauer, Georg M.

“…Infection with hepatitis C virus (HCV) typically leads to persistent infection, with >170 million people estimated to be affected worldwide, putting them at…”
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People With Hepatitis B Virus/Human Immunodeficiency Virus Coinfection Should Be Prioritized in HBV Cure Research by Vinikoor, Michael J, Lauer, Georg M

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Fc Glycan-Mediated Regulation of Placental Antibody Transfer by Jennewein, Madeleine F., Goldfarb, Ilona, Dolatshahi, Sepideh, Cosgrove, Cormac, Noelette, Francesca J., Krykbaeva, Marina, Das, Jishnu, Sarkar, Aniruddh, Gorman, Matthew J., Fischinger, Stephanie, Boudreau, Carolyn M., Brown, Joelle, Cooperrider, Jennifer H., Aneja, Jasneet, Suscovich, Todd J., Graham, Barney S., Lauer, Georg M., Goetghebuer, Tessa, Marchant, Arnaud, Lauffenburger, Douglas, Kim, Arthur Y., Riley, Laura E., Alter, Galit

“…Despite the worldwide success of vaccination, newborns remain vulnerable to infections. While neonatal vaccination has been hampered by maternal…”
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The epigenetic landscape of T cell exhaustion by Sen, Debattama R., Kaminski, James, Barnitz, R. Anthony, Kurachi, Makoto, Gerdemann, Ulrike, Yates, Kathleen B., Tsao, Hsiao-Wei, Godec, Jernej, LaFleur, Martin W., Brown, Flavian D., Tonnerre, Pierre, Chung, Raymond T., Tully, Damien C., Allen, Todd M., Frahm, Nicole, Lauer, Georg M., Wherry, E. John, Yosef, Nir, Haining, W. Nicholas

“…Exhausted T cells in cancer and chronic viral infection express distinctive patterns of genes, including sustained expression of programmed cell death protein…”
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Implementation of a controlled human infection model for evaluation of HCV vaccine candidates by Barnes, Eleanor, Cooke, Graham S, Lauer, Georg M, Chung, Raymond T

“…Hepatitis C virus (HCV) remains a major global health concern. Directly acting antiviral (DAA) drugs have transformed the treatment of HCV. However, it has…”
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Epigenetic scars of CD8+ T cell exhaustion persist after cure of chronic infection in humans by Yates, Kathleen B., Tonnerre, Pierre, Martin, Genevieve E., Gerdemann, Ulrike, Al Abosy, Rose, Comstock, Dawn E., Weiss, Sarah A., Wolski, David, Tully, Damien C., Chung, Raymond T., Allen, Todd M., Kim, Arthur Y., Fidler, Sarah, Fox, Julie, Frater, John, Lauer, Georg M., Haining, W. Nicholas, Sen, Debattama R.

“…T cell exhaustion is an induced state of dysfunction that arises in response to chronic infection and cancer. Exhausted CD8 + T cells acquire a distinct…”
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Progenitor and Terminal Subsets of CD8⁺ T Cells Cooperate to Contain Chronic Viral Infection by Paley, Michael A., Kroy, Daniela C., Odorizzi, Pamela M., Johnnidis, Jonathan B., Dolfi, Douglas V., Barnett, Burton E., Bikoff, Elizabeth K., Robertson, Elizabeth J., Lauer, Georg M., Reiner, Steven L., Wherry, E. John

“…Chronic infections strain the regenerative capacity of antiviral T lymphocyte populations, leading to failure in long-term immunity. The cellular and molecular…”
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Bystander Chronic Infection Negatively Impacts Development of CD8+ T Cell Memory by Stelekati, Erietta, Shin, Haina, Doering, Travis A., Dolfi, Douglas V., Ziegler, Carly G., Beiting, Daniel P., Dawson, Lucas, Liboon, Jennifer, Wolski, David, Ali, Mohammed-Alkhatim A., Katsikis, Peter D., Shen, Hao, Roos, David S., Haining, W. Nicholas, Lauer, Georg M., Wherry, E. John

“…Epidemiological evidence suggests that chronic infections impair immune responses to unrelated pathogens and vaccines. The underlying mechanisms, however, are…”
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A prophylactic hepatitis C virus vaccine: A distant peak still worth climbing by Baumert, Thomas F, Fauvelle, Catherine, Chen, Diana Y, Lauer, Georg M

“…Summary Hepatitis C virus (HCV) infects an estimated more than 150 million people and is a leading cause of liver disease worldwide. The development of…”
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The effects of female sex, viral genotype, and IL28B genotype on spontaneous clearance of acute hepatitis C virus infection by Grebely, Jason, Page, Kimberly, Sacks‐Davis, Rachel, Loeff, Maarten Schim, Rice, Thomas M., Bruneau, Julie, Morris, Meghan D., Hajarizadeh, Behzad, Amin, Janaki, Cox, Andrea L., Kim, Arthur Y., McGovern, Barbara H., Schinkel, Janke, George, Jacob, Shoukry, Naglaa H., Lauer, Georg M., Maher, Lisa, Lloyd, Andrew R., Hellard, Margaret, Dore, Gregory J., Prins, Maria

“…Although 20%‐40% of persons with acute hepatitis C virus (HCV) infection demonstrate spontaneous clearance, the time course and factors associated with…”
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Early Transcriptional Divergence Marks Virus-Specific Primary Human CD8+ T Cells in Chronic versus Acute Infection by Wolski, David, Foote, Peter K., Chen, Diana Y., Lewis-Ximenez, Lia L., Fauvelle, Catherine, Aneja, Jasneet, Walker, Andreas, Tonnerre, Pierre, Torres-Cornejo, Almudena, Kvistad, Daniel, Imam, Sabrina, Waring, Michael T., Tully, Damien C., Allen, Todd M., Chung, Raymond T., Timm, Jörg, Haining, W. Nicholas, Kim, Arthur Y., Baumert, Thomas F., Lauer, Georg M.

“…Distinct molecular pathways govern the differentiation of CD8+ effector T cells into memory or exhausted T cells during acute and chronic viral infection, but…”
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Cutting Edge: B Cell-Intrinsic T-bet Expression Is Required To Control Chronic Viral Infection by Barnett, Burton E, Staupe, Ryan P, Odorizzi, Pamela M, Palko, Olesya, Tomov, Vesselin T, Mahan, Alison E, Gunn, Bronwyn, Chen, Diana, Paley, Michael A, Alter, Galit, Reiner, Steven L, Lauer, Georg M, Teijaro, John R, Wherry, E John

“…The role of Ab and B cells in preventing infection is established. In contrast, the role of B cell responses in containing chronic infections remains poorly…”
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Aspirin for Metabolic Dysfunction–Associated Steatotic Liver Disease Without Cirrhosis: A Randomized Clinical Trial by Simon, Tracey G, Wilechansky, Robert M, Stoyanova, Stefania, Grossman, Alessandra, Dichtel, Laura E, Lauer, Georg M, Miller, Karen K, Hoshida, Yujin, Corey, Kathleen E, Loomba, Rohit, Chung, Raymond T, Chan, Andrew T

“…IMPORTANCE: Aspirin may reduce severity of metabolic dysfunction–associated steatotic liver disease (MASLD) and lower the incidence of end-stage liver disease…”
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Hepatitis B virus DNA and RNA persist in liver after serologic recovery in persons with hepatitis C virus by Grudda, Tanner, Thomas, David L, Kirk, Gregory D, Mehta, Shruti H, Astemborski, Jacquie, Lauer, Georg M, Balagopal, Ashwin, Thio, Chloe L

“…After recovery from a hepatitis B virus (HBV) infection, reactivation can occur with immunosuppression; thus, it is assumed that replication competent HBV…”
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Differentiation of exhausted CD8+ T cells after termination of chronic antigen stimulation stops short of achieving functional T cell memory by Tonnerre, Pierre, Wolski, David, Subudhi, Sonu, Aljabban, Jihad, Hoogeveen, Ruben C., Damasio, Marcos, Drescher, Hannah K., Bartsch, Lea M., Tully, Damien C., Sen, Debattama R., Bean, David J., Brown, Joelle, Torres-Cornejo, Almudena, Robidoux, Maxwell, Kvistad, Daniel, Alatrakchi, Nadia, Cui, Ang, Lieb, David, Cheney, James A., Gustafson, Jenna, Lewis-Ximenez, Lia L., Massenet-Regad, Lucile, Eisenhaure, Thomas, Aneja, Jasneet, Haining, W. Nicholas, Chung, Raymond T., Hacohen, Nir, Allen, Todd M., Kim, Arthur Y., Lauer, Georg M.

“…T cell exhaustion is associated with failure to clear chronic infections and malignant cells. Defining the molecular mechanisms of T cell exhaustion and…”
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Hepatitis C Virus Infection by Lauer, Georg M, Walker, Bruce D

“…Hepatitis C virus (HCV) infects an estimated 170 million persons worldwide and thus represents a viral pandemic, one that is five times as widespread as…”
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Hepatitis B virus infection and the immune response: The big questions by Boeijen, Lauke L., Hoogeveen, Ruben C., Boonstra, Andre, Lauer, Georg M.

“…Clinical events and the host immune response during hepatitis B virus (HBV) infection are intricately linked. Despite decades of research, important questions…”
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Hepatitis C Virus as a Unique Human Model Disease to Define Differences in the Transcriptional Landscape of T Cells in Acute versus Chronic Infection by Wolski, David, Lauer, Georg M

“…The hepatitis C virus is unique among chronic viral infections in that an acute outcome with complete viral elimination is observed in a minority of infected…”
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