Search Results - "LAUBE, BODO"

Thermophoretic analysis of ligand-specific conformational states of the inhibitory glycine receptor embedded in copolymer nanodiscs by Bernhard, Max, Laube, Bodo

“…The glycine receptor (GlyR), a member of the pentameric ligand-gated ion channel family (pLGIC), displays remarkable variations in the affinity and efficacy of…”
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Mutations in GRIN2A and GRIN2B encoding regulatory subunits of NMDA receptors cause variable neurodevelopmental phenotypes by Endele, Sabine, Rosenberger, Georg, Geider, Kirsten, Popp, Bernt, Tamer, Ceyhun, Stefanova, Irina, Milh, Mathieu, Kortum, Fanny, Fritsch, Angela, Pientka, Friederike K, Hellenbroich, Yorck, Kalscheuer, Vera M, Kohlhase, Jurgen, Moog, Ute, Rappold, Gudrun, Rauch, Anita, Ropers, Hans-Hilger, von Spiczak, Sarah, Tonnies, Holger, Villeneuve, Nathalie, Villard, Laurent, Zabel, Bernhard, Zenker, Martin, Laube, Bodo, Reis, Andre, Wieczorek, Dagmar, Van Maldergem, Lionel, Kutsche, Kerstin

“…N-methyl-D-aspartate (NMDA) receptors mediate excitatory neurotransmission in the mammalian brain. Two glycine-binding NR1 subunits and two glutamate-binding…”
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NMDA Receptor-Mediated Signaling Pathways Enhance Radiation Resistance, Survival and Migration in Glioblastoma Cells-A Potential Target for Adjuvant Radiotherapy by Müller-Längle, Adriana, Lutz, Henrik, Hehlgans, Stephanie, Rödel, Franz, Rau, Kerstin, Laube, Bodo

“…Glioblastoma is one of the most aggressive malignant brain tumors, with a survival time less than 15 months and characterized by a high radioresistance and the…”
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Coupling of a viral K+-channel with a glutamate-binding-domain highlights the modular design of ionotropic glutamate-receptors by Schönrock, Michael, Thiel, Gerhard, Laube, Bodo

“…Ionotropic glutamate receptors (iGluRs) mediate excitatory neuronal signaling in the mammalian CNS. These receptors are critically involved in diverse…”
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Analysis of M4 Transmembrane Segments in NMDA Receptor Function: A Negative Allosteric Modulatory Site at the GluN1 M4 is Determining the Efficiency of Neurosteroid Modulation by Langer, Kai, Müller-Längle, Adriana, Wempe, Jannik, Laube, Bodo

“…Ionotropic glutamate receptors (iGluRs) are tetrameric ligand-gated ion channels that play a crucial role in excitatory synaptic transmission in the central…”
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Impaired GABAergic transmission and altered hippocampal synaptic plasticity in collybistin-deficient mice by Papadopoulos, Theofilos, Korte, Martin, Eulenburg, Volker, Kubota, Hisahiko, Retiounskaia, Marina, Harvey, Robert J, Harvey, Kirsten, O'Sullivan, Gregory A, Laube, Bodo, Hülsmann, Swen, Geiger, Jörg R P, Betz, Heinrich

“…Collybistin (Cb) is a brain‐specific guanine nucleotide exchange factor that has been implicated in plasma membrane targeting of the postsynaptic scaffolding…”
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Probing the pharmacological properties of distinct subunit interfaces within heteromeric glycine receptors reveals a functional ββ agonist-binding site by Dutertre, Sébastien, Drwal, Malgorzata, Laube, Bodo, Betz, Heinrich

“…J. Neurochem. (2012) 122, 38–47. Synaptic glycine receptors (GlyRs) are hetero‐pentameric chloride channels composed of α and β subunits, which are activated…”
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An intramembrane aromatic network determines pentameric assembly of Cys-loop receptors by Haeger, Svenja, Laube, Bodo, Schmalzing, Günther, Betz, Heinrich, Detro-Dassen, Silvia, Kuzmin, Dmitry, Lang, Niklas, Tsetlin, Victor, Kilb, Michael

“…The Cys-loop receptors are pentameric ligand-gated ion channels important in fast synaptic transmission. By examining the pentamerization properties of…”
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Modulation of glycine receptor function: a novel approach for therapeutic intervention at inhibitory synapses? by Laube, Bodo, Maksay, Gábor, Schemm, Rudolf, Betz, Heinrich

“…Transmitter-gated ion channels mediate rapid synaptic transmission in the CNS and constitute important targets for many neuroactive drugs. Inhibitory glycine…”
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The N-terminal domains of both NR1 and NR2 subunits determine allosteric Zn2+ inhibition and glycine affinity of N-methyl-D-aspartate receptors by Madry, Christian, Mesic, Ivana, Betz, Heinrich, Laube, Bodo

“…The N-methyl-D-aspartate (NMDA) subtype of ionotropic glutamate receptors (iGluRs) is a tetrameric protein composed of homologous NR1 and NR2 subunits, which…”
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Deletion of the Mouse Glycine Transporter 2 Results in a Hyperekplexia Phenotype and Postnatal Lethality by Gomeza, Jesús, Ohno, Koji, Hülsmann, Swen, Armsen, Wencke, Eulenburg, Volker, Richter, Diethelm W, Laube, Bodo, Betz, Heinrich

“…The glycine transporter subtype 2 (GlyT2) is localized in the axon terminals of glycinergic neurons. Mice deficient in GlyT2 are normal at birth but during the…”
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Evidence for a Tetrameric Structure of Recombinant NMDA Receptors by Laube, Bodo, Kuhse, Jochen, Betz, Heinrich

“…The amino acids L-glutamate and glycine are essential agonists of the excitatory NMDA receptor, a subtype of the ionotropic glutamate receptor family. The…”
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Formation of NR1/NR2 and NR1/NR3 Heterodimers Constitutes the Initial Step in N-Methyl-D-aspartate Receptor Assembly by Schüler, Thomas, Mesic, Ivana, Madry, Christian, Bartholomäus, Ingo, Laube, Bodo

“…N-Methyl-d-aspartate (NMDA) receptors are tetrameric protein complexes composed of the glycine-binding NR1 subunit with a glutamate-binding NR2 and/or…”
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Molecular basis for convergent evolution of glutamate recognition by pentameric ligand-gated ion channels by Lynagh, Timothy, Beech, Robin N., Lalande, Maryline J., Keller, Kevin, Cromer, Brett A., Wolstenholme, Adrian J., Laube, Bodo

“…Glutamate is an indispensable neurotransmitter, triggering postsynaptic signals upon recognition by postsynaptic receptors. We questioned the phylogenetic…”
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Positive Modulatory Interactions of NMDA Receptor GluN1/2B Ligand Binding Domains Attenuate Antagonists Activity by Bledsoe, Douglas, Tamer, Ceyhun, Mesic, Ivana, Madry, Christian, Klein, Bradley G, Laube, Bodo, Costa, Blaise M

“…N-methyl D-aspartate receptors (NMDAR) play crucial role in normal brain function and pathogenesis of neurodegenerative and psychiatric disorders. Functional…”
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Comparative pharmacology of flatworm and roundworm glutamate-gated chloride channels: Implications for potential anthelmintics by Lynagh, Timothy, Cromer, Brett A., Dufour, Vanessa, Laube, Bodo

“…•Flatworm and roundworm glutamate-gated chloride channels (GluCls) were compared.•Several glutamate analogues activated both GluCls in the millimolar…”
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Molecular Determinants of Agonist Discrimination by NMDA Receptor Subunits: Analysis of the Glutamate Binding Site on the NR2B Subunit by Laube, Bodo, Hirai, Hirokazu, Sturgess, Mike, Betz, Heinrich, Kuhse, Jochen

“…NMDA receptors require both L-glutamate and the coagonist glycine for efficient channel activation. The glycine binding site of these heteromeric receptor…”
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Supralinear potentiation of NR1/NR3A excitatory glycine receptors by Zn²⁺ and NR1 antagonist by Madry, Christian, Betz, Heinrich, Geiger, Jörg R.P, Laube, Bodo

“…Coassembly of the glycine-binding NMDA receptor subunits NR1 and NR3A results in excitatory glycine receptors of low efficacy. Here, we report that micromolar…”
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Disruption of Interdomain Interactions in the Glutamate Binding Pocket Affects Differentially Agonist Affinity and Efficacy of N-methyl-d-aspartate Receptor Activation by Maier, Wolfgang, Schemm, Rudolf, Grewer, Christof, Laube, Bodo

“…In ionotropic glutamate receptors, agonist binding occurs in a conserved clam shell-like domain composed of the two lobes D1 and D2. Docking of glutamate into…”
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Kinetic and mutational analysis of Zn2+ modulation of recombinant human inhibitory glycine receptors by Laube, Bodo, Kuhse, Jochen, Betz, Heinrich

“…The effects of Zn 2+ on glycine receptor (GlyR) currents were analysed in Xenopus oocytes and human embryonic kidney cells expressing homomeric human wild-type…”
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