Search Results - "LAU, Cecilia"

Curcumin: An age-old anti-inflammatory and anti-neoplastic agent by Fadus, Matthew C., Lau, Cecilia, Bikhchandani, Jai, Lynch, Henry T.

“…Curcumin is a natural anti-inflammatory agent that has been used for treating medical conditions for many years. Several experimental and pharmacologic trials…”
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Preclinical evaluation of the mTOR–PI3K inhibitor BEZ235 in nasopharyngeal cancer models by Ma, Brigette B.Y, Lui, Vivian W.Y, Hui, Connie W.C, Lau, Cecilia P.Y, Wong, Chi H, Hui, Edwin P, Ng, Margaret H.L, Cheng, Suk H, Tsao, Sai W, Tsang, Chi-Man, Cheung, Crystal S.F, Ho, Kakiu, Chan, Anthony T.C

“…Abstract The dual PI3K–mTOR inhibitor BEZ235 was evaluated in preclinical models of nasopharyngeal carcinoma (NPC). The IC50 value of BEZ235 for growth was in…”
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Preclinical evaluation of the AKT inhibitor MK-2206 in nasopharyngeal carcinoma cell lines by Ma, Brigette B. Y., Lui, Vivian W. Y., Hui, Connie W. C., Lau, Cecilia P. Y., Wong, Chi-Hang, Hui, Edwin P., Ng, Margaret H., Tsao, S. W., Li, Yan, Chan, Anthony T. C.

“…Summary Nasopharyngeal carcinoma (NPC) is endemic to Asia and over 40 % of NPC tissues harbor PIK3CA amplifications. This study characterized the preclinical…”
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Cucurbitacin I elicits anoikis sensitization, inhibits cellular invasion and in vivo tumor formation ability of nasopharyngeal carcinoma cells by Lui, Vivian W.Y., Yau, Daisy M.S., Wong, Elaine Y.L., Ng, Yuen-Keng, Lau, Cecilia P.-K., Ho, Yeung, Chan, Jessica P.L., Hong, Bo, Ho, Kakiu, Cheung, Crystal S., Tsang, Chi-Man, Tsao, Sai-Wah, Chan, Anthony T.C.

“…Nasopharyngeal carcinoma (NPC) is an Asian-prevalent head and neck cancer with high invasiveness. Although several important risk factors for NPC development…”
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Preclinical evaluation of the PI3K-mTOR dual inhibitor PF-04691502 as a novel therapeutic drug in nasopharyngeal carcinoma by Wong, Chi Hang, Loong, Herbert H., Hui, Connie W. C., Lau, Cecilia P. Y., Hui, Edwin P., Ma, Brigette B. Y., Chan, Anthony T. C.

“…Summary Nasopharyngeal carcinoma (NPC) is common in Southeast Asia and over 40 % of NPC tissues have PIK3CA amplification. This study characterized the…”
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Efficacy and safety of antimicrobial stewardship prospective audit and feedback in patients hospitalized with COVID-19: A protocol for a pragmatic clinical trial by Chen, Justin Z, Hoang, Holly L, Yaskina, Maryna, Kabbani, Dima, Doucette, Karen E, Smith, Stephanie W, Lau, Cecilia, Stewart, Jackson, Zurek, Karen, Schultz, Morgan, Cervera, Carlos

“…The use of broad-spectrum antibiotics is widespread in patients with COVID-19 despite a low prevalence of bacterial co-infection, raising concerns for the…”
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The activity of mTOR inhibitor RAD001 (everolimus) in nasopharyngeal carcinoma and cisplatin-resistant cell lines by Ma, Brigette B. Y., Lui, Vivian W. Y., Hui, Edwin P., Lau, Cecilia P. Y., Ho, Kakiu, Ng, Margaret H. L., Cheng, S. H., Tsao, Sai-Wah, Chan, Anthony T. C.

“…Summary Phosphorylated (pi-) protein kinase B (AKT) is commonly expressed in nasopharyngeal carcinoma (NPC) cell lines and tissues, suggesting the involvement…”
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Preclinical evaluation of combined TKI-258 and RAD001 in hepatocellular carcinoma by Chan, Stephen L., Wong, Chi-Hang, Lau, Cecilia P. Y., Zhou, Qian, Hui, Connie W. C., Lui, Vivian W. Y., Ma, Brigette B. Y., Chan, Anthony T. C., Yeo, Winnie

“…Purpose RAD001 targets at the mammalian target of rapamycin (mTOR), while TKI-258 is a potent tyrosine kinase inhibitor targeting at fibroblast growth factor…”
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Preclinical evaluation of sunitinib as single agent or in combination with chemotherapy in nasopharyngeal carcinoma by Hui, Edwin Pun, Lui, Vivian W. Y., Wong, Cesar S. C., Ma, Brigette B. Y., Lau, Cecilia P. Y., Cheung, Crystal S. F., Ho, Kakiu, Cheng, Suk-hang, Ng, Margaret H. L., Chan, Anthony T. C.

“…Summary Purpose : Sunitinib is a multi-target receptor tyrosine kinase (RTK) inhibitor against vascular endothelial growth factor receptors, platelet-derived…”
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High serum vascular endothelial growth factor levels predict poor prognosis after radiofrequency ablation of hepatocellular carcinoma: importance of tumor biomarker in ablative therapies by Poon, Ronnie T P, Lau, Cecilia, Pang, Roberta, Ng, Kelvin K, Yuen, Jimmy, Fan, Sheung Tat

“…Radiofrequency ablation (RFA) is a recently developed treatment for hepatocellular carcinoma (HCC). Thus far, the prognostic impact of tumor biomarkers has not…”
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Tissue Factor Expression Correlates with Tumor Angiogenesis and Invasiveness in Human Hepatocellular Carcinoma by POON, Ronnie Tung-Ping, LAU, Cecilia Pik-Yuk, HO, Joanna Wen-Ying, YU, Wan-Ching, FAN, Sheung-Tat, WONG, John

“…Purpose: Recent studies have shown that tissue factor (TF) may be involved in tumor angiogenesis and metastasis. The role of TF in hepatocellular carcinoma…”
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Significance of circulating endothelial progenitor cells in hepatocellular carcinoma by Ho, Joanna W. Y., Pang, Roberta W. C., Lau, Cecilia, Sun, Chris K., Yu, Wan Ching, Fan, Sheung Tat, Poon, Ronnie T. P.

“…This study evaluated the significance of circulating bone marrow‐derived endothelial progenitor cells (EPCs) in patients with hepatocellular carcinoma (HCC), a…”
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Activity of the MEK inhibitor selumetinib (AZD6244; ARRY-142886) in nasopharyngeal cancer cell lines by Ma, Brigette B. Y., Lui, Vivian W. Y., Cheung, Crystal S., Lau, Cecilia P. Y., Ho, Kakiu, Hui, Edwin P., Tsui, Stephen K. W., Ng, Margaret H., Cheng, S. H., Ng, Patrick K. S., Tsao, Sai Wai, Chan, Anthony T. C.

“…Summary This study evaluated the preclinical activity of selumetinib (AZD6244, ARRY-142866), an inhibitor of the mitogen-activated protein kinase kinase (MAPKK…”
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Quantitative correlation of serum levels and tumor expression of vascular endothelial growth factor in patients with hepatocellular carcinoma by POON, Ronnie Tung-Ping, LAU, Cecilia Pik-Yuk, CHEUNG, Siu-Tim, YU, Wun-Ching, FAN, Sheung-Tat

“…Recent studies have suggested that serum levels of vascular endothelial growth factor (VEGF) may provide useful prognostic information in patients with various…”
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Tumor Microvessel Density as a Predictor of Recurrence After Resection of Hepatocellular Carcinoma: A Prospective Study by POON, Ronnie Tung-Ping, NG, Irene Oi-Lin, LAU, Cecilia, YU, Wun-Ching, YANG, Zhen-Fan, FAN, Sheung-Tat, WONG, John

“…This study prospectively evaluated the correlation of tumor microvessel density (MVD) with clinicopathologic features and postoperative recurrence in patients…”
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Predictors of Hazardous Drinking Behavior in 1,340 Adult Trauma Patients: A Computerized Alcohol Screening and Intervention Study by Ewing, Tyler, BS, Barrios, Cristobal, MD, Lau, Cecilia, BS, Patel, Madhukar S., ScM, Cui, Eric, BS, Garcia, Stephanie Diana, BA, Kong, Allen, MD, Lotfipour, Shahram, MD, MPH, FACEP, Lekawa, Michael, MD, FACS, Malinoski, Darren, MD, FACS

“…Background Alcohol screening and brief intervention (SBI) is used to decrease alcohol consumption, health care costs, and injury recidivism in trauma patients…”
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Both antiangiogenesis- and angiogenesis-independent effects are responsible for hepatocellular carcinoma growth arrest by tyrosine kinase inhibitor PTK787/ZK222584 by Liu, Yuqing, Poon, Ronnie T, Li, Qinyu, Kok, Tsz Wai, Lau, Cecilia, Fan, Sheung Tat

“…Vascular endothelial growth factor (VEGF) plays an important role in tumor angiogenesis of hepatocellular carcinoma. Inhibition of VEGF receptors could…”
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Tumor cyclooxygenase-2 levels correlate with tumor invasiveness in human hepatocellular carcinoma by Tang, Terence-C, Poon, Ronnie-T, Lau, Cecilia-P, Xie, Dan, Fan, Sheung-Tat

“…AIM: Recent studies suggested that cyclooxygenase-2 (COX-2) enhances tumor angiogenesis via upregulation of vascular endothelial growth factor (VEGF). Although…”
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Clinical Significance of Thrombospondin 1 Expression in Hepatocellular Carcinoma by Poon, Ronnie T, Chung, Ka Kit, Cheung, Siu Tim, Lau, Cecilia P, Tong, See Wai, Leung, Ka Ling, Yu, Wan Ching, Tuszynski, George P, Fan, Sheung Tat

“…Purpose: Thrombospondin 1 (THBS 1) is a matricellular protein capable of modulating angiogenesis. However, the actual role of THBS 1 in angiogenesis and tumor…”
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TP53-induced glycolysis and apoptosis regulator promotes proliferation and invasiveness of nasopharyngeal carcinoma cells by WONG, ELAINE YUE LING, WONG, SZE-CHUEN CESAR, CHAN, CHARLES MING LOK, LAM, EMILY KAI YEE, HO, LOUISA YEUNG, LAU, CECILIA PIK YUK, AU, THOMAS CHI CHUEN, CHAN, AMANDA KIT CHING, TSANG, CHI MAN, TSAO, SAI WAH, LUI, VIVIAN WAI YAN, CHAN, ANTHONY TAK CHEUNG

“…The TP53-induced glycolysis and apoptosis regulator (TIGAR) is the protein product of the p53 target gene, C12orf5. TIGAR blocks glycolysis and promotes…”
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