Search Results - "LATTIME, E"

Oncolytic viruses: focusing on the tumor microenvironment by de Vries, C R, Kaufman, H L, Lattime, E C

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The addition of recombinant vaccinia HER2/neu to oncolytic vaccinia-GMCSF given into the tumor microenvironment overcomes MDSC-mediated immune escape and systemic anergy by de Vries, C R, Monken, C E, Lattime, E C

“…Effective immunotherapeutic strategies require the ability to generate a systemic antigen-specific response capable of impacting both primary and metastatic…”
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A phase I trial of pox PSA vaccines (PROSTVAC-VF) with B7-1, ICAM-1, and LFA-3 co-stimulatory molecules (TRICOM) in patients with prostate cancer by DiPaola, R S, Plante, M, Kaufman, H, Petrylak, D P, Israeli, R, Lattime, E, Manson, K, Schuetz, T

“…Based on previous studies that demonstrated the safety profile and preliminary clinical activity of prostate specific antigen (PSA) targeted therapeutic…”
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Tumor-induced interleukin-10 inhibits type 1 immune responses directed at a tumor antigen as well as a non-tumor antigen present at the tumor site by HALAK, B. K, MAGUIRE, H. C, LATTIME, E. C

“…Interleukin (IL)-10 is a potent immunosuppressive cytokine that has been found to be present at the tumor site in a wide variety of human cancers, including…”
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Interleukin 10 production by human melanoma by SATO, T, MCCUE, P, MASUOKA, K, SALWEN, S, LATTIME, E. C, MASTRANGELO, M. J, BERD, D

“…Interleukin 10 (IL-10) has the physiological role of down-regulating cell-mediated immunity. We have recently reported that mRNA for IL-10 was present in most…”
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De novo Decorin Gene Expression Suppresses the Malignant Phenotype in Human Colon Cancer Cells by Santra, Manoranjan, Skorski, Tomasz, Calabretta, Bruno, Lattime, Edmund C., Iozzo, Renato V.

“…The rapid progress in the cloning of proteoglycan genes has enabled investigators to examine in depth the functional roles these polyhedric molecules play in…”
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Intratumoral recombinant GM-CSF-encoding virus as gene therapy in patients with cutaneous melanoma by Mastrangelo, M J, Maguire, Jr, H C, Eisenlohr, L C, Laughlin, C E, Monken, C E, McCue, P A, Kovatich, A J, Lattime, E C

“…Seven immunocompetent, revaccinated patients with surgically incurable cutaneous melanoma underwent treatment of dermal and/or subcutaneous metastases with…”
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Use of dendritic cells to immunize against cancers overexpressing p53 by LUTZKER, Stuart G, LATTIME, Edmund C

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Intralesional vaccinia/GM-CSF recombinant virus in the treatment of metastatic melanoma by Mastrangelo, M J, Maguire, H C, Lattime, E C

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Virotherapy clinical trials for regional disease: in situ immune modulation using recombinant poxvirus vectors by Mastrangelo, Michael J, Lattime, Edmund C

“…The ability of viruses to readily infect tumor cells both in vitro and in vivo has resulted in their study as antitumor agents through a variety of strategies…”
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Intravesical gene therapy : in vivo gene transfer using recombinant vaccinia virus vectors by LEE, S. S, EISENLOHR, L. C, MCCUE, P. A, MASTRANGELO, M. J, LATTIME, E. C

“…Intratumoral gene transfer may be a significant tool in active immunotherapy. The ability to insert functional genes into a tumor in vitro and in vivo using…”
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Murine bladder carcinoma cells present antigen to BCG-specific CD4+ T-cells by LATTIME, E. C, GOMELLA, L. G, MCCUE, P. A

“…Intravesical administration of Bacillus Calmette-Guérin (BCG) is the most effective therapy for superficial transitional cell carcinoma of the bladder although…”
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Poxvirus vectors: orphaned and underappreciated by Mastrangelo, M J, Eisenlohr, L C, Gomella, L, Lattime, E C

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Gene therapy for human cancer: an essay for clinicians by Mastrangelo, M J, Berd, D, Nathan, F E, Lattime, E C

“…In the last decade our understanding of the processes that govern growth and differentiation has become quite sophisticated. A variety of tumor suppressor…”
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In situ cytokine gene transfection using vaccinia virus vectors by Lattime, E C, Lee, S S, Eisenlohr, L C, Mastrangelo, M J

“…Studies by a number of investigators have focused on inducing tumor-specific immunity as a therapeutic approach to cancer. Successful immunotherapeutic…”
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Phase i study of intravesical vaccinia virus as a vector for gene therapy of bladder cancer by Gomella, L G, Mastrangelo, M J, McCue, P A, Maguire HC, J R, Mulholland, S G, Lattime, E C

“…Vaccinia virus is a DNA poxvirus previously used as a vaccine to eradicate smallpox. The virus has a high efficiency of infection, replicates in the cytoplasm…”
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Expression of cytokine mRNA in human melanoma tissues by LATTIME, E. C, MASTRANGELO, M. J, BAGASRA, O, WEN LI, BERD, D

“…We have reported that patients with metastatic melanoma treated with an autologous, dinitrophenol-modified vaccine develop inflammatory responses at tumor…”
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Induction of TH1- and TH2-associated cytokine mRNA in mouse bladder following intravesical growth of the murine bladder tumor MB49 and BCG immunotherapy by MCAVENEY, K. M, GOMELLA, L. G, LATTIME, E. C

“…Productive immunity to murine and human parasites is associated with the development of a type I T cell response (interferon-gamma-producing) while type II…”
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Limiting dilution analysis of TNF producing cells in C3H/HeJ mice by Lattime, EC, Stoppacciaro, A, Stutman, O

“…A limiting dilution assay (LDA) that measures the frequency of TNF producing cells is described. LDA determination is based on the inhibition of growth of a…”
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Tumor growth in vivo selects for resistance to tumor necrosis factor by Lattime, EC, Stutman, O

“…The relationship between in vivo tumor growth and resistance to TNF in WEHI-164 cells has been examined. When a highly TNF-sensitive clone of WEHI-164 was…”
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