Search Results - "LATOCHA, Dorian H"

6-Formylindolo(3,2-b)Carbazole (FICZ) Modulates the Signalsome Responsible for RA-Induced Differentiation of HL-60 Myeloblastic Leukemia Cells by Bunaciu, Rodica P, Jensen, Holly A, MacDonald, Robert J, LaTocha, Dorian H, Varner, Jeffrey D, Yen, Andrew

“…6-Formylindolo(3,2-b)carbazole (FICZ) is a photoproduct of tryptophan and an endogenous high affinity ligand for aryl hydrocarbon receptor (AhR). It was…”
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BCR-ABL1 promotes leukemia by converting p27 into a cytoplasmic oncoprotein by Agarwal, Anupriya, Mackenzie, Ryan J., Besson, Arnaud, Jeng, Sophia, Carey, Alyssa, LaTocha, Dorian H., Fleischman, Angela G., Duquesnes, Nicolas, Eide, Christopher A., Vasudevan, Kavin B., Loriaux, Marc M., Firpo, Eduardo, Cortes, Jorge E., McWeeney, Shannon, O’Hare, Thomas, Roberts, James M., Druker, Brian J., Deininger, Michael W.

“…Recent studies have revealed that p27, a nuclear cyclin-dependent kinase (Cdk) inhibitor and tumor suppressor, can acquire oncogenic activities upon…”
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Threshold Levels of ABL Tyrosine Kinase Inhibitors Retained in Chronic Myeloid Leukemia Cells Determine Their Commitment to Apoptosis by O'HARE, Thomas, EIDE, Christopher A, RIDDLE, Steven M, MARKS, Bryan D, VOGEI, Kurt W, KOOP, Dennis R, APGAR, John, TYNER, Jeffrey W, DEININGER, Michael W, DRUKER, Brian J, AGARWAL, Anupriya, ADRIAN, Lauren T, ZABRISKIE, Matthew S, MACKENZIE, Ryan J, LATOCHA, Dorian H, JOHNSON, Kara J, HUIHONG YOU, LUO, Jenny

“…The imatinib paradigm in chronic myelogenous leukemia (CML) established continuous BCR-ABL inhibition as a design principle for ABL tyrosine kinase inhibitors…”
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TNFα facilitates clonal expansion of JAK2V617F positive cells in myeloproliferative neoplasms by Fleischman, Angela G., Aichberger, Karl J., Luty, Samuel B., Bumm, Thomas G., Petersen, Curtis L., Doratotaj, Shirin, Vasudevan, Kavin B., LaTocha, Dorian H., Yang, Fei, Press, Richard D., Loriaux, Marc M., Pahl, Heike L., Silver, Richard T., Agarwal, Anupriya, O'Hare, Thomas, Druker, Brian J., Bagby, Grover C., Deininger, Michael W.

“…Proinflammatory cytokines such as TNFα are elevated in patients with myeloproliferative neoplasms (MPN), but their contribution to disease pathogenesis is…”
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6-Formylindolo by Bunaciu, Rodica P, Jensen, Holly A, MacDonald, Robert J, LaTocha, Dorian H, Varner, Jeffrey D, Yen, Andrew

“…6-Formylindolo(3,2-b)carbazole (FICZ) is a photoproduct of tryptophan and an endogenous high affinity ligand for aryl hydrocarbon receptor (AhR). It was…”
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6-Formylindolo Modulates the Signalsome Responsible for RA-Induced Differentiation of HL-60 Myeloblastic Leukemia Cells by Bunaciu, Rodica P, Jensen, Holly A, MacDonald, Robert J, LaTocha, Dorian H, Varner, Jeffrey D, Yen, Andrew

“…6-Formylindolo(3,2-b)carbazole (FICZ) is a photoproduct of tryptophan and an endogenous high affinity ligand for aryl hydrocarbon receptor (AhR). It was…”
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Dasatinib Shows Therapeutic Potential in the Murine Xenograft Model for TCF3 rearranged Acute Lymphoblastic Leukemia by Lenz, Kyle, Thompson, Sarah, Goloviznina, Natalya A., Huan, Jianya, LaTocha, Dorian H, Druker, Brian J., Tyner, Jeffrey W., Kurre, Peter, Chang, Bill H

“…Transcription Factor 3 (TCF3) rearrangements are a recurring chromosomal abnormality in B-cell Precursor Acute Lymphoblastic Leukemia (BCP-ALL) occurring in…”
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Exaggerated Response To Toll-Like Receptor Agonist Contributes To Excessive TNF Production In Myeloproliferative Neoplasm by Fleischman, Angela G., Luty, Samuel B, Garbati, Michael R, Edmiston, J Blair, Royer, Lacey R, LaTocha, Dorian H, Bagby, Grover C., Druker, Brian J.

“…Tumor Necrosis Factor-alpha (TNF) is elevated in myeloproliferative neoplasm (MPN) and plays a key role in expansion of the JAK2V617F neoplastic clone. Because…”
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Threshold levels of ABL tyrosine kinase inhibitors retained in chronic myeloid leukemia cells define commitment to apoptosis by O’Hare, Thomas, Eide, Christopher A., Agarwal, Anupriya, Adrian, Lauren T., Zabriskie, Matthew S., MacKenzie, Ryan J., LaTocha, Dorian H., Johnson, Kara J., You, Huihong, Luo, Jenny, Riddle, Steven M., Marks, Bryan D., Vogel, Kurt W., Koop, Dennis R., Apgar, John, Tyner, Jeffrey W., Deininger, Michael W., Druker, Brian J.

“…The imatinib paradigm in chronic myeloid leukemia (CML) established continuous BCR-ABL inhibition as a design principle for ABL tyrosine kinase inhibitors…”
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Cryptic Intracellular Retention of ABL Tyrosine Kinase Inhibitors within CML Cells Mediates Apoptosis Commitment Following Acute Drug Exposure by O'Hare, Thomas, Eide, Christopher A., Adrian, Lauren T., Agarwal, Anupriya, Zabriskie, Matthew S., MacKenzie, Ryan, LaTocha, Dorian H., You, Huihong, Luo, Jenny, Riddle, Steven M., Marks, Bryan, Koop, Dennis R., Apgar, John, Deininger, Michael W., Druker, Brian J.

“…Abstract 3504 The imatinib paradigm established continuous BCR-ABL inhibition as a design principle for ABL tyrosine kinase inhibitors (TKIs). However,…”
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p27 Is Mislocalized to the Cytoplasm by BCR-ABL In a Kinase-Independent Manner and Contributes to Leukemogenesis by Agarwal, Anupriya, Meckenzie, Ryan J, O'Hare, Thomas, Vasudevan, Kavin B, LaTocha, Dorian H, Loriaux, Marc M, Firpo, Eduardo, Roberts, James M, Druker, Brian J, Deininger, Michael W

“…Abstract 512 BCR-ABL promotes cell cycle progression by interfering with the regulatory functions of p27, a cyclin dependent kinase (Cdk) inhibitor and tumor…”
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6-Formylindolo(3,2-b)Carbazole (FICZ) Modulates the Signalsome Responsible for RA-Induced Differentiation of HL-60 Myeloblastic Leukemia Cells: e0135668 by Bunaciu, Rodica P, Jensen, Holly A, MacDonald, Robert J, LaTocha, Dorian H, Varner, Jeffrey D, Yen, Andrew

“…6-Formylindolo(3,2-b)carbazole (FICZ) is a photoproduct of tryptophan and an endogenous high affinity ligand for aryl hydrocarbon receptor (AhR). It was…”
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Adrenocorticotropic hormone controls Concanavalin A activation of rat lymphocytes by modulating IL-2 production by Wermerskirchen, Angela S., LaTocha, Dorian H., Clarke, Benjamin L.

“…The initiation of DNA synthesis and secretion of Interleukin 2 (IL-2) was measured in isolated rat splenic lymphocytes following activation with Concanavalin A…”
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