Search Results - "LATHAM, Patricia S"

Interactions between hepatic iron and lipid metabolism with possible relevance to steatohepatitis by Ahmed, Umbreen, Latham, Patricia S, Oates, Phillip S

“…The liver is an important site for iron and lipid metabolism and the main site for the interactions between these two metabolic pathways. Although conflicting…”
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Genomes of Fasciola hepatica from the Americas Reveal Colonization with Neorickettsia Endobacteria Related to the Agents of Potomac Horse and Human Sennetsu Fevers by McNulty, Samantha N, Tort, Jose F, Rinaldi, Gabriel, Fischer, Kerstin, Rosa, Bruce A, Smircich, Pablo, Fontenla, Santiago, Choi, Young-Jun, Tyagi, Rahul, Hallsworth-Pepin, Kymberlie, Mann, Victoria H, Kammili, Lakshmi, Latham, Patricia S, Dell'Oca, Nicolas, Dominguez, Fernanda, Carmona, Carlos, Fischer, Peter U, Brindley, Paul J, Mitreva, Makedonka

“…Food borne trematodes (FBTs) are an assemblage of platyhelminth parasites transmitted through the food chain, four of which are recognized as neglected…”
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Effects of rIL2/anti-IL2 antibody complex on chikungunya virus-induced chronic arthritis in a mouse model by Tritsch, Sarah R., Porzucek, Abigail J., Schwartz, Arnold M., Proctor, Abigale M., Amdur, Richard L., Latham, Patricia S., Simon, Gary L., Mores, Christopher N., Chang, Aileen Y.

“…Chikungunya virus (CHIKV) is characterized by disabling joint pain that can cause persistent arthritis in approximately one-fourth of patients. Currently, no…”
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Aldehydes alter TGF-β signaling and induce obesity and cancer by Yang, Xiaochun, Bhowmick, Krishanu, Rao, Shuyun, Xiang, Xiyan, Ohshiro, Kazufumi, Amdur, Richard L., Hassan, Md. Imtaiyaz, Mohammad, Taj, Crandall, Keith, Cifani, Paolo, Shetty, Kirti, Lyons, Scott K., Merrill, Joseph R., Vegesna, Anil K., John, Sahara, Latham, Patricia S., Crawford, James M., Mishra, Bibhuti, Dasarathy, Srinivasan, Wang, Xin Wei, Yu, Herbert, Wang, Zhanwei, Huang, Hai, Krainer, Adrian R., Mishra, Lopa

“…Obesity and fatty liver diseases—metabolic dysfunction-associated steatotic liver disease (MASLD) and metabolic dysfunction-associated steatohepatitis…”
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ND-13, a DJ-1-Derived Peptide, Attenuates the Renal Expression of Fibrotic and Inflammatory Markers Associated with Unilateral Ureter Obstruction by De Miguel, Carmen, Kraus, Abigayle C, Saludes, Mitchell A, Konkalmatt, Prasad, Ruiz Domínguez, Almudena, Asico, Laureano D, Latham, Patricia S, Offen, Daniel, Jose, Pedro A, Cuevas, Santiago

“…DJ-1 is a redox-sensitive chaperone with reported antioxidant and anti-inflammatory properties in the kidney. The 20 amino acid (aa) peptide ND-13 consists of…”
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The effect of HIV infection and HCV viremia on inflammatory mediators and hepatic injury-The Women's Interagency HIV Study by Keating, Sheila M, Dodge, Jennifer L, Norris, Philip J, Heitman, John, Gange, Stephen J, French, Audrey L, Glesby, Marshall J, Edlin, Brian R, Latham, Patricia S, Villacres, Maria C, Greenblatt, Ruth M, Peters, Marion G

“…Hepatitis C virus infection induces inflammation and while it is believed that HIV co-infection enhances this response, HIV control may reduce inflammation and…”
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A Mouse Model for Studying Post-Acute Arthritis of Chikungunya by Chang, Aileen Y, Tritsch, Sarah R, Porzucek, Abigail J, Schwartz, Arnold M, Seyler-Schmidt, Margaux, Glass, Arielle, Latham, Patricia S, Reid, St Patrick, Simon, Gary L, Mores, Christopher N

“…Chikungunya virus (CHIKV) was introduced to the Americas in 2013, causing two million infections across over thirty countries. CHIKV causes a chronic…”
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Tumour DDR1 promotes collagen fibre alignment to instigate immune exclusion by Sun, Xiujie, Wu, Bogang, Chiang, Huai-Chin, Deng, Hui, Zhang, Xiaowen, Xiong, Wei, Liu, Junquan, Rozeboom, Aaron M., Harris, Brent T., Blommaert, Eline, Gomez, Antonio, Garcia, Roderic Espin, Zhou, Yufan, Mitra, Payal, Prevost, Madeleine, Zhang, Deyi, Banik, Debarati, Isaacs, Claudine, Berry, Deborah, Lai, Catherine, Chaldekas, Krysta, Latham, Patricia S., Brantner, Christine A., Popratiloff, Anastas, Jin, Victor X., Zhang, Ningyan, Hu, Yanfen, Pujana, Miguel Angel, Curiel, Tyler J., An, Zhiqiang, Li, Rong

“…Immune exclusion predicts poor patient outcomes in multiple malignancies, including triple-negative breast cancer (TNBC) 1 . The extracellular matrix (ECM)…”
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TRIM28 promotes luminal cell plasticity in a mouse model of prostate cancer by Yende, Ashutosh S., Williams, Emily C., Pletcher, Andrew, Helfand, Alexandra, Ibeawuchi, Helen, North, Tanya M., Latham, Patricia S., Horvath, Anelia, Shibata, Maho

“…The Tripartite motif-containing 28 (TRIM28) transcriptional cofactor is significantly upregulated in high-grade and metastatic prostate cancers. To study the…”
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Gut Colonization with Methanogenic Archaea Lowers Plasma Trimethylamine N-oxide Concentrations in Apolipoprotein e−/− Mice by Ramezani, Ali, Nolin, Thomas D., Barrows, Ian R., Serrano, Myrna G., Buck, Gregory A., Regunathan-Shenk, Renu, West, Raymond E., Latham, Patricia S., Amdur, Richard, Raj, Dominic S.

“…A mechanistic link between trimethylamine N-oxide (TMAO) and atherogenesis has been reported. TMAO is generated enzymatically in the liver by the oxidation of…”
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Impaired reciprocal regulation between SIRT6 and TGF‐β signaling in fatty liver by Xiang, Xiyan, Ohshiro, Kazufumi, Zaidi, Sobia, Yang, Xiaochun, Bhowmick, Krishanu, Vegesna, Anil K., Bernstein, David, Crawford, James M., Mishra, Bibhuti, Latham, Patricia S., Gough, Nancy R., Rao, Shuyun, Mishra, Lopa

“…Dysregulated transforming growth factor‐beta (TGF‐β) signaling contributes to fibrotic liver disease and hepatocellular cancer (HCC), both of which are…”
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CD137 agonist potentiates the abscopal efficacy of nanoparticle-based photothermal therapy for melanoma by Balakrishnan, Preethi Bala, Ledezma, Debbie K., Cano-Mejia, Juliana, Andricovich, Jaclyn, Palmer, Erica, Patel, Vishal A., Latham, Patricia S., Yvon, Eric S., Villagra, Alejandro, Fernandes, Rohan, Sweeney, Elizabeth E.

“…Despite the promise of immunotherapy such as the immune checkpoint inhibitors (ICIs) anti-PD-1 and anti-CTLA-4 for advanced melanoma, only 26%–52% of patients…”
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β2-spectrin (SPTBN1) as a therapeutic target for diet-induced liver disease and preventing cancer development by Rao, Shuyun, Yang, Xiaochun, Ohshiro, Kazufumi, Zaidi, Sobia, Wang, Zhanhuai, Shetty, Kirti, Xiang, Xiyan, Hassan, Md Imtaiyaz, Mohammad, Taj, Latham, Patricia S, Nguyen, Bao-Ngoc, Wong, Linda, Yu, Herbert, Al-Abed, Yousef, Mishra, Bibhuti, Vacca, Michele, Guenigault, Gareth, Allison, Michael E D, Vidal-Puig, Antonio, Benhammou, Jihane N, Alvarez, Marcus, Pajukanta, Päivi, Pisegna, Joseph R, Mishra, Lopa

“…The prevalence of nonalcoholic steatohepatitis (NASH) and liver cancer is increasing. De novo lipogenesis and fibrosis contribute to disease progression and…”
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Targeting the E3 Ubiquitin Ligase PJA1 Enhances Tumor-Suppressing TGFβ Signaling by Chen, Jian, Mitra, Abhisek, Li, Shulin, Song, Shumei, Nguyen, Bao-Ngoc, Chen, Jiun-Sheng, Shin, Ji-Hyun, Gough, Nancy R, Lin, Paul, Obias, Vincent, He, Aiwu Ruth, Yao, Zhixing, Malta, Tathiane M, Noushmehr, Houtan, Latham, Patricia S, Su, Xiaoping, Rashid, Asif, Mishra, Bibhuti, Wu, Ray-Chang, Mishra, Lopa

“…RING-finger E3 ligases are instrumental in the regulation of inflammatory cascades, apoptosis, and cancer. However, their roles are relatively unknown in…”
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Downregulation of miR-375 contributes to ERBB2-mediated VEGFA overexpression in esophageal cancer by Ren, Shuchang, Tan, Xiaohui, Fu, Melinda Z., Ren, Shuyang, Wu, Xiaoling, Chen, Tao, Latham, Patricia S., Lin, Paul, Man, Yan-gao, Fu, Sidney W.

“…Esophageal cancer (EC) is a lethal cancer with an extremely aggressive nature and poor survival rate. However, the molecular mechanisms driving the occurrence…”
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Mechanistically based blood proteomic markers in the TGF-β pathway stratify risk of hepatocellular cancer in patients with cirrhosis by Xiang, Xiyan, Bhowmick, Krishanu, Shetty, Kirti, Ohshiro, Kazufumi, Yang, Xiaochun, Wong, Linda L, Yu, Herbert, Latham, Patricia S, Satapathy, Sanjaya K, Brennan, Christina, Dima, Richard J, Chambwe, Nyasha, Sharifova, Gulru, Cacaj, Fellanza, John, Sahara, Crawford, James M, Huang, Hai, Dasarathy, Srinivasan, Krainer, Adrian R, He, Aiwu R, Amdur, Richard L, Mishra, Lopa

“…Hepatocellular carcinoma (HCC) is the third leading cause of death from cancer worldwide but is often diagnosed at an advanced incurable stage. Yet, despite…”
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Using quantitative immunohistochemistry in patients at high risk for hepatocellular cancer by Zaidi, Sobia, Amdur, Richard, Xiang, Xiyan, Yu, Herbert, Wong, Linda L, Rao, Shuyun, He, Aiwu R, Amin, Karan, Zaheer, Daewa, Narayan, Raj K, Satapathy, Sanjaya K, Latham, Patricia S, Shetty, Kirti, Guha, Chandan, Gough, Nancy R, Mishra, Lopa

“…Hepatocellular carcinoma (HCC) is the primary form of liver cancer and a major cause of cancer death worldwide. Early detection is key to effective treatment…”
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microRNA-196b promotes esophageal squamous cell carcinogenesis and chemoradioresistance by inhibiting EPHA7, thereby restoring EPHA2 activity by Tan, Xiaohui, Ren, Shuchang, Fu, Melinda Z, Ren, Shuyang, Yang, Canyuan, Wu, Xiaoling, Chen, Tao, Latham, Patricia S, Meltzer, Stephen J, Fu, Sidney W

“…Esophageal cancer (EC) is extremely aggressive and has a very poor survival rate. Esophageal squamous cell carcinoma (ESCC) accounts for 80% of all ECs…”
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Hepatic fibrosis and immune phenotype vary by HCV viremia in HCV/HIV co-infected subjects: A Women's interagency HIV study by Desai, Seema N., Dodge, Jennifer L., Landay, Alan L., Glesby, Marshall J., Latham, Patricia S., Villacres, Maria C., French, Audrey L., Gange, Stephen J., Greenblatt, Ruth M., Peters, Marion G.

“…HCV and HIV independently lead to immune dysregulation. The mechanisms leading to advanced liver disease progression in HCV/HIV coinfected subjects remain…”
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Resistin expression correlates with steatohepatitis in morbidly obese patients by Edwards, Claire R., Hindle, A. Katharine, Latham, Patricia S., Fu, Sidney W., Brody, Fred J.

“…Background Morbidly obese patients are at risk for nonalcoholic steatohepatitis (NASH) even in the absence of risk factors for liver disease. Unfortunately,…”
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