Search Results - "LASTER, Michael J"

Contrasting Roles of the N-Methyl-d-Aspartate Receptor in the Production of Immobilization by Conventional and Aromatic Anesthetics by Eger, Edmond I, Liao, Mark, Laster, Michael J., Won, Albert, Popovich, John, Raines, Douglas E., Solt, Ken, Dutton, Robert C., Cobos, Franklin V., Sonner, James M.

“…We hypothesized that N-methyl-d-aspartate (NMDA) receptors mediate some or all of the capacity of inhaled anesthetics to prevent movement in the face of…”
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GABAA Receptor Blockade Antagonizes the Immobilizing Action of Propofol but Not Ketamine or Isoflurane in a Dose-Related Manner by Bovill, James G., Sonner, James M., Zhang, Yi, Stabernack, Caroline, Abaigar, Wella, Xing, Yilei, Laster, Michael J.

“…The enhancing action of propofol on γ-amino-n-butyric acid subtype A (GABAA) receptors purportedly underlies its anesthetic effects. However, a recent study…”
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The concentration of isoflurane required to suppress learning depends on the type of learning by DUTTON, Robert C, MAURER, Anya J, SONNER, James M, FANSELOW, Michael S, LASTER, Michael J, EGER, Edmond I

“…Recent reports suggest that one type of learning, fear conditioning to context, requires more neural processing than a related type, fear conditioning to tone…”
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Temporal summation governs part of the minimum alveolar concentration of isoflurane anesthesia by DUTTON, Robert C, YI ZHANG, STABERNACK, Caroline R, LASTER, Michael J, SONNER, James M, EGER, Edmond I

“…General anesthesia may delay the onset of movement in response to noxious stimulation. The authors hypothesized that the production of immobility could involve…”
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Isoflurane causes anterograde but not retrograde amnesia for pavlovian fear conditioning by DUTTON, Robert C, MAURER, Anya J, SONNER, James M, FANSELOW, Michael S, LASTER, Michael J, EGER, Edmond I

“…Production of retrograde amnesia by anesthetics would indicate that these drugs can disrupt mechanisms that stabilize memory. Such disruption would allow…”
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Blockade of 5-HT2A Receptors May Mediate or Modulate Part of the Immobility Produced by Inhaled Anesthetics by Zhang, Yi, Laster, Michael J., Eger, Edmond I, Stabernack, Caroline R., Sonner, James M.

“…Many inhaled anesthetics block the in vitro effect of the excitatory neurotransmitter serotonin on the 5-HT2A receptor, supporting the view that this receptor…”
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The Effect of Rigidity, Shape, Unsaturation, and Length on the Anesthetic Potency of Hydrocarbons by Eger, Edmond I, Laster, Michael J.

“…We previously hypothesized that anesthesia results from an action on two sites separated by 5 Å. The hypothesis relied on the finding that fluorinated alkanes…”
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Recovery and kinetic characteristics of desflurane and sevoflurane in volunteers after 8-h exposure, including kinetics of degradation products by EGER, E. I, BOWLAND, T, IONESCU, P, LASTER, M. J, FANG, Z, GONG, D, SONNER, J, WEISKOPF, R. B

“…Desflurane and sevoflurane permit speedier changes in anesthetic partial pressures than do older halogenated anesthetics. The authors determined the kinetic…”
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Determination of the EC50 amnesic concentration of etomidate and its diffusion profile in brain tissue : Implications for in vitro studies by BENKWITZ, Claudia, LIAO, Mark, LASTER, Michael J, SONNER, James M, EGER, Edmond I, PEARCE, Robert A

“…Etomidate is a widely used general anesthetic that has become a useful tool to investigate mechanisms of anesthetic action in vivo and in brain slices…”
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Obesity Modestly Affects Inhaled Anesthetic Kinetics in Humans by LEMMENS, Hendrikus J. M, SAIDMAN, Lawrence J, EGER, Edmond I, LASTER, Michael J

“…Few studies have determined the effect of obesity on inhaled anesthetic pharmacokinetics. We hypothesized that the solubility of potent inhaled anesthetics in…”
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Anesthetic Properties of Carbon Dioxide in the Rat by Brosnan, Robert J., Eger, Edmond I., Laster, Michael J., Sonner, James M.

“…Carbon dioxide decreases halothane minimum alveolar concentrations (MAC) in dogs when Paco(2) exceeds 95 mm Hg. We sought to confirm these findings for several…”
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Increasing the Duration of Isoflurane Anesthesia Decreases the Minimum Alveolar Anesthetic Concentration in 7-Day-Old but Not in 60-Day-Old Rats by Stratmann, Greg, Sall, Jeffrey W., Eger, Edmond I, Laster, Michael J., Bell, Joseph S., May, Laura D. V., Eilers, Helge, Krause, Martin, Heusen, Frank v. d., Gonzalez, Heidi E.

“…While studying neurotoxicity in rats, we observed that the anesthetic minimum alveolar anesthetic concentration (MAC) of isoflurane decreases with increasing…”
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The Ventilatory Stimulant Doxapram Inhibits TASK Tandem Pore (K2P) Potassium Channel Function but Does Not Affect Minimum Alveolar Anesthetic Concentration by Cotten, Joseph F., Keshavaprasad, Bharat, Laster, Michael J., Eger, Edmond I., Yost, C Spencer

“…TWIK-related acid-sensitive K+-1 (TASK-1 [KCNK3]) and TASK-3 (KCNK9) are tandem pore (K2P) potassium (K) channel subunits expressed in carotid bodies and the…”
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β3-Containing Gamma-Aminobutyric AcidA Receptors Are Not Major Targets for the Amnesic and Immobilizing Actions of Isoflurane by Liao, Mark, Sonner, James M., Jurd, Rachel, Rudolph, Uwe, Borghese, Cecilia M., Harris, R Adron, Laster, Michael J., Eger, Edmond I

“…Mice bearing an N265M point mutation in the gamma-aminobutyric acid (GABA)A receptor β3 subunit resist various anesthetic effects of propofol and etomidate…”
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Inhaled Anesthetics Do Not Combine to Produce Synergistic Effects Regarding Minimum Alveolar Anesthetic Concentration in Rats by Eger, Edmond I, Tang, Michael, Liao, Mark, Laster, Michael J., Solt, Ken, Flood, Pamela, Jenkins, Andrew, Raines, Douglas, Hendrickx, Jan F., Shafer, Steven L., Yasumasa, Tanifuji, Sonner, James M.

“…We hypothesized that pairs of inhaled anesthetics having divergent potencies [one acting weakly at minimum alveolar anesthetic concentration (MAC); one acting…”
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Lidocaine, MK-801, and MAC by Zhang, Yi, Laster, Michael J., Eger, Edmond I, Sharma, Manohar, Sonner, James M.

“…Previous studies have found that the local anesthetic/sodium channel blocker lidocaine decreased MAC by maximum amounts approximately equal to the decreases…”
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Glycine receptors mediate part of the immobility produced by inhaled anesthetics by YI ZHANG, LASTER, Michael J, HARA, Koji, HARRIS, R. Adron, EGER, Edmond I, STABERNACK, Caroline R, SONNER, James M

“…Many inhaled anesthetics potentiate the effect of glycine on inhibitory strychnine-sensitive glycine receptors in vitro, supporting the view that this receptor…”
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Intrathecal Veratridine Administration Increases Minimum Alveolar Concentration in Rats by Zhang, Yi, Sharma, Manohar, Eger, Edmond I, Laster, Michael J., Hemmings, Hugh C., Harris, R Adron

“…Results from several studies point to sodium channels as potential mediators of the immobility produced by inhaled anesthetics. We hypothesized that the…”
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Gamma-Aminobutyric AcidA Receptors Do Not Mediate the Immobility Produced by Isoflurane by Zhang, Yi, Sonner, James M., Eger, Edmond I, Stabernack, Caroline R., Laster, Michael J., Raines, Douglas E., Harris, R. Adron

“…Many inhaled anesthetics enhance the effect of the inhibitory neurotransmitter gamma aminobutyric acid (GABA), supporting the view that the GABAA receptor…”
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A Comparison of the Molecular Bases for N-Methyl-d-Aspartate-Receptor Inhibition Versus Immobilizing Activities of Volatile Aromatic Anesthetics by Sewell, Jason C., Raines, Douglas E., Eger, Edmond I, Laster, Michael J., Sear, John W.

“…Aromatic anesthetics exhibit a wide range of N-methyl-d-aspartate (NMDA) receptor inhibitory potencies and immobilizing activities. We sought to characterize…”
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