Search Results - "LASSMANN, Silke"

Multinational proficiency tests for EGFR exon 20 insertions reveal that the assay design matters by Ihle, Michaela A., Heydt, Carina, Schultheis, Anne Maria, Stöhr, Robert, Haller, Florian, Herold, Sylvia, Aust, Daniela, Dietmaier, Wolfgang, Evert, Matthias, Eszlinger, Markus, Haak, Anja, Laßmann, Silke, Vorholt, Daniela, Breitenbücher, Frank, Werner, Martin, Streubel, Anna, Mairinger, Thomas, Grassow-Narlik, Maja, Merkelbach-Bruse, Sabine

“…Insertion mutations in exon 20 of the epidermal growth factor receptor gene ( EGFR exon20ins) are rare, heterogeneous alterations observed in non-small cell…”
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Surgical management of lower-grade glioma in the spotlight of the 2016 WHO classification system by Delev, Daniel, Heiland, Dieter Henrik, Franco, Pamela, Reinacher, Peter, Mader, Irina, Staszewski, Ori, Lassmann, Silke, Grau, Stefan, Schnell, Oliver

“…Purpose According to the 2016 WHO classification lower-grade gliomas consist of three groups: IDH- mutated and 1p/19q co-deleted, IDH- mutated and IDH-…”
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Early assessment of circulating tumor DNA after curative‐intent resection predicts tumor recurrence in early‐stage and locally advanced non‐small‐cell lung cancer by Waldeck, Silvia, Mitschke, Jan, Wiesemann, Sebastian, Rassner, Michael, Andrieux, Geoffroy, Deuter, Max, Mutter, Jurik, Lüchtenborg, Anne‐Marie, Kottmann, Daniel, Titze, Laurin, Zeisel, Christoph, Jolic, Martina, Philipp, Ulrike, Lassmann, Silke, Bronsert, Peter, Greil, Christine, Rawluk, Justyna, Becker, Heiko, Isbell, Lisa, Müller, Alexandra, Doostkam, Soroush, Passlick, Bernward, Börries, Melanie, Duyster, Justus, Wehrle, Julius, Scherer, Florian, von Bubnoff, Nikolas

“…Circulating tumor DNA (ctDNA) has demonstrated great potential as a noninvasive biomarker to assess minimal residual disease (MRD) and profile tumor genotypes…”
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Targeting of Cell Surface Proteolysis of Collagen XVII Impedes Squamous Cell Carcinoma Progression by Galiger, Célimène, Löffek, Stefanie, Stemmler, Marc P., Kroeger, Jasmin K., Mittapalli, Venugopal R., Fauth, Lisa, Esser, Philipp R., Kern, Johannes S., Meiss, Frank, Laßmann, Silke, Bruckner-Tuderman, Leena, Franzke, Claus-Werner

“…Squamous cell carcinoma (SCC) is one of the most common skin cancers and causes significant morbidity. Although the expression of the epithelial adhesion…”
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EGFR, HER2 and HER3 dimerization patterns guide targeted inhibition in two histotypes of esophageal cancer by Fichter, Christiane Daniela, Timme, Sylvia, Braun, Julia Alexandra, Gudernatsch, Verena, Schöpflin, Anja, Bogatyreva, Lioudmilla, Geddert, Helene, Faller, Gerhard, Klimstra, David, Tang, Laura, Hauschke, Dieter, Werner, Martin, Lassmann, Silke

“…Receptor tyrosine kinases (RTKs) are in the focus of targeted therapy for epithelial tumors. Our study addressed the role of EGFR, HER2 and HER3 expression and…”
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Selective inhibition of esophageal cancer cells by combination of HDAC inhibitors and Azacytidine by Ahrens, Theresa D, Timme, Sylvia, Hoeppner, Jens, Ostendorp, Jenny, Hembach, Sina, Follo, Marie, Hopt, Ulrich T, Werner, Martin, Busch, Hauke, Boerries, Melanie, Lassmann, Silke

“…Esophageal cancers are highly aggressive tumors with poor prognosis despite some recent advances in surgical and radiochemotherapy treatment options. This…”
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Specific role of RhoC in tumor invasion and metastasis by Lang, Sarah, Busch, Hauke, Boerries, Melanie, Brummer, Tilman, Timme, Sylvia, Lassmann, Silke, Aktories, Klaus, Schmidt, Gudula

“…Rho GTPases are regulators of many cellular functions and are often dysregulated in cancer. However, the precise role of Rho proteins for tumor development is…”
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Are Caudal-Type Homeobox Genes Causal for Gastro-Esophageal Reflux Disease and Barrett's Esophagus? by Laßmann, Silke, Werner, Martin

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Epithelioid hemangioendotheliomas of the liver and lung in children and adolescents by Hettmer, Simone, Andrieux, Geoffroy, Hochrein, Jochen, Kurz, Philipp, Rössler, Jochen, Lassmann, Silke, Werner, Martin, Bubnoff, Nikolas, Peters, Christoph, Koscielniak, Ewa, Sparber‐Sauer, Monika, Niemeyer, Charlotte, Mentzel, Thomas, Busch, Hauke, Boerries, Melanie

“…Epithelioid hemangioendothelioma (EHE) is a rare, vascular sarcoma. Visceral forms arise in the liver/ lungs. We review the clinical and molecular phenotype of…”
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Alpha-folate Receptor Expression in Epithelial Ovarian Carcinoma and Non-neoplastic Ovarian Tissue by MARKERT, Susanne, LASSMANN, Silke, GABRIEL, Boris, KLAR, Maximilian, WERNER, Martin, GITSCH, Gerald, KRATZ, Felix, HASENBURG, Annette

“…Background: The goal of this study was to evaluate the expression pattern and intracellular localization of alpha-folate receptor (α-FR) protein in human…”
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The Clinically Used Iron Chelator Deferasirox Is an Inhibitor of Epigenetic JumonjiC Domain-Containing Histone Demethylases by Roatsch, Martin, Hoffmann, Inga, Abboud, Martine I, Hancock, Rebecca L, Tarhonskaya, Hanna, Hsu, Kuo-Feng, Wilkins, Sarah E, Yeh, Tzu-Lan, Lippl, Kerstin, Serrer, Kerstin, Moneke, Isabelle, Ahrens, Theresa D, Robaa, Dina, Wenzler, Sandra, Barthes, Nicolas P. F, Franz, Henriette, Sippl, Wolfgang, Lassmann, Silke, Diederichs, Sven, Schleicher, Erik, Schofield, Christopher J, Kawamura, Akane, Schüle, Roland, Jung, Manfred

“…Fe­(II)- and 2-oxoglutarate (2OG)-dependent JumonjiC domain-containing histone demethylases (JmjC KDMs) are “epigenetic eraser” enzymes involved in the…”
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Aurora Kinase A Messenger RNA Overexpression Is Correlated with Tumor Progression and Shortened Survival in Head and Neck Squamous Cell Carcinoma by REITER, Rudolf, GAIS, Peter, WALCH, Axel, JÜTTING, Uta, STEUER-VOGT, Miriam K, PICKHARD, Anja, BINK, Karin, RAUSER, Sandra, LASSMANN, Silke, HÖFLER, Heinz, WERNER, Martin

“…Purpose: Aurora kinase A (AURKA/STK15/BTAK) encodes a serine/threonine kinase associated with chromosomal distribution and its up-regulation induces…”
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Silencing of the EPHB3 tumor-suppressor gene in human colorectal cancer through decommissioning of a transcriptional enhancer by Jägle, Sabine, Rönsch, Kerstin, Timme, Sylvia, Andrlová, Hana, Bertrand, Miriam, Jäger, Marcel, Proske, Amelie, Schrempp, Monika, Yousaf, Afsheen, Michoel, Tom, Zeiser, Robert, Werner, Martin, Lassmann, Silke, Hecht, Andreas

“…The protein tyrosine kinase Ephrin type-B receptor 3 (EPHB3) counteracts tumor-cell dissemination by regulating intercellular adhesion and repulsion and acts…”
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Loss of LSR affects epithelial barrier integrity and tumor xenograft growth of CaCo-2 cells by Czulkies, Bernd A, Mastroianni, Justin, Lutz, Lisa, Lang, Sarah, Schwan, Carsten, Schmidt, Gudula, Lassmann, Silke, Zeiser, Robert, Aktories, Klaus, Papatheodorou, Panagiotis

“…The lipolysis-stimulated lipoprotein receptor (LSR) is a lipoprotein receptor, serves as host receptor for clostridial iota-like toxins and is involved in the…”
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ATM mutations and E-cadherin expression define sensitivity to EGFR-targeted therapy in colorectal cancer by Geißler, Anna-Lena, Geißler, Miriam, Kottmann, Daniel, Lutz, Lisa, Fichter, Christiane D, Fritsch, Ralph, Weddeling, Britta, Makowiec, Frank, Werner, Martin, Lassmann, Silke

“…EGFR-targeted therapy is a key treatment approach in patients with RAS wildtype metastatic colorectal cancers (CRC). Still, also RAS wildtype CRC may be…”
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Multiplex genotyping of KRAS point mutations in tumor cell DNA by allele-specific real-time PCR on a centrifugal microfluidic disk segment by Strohmeier, Oliver, Laßmann, Silke, Riedel, Bianca, Mark, Daniel, Roth, Günter, Werner, Martin, Zengerle, Roland, von Stetten, Felix

“…Point Mutations on the Kirsten rat sarcoma viral oncogene homolog ( KRAS ) have been identified as an important predictive biomarker for response to cancer…”
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Report of the Molecular Pathology Working Group : 105th annual meeting of the German Society for Pathology by Siebolts, Udo, Laßmann, Silke, Pfarr, Nicole

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Metadherin exon 11 skipping variant enhances metastatic spread of ovarian cancer by Haug, Stefan, Schnerch, Dominik, Halbach, Sebastian, Mastroianni, Justin, Dumit, Verónica I., Follo, Marie, Hasenburg, Annette, Köhler, Martin, Dierbach, Heide, Herzog, Sebastian, Proske, Amelie, Werner, Martin, Dengjel, Joern, Brummer, Tilman, Laßmann, Silke, Wäsch, Ralph, Zeiser, Robert

“…Metastatic ovarian cancer has a dismal prognosis and current chemotherapeutic approaches have very limited success. Metadherin (MTDH) is expressed in human…”
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The Atypical Kinase RIOK1 Promotes Tumor Growth and Invasive Behavior by Weinberg, Florian, Reischmann, Nadine, Fauth, Lisa, Taromi, Sanaz, Mastroianni, Justin, Köhler, Martin, Halbach, Sebastian, Becker, Andrea C., Deng, Niantao, Schmitz, Tatjana, Uhl, Franziska Maria, Herbener, Nicola, Riedel, Bianca, Beier, Fabian, Swarbrick, Alexander, Lassmann, Silke, Dengjel, Jörn, Zeiser, Robert, Brummer, Tilman

“…Despite being overexpressed in different tumor entities, RIO kinases are hardly characterized in mammalian cells. We investigated the role of these atypical…”
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Comprehensive genetic profiling and molecularly guided treatment for patients with primary CNS tumors by Kuehn, Julia C., Metzger, Patrick, Neidert, Nicolas, Matysiak, Uta, Gräßel, Linda, Philipp, Ulrike, Bleul, Sabine, Pauli, Thomas, Falkenstein, Julia, Bertemes, Henriette, Cysar, Stepan, Hess, Maria Elena, Frey, Anna Verena, Duque-Afonso, Jesús, Schorb, Elisabeth, Machein, Marcia, Beck, Jürgen, Schnell, Oliver, von Bubnoff, Nikolas, Illert, Anna L., Peters, Christoph, Brummer, Tilman, Prinz, Marco, Miething, Cornelius, Becker, Heiko, Lassmann, Silke, Werner, Martin, Börries, Melanie, Duyster, Justus, Heiland, Dieter H., Sankowski, Roman, Scherer, Florian

“…Despite major advances in molecular profiling and classification of primary brain tumors, personalized treatment remains limited for most patients. Here, we…”
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