Search Results - "LASSAM, Norman J"

Phenotypic variation in eight extended CDKN2A germline mutation familial atypical multiple mole melanoma-pancreatic carcinoma-prone families: The familial atypical multiple mole melanoma-pancreatic carcinoma syndrome by LYNCH, Henry T, BRAND, Randall E, KERN, Scott, HOGG, David, DETERS, Carolyn A, FUSARO, Ramon M, LYNCH, Jane F, LING LIU, KNEZETIC, Joseph, LASSAM, Norman J, GOGGINS, Michael

“…Abstract BACKGROUND Hereditary pancreatic carcinoma shows extant phenotypic and genotypic heterogeneity as evidenced by its integral association with a variety…”
Get full text

CDKN2A Mutations in Multiple Primary Melanomas by Monzon, Jose, Liu, Ling, Brill, Herbert, Goldstein, Alisa M, Tucker, Margaret A, From, Lynn, McLaughlin, John, Hogg, David, Lassam, Norman J

“…Some patients with cancer have one or more subsequent primary tumors of the same histologic subtype. This phenomenon can be explained by the long-term exposure…”
Get full text

Concurrent acute lymphoblastic leukemia and juvenile pilocytic astrocytoma in a pediatric patient by KIM, Amanda L, FERNANDEZ, Conrad V, GREER, Wenda L, HOGG, David, LASSAM, Norman J, RESCH, Lothar

“…The concurrence of acute lymphoblastic leukemia (ALL) and an asymptomatic juvenile pilocytic astrocytoma is described. A 6-year-old boy without clinical…”
Get full text

MLK‐3 activates the SAPK/JNK and p38/RK pathways via SEK1 and MKK3/6 by Tibbles, L. A., Ing, Y. L., Kiefer, F., Chan, J., Iscove, N., Woodgett, J. R., Lassam, N. J.

“…Mixed lineage kinase‐3 (MLK‐3) is a 97 kDa serine/threonine kinase with multiple interaction domains, including a Cdc42 binding motif, but unknown function…”
Get full text

Immunoprecipitation of protein kinase activity from adenovirus 5-infected cells using antiserum directed against tumour antigens by LASSAM, NORMAN J, BAYLEY, STANLEY T, GRAHAM, FRANK L, BRANTON, PHILIP E

Get full text

Patients with both pancreatic adenocarcinoma and melanoma may harbor germline CDKN2A mutations by Lal, Geeta, Liu, Ling, Hogg, David, Lassam, Norman J., Redston, Mark S., Gallinger, Steven

“…Germline mutations of the CDKN2A tumor suppressor gene have been identified in melanoma kindreds linked to 9p21, and pancreatic adenocarcinoma is the second…”
Get full text

Translational control in the mealworm, Tenebrio molitor by LASSAM, NORMAN J, LERER, HARVEY, WHITE, BRADLEY N

Get full text

CDKN2A mutation in a non‐FAMMM kindred with cancers at multiple sites results in a functionally abnormal protein by Sun, Sophie, Pollock, Pamela M., Liu, Ling, Karimi, Sepideh, Jothy, Serge, Milner, Benedict J., Renwick, Andrew, Lassam, Norman J., Hayward, Nicholas K., Hogg, David, Narod, Steven A., Foulkes, William D.

“…The CDKN2A gene encodes p16 (CDKN2A), a cell‐cycle inhibitor protein which prevents inappropriate cell cycling and, hence, proliferation. Germ‐line mutations…”
Get full text

Phenotypic variation in eight extended CDKN2A germline mutation familial atypical multiple mole melanoma–pancreatic carcinoma–prone families by Lynch, Henry T., Brand, Randall E., Hogg, David, Deters, Carolyn A., Fusaro, Ramon M., Lynch, Jane F., Liu, Ling, Knezetic, Joseph, Lassam, Norman J., Goggins, Michael, Kern, Scott

“…BACKGROUND Hereditary pancreatic carcinoma shows extant phenotypic and genotypic heterogeneity as evidenced by its integral association with a variety of…”
Get full text

Phenotypic variation in eight extended CDKN2A germline mutation familial atypical multiple mole melanoma-pancreatic carcinoma-prone families: the familial atypical mole melanoma-pancreatic carcinoma syndrome by Lynch, Henry T, Brand, Randall E, Hogg, David, Deters, Carolyn A, Fusaro, Ramon M, Lynch, Jane F, Liu, Ling, Knezetic, Joseph, Lassam, Norman J, Goggins, Michael, Kern, Scott

“…Hereditary pancreatic carcinoma shows extant phenotypic and genotypic heterogeneity as evidenced by its integral association with a variety of hereditary…”
Get full text

MLK-3: identification of a widely-expressed protein kinase bearing an SH3 domain and a leucine zipper-basic region domain by Ing, Y L, Leung, I W, Heng, H H, Tsui, L C, Lassam, N J

“…We have identified a novel protein kinase, designated MLK-3, from human thymus using RT-PCR and cDNA library screening. The deduced open reading frame, derived…”
Get more information

Patients with both pancreatic adenocarcinoma and melanoma may harbor germlineCDKN2A mutations by Lal, Geeta, Liu, Ling, Hogg, David, Lassam, Norman J., Redston, Mark S., Gallinger, Steven

Get full text

VEGF receptor subtypes KDR and FLT1 show different sensitivities to heparin and placenta growth factor by Terman, B, Khandke, L, Dougher-Vermazan, M, Maglione, D, Lassam, N J, Gospodarowicz, D, Persico, M G, Böhlen, P, Eisinger, M

“…Vascular endothelial growth factor (VEGF) is an angiogenic growth factor which binds to two structurally related tyrosine kinase receptors denoted KDR and…”
Get more information

Lack of germ-line mutations of CDK4, p16(INK4A), and p15(INK4B) in families with glioma by Gao, L, Liu, L, van Meyel, D, Cairncross, G, Forsyth, P, Kimmel, D, Jenkins, R B, Lassam, N J, Hogg, D

“…Gliomas are tumors of the central nervous system that may be inherited in some patients. The gene(s) responsible for the clustering of gliomas in families have…”
Get full text

CDKN2A Mutations in Multiple Primary Melanomas by Bystryn, J C

“…To the Editor: The clinical relevance of the conclusion of Monzon et al. (March 26 issue) 1 that patients with multiple melanomas have a germ-line mutation of…”
Get full text

Affected members of melanoma‐prone families with linkage to 9p21 but lacking mutations in CDKN2A do not harbor mutations in the coding regions of either CDKN2B or p19 ARF by Liu, Ling, Goldstein, Alisa M., Tucker, Margaret A., Brill, Herbert, Gruis, Nelleke A., Hogg, David, Lassam, Norman J.

Get full text

Absence of the L37P polymorphism in exon 1 of theCDKN2Agene by Fung, James J.F., Liu, Ling, Gao, Luzhang, Monzon, Jose, Lassam, Norman J, Hogg, David

Get full text

Role of the cyclin-dependent kinase inhibitor CDKN2A in familial melanoma by Hogg, D, Brill, H, Liu, L, Monzon, J, Summers, A, From, L, Lassam, N J

“…Approximately 8 to 12% of melanoma appears to be inherited in an autosomal dominant form. Although most early stage melanomas can be treated successfully by…”
Get more information

Fine mapping of the MLK-3 gene within 11q13 and its exclusion as the MEN1 susceptibility gene by LASSAM, N. J, LIN, Z, SHENNAN, M. G, COURSEAUX, A, TEH, B. T, GAUDRAY, P, LARSSON, C

“…MLK-3 kinase is a widely expressed serine/ threonine kinase that bears multiple protein interaction domains and regulates signals mediated by the…”
Get full text

Affected members of melanoma-prone families with linkage to 9p21 but lacking mutations in CDKN2A do not harbor mutations in the coding regions of either CDKN2B or p19ARF by Liu, Ling, Goldstein, Alisa M., Tucker, Margaret A., Brill, Herbert, Gruis, Nelleke A., Hogg, David, Lassam, Norman J.

“…Mutations in the gene encoding the cell cycle inhibitor CDKN2A have been identified in some melanoma kindreds linked to 9p21. However, many such families show…”
Get full text