Search Results - "LASKO, Loren M"

Targeting Lineage-specific MITF Pathway in Human Melanoma Cell Lines by A-485, the Selective Small-molecule Inhibitor of p300/CBP by Wang, Rui, He, Yupeng, Robinson, Valerie, Yang, Ziping, Hessler, Paul, Lasko, Loren M, Lu, Xin, Bhathena, Anahita, Lai, Albert, Uziel, Tamar, Lam, Lloyd T

“…Metastatic melanoma is responsible for approximately 80% of deaths from skin cancer. Microphthalmia-associated transcription factor (MITF) is a…”
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Discovery of a Potent and Selective Covalent p300/CBP Inhibitor by Mastracchio, Anthony, Lai, Chunqiu, Digiammarino, Enrico, Ready, Damien B, Lasko, Loren M, Bromberg, Kenneth D, McClellan, William J, Montgomery, Debra, Manaves, Vlasios, Shaw, Bailin, Algire, Mikkel, Patterson, Melanie J, Sun, Chaohong C, Rosenberg, Saul, Lai, Albert, Michaelides, Michael R

“…Aberrant gene activation driven by the histone acetyltransferases p300 and CREB binding protein (CBP) has been linked to several diseases, including cancers…”
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Discovery of a selective catalytic p300/CBP inhibitor that targets lineage-specific tumours by Lasko, Loren M., Jakob, Clarissa G., Edalji, Rohinton P., Qiu, Wei, Montgomery, Debra, Digiammarino, Enrico L., Hansen, T. Matt, Risi, Roberto M., Frey, Robin, Manaves, Vlasios, Shaw, Bailin, Algire, Mikkel, Hessler, Paul, Lam, Lloyd T., Uziel, Tamar, Faivre, Emily, Ferguson, Debra, Buchanan, Fritz G., Martin, Ruth L., Torrent, Maricel, Chiang, Gary G., Karukurichi, Kannan, Langston, J. William, Weinert, Brian T., Choudhary, Chunaram, de Vries, Peter, Kluge, Arthur F., Patane, Michael A., Van Drie, John H., Wang, Ce, McElligott, David, Kesicki, Ed, Marmorstein, Ronen, Sun, Chaohong, Cole, Philip A., Rosenberg, Saul H., Michaelides, Michael R., Lai, Albert, Bromberg, Kenneth D.

“…A potent and selective catalytic inhibitor of p300/CBP histone acetyltransferases suppresses tumour proliferation across multiple cell lineages, illustrating…”
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IL-23 induces regulatory T cell plasticity with implications for inflammatory skin diseases by Kannan, Arun K., Su, Zhi, Gauvin, Donna M., Paulsboe, Stephanie E., Duggan, Ryan, Lasko, Loren M., Honore, Prisca, Kort, Michael E., McGaraughty, Steve P., Scott, Victoria E., Gauld, Stephen B.

“…Foxp3 + regulatory T cells (Tregs) represent a major fraction of skin resident T cells. Although normally protective, Tregs have been shown to produce…”
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The SUV4-20 inhibitor A-196 verifies a role for epigenetics in genomic integrity by Bromberg, Kenneth D, Mitchell, Taylor R H, Upadhyay, Anup K, Jakob, Clarissa G, Jhala, Manisha A, Comess, Kenneth M, Lasko, Loren M, Li, Conglei, Tuzon, Creighton T, Dai, Yujia, Li, Fengling, Eram, Mohammad S, Nuber, Alexander, Soni, Niru B, Manaves, Vlasios, Algire, Mikkel A, Sweis, Ramzi F, Torrent, Maricel, Schotta, Gunnar, Sun, Chaohong, Michaelides, Michael R, Shoemaker, Alex R, Arrowsmith, Cheryl H, Brown, Peter J, Santhakumar, Vijayaratnam, Martin, Alberto, Rice, Judd C, Chiang, Gary G, Vedadi, Masoud, Barsyte-Lovejoy, Dalia, Pappano, William N

“…Editorial Summary SUV4-20 members mediate the di- and trimethylation of lysine 20 on histone H4. A chemical screen led to the identification of A-196 as a…”
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ABT-888, an Orally Active Poly(ADP-Ribose) Polymerase Inhibitor that Potentiates DNA-Damaging Agents in Preclinical Tumor Models by DONAWHO, Cherrie K, YAN LUO, FERGUSON, Debra C, GHOREISHI-HAACK, Nayereh S, GRIMM, David R, GUAN, Ran, HAN, Edward K, HOLLEY-SHANKS, Rhonda R, HRISTOV, Boris, IDLER, Kenneth B, JARVIS, Ken, JOHNSON, Eric F, YANPING LUO, KLEINBERG, Lawrence R, KLINGHOFER, Vered, LASKO, Loren M, XUESONG LIU, MARSH, Kennan C, MCGONIGAL, Thomas P, MEULBROEK, Jonathan A, OLSON, Amanda M, PALMA, Joann P, RODRIGUEZ, Luis E, PENNING, Thomas D, YAN SHI, STAVROPOULOS, Jason A, TSURUTANI, Alan C, ZHU, Gui-Dong, ROSENBERG, Saul H, GIRANDA, Vincent L, FROST, David J, BAUCH, Joy L, BOUSKA, Jennifer J, BONTCHEVA-DIAZ, Velitchka D, COX, Bryan F, DEWEESE, Theodore L, DILLEHAY, Larry E

“…Purpose: To evaluate the preclinical pharmacokinetics and antitumor efficacy of a novel orally bioavailable poly(ADP-ribose) polymerase (PARP) inhibitor,…”
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Discovery of spirohydantoins as selective, orally bioavailable inhibitors of p300/CBP histone acetyltransferases by Ji, Zhiqin, Clark, Richard F., Bhat, Vikram, Matthew Hansen, T., Lasko, Loren M., Bromberg, Kenneth D., Manaves, Vlasios, Algire, Mikkel, Martin, Ruth, Qiu, Wei, Torrent, Maricel, Jakob, Clarissa G., Liu, Hong, Cole, Philip A., Marmorstein, Ronen, Kesicki, Edward A., Lai, Albert, Michaelides, Michael R.

“…[Display omitted] p300 and CREB-binding protein (CBP) are essential for a multitude of cellular processes. Dysregulation of p300/CBP histone acetyltransferase…”
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Author Correction: Discovery of a selective catalytic p300/CBP inhibitor that targets lineage-specific tumours by Lasko, Loren M., Jakob, Clarissa G., Edalji, Rohinton P., Qiu, Wei, Montgomery, Debra, Digiammarino, Enrico L., Hansen, T. Matt, Risi, Roberto M., Frey, Robin, Manaves, Vlasios, Shaw, Bailin, Algire, Mikkel, Hessler, Paul, Lam, Lloyd T., Uziel, Tamar, Faivre, Emily, Ferguson, Debra, Buchanan, Fritz G., Martin, Ruth L., Torrent, Maricel, Chiang, Gary G., Karukurichi, Kannan, Langston, J. William, Weinert, Brian T., Choudhary, Chunaram, de Vries, Peter, Kluge, Arthur F., Patane, Michael A., Van Drie, John H., Wang, Ce, McElligott, David, Kesicki, Edward A., Marmorstein, Ronen, Sun, Chaohong, Cole, Philip A., Rosenberg, Saul H., Michaelides, Michael R., Lai, Albert, Bromberg, Kenneth D.

“…In the originally published version of this Letter, the authors Arthur F. Kluge, Michael A. Patane and Ce Wang were inadvertently omitted from the author list…”
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Hit to Lead optimization of a novel class of squarate-containing polo-like kinases inhibitors by Zhang, Qingwei, Xia, Zhiren, Mitten, Michael J., Lasko, Loren M., Klinghofer, Vered, Bouska, Jennifer, Johnson, Eric F., Penning, Thomas D., Luo, Yan, Giranda, Vincent L., Shoemaker, Alexander R., Stewart, Kent D., Djuric, Stevan W., Vasudevan, Anil

“…A high throughput screening (HTS) hit, 1 (Plk1 Ki=2.2μM) was optimized and evaluated for the enzymatic inhibition of Plk-1 kinase. Molecular modeling suggested…”
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Pyrimidine-Based Tricyclic Molecules as Potent and Orally Efficacious Inhibitors of Wee1 Kinase by Tong, Yunsong, Torrent, Maricel, Florjancic, Alan S, Bromberg, Kenneth D, Buchanan, Fritz G, Ferguson, Debra C, Johnson, Eric F, Lasko, Loren M, Maag, David, Merta, Philip J, Olson, Amanda M, Osterling, Donald J, Soni, Nirupama, Shoemaker, Alexander R, Penning, Thomas D

“…Aided by molecular modeling, compounds with a pyrimidine-based tricyclic scaffold were designed and confirmed to inhibit Wee1 kinase. Structure–activity…”
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Abstract LB-A23: Discovery of a potent catalytic p300/CBP inhibitor that targets lineage-specific tumors by Bromberg, Kenneth D., Lasko, Loren M., Jakob, Clarissa G., Qiu, Wei, Montgomery, Debra, Digiammarino, Enrico L., Hansen, Todd M., Risi, Roberto M., Frey, Robin R., Manaves, Vlasios, Shaw, Bailin, Algire, Mikkel, Hessler, Paul, Lam, Lloyd T., Uziel, Tamar, Favire, Emily, Ferguson, Debra, Buchanan, Fritz G., Martin, Ruth L., Torrent, Maricel, Rosenberg, Saul H., Michaelides, Michael R., Lai, Albert

“…The dynamic and reversible acetylation of proteins catalyzed by histone acetyltransferases (HATs) and histone deacetylases (HDACs) is a major epigenetic…”
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Discovery of a potent catalytic p300/CBP inhibitor that targets lineage-specific tumors by Lasko, Loren M., Jakob, Clarissa G., Edalji, Rohinton P., Qiu, Wei, Montgomery, Debra, Digiammarino, Enrico L., Hansen, T. Matt, Risi, Roberto M., Frey, Robin, Manaves, Vlasios, Shaw, Bailin, Algire, Mikkel, Hessler, Paul, Lam, Lloyd T., Uziel, Tamar, Faivre, Emily, Ferguson, Debra, Buchanan, Fritz G., Martin, Ruth L., Torrent, Maricel, Chiang, Gary G., Karukurichi, Kannan, Langston, J. William, Weinert, Brian T., Choudhary, Chunaram, de Vries, Peter, Van Drie, John H., McElligott, David, Kesicki, Ed, Marmorstein, Ronen, Sun, Chaohong, Cole, Philip A., Rosenberg, Saul H., Michaelides, Michael R., Lai, Albert, Bromberg, Kenneth D.

“…The dynamic and reversible acetylation of proteins catalyzed by histone acetyltransferases (HATs) and histone deacetylases (HDACs) is a major epigenetic…”
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