Search Results - "LASKIN, Jeffrey D"

Role of Macrophages in Acute Lung Injury and Chronic Fibrosis Induced by Pulmonary Toxicants by Laskin, Debra L, Malaviya, Rama, Laskin, Jeffrey D

“…Abstract A diverse group of toxicants has been identified that cause injury to the lung including gases (eg, ozone, chlorine), particulates/aerosols (eg,…”
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Macrophages and Tissue Injury: Agents of Defense or Destruction? by LASKIN, Debra L, SUNIL, Vasanthi R, GARDNER, Carol R, LASKIN, Jeffrey D

“…The past several years have seen the accumulation of evidence demonstrating that tissue injury induced by diverse toxicants is due not only to their direct…”
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Pulmonary toxicants and fibrosis: innate and adaptive immune mechanisms by Malaviya, Rama, Kipen, Howard M., Businaro, Rita, Laskin, Jeffrey D., Laskin, Debra L.

“…Pulmonary fibrosis is characterized by destruction and remodeling of the lung due to an accumulation of collagen and other extracellular matrix components in…”
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Characterization of Distinct Macrophage Subpopulations during Nitrogen Mustard-Induced Lung Injury and Fibrosis by Venosa, Alessandro, Malaviya, Rama, Choi, Hyejeong, Gow, Andrew J, Laskin, Jeffrey D, Laskin, Debra L

“…Nitrogen mustard (NM) is an alkylating agent known to cause extensive pulmonary injury progressing to fibrosis. This is accompanied by a persistent macrophage…”
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Localization of the placental BCRP/ ABCG2 transporter to lipid rafts: Role for cholesterol in mediating efflux activity by Szilagyi, John T, Vetrano, Anna M, Laskin, Jeffrey D, Aleksunes, Lauren M

“…Abstract Introduction The breast cancer resistance protein (BCRP/ ABCG2 ) is an efflux transporter in the placental barrier. By transporting chemicals from the…”
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Mechanisms of oxidant generation by catalase by Heck, Diane E., Shakarjian, Michael, Kim, Hong Duck, Laskin, Jeffrey D., Vetrano, Anna M.

“…The enzyme catalase converts solar radiation into reactive oxidant species (ROS). In this study, we report that several bacterial catalases (hydroperoxidases,…”
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Protective role of spleen-derived macrophages in lung inflammation, injury, and fibrosis induced by nitrogen mustard by Venosa, Alessandro, Malaviya, Rama, Gow, Andrew J, Hall, Leroy, Laskin, Jeffrey D, Laskin, Debra L

“…Nitrogen mustard (NM) is a vesicant that causes lung injury and fibrosis, accompanied by a persistent macrophage inflammatory response. In these studies we…”
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Application of the Amplex red/horseradish peroxidase assay to measure hydrogen peroxide generation by recombinant microsomal enzymes by Mishin, Vladimir, Gray, Joshua P., Heck, Diane E., Laskin, Debra L., Laskin, Jeffrey D.

“…The formation of reactive oxygen species by the cytochrome P450 monooxygenase system is thought to be due to autoxidation of NADPH-cytochrome P450 reductase…”
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Macrophage activation by factors released from acetaminophen-injured hepatocytes: Potential role of HMGB1 by Dragomir, Ana-Cristina, Laskin, Jeffrey D., Laskin, Debra L.

“…Toxic doses of acetaminophen (AA) cause hepatocellular necrosis. Evidence suggests that activated macrophages contribute to the pathogenic process; however,…”
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Mechanisms Mediating the Vesicant Actions of Sulfur Mustard after Cutaneous Exposure by Shakarjian, Michael P., Heck, Diane E., Gray, Joshua P., Sinko, Patrick J., Gordon, Marion K., Casillas, Robert P., Heindel, Ned D., Gerecke, Donald R., Laskin, Debra L., Laskin, Jeffrey D.

“…Sulfur mustard (SM), a chemical weapon first employed during World War I, targets the skin, eyes, and lung. It remains a significant military and civilian…”
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Classical and alternative macrophage activation in the lung following ozone-induced oxidative stress by Sunil, Vasanthi R., Patel-Vayas, Kinal, Shen, Jianliang, Laskin, Jeffrey D., Laskin, Debra L.

“…Ozone is a pulmonary irritant known to cause oxidative stress, inflammation and tissue injury. Evidence suggests that macrophages play a role in the pathogenic…”
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Systematic Development and Characterization of Novel, High Drug-Loaded, Photostable, Curcumin Solid Lipid Nanoparticle Hydrogel for Wound Healing by Sandhu, Simarjot Kaur, Kumar, Suneel, Raut, Jayant, Singh, Mandeep, Kaur, Sandeep, Sharma, Garima, Roldan, Tomas L, Trehan, Sonia, Holloway, Jennifer, Wahler, Gabriella, Laskin, Jeffrey D, Sinko, Patrick J, Berthiaume, Francois, Michniak-Kohn, Bozena, Rishi, Praveen, Ganesh, Narayanan, Kaur, Indu Pal

“…The study aims to develop high drug-loaded (about 15% lipid matrix) curcumin solid lipid nanoparticles (CSLNs) for wound healing. CSLNs prepared by hot,…”
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Repurposing FDA‐approved drugs to treat chemical weapon toxicities: Interactive case studies for trainees by Aleksunes, Lauren M., Gray, Joshua P., Meshanni, Jaclynn, Laskin, Jeffrey D., Laskin, Debra L.

“…The risk of a terrorist attack in the United States has created challenges on how to effectively treat toxicities that result from exposure to chemical…”
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Inflammatory effects of inhaled sulfur mustard in rat lung by Malaviya, Rama, Sunil, Vasanthi R., Cervelli, Jessica, Anderson, Dana R., Holmes, Wesley W., Conti, Michele L., Gordon, Ronald E., Laskin, Jeffrey D., Laskin, Debra L.

“…Inhalation of sulfur mustard (SM), a bifunctional alkylating agent that causes severe lung damage, is a significant threat to both military and civilian…”
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Optimizing Nanosuspension Drug Release and Wound Healing Using a Design of Experiments Approach: Improving the Drug Delivery Potential of NDH-4338 for Treating Chemical Burns by Roldan, Tomas L, Li, Shike, Guillon, Christophe, Heindel, Ned D, Laskin, Jeffrey D, Lee, In Heon, Gao, Dayuan, Sinko, Patrick J

“…NDH-4338 is a highly lipophilic prodrug comprising indomethacin and an acetylcholinesterase inhibitor. A design of experiments approach was used to synthesize,…”
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Differential metabolism of 4-hydroxynonenal in liver, lung and brain of mice and rats by Zheng, Ruijin, Dragomir, Ana-Cristina, Mishin, Vladimir, Richardson, Jason R., Heck, Diane E., Laskin, Debra L., Laskin, Jeffrey D.

“…The lipid peroxidation end-product 4-hydroxynonenal (4-HNE) is generated in tissues during oxidative stress. As a reactive aldehyde, it forms Michael adducts…”
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Anti-TNFα therapy in inflammatory lung diseases by Malaviya, Rama, Laskin, Jeffrey D, Laskin, Debra L

“…Increased levels of tumor necrosis factor (TNF) α have been linked to a number of pulmonary inflammatory diseases including asthma, chronic obstructive…”
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Sulfur mustard-induced pulmonary injury: Therapeutic approaches to mitigating toxicity by Weinberger, Barry, Laskin, Jeffrey D, Sunil, Vasanthi R, Sinko, Patrick J, Heck, Diane E, Laskin, Debra L

“…Abstract Sulfur mustard (SM) is highly toxic to the lung inducing both acute and chronic effects including upper and lower obstructive disease, airway…”
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Biodistribution and renal clearance of biocompatible lung targeted poly(ethylene glycol) (PEG) nanogel aggregates by Deshmukh, Manjeet, Kutscher, Hilliard L., Gao, Dayuan, Sunil, Vasanthi R., Malaviya, Rama, Vayas, Kinal, Stein, Stanley, Laskin, Jeffrey D., Laskin, Debra L., Sinko, Patrick J.

“…A novel stabilized aggregated nanogel particle (SANP) drug delivery system was prepared for injectable passive lung targeting. Gel nanoparticles (GNPs) were…”
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Depilatory double‐disc mouse model for evaluation of vesicant dermal injury pharmacotherapy countermeasures by Roldan, Tomas L., Li, Shike, Laskin, Jeffrey D., Gao, Dayuan, Sinko, Patrick J.

“…Background Sulfur mustard (SM) is a chemical warfare vesicant that severely injures exposed eyes, lungs, and skin. Mechlorethamine hydrochloride (NM) is widely…”
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