Search Results - "LARUSSO, Nicholas"

Primary Sclerosing Cholangitis by Lazaridis, Konstantinos N, LaRusso, Nicholas F

“…This review summarizes the current understanding of primary sclerosing cholangitis, a persistent, progressive disease for which there is no definitive therapy…”
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The Cholangiopathies by Lazaridis, Konstantinos N., MD, LaRusso, Nicholas F., MD

“…Abstract Cholangiocytes (ie, the epithelial cells that line the bile ducts) are an important subset of liver cells. They are actively involved in the…”
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In Memoriam—Martin Brotman, (1939–2020) by LaRusso, Nicholas F.

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Exosomes in the pathogenesis, diagnostics and therapeutics of liver diseases by Masyuk, Anatoliy I, Masyuk, Tatyana V, LaRusso, Nicholas F

“…Summary Exosomes are small (30–100 nm in diameter) extracellular membrane-enclosed vesicles released by different cell types into the extracellular space or…”
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Cholangiocyte pathobiology by Banales, Jesus M., Huebert, Robert C., Karlsen, Tom, Strazzabosco, Mario, LaRusso, Nicholas F., Gores, Gregory J.

“…Cholangiocytes, the epithelial cells lining the intrahepatic and extrahepatic bile ducts, are highly specialized cells residing in a complex anatomic niche…”
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Macrophages make a difference in cholestatic liver diseases - but how? by Trussoni, Christy E, LaRusso, Nicholas F

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Extracellular vesicles in liver pathobiology: Small particles with big impact by Hirsova, Petra, Ibrahim, Samar H., Verma, Vikas K., Morton, Leslie A., Shah, Vijay H., LaRusso, Nicholas F., Gores, Gregory J., Malhi, Harmeet

“…Extracellular vesicles (EVs) are nanometer‐sized, membrane‐bound vesicles released by cells into the extracellular milieu. EVs are now recognized to play a…”
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An aged immune system drives senescence and ageing of solid organs by Yousefzadeh, Matthew J., Flores, Rafael R., Zhu, Yi, Schmiechen, Zoe C., Brooks, Robert W., Trussoni, Christy E., Cui, Yuxiang, Angelini, Luise, Lee, Kyoo-A, McGowan, Sara J., Burrack, Adam L., Wang, Dong, Dong, Qing, Lu, Aiping, Sano, Tokio, O’Kelly, Ryan D., McGuckian, Collin A., Kato, Jonathan I., Bank, Michael P., Wade, Erin A., Pillai, Smitha P. S., Klug, Jenna, Ladiges, Warren C., Burd, Christin E., Lewis, Sara E., LaRusso, Nicholas F., Vo, Nam V., Wang, Yinsheng, Kelley, Eric E., Huard, Johnny, Stromnes, Ingunn M., Robbins, Paul D., Niedernhofer, Laura J.

“…Ageing of the immune system, or immunosenescence, contributes to the morbidity and mortality of the elderly 1 , 2 . To define the contribution of immune system…”
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Release of luminal exosomes contributes to TLR4-mediated epithelial antimicrobial defense by Hu, Guoku, Gong, Ai-Yu, Roth, Amanda L, Huang, Bing Q, Ward, Honorine D, Zhu, Guan, Larusso, Nicholas F, Hanson, Nancy D, Chen, Xian-Ming

“…Exosomes are membranous nanovesicles released by most cell types from multi-vesicular endosomes. They are speculated to transfer molecules to neighboring or…”
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Primary Sclerosing Cholangitis Risk Estimate Tool (PREsTo) Predicts Outcomes of the Disease: A Derivation and Validation Study Using Machine Learning by Eaton, John E., Vesterhus, Mette, McCauley, Bryan M., Atkinson, Elizabeth J., Schlicht, Erik M., Juran, Brian D., Gossard, Andrea A., LaRusso, Nicholas F., Gores, Gregory J., Karlsen, Tom H., Lazaridis, Konstantinos N.

“…Improved methods are needed to risk stratify and predict outcomes in patients with primary sclerosing cholangitis (PSC). Therefore, we sought to derive and…”
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A randomized, placebo-controlled, phase II study of obeticholic acid for primary sclerosing cholangitis by Kowdley, Kris V., Vuppalanchi, Raj, Levy, Cynthia, Floreani, Annarosa, Andreone, Pietro, LaRusso, Nicholas F., Shrestha, Roshan, Trotter, James, Goldberg, David, Rushbrook, Simon, Hirschfield, Gideon M., Schiano, Thomas, Jin, Yuying, Pencek, Richard, MacConell, Leigh, Shapiro, David, Bowlus, Christopher L.

“…Primary sclerosing cholangitis (PSC) is a rare, cholestatic liver disease with no currently approved therapies. Obeticholic acid (OCA) is a potent farnesoid X…”
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Absence of the intestinal microbiota exacerbates hepatobiliary disease in a murine model of primary sclerosing cholangitis by Tabibian, James H., O'Hara, Steven P., Trussoni, Christy E., Tietz, Pamela S., Splinter, Patrick L., Mounajjed, Taofic, Hagey, Lee R., LaRusso, Nicholas F.

“…Primary sclerosing cholangitis (PSC) is a chronic, idiopathic, fibroinflammatory cholangiopathy. The role of the microbiota in PSC etiopathogenesis may be…”
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Macrophages contribute to the pathogenesis of sclerosing cholangitis in mice by Guicciardi, Maria Eugenia, Trussoni, Christy E., Krishnan, Anuradha, Bronk, Steven F., Lorenzo Pisarello, Maria J., O'Hara, Steven P., Splinter, Patrick L., Gao, Yandong, Vig, Pamela, Revzin, Alexander, LaRusso, Nicholas F., Gores, Gregory J.

“…[Display omitted] •Peribiliary macrophages are increased in PSC and animal models of PSC.•Both M1-like and M2-like peribiliary macrophages are…”
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Cholangiocyte senescence by way of N‐ras activation is a characteristic of primary sclerosing cholangitis by Tabibian, James H., O'Hara, Steven P., Splinter, Patrick L., Trussoni, Christy E., LaRusso, Nicholas F.

“…Primary sclerosing cholangitis (PSC) is an incurable cholangiopathy of unknown etiopathogenesis. Here we tested the hypothesis that cholangiocyte senescence is…”
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The Spectrum of Reactive Cholangiocytes in Primary Sclerosing Cholangitis by Guicciardi, Maria Eugenia, Trussoni, Christy E., LaRusso, Nicholas F., Gores, Gregory J.

“…Cholangiocytes are the target of a group of chronic liver diseases termed the “cholangiopathies,” in which cholangiocytes react to exogenous and endogenous…”
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In Memoriam: Alan F. Hofmann, MD, PhD, May 17, 1931, to September 7, 2021 by Barrett, Kim E., LaRusso, Nicholas F.

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Epigenetics in the Primary Biliary Cholangitis and Primary Sclerosing Cholangitis by Cheung, Angela C, LaRusso, Nicholas F, Gores, Gregory J, Lazaridis, Konstantinos N

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The Achilles’ heel of senescent cells: from transcriptome to senolytic drugs by Zhu, Yi, Tchkonia, Tamara, Pirtskhalava, Tamar, Gower, Adam C., Ding, Husheng, Giorgadze, Nino, Palmer, Allyson K., Ikeno, Yuji, Hubbard, Gene B., Lenburg, Marc, O'Hara, Steven P., LaRusso, Nicholas F., Miller, Jordan D., Roos, Carolyn M., Verzosa, Grace C., LeBrasseur, Nathan K., Wren, Jonathan D., Farr, Joshua N., Khosla, Sundeep, Stout, Michael B., McGowan, Sara J., Fuhrmann‐Stroissnigg, Heike, Gurkar, Aditi U., Zhao, Jing, Colangelo, Debora, Dorronsoro, Akaitz, Ling, Yuan Yuan, Barghouthy, Amira S., Navarro, Diana C., Sano, Tokio, Robbins, Paul D., Niedernhofer, Laura J., Kirkland, James L.

“…Summary The healthspan of mice is enhanced by killing senescent cells using a transgenic suicide gene. Achieving the same using small molecules would have a…”
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A Cellular Micro-RNA, let-7i, Regulates Toll-like Receptor 4 Expression and Contributes to Cholangiocyte Immune Responses against Cryptosporidium parvum Infection by Chen, Xian-Ming, Splinter, Patrick L., O'Hara, Steven P., LaRusso, Nicholas F.

“…Toll-like receptors (TLRs) are important pathogen recognition molecules and are key to epithelial immune responses to microbial infection. However, the…”
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HDAC6 Inhibition Restores Ciliary Expression and Decreases Tumor Growth by GRADILONE, Sergio A, RADTKE, Brynn N, BOGERT, Pamela S, HUANG, Bing Q, GAJDOS, Gabriella B, LARUSSO, Nicholas F

“…Primary cilia are multisensory organelles recently found to be absent in some tumor cells, but the mechanisms of deciliation and the role of cilia in tumor…”
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