Search Results - "LARSEN, Thomas O"

Safety of the fungal workhorses of industrial biotechnology: update on the mycotoxin and secondary metabolite potential of Aspergillus niger, Aspergillus oryzae, and Trichoderma reesei by Frisvad, Jens C., Møller, Lars L. H., Larsen, Thomas O., Kumar, Ravi, Arnau, José

“…This review presents an update on the current knowledge of the secondary metabolite potential of the major fungal species used in industrial biotechnology,…”
Get full text

Dereplication of Microbial Natural Products by LC-DAD-TOFMS by Nielsen, Kristian F, Månsson, Maria, Rank, Christian, Frisvad, Jens Christian, Larsen, Thomas O

“…Dereplication, the rapid identification of known compounds present in a mixture, is crucial to the fast discovery of novel natural products. Determining the…”
Get full text

Fumonisin and ochratoxin production in industrial Aspergillus niger strains by Frisvad, Jens C, Larsen, Thomas O, Thrane, Ulf, Meijer, Martin, Varga, Janos, Samson, Robert A, Nielsen, Kristian F

“…Aspergillus niger is perhaps the most important fungus used in biotechnology, and is also one of the most commonly encountered fungi contaminating foods and…”
Get full text

Review of secondary metabolites and mycotoxins from the Aspergillus niger group by Nielsen, Kristian Fog, Mogensen, Jesper Mølgaard, Johansen, Maria, Larsen, Thomas O, Frisvad, Jens Christian

“…Filamentous fungi in the Aspergillus section Nigri (the black aspergilli) represent some of the most widespread food and feed contaminants known but they are…”
Get full text

Extrolites of Aspergillus fumigatus and Other Pathogenic Species in Aspergillus Section Fumigati by Frisvad, Jens C, Larsen, Thomas O

“…Aspergillus fumigatus is an important opportunistic human pathogen known for its production of a large array of extrolites. Up to 63 species have been…”
Get full text

Novofumigatonin biosynthesis involves a non-heme iron-dependent endoperoxide isomerase for orthoester formation by Matsuda, Yudai, Bai, Tongxuan, Phippen, Christopher B. W., Nødvig, Christina S., Kjærbølling, Inge, Vesth, Tammi C., Andersen, Mikael R., Mortensen, Uffe H., Gotfredsen, Charlotte H., Abe, Ikuro, Larsen, Thomas O.

“…Novofumigatonin ( 1 ), isolated from the fungus Aspergillus novofumigatus , is a heavily oxygenated meroterpenoid containing a unique orthoester moiety…”
Get full text

Accurate prediction of secondary metabolite gene clusters in filamentous fungi by Andersen, Mikael R, Nielsen, Jakob B, Klitgaard, Andreas, Petersen, Lene M, Zachariasen, Mia, Hansen, Tilde J, Blicher, Lene H, Gotfredsen, Charlotte H, Larsen, Thomas O, Nielsen, Kristian F, Mortensen, Uffe H

“…Biosynthetic pathways of secondary metabolites from fungi are currently subject to an intense effort to elucidate the genetic basis for these compounds due to…”
Get full text

Formation of sclerotia and production of indoloterpenes by Aspergillus niger and other species in section Nigri by Frisvad, Jens C, Petersen, Lene M, Lyhne, E Kirstine, Larsen, Thomas O

“…Several species in Aspergillus section Nigri have been reported to produce sclerotia on well-known growth media, such as Czapek yeast autolysate (CYA) agar,…”
Get full text

The importance of mass spectrometric dereplication in fungal secondary metabolite analysis by Nielsen, Kristian F, Larsen, Thomas O

“…Having entered the Genomic Era, it is now evident that the biosynthetic potential of filamentous fungi is much larger than was thought even a decade ago. Fungi…”
Get full text

Solonamide B inhibits quorum sensing and reduces Staphylococcus aureus mediated killing of human neutrophils by Nielsen, Anita, Månsson, Maria, Bojer, Martin S, Gram, Lone, Larsen, Thomas O, Novick, Richard P, Frees, Dorte, Frøkiær, Hanne, Ingmer, Hanne

“…Methicillin-resistant Staphylococcus aureus (MRSA) continues to be a serious human pathogen, and particularly the spread of community associated (CA)-MRSA…”
Get full text

Tenuazonic acid from Stemphylium loti inhibits the plant plasma membrane H⁺-ATPase by a mechanism involving the C-terminal regulatory domain by Bjørk, Peter K., Rasmussen, Silas A., Gjetting, Sisse K., Havshøi, Nanna W., Petersen, Thomas Isbrandt, Ipsen, Johan Ø., Larsen, Thomas O., Fuglsang, Anja T.

“…• Pathogenic fungi often target the plant plasma membrane (PM) H⁺-ATPase during infection. To identify pathogenic compounds targeting plant H⁺-ATPases, we…”
Get full text

Accurate dereplication of bioactive secondary metabolites from marine-derived fungi by UHPLC-DAD-QTOFMS and a MS/HRMS library by Kildgaard, Sara, Mansson, Maria, Dosen, Ina, Klitgaard, Andreas, Frisvad, Jens C, Larsen, Thomas O, Nielsen, Kristian F

“…In drug discovery, reliable and fast dereplication of known compounds is essential for identification of novel bioactive compounds. Here, we show an integrated…”
Get full text

Bioactive Ascochlorin Analogues from the Marine-Derived Fungus Stilbella fimetaria by Subko, Karolina, Kildgaard, Sara, Vicente, Francisca, Reyes, Fernando, Genilloud, Olga, Larsen, Thomas O

“…The marine-derived fungus is a chemically talented fungus producing several classes of bioactive metabolites, including meroterpenoids of the ascochlorin…”
Get full text

Production of bioactive secondary metabolites by marine vibrionaceae by Mansson, Maria, Gram, Lone, Larsen, Thomas O

“…Bacteria belonging to the Vibrionaceae family are widespread in the marine environment. Today, 128 species of vibrios are known. Several of them are infamous…”
Get full text

Norlichexanthone Reduces Virulence Gene Expression and Biofilm Formation in Staphylococcus aureus by Baldry, Mara, Nielsen, Anita, Bojer, Martin S, Zhao, Yu, Friberg, Cathrine, Ifrah, Dan, Glasser Heede, Nina, Larsen, Thomas O, Frøkiær, Hanne, Frees, Dorte, Zhang, Lixin, Dai, Huanqin, Ingmer, Hanne

“…Staphylococcus aureus is a serious human pathogen and antibiotic resistant, community-associated strains, such as the methicillin resistant S. aureus (MRSA)…”
Get full text

Production of the antimicrobial compound tetrabromopyrrole and the Pseudomonas quinolone system precursor, 2-heptyl-4-quinolone, by a novel marine species Pseudoalteromonas galatheae sp. nov by Paulsen, Sara Skøtt, Isbrandt, Thomas, Kirkegaard, Markus, Buijs, Yannick, Strube, Mikael Lenz, Sonnenschein, Eva C., Larsen, Thomas O., Gram, Lone

“…Novel antimicrobials are urgently needed due to the rapid spread of antibiotic resistant bacteria. In a genome-wide analysis of Pseudoalteromonas strains, one…”
Get full text

Genomic and Chemical Diversity of Bacillus subtilis Secondary Metabolites against Plant Pathogenic Fungi by Kiesewalter, Heiko T, Lozano-Andrade, Carlos N, Wibowo, Mario, Strube, Mikael L, Maróti, Gergely, Snyder, Dan, Jørgensen, Tue Sparholt, Larsen, Thomas O, Cooper, Vaughn S, Weber, Tilmann, Kovács, Ákos T

“…produces a wide range of secondary metabolites providing diverse plant growth-promoting and biocontrol abilities. These secondary metabolites include…”
Get full text

A Concise Total Synthesis of the Fungal Isoquinoline Alkaloid TMC-120B by Haidar, Ahmad K, Kjeldsen, Niels D, Troelsen, Nikolaj S, Previtali, Viola, Lundquist, Kasper P, Larsen, Thomas O, Clausen, Mads H

“…Recent reports of antiepileptic activity of the fungal alkaloid TMC-120B have renewed the interest in this natural product. Previous total syntheses of…”
Get full text

Inhibition of virulence gene expression in Staphylococcus aureus by novel depsipeptides from a marine photobacterium by Mansson, Maria, Nielsen, Anita, Kjærulff, Louise, Gotfredsen, Charlotte H, Wietz, Matthias, Ingmer, Hanne, Gram, Lone, Larsen, Thomas O

“…During a global research expedition, more than five hundred marine bacterial strains capable of inhibiting the growth of pathogenic bacteria were collected…”
Get full text

Distribution of sterigmatocystin in filamentous fungi by Rank, Christian, Nielsen, Kristian F., Larsen, Thomas O., Varga, Janos, Samson, Rob A., Frisvad, Jens C.

“…During the last 50 y, the carcinogenic mycotoxin sterigmatocystin (ST) has been reported in several phylogenetically and phenotypically different genera:…”
Get full text