Search Results - "LARREA, Fernando"
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EB1089 Increases the Antiproliferative Response of Lapatinib in Combination with Antiestrogens in HER2-Positive Breast Cancer Cells
Published in International journal of molecular sciences (01-03-2024)“…HER2-positive breast cancer is associated with aggressive behavior and reduced survival rates. Calcitriol restores the antiproliferative activity of…”
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The Phytochemical α-Mangostin Inhibits Cervical Cancer Cell Proliferation and Tumor Growth by Downregulating E6/E7-HPV Oncogenes and KCNH1 Gene Expression
Published in International journal of molecular sciences (03-02-2023)“…Cervical cancer is the fourth most common cancer among women worldwide. The main factor associated with the onset and progression of this neoplasia is the…”
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3
Endothelium-Dependent Induction of Vasculogenic Mimicry in Human Triple-Negative Breast Cancer Cells Is Inhibited by Calcitriol and Curcumin
Published in International journal of molecular sciences (11-07-2022)“…In highly aggressive tumors, cancer cells may form channel-like structures through a process known as vasculogenic mimicry (VM). VM is generally associated…”
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The Inhibition of the FGFR/PI3K/Akt Axis by AZD4547 Disrupts the Proangiogenic Microenvironment and Vasculogenic Mimicry Arising from the Interplay between Endothelial and Triple-Negative Breast Cancer Cells
Published in International journal of molecular sciences (01-09-2023)“…Vasculogenic mimicry (VM), a process in which aggressive cancer cells form tube-like structures, plays a crucial role in providing nutrients and escape routes…”
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Calcitriol Inhibits the Proliferation of Triple-Negative Breast Cancer Cells through a Mechanism Involving the Proinflammatory Cytokines IL-1β and TNF-α
Published in Journal of immunology research (01-01-2019)“…Triple-negative breast cancer (TNBC) is one of the most aggressive tumors, with poor prognosis and high metastatic capacity. The aggressive behavior may…”
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6
Evidence of sexual dimorphism in placental vitamin D metabolism: Testosterone inhibits calcitriol-dependent cathelicidin expression
Published in The Journal of steroid biochemistry and molecular biology (01-10-2016)“…[Display omitted] •Testosterone stimulates CYP24A1and inhibits CYP27B1 placental gene expression.•Testosterone phosphorylates CREB in a cAMP independent and AR…”
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Estradiol and progesterone synthesis in human placenta is stimulated by calcitriol
Published in Journal of steroid biochemistry and molecular biology (01-03-2007)“…Calcitriol exerts a diverse range of biological actions including the control of growth and cell differentiation, modulation of hormone secretion, and…”
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Journal Article Conference Proceeding -
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Regulation of CYP27B1 and CYP24A1 gene expression by recombinant pro-inflammatory cytokines in cultured human trophoblasts
Published in The Journal of steroid biochemistry and molecular biology (01-10-2014)“…•Cytokines regulate calcitriol metabolism in human placenta.•INFγ contributes to calcitriol anabolism.•TNFα favors the catabolism of calcitriol. Placenta is an…”
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Enhancing Tamoxifen Therapy with α-Mangostin: Synergistic Antiproliferative Effects on Breast Cancer Cells and Potential Reduced Endometrial Impact
Published in Pharmaceuticals (Basel, Switzerland) (01-11-2023)“…Breast cancer is the most prevalent neoplasia among women worldwide. For the estrogen receptor-positive (ER+) phenotype, tamoxifen is the standard hormonal…”
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Cord Serum Calcitriol Inversely Correlates with Maternal Blood Pressure in Urinary Tract Infection-Affected Pregnancies: Sex-Dependent Immune Implications
Published in Nutrients (04-09-2021)“…Urinary tract infections (UTI) during pregnancy are frequently associated with hypertensive disorders, increasing the risk of perinatal morbidity. Calcitriol,…”
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11
Gene transcription profiling of astheno- and normo-zoospermic sperm subpopulations
Published in Asian journal of andrology (01-11-2020)“…Spermatozoa contain a repertoire of RNAs considered to be potential functional fertility biomarkers. In this study, the gene expression of human sperm…”
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Effects of Semen Processing on Sperm Function: Differences between Swim-Up and Density Gradient Centrifugation
Published in The world journal of men's health (01-10-2021)“…Andrology research has evolved notoriously in the latest years, particularly since male factor contribution to couple infertility has been undoubtedly…”
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Astemizole synergizes calcitriol antiproliferative activity by inhibiting CYP24A1 and upregulating VDR: a novel approach for breast cancer therapy
Published in PloS one (12-09-2012)“…Calcitriol antiproliferative effects include inhibition of the oncogenic ether-à-go-go-1 potassium channel (Eag1) expression, which is necessary for cell cycle…”
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14
Evaluation of ligand selectivity using reporter cell lines stably expressing estrogen receptor alpha or beta
Published in Biochemical pharmacology (14-05-2006)“…Estrogens control transcriptional responses through binding to two different nuclear receptors, estrogen receptor α (ERα) and β (ERβ). Since these two ER…”
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In vivo dual targeting of the oncogenic Ether-à-go-go-1 potassium channel by calcitriol and astemizole results in enhanced antineoplastic effects in breast tumors
Published in BMC cancer (03-10-2014)“…The oncogenic ether-à-go-go-1 potassium channel (EAG1) activity and expression are necessary for cell cycle progression and tumorigenesis. The active vitamin D…”
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16
Protein restriction during pregnancy affects maternal liver lipid metabolism and fetal brain lipid composition in the rat
Published in American journal of physiology: endocrinology and metabolism (01-02-2010)“…Suboptimal developmental environments program offspring to lifelong metabolic problems. The aim of this study was to determine the impact of protein…”
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Journal Article -
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TRPM8, a versatile channel in human sperm
Published in PloS one (30-06-2009)“…The transient receptor potential channel (TRP) family includes more than 30 proteins; they participate in various Ca(2+) dependent processes. TRPs are…”
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Comparison of Bioethanol Production of Starches from Different Andean Tubers
Published in Chemical engineering transactions (01-06-2020)“…Bioethanol from starchy biomass represents 60% of the global generation. In Ecuador, there is an annual production of potato, cassava and sweet potato of over…”
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Calcitriol affects hCG gene transcription in cultured human syncytiotrophoblasts
Published in Reproductive biology and endocrinology (22-01-2008)“…In pregnancy, maternal serum concentrations of calcitriol significantly rise as a result of increased renal and placental contribution in order to assure…”
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Effects of a Maternal Low Protein Isocaloric Diet on Milk Leptin and Progeny Serum Leptin Concentration and Appetitive Behavior in the First 21 Days of Neonatal Life in the Rat
Published in Pediatric research (01-04-2008)“…Suboptimal developmental environments program offspring to lifelong metabolic problems. We evaluated effects of maternal isocaloric low protein diet during…”
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