Search Results - "LAROCHETTE, N"

Mitochondria as therapeutic targets for cancer chemotherapy by Galluzzi, L, Larochette, N, Zamzami, N, Kroemer, G

“…Mitochondria are vital for cellular bioenergetics and play a central role in determining the point-of-no-return of the apoptotic process. As a consequence,…”
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GAPDH, a novel regulator of the pro-apoptotic mitochondrial membrane permeabilization by TARZE, A, DEMAND, A, LE BRAS, M, MAILLIER, E, MOLLE, D, LAROCHETTE, N, ZAMZAMI, N, JAN, G, KROEMER, G, BRENNER, C

“…Glyceraldehyde-3-phosphate dehydrogenase (GAPDH) is a pleiotropic enzyme that is overexpressed in apoptosis and in several human chronic pathologies. Here, we…”
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Hierarchical involvement of Bak, VDAC1 and Bax in cisplatin-induced cell death by Tajeddine, N, Galluzzi, L, Kepp, O, Hangen, E, Morselli, E, Senovilla, L, Araujo, N, Pinna, G, Larochette, N, Zamzami, N, Modjtahedi, N, Harel-Bellan, A, Kroemer, G

“…Following the screening of a battery of distinct small-interfering RNAs that target various components of the apoptotic machinery, we found that knockdown of…”
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Mitochondrial permeability transition in apoptosis and necrosis by Zamzami, N, Larochette, N, Kroemer, G

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hTERT: a novel endogenous inhibitor of the mitochondrial cell death pathway by MASSARD, C, ZERMATI, Y, PAULEAU, A.-L, LAROCHETTE, N, METIVIER, D, SABATIER, L, KROEMER, G, SORIA, J.-C

“…hTERT is the catalytic subunit of the telomerase and is hence required for telomerase maintenance activity and cancer cell immortalization. Here, we show that…”
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Mitochondrio‐nuclear translocation of AIF in apoptosis and necrosis by Daugas, Eric, Susin, Santos A., Zamzami, Naoufal, Ferri, Karine F., Irinopoulou, Theano, Larochette, Nathanael, Prévost, Marie‐Christine, Leber, Brian, Andrews, David, Penninger, Josef, Kroemer, Guido

“…Apoptosis inducing factor (AIF) is a novel apoptotic effector protein that induces chro‐matin condensation and large‐scale (—50 kbp) DNA fragmentation when…”
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Structure-function analysis of the interaction between Bax and the cytomegalovirus-encoded protein vMIA by PAULEAU, A.-L, LAROCHETTE, N, GIORDANETTO, F, SCHOLZ, S. R, PONCET, D, ZAMZAMI, N, GOLDMACHER, V. S, KROEMER, G

“…The viral mitochondrial inhibitor of apoptosis (vMIA) encoded by the human cytomegalovirus exerts cytopathic effects and neutralizes the proapoptotic…”
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Human immunodeficiency virus 1 envelope glycoprotein complex-induced apoptosis involves mammalian target of rapamycin/FKBP12-rapamycin-associated protein-mediated p53 phosphorylation by Castedo, M, Ferri, K F, Blanco, J, Roumier, T, Larochette, N, Barretina, J, Amendola, A, Nardacci, R, Métivier, D, Este, J A, Piacentini, M, Kroemer, G

“…Syncytia arising from the fusion of cells expressing a lymphotropic human immunodeficiency virus (HIV)-1-encoded envelope glycoprotein complex (Env) gene with…”
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Unexpected role of the phosphate carrier in mitochondrial fragmentation by Pauleau, A-L, Galluzzi, L, Scholz, S R, Larochette, N, Kepp, O, Kroemer, G

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Palmitate induces apoptosis via a direct effect on mitochondria by de Pablo, M A, Susin, S A, Jacotot, E, Larochette, N, Costantini, P, Ravagnan, L, Zamzami, N, Kroemer, G

“…The fatty acid palmitate can induce apoptosis. Here we show that the palmitate-induced dissipation of the mitochondrial transmembrane potential (Delta Psi m),…”
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Calreticulin exposure dictates the immunogenicity of cancer cell death by Obeid, Michel, Tesniere, Antoine, Ghiringhelli, François, Fimia, Gian Maria, Apetoh, Lionel, Perfettini, Jean-Luc, Castedo, Maria, Mignot, Grégoire, Panaretakis, Theoharis, Casares, Noelia, Métivier, Didier, Larochette, Nathanael, van Endert, Peter, Ciccosanti, Fabiola, Piacentini, Mauro, Zitvogel, Laurence, Kroemer, Guido

“…Anthracyclin-treated tumor cells are particularly effective in eliciting an anticancer immune response, whereas other DNA-damaging agents such as etoposide and…”
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Quiescence Preconditioned Human Multipotent Stromal Cells Adopt a Metabolic Profile Favorable for Enhanced Survival under Ischemia by Moya, Adrien, Larochette, Nathanaël, Paquet, Joseph, Deschepper, Mickael, Bensidhoum, Morad, Izzo, Valentina, Kroemer, Guido, Petite, Hervé, Logeart‐Avramoglou, Delphine

“…A major impediment to the development of therapies with mesenchymal stem cells/multipotent stromal cells (MSC) is the poor survival and engraftment of MSCs at…”
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Inhibition of Macroautophagy Triggers Apoptosis by Boya, Patricia, González-Polo, Rosa-Ana, Casares, Noelia, Perfettini, Jean-Luc, Dessen, Philippe, Larochette, Nathanael, Métivier, Didier, Meley, Daniel, Souquere, Sylvie, Yoshimori, Tamotsu, Pierron, Gérard, Codogno, Patrice, Kroemer, Guido

“…Article Usage Stats Services MCB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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apoptosis/autophagy paradox: autophagic vacuolization before apoptotic death by González-Polo, Rosa-Ana, Boya, Patricia, Pauleau, Anne-Laure, Jalil, Abdelali, Larochette, Nathanael, Souquère, Sylvie, Eskelinen, Eeva-Liisa, Pierron, Gérard, Saftig, Paul, Kroemer, Guido

“…Autophagic cell death is morphologically characterized by an accumulation of autophagic vacuoles. Here, we show that inactivation of LAMP2 by RNA interference…”
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AIF deficiency compromises oxidative phosphorylation by Vahsen, Nicola, Candé, Céline, Brière, Jean‐Jacques, Bénit, Paule, Joza, Nicholas, Larochette, Nathanael, Mastroberardino, Pier Giorgio, Pequignot, Marie O, Casares, Noelia, Lazar, Vladimir, Feraud, Olivier, Debili, Najet, Wissing, Silke, Engelhardt, Silvia, Madeo, Frank, Piacentini, Mauro, Penninger, Josef M, Schägger, Hermann, Rustin, Pierre, Kroemer, Guido

“…Apoptosis‐inducing factor (AIF) is a mitochondrial flavoprotein that, after apoptosis induction, translocates to the nucleus where it participates in apoptotic…”
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Apoptosis-inducing factor (AIF): a novel caspase-independent death effector released from mitochondria by Candé, Céline, Cohen, Isabelle, Daugas, Eric, Ravagnan, Luigi, Larochette, Nathanael, Zamzami, Naoufal, Kroemer, Guido

“…Apoptosis-inducing factor (AIF) is a phylogenetically ancient mitochondrial intermembrane flavoprotein endowed with the unique capacity to induce…”
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DNA binding is required for the apoptogenic action of apoptosis inducing factor by Wu, Hao, Ye, Hong, Cande, Celine, Stephanou, Nicolas C, Jiang, Sulin, Gurbuxani, Sundeep, Larochette, Nathanael, Daugas, Eric, Garrido, Carmen, Kroemer, Guido

“…The execution of apoptosis or programmed cell death comprises both caspase-dependent and caspase-independent processes. Apoptosis inducing factor (AIF) was…”
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Essential role of p53 phosphorylation by p38 MAPK in apoptosis induction by the HIV-1 envelope by Perfettini, Jean-Luc, Castedo, Maria, Nardacci, Roberta, Ciccosanti, Fabiola, Boya, Patricia, Roumier, Thomas, Larochette, Nathanael, Piacentini, Mauro, Kroemer, Guido

“…The proapoptotic activity of the transcription factor p53 critically depends on the phosphorylation of serine 46 (p53S46P). Here, we show that syncytia…”
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Molecular characterization of mitochondrial apoptosis-inducing factor by Kroemer, Guido, Susin, Santos A, Lorenzo, Hans K, Zamzami, Naoufal, Marzo, Isabel, Snow, Bryan E, Brothers, Greg M, Mangion, Joan, Jacotot, Etienne, Costantini, Paola, Loeffler, Markus, Larochette, Nathanael, Goodlett, David R, Aebersold, Ruedi, Siderovski, David P, Penninger, Josef M

“…Mitochondria play a key part in the regulation of apoptosis (cell death). Their intermembrane space contains several proteins that are liberated through the…”
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Mitochondrial release of caspase-2 and -9 during the apoptotic process by Susin, S A, Lorenzo, H K, Zamzami, N, Marzo, I, Brenner, C, Larochette, N, Prévost, M C, Alzari, P M, Kroemer, G

“…The barrier function of mitochondrial membranes is perturbed early during the apoptotic process. Here we show that the mitochondria contain a caspase-like…”
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