Search Results - "LAROCCA, Thomas"

Physiological geroscience: targeting function to increase healthspan and achieve optimal longevity by Seals, Douglas R., Justice, Jamie N., LaRocca, Thomas J.

“…Most nations of the world are undergoing rapid and dramatic population ageing, which presents great socio‐economic challenges, as well as opportunities, for…”
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Repetitive elements as a transcriptomic marker of aging: Evidence in multiple datasets and models by LaRocca, Thomas J., Cavalier, Alyssa N., Wahl, Devin

“…Transcriptomic markers of aging can be useful for studying age‐related processes and diseases. However, noncoding repetitive element (RE) transcripts, which…”
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Expression of Exosome Biogenesis Genes Is Differentially Altered by Aging in the Mouse and in the Human Brain During Alzheimer’s Disease by Lark, Daniel S, LaRocca, Thomas J

“…Abstract Extracellular vesicles like exosomes are secreted by numerous cell types in a variety of tissues. Exosomes have been implicated in both aging and…”
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Healthy lifestyle-based approaches for successful vascular aging by Rossman, Matthew J, LaRocca, Thomas J, Martens, Christopher R, Seals, Douglas R

“…This review summarizes a presentation given at the 2016 Gerontological Society of America Annual Meeting as part of the Vascular Aging Workshop. The…”
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The reverse transcriptase inhibitor 3TC modulates hippocampal transcriptome signatures of inflammation in tauopathy model mice by Wahl, Devin, Grant, Randy A., LaRocca, Thomas J.

“…Reducing neuroinflammation, a key contributor to brain aging and neurodegenerative diseases, is a promising strategy for improving cognitive function in these…”
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Mitochondria‐targeted antioxidant (MitoQ) ameliorates age‐related arterial endothelial dysfunction in mice by Gioscia‐Ryan, Rachel A., LaRocca, Thomas J., Sindler, Amy L., Zigler, Melanie C., Murphy, Michael P., Seals, Douglas R.

“…Key points The development of age‐related arterial endothelial dysfunction, a key antecedent of increased cardiovascular disease (CVD) risk, is mediated…”
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MicroRNA changes in human arterial endothelial cells with senescence: Relation to apoptosis, eNOS and inflammation by Rippe, Catarina, Blimline, Mark, Magerko, Katherine A., Lawson, Brooke R., LaRocca, Thomas J., Donato, Anthony J., Seals, Douglas R.

“…A senescent phenotype in endothelial cells is associated with increased apoptosis, reduced endothelial nitric oxide synthase (eNOS) and inflammation, which are…”
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TDP-43 knockdown causes innate immune activation via protein kinase R in astrocytes by LaRocca, Thomas J., Mariani, Andrea, Watkins, Linda R., Link, Christopher D.

“…TAR-DNA binding protein 43 (TDP-43) is a multifunctional RNA binding protein directly implicated in the etiology of amyotrophic lateral sclerosis (ALS)…”
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Nutrition and other Lifestyle Influences on Arterial Aging by LaRocca, Thomas J, Martens, Christopher R, Seals, Douglas R

“…Abstract As our world’s population ages, cardiovascular diseases (CVD) will become an increasingly urgent public health problem. A key antecedent to clinical…”
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Amyloid beta acts synergistically as a pro-inflammatory cytokine by LaRocca, Thomas J., Cavalier, Alyssa N., Roberts, Christine M., Lemieux, Maddie R., Ramesh, Pooja, Garcia, Micklaus A., Link, Christopher D.

“…The amyloid beta (Aβ) peptide is believed to play a central role in Alzheimer's disease (AD), the most common age-related neurodegenerative disorder. However,…”
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Matricellular Protein CCN5 Reverses Established Cardiac Fibrosis by Jeong, Dongtak, PhD, Lee, Min-Ah, MS, Li, Yan, MS, Yang, Dong Kwon, DVM, PhD, Kho, Changwon, PhD, Oh, Jae Gyun, PhD, Hong, Gyeongdeok, BS, Lee, Ahyoung, PhD, Song, Min Ho, BS, LaRocca, Thomas J., MD, PhD, Chen, Jiqiu, MD, Liang, Lifan, MD, Mitsuyama, Shinichi, MD, PhD, D'Escamard, Valentina, PhD, Kovacic, Jason C., MD, PhD, Kwak, Tae Hwan, MS, Hajjar, Roger J., MD, Park, Woo Jin, PhD

“…Abstract Background Cardiac fibrosis (CF) is associated with increased ventricular stiffness and diastolic dysfunction and is an independent predictor of…”
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Novel Strategies for Healthy Brain Aging by Wahl, Devin, Cavalier, Alyssa N., LaRocca, Thomas J.

“…One of the best strategies for healthy brain aging is regular aerobic exercise. Commonly studied “anti-aging” compounds may mimic some effects of exercise on…”
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Dietary rapamycin supplementation reverses age‐related vascular dysfunction and oxidative stress, while modulating nutrient‐sensing, cell cycle, and senescence pathways by Lesniewski, Lisa A., Seals, Douglas R., Walker, Ashley E., Henson, Grant D., Blimline, Mark W., Trott, Daniel W., Bosshardt, Gary C., LaRocca, Thomas J., Lawson, Brooke R., Zigler, Melanie C., Donato, Anthony J.

“…Summary Inhibition of mammalian target of rapamycin, mTOR, extends lifespan and reduces age‐related disease. It is not known what role mTOR plays in the…”
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You're only as old as your arteries: translational strategies for preserving vascular endothelial function with aging by Seals, Douglas R, Kaplon, Rachelle E, Gioscia-Ryan, Rachel A, LaRocca, Thomas J

“…Endothelial dysfunction develops with age and increases the risk of age-associated vascular disorders. Nitric oxide insufficiency, oxidative stress, and…”
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Translational evidence that impaired autophagy contributes to arterial ageing by LaRocca, Thomas J., Henson, Grant D., Thorburn, Andrew, Sindler, Amy L., Pierce, Gary L., Seals, Douglas R.

“…Key points •  Advancing age is the major risk factor for the development of cardiovascular diseases. •  Arterial endothelial dysfunction, characterized by…”
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ADAR Dysfunction in Brain Aging and Alzheimer's Disease by McEntee, Cali M., Cavalier, Alyssa N., LaRocca, Thomas J.

“…Neuroinflammation is a central mechanism of brain aging and neurodegenerative disease, but why neuroinflammation develops with aging is incompletely…”
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Healthy Aging Interventions Reduce Repetitive Element Transcripts by Wahl, Devin, Cavalier, Alyssa N, Smith, Meghan, Seals, Douglas R, LaRocca, Thomas J

“…Abstract Transcripts from noncoding repetitive elements (REs) in the genome may be involved in aging. However, they are often ignored in transcriptome studies…”
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The autophagy enhancer spermidine reverses arterial aging by LaRocca, Thomas J., Gioscia-Ryan, Rachel A., Hearon, Christopher M., Seals, Douglas R.

“…•We assessed the potential for spermidine supplementation to prevent/reverse arterial aging.•Spermidine reduced arterial stiffness and improved arterial…”
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Child Neurology: Remarkable Recovery From Severe Acute Necrotizing Encephalopathy by Silverman, Andrew, Sasaki, Matthew, Espíndola Lima, José Eduardo, Cheronis, Chrisoula, Lin, Grant L, Johnson, Alexandra, Dahmoush, Hisham, Archer, Eva, Grekov, Karolina, LaRocca, Thomas J, Van Haren, Keith

“…A previously healthy 6-year-old girl presented with several days of fever before a generalized seizure. Laboratory investigation revealed elevated liver…”
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Aerobic Exercise and Other Healthy Lifestyle Factors That Influence Vascular Aging by Santos-Parker, Jessica R, LaRocca, Thomas J, Seals, Douglas R

“…Cardiovascular diseases (CVDs) remain the leading cause of death in the United States and other modern societies. Advancing age is the major risk factor for…”
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