Search Results - "LARGIS, E. E"

Hypercholesterolemia in the Rabbit Induced by Feeding Graded Amounts of Low-Level Cholesterol: Methodological Considerations Regarding Individual Variability in Response to Dietary Cholesterol and Development of Lesion Type by Kolodgie, Frank D, Katocs, Andrew S. Jr, Largis, Elwood E, Wrenn, Simeon M, Cornhill, J. Fredrick, Herderick, Edward E, Lee, Sue J, Virmani, Renu

“…While a number of studies have presented detailed examinations of lesion development in the cholesterol-fed rabbit, individual variability in response to…”
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Beta-3 adrenoceptor selectivity of the dioxolane dicarboxylate phenethanolamines by Dolan, J A, Muenkel, H A, Burns, M G, Pellegrino, S M, Fraser, C M, Pietri, F, Strosberg, A D, Largis, E E, Dutia, M D, Bloom, J D

“…The beta-1, beta-2 and beta-3 adrenergic properties of several benzodioxole-containing phenethanolamines were determined in vitro in both functional and…”
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CL 277,082: a novel inhibitor of ACAT-catalyzed cholesterol esterification and cholesterol absorption by Largis, E E, Wang, C H, DeVries, V G, Schaffer, S A

“…CL 277,082 (I) was found to be a potent inhibitor of acyl CoA:cholesterol acyltransferase (ACAT, EC 2.3.1.26) in microsomes from a variety of tissues with IC50…”
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Prodrugs of CL316243: a selective β3-adrenergic receptor agonist for treating obesity and diabetes by Sum, F.W., Gilbert, A., Venkatesan, A.M., Lim, K., Wong, V., O'Dell, M., Francisco, G., Chen, Z., Grosu, G., Baker, J., Ellingboe, J., Malamas, M., Gunawan, I., Primeau, J., Largis, E., Steiner, K.

“…CL316243 is a highly selective and potent β 3-adrenergic receptor agonist, and has been shown in rodent models to be an effective agent for treating obesity…”
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Disodium (R,R)-5-[2-[[2-(3-chlorophenyl)-2-hydroxyethyl]-amino] propyl]-1,3-benzodioxole-2,2-dicarboxylate (CL 316,243). A potent beta-adrenergic agonist virtually specific for beta 3 receptors. A promising antidiabetic and antiobesity agent by Bloom, J D, Dutia, M D, Johnson, B D, Wissner, A, Burns, M G, Largis, E E, Dolan, J A, Claus, T H

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Disodium (R,R)-5[2-[[2-γ(3-chlorophenyl)-2-hydroxyethyl]-amino]propyl]-1,3-benzodioxole-2,2-dicarboxylate (CL 316,243). A potent β-adrenergic agonist virtually specific for β3 receptors. A promising antidiabetic and antiobesity agent by BLOOM, J. D, DUTIA, M. D, JOHNSON, B. D, WISSNER, A, BURNS, M. G, LARGIS, E. E, DOLAN, J. A, CLAUS, T. H

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Potential antiatherosclerotic agents. 6. Hypocholesterolemic trisubstituted urea analogs by DeVries, Vern G, Bloom, Jonathan D, Dutia, Minu D, Katocs, Andrew S, Largis, Elwood E

“…The discovery that a series of N,N-dialkyl-N'-arylureas were inhibitors of the ACAT enzyme has led to a structure-activity study involving the systematic…”
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Potential antiatherosclerotic agents. 5. An acyl-CoA:cholesterol O-acyltransferase inhibitor with hypocholesterolemic activity by DeVries, V G, Schaffer, S A, Largis, E E, Dutia, M D, Wang, C H, Bloom, J D, Katocs, Jr, A S

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Disodium (R,R)-5-[2-[[2-(3-chlorophenyl)-2-hydroxyethyl]amino]propyl]-1,3-benzodioxole-2,2-dicarboxylate (CL 316,243). A potent .beta.-adrenergic agonist virtually specific for .beta.3 receptors. A promising antidiabetic and antiobesity agent by Bloom, Jonathan D, Dutia, Minu D, Johnson, Bernard D, Wissner, Allan, Burns, Michael G, Largis, Elwood E, Dolan, Jo Alene, Claus, Thomas H

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Potential antiatherosclerotic agents. 2. (Aralkylamino)- and (alkylamino)benzoic acid analogs of cetaben by Albright, J. Donald, DeVries, Vern G, Largis, Elwood E, Miner, Thomas G, Reich, Marvin F, Schaffer, Sheldon A, Shepherd, Robert G, Upeslacis, Janis

“…The syntheses of a series of (aralkylamino)- and (alkylamino)benzoic acids, as well as the corresponding esters and sodium salts, are described. The compounds…”
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Potential antiatherosclerotic agents. 4. [(Functionalized-alkyl)amino]benzoic acid analogs of cetaben by DeVries, Vern G, Largis, Elwood E, Miner, Thomas G, Shepherd, Robert G, Upeslacis, Janis

“…The synthesis of a series of analogues in which the alkyl group of cetaben is substituted with various functional groups or replaced entirely by a…”
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Cyclic amine sulfonamides as linkers in the design and synthesis of novel human beta(3) adrenergic receptor agonists by Sum, Fuk Wah, Wong, Victoria, Han, Stella, Largis, Elwood, Mulvey, Ruth, Tillett, Jeff

“…Piperidine, pyrrolidine, and azetidine sulfonamides were examined as linkers in designing novel human beta(3) adrenergic receptor (beta(3)-AR) agonists. The…”
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Antilipolytic action of tolbutamide in isolated fat cells of the rat by Allen, D O, Largis, E E, Ashmore, J

“…Concentrations of tolbutamide from 0.25 to 4.0 mg. per milliliter were found to inhibit epinephrine-stimulated lipolysis in isolated fat cells of the rat. At a…”
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Transport of amino acids via the mesenteric lymph duct in rats by Jacobs, J A, Largis, E E

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Effect of protein inhibitors on protein and amino acids in mesenteric lymph by Jacobs, F A, Largis, E E

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Effect of varying K+ concentrations on phosphorylase activity, lipolysis, and cAMP levels in perfused rat heart by Largis, E E, Ashmore, J, Toomey, R E

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Perifused fat cells. Effect of lipolytic agents by Katocs, Jr, A S, Largis, E E, Allen, D O, Ashmore, J

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Novel (4-piperidin-1-yl)-phenyl sulfonamides as potent and selective human beta(3) agonists by Hu, B, Ellingboe, J, Han, S, Largis, E, Lim, K, Malamas, M, Mulvey, R, Niu, C, Oliphant, A, Pelletier, J, Singanallore, T, Sum, F W, Tillett, J, Wong, V

“…A series of novel (4-piperidin-1-yl)-phenyl sulfonamides was prepared and evaluated for their biological activity on the human beta(3)-adrenergic receptor…”
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Isoproterenol and glucagon effects in perfused hearts from spontaneously hypertensive and normotensive rats by Largis, E E, Allen, D O, Clark, J, Ashmore, J

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The effects of endothelial cell-conditioned media on the proliferation of aortic smooth muscle cells and 3T3 cells in culture by Wang, C H, Largis, E E, Schaffer, S A

“…Normal aortic endothelial cells cultured in serum-free medium elaborate a factor(s) which cause the proliferation of smooth muscle cells or 3T3 cells grown in…”
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