Search Results - "LARGHERO, Jérôme"

Transplantation of Human Embryonic Stem Cell–Derived Cardiovascular Progenitors for Severe Ischemic Left Ventricular Dysfunction by Menasché, Philippe, Vanneaux, Valérie, Hagège, Albert, Bel, Alain, Cholley, Bernard, Parouchev, Alexandre, Cacciapuoti, Isabelle, Al-Daccak, Reem, Benhamouda, Nadine, Blons, Hélène, Agbulut, Onnik, Tosca, Lucie, Trouvin, Jean-Hugues, Fabreguettes, Jean-Roch, Bellamy, Valérie, Charron, Dominique, Tartour, Eric, Tachdjian, Gérard, Desnos, Michel, Larghero, Jérôme

“…In addition to scalability, human embryonic stem cells (hESCs) have the unique advantage of allowing their directed differentiation toward lineage-specific…”
Get full text

The Myoblast Autologous Grafting in Ischemic Cardiomyopathy (MAGIC) Trial : First Randomized Placebo-Controlled Study of Myoblast Transplantation by MENASCHE, Philippe, ALFIERI, Ottavio, LAKE, Stephen, CHATELLIER, Gilles, SOLOMON, Scott, DESNOS, Michel, HAGEGE, Albert A, JANSSENS, Stefan, MCKENNA, William, REICHENSPURNER, Hermann, TRINQUART, Ludovic, VILQUIN, Jean-Thomas, MAROLLEAU, Jean-Pierre, SEYMOUR, Barbara, LARGHERO, Jérome

“…Phase I clinical studies have demonstrated the feasibility of implanting autologous skeletal myoblasts in postinfarction scars. However, they have failed to…”
Get full text

Self-organization and culture of Mesenchymal Stem Cell spheroids in acoustic levitation by Jeger-Madiot, Nathan, Arakelian, Lousineh, Setterblad, Niclas, Bruneval, Patrick, Hoyos, Mauricio, Larghero, Jérôme, Aider, Jean-Luc

“…In recent years, 3D cell culture models such as spheroid or organoid technologies have known important developments. Many studies have shown that 3D cultures…”
Get full text

Determinants of CD19-positive vs CD19-negative relapse after tisagenlecleucel for B-cell acute lymphoblastic leukemia by Dourthe, Marie-Emilie, Rabian, Florence, Yakouben, Karima, Chevillon, Florian, Cabannes-Hamy, Aurélie, Méchinaud, Françoise, Grain, Audrey, Chaillou, Delphine, Rahal, Ilhem, Caillat-Zucman, Sophie, Lesprit, Emmanuelle, Naudin, Jérôme, Roupret-Serzec, Julie, Parquet, Nathalie, Brignier, Anne, Guérin-El Khourouj, Valérie, Lainey, Elodie, Caye-Eude, Aurélie, Cavé, Hélène, Clappier, Emmanuelle, Mathis, Stéphanie, Azoulay, Elie, Dalle, Jean Hugues, Dhédin, Nathalie, Madelaine, Isabelle, Larghero, Jérôme, Boissel, Nicolas, Baruchel, André

“…Tisagenlecleucel therapy has shown promising efficacy for relapsed/refractory (R/R) B-cell precursor acute lymphoblastic leukemia (BCP-ALL). However, relapses…”
Get full text

Human embryonic stem cell-derived cardiac progenitors for severe heart failure treatment: first clinical case report by Menasché, Philippe, Vanneaux, Valérie, Hagège, Albert, Bel, Alain, Cholley, Bernard, Cacciapuoti, Isabelle, Parouchev, Alexandre, Benhamouda, Nadine, Tachdjian, Gérard, Tosca, Lucie, Trouvin, Jean-Hugues, Fabreguettes, Jean-Roch, Bellamy, Valérie, Guillemain, Romain, Suberbielle Boissel, Caroline, Tartour, Eric, Desnos, Michel, Larghero, Jérôme

“…Comparative studies suggest that stem cells committed to a cardiac lineage are more effective for improving heart function than those featuring an…”
Get full text

Regulation of globin-heme balance in Diamond-Blackfan anemia by HSP70/GATA1 by Rio, Sarah, Gastou, Marc, Karboul, Narjesse, Derman, Raphaёl, Suriyun, Thunwarat, Manceau, Hana, Leblanc, Thierry, El Benna, Jamel, Schmitt, Caroline, Azouzi, Slim, Larghéro, Jérome, Karim, Zoubida, Macias-Garcia, Alejandra, Chen, Jane-Jane, Hermine, Olivier, Courtois, Geneviève, Puy, Hervé, Gouya, Laurent, Mohandas, Narla, Da Costa, Lydie

“…Diamond-Blackfan anemia (DBA) is a congenital erythroblastopenia that is characterized by a blockade in erythroid differentiation related to impaired ribosome…”
Get full text

Genome-edited, donor-derived allogeneic anti-CD19 chimeric antigen receptor T cells in paediatric and adult B-cell acute lymphoblastic leukaemia: results of two phase 1 studies by Benjamin, Reuben, Yallop, Deborah, Jozwik, Agnieszka, Mirci-Danicar, Oana C, Lucchini, Giovanna, Pinner, Danielle, Jain, Nitin, Maus, Marcela V, Frigault, Matthew J, Mohty, Mohamad, Gianella-Borradori, Athos, Binlich, Florence, Vitry, Fabien, Thomas, Elisabeth, Philippe, Anne, Dupouy, Sandra, Marchiq, Ibtissam, Almena-Carrasco, Maria, Ferry, Nicolas, Veys, Paul, Qasim, Waseem, Graham, Charlotte, Yallop, Deborah, Jozwik, Agnieszka, Pagliuca, Antonio, Kassam, Shireen, Kazmi, Majid, Kuhnl, Andrea, Metaxa, Victoria, Bonganay, Laarni, Stewart, Orla, Catt, Lorraine, Lewis, Jen, Farzaneh, Farzin, Chappell, Jackie, Mason, Alice, Dunlop, Alan, Cheung, Gary, Giemza, Elka, Qasim, Waseem, Ciocarlie, Oana, Lucchini, Giovanna, Pinner, Danielle, Chu, Jan, Amrolia, Persis, Chiesa, Robert, Silva, Juliana, Finch, Maria, Young, Lindsey, Samarasinghe, Sujith, Rao, Anupama, Vora, Ajay, Gilmour, Kimberley, Rivat, Christine, Murphy, Clare, Ahsan, Gulrukh, Said Shamsah, Rasha, James, Jesmina, Inglott, Sarah, Wright, Gary, Izotova, Natalia, Jain, Nitin, Konopleva, Marina, Wierda, William, Jabbour, Elias, Kebrieai, Partow, McGee, Kara, Frigault, Matthew, Brown, Jami, Hock, Hanno, McKeown, Meaghan A, Mathews, Richard, Spitzer, Thomas, Boissel, Nicolas, Raffoux, Emmanuel, Lengliné, Etienne, Itzykson, Raphael, Rabian, Florence, Larghero, Jérôme, Madelaine, Isabelle, Azoulay, Elie, Caillat-Zucman, Sophie, Meunier, Martine, Celli-Lebras, Karine, Tremorin, Marie-Thérèse, Baruchel, André, Grain, Audrey, Alimi, Aurélia, Roupret, Julie, Chaillou, Delphine, Fenneteau, Odile, Lainey, Elodie, Naudin, Jerome, Brissot, Eolia, Dulery, Remy, Malard, Florent, Mediavilla, Clémence, Bonnin, Agnès, Ledraa, Tounes, Daguenel-Nguyen, Anne

“…Genome-edited donor-derived allogeneic anti-CD19 chimeric antigen receptor (CAR) T cells offer a novel form of CAR-T-cell product that is available for…”
Get full text

Towards a clinical use of human embryonic stem cell-derived cardiac progenitors: a translational experience by Menasché, Philippe, Vanneaux, Valérie, Fabreguettes, Jean-Roch, Bel, Alain, Tosca, Lucie, Garcia, Sylvie, Bellamy, Valérie, Farouz, Yohan, Pouly, Julia, Damour, Odile, Périer, Marie-Cécile, Desnos, Michel, Hagège, Albert, Agbulut, Onnik, Bruneval, Patrick, Tachdjian, Gérard, Trouvin, Jean-Hugues, Larghero, Jérôme

“…There is now compelling evidence that cells committed to a cardiac lineage are most effective for improving the function of infarcted hearts. This has been…”
Get full text

Convergence of microengineering and cellular self-organization towards functional tissue manufacturing by Laurent, Jérémie, Blin, Guillaume, Chatelain, Francois, Vanneaux, Valérie, Fuchs, Alexandra, Larghero, Jérôme, Théry, Manuel

“…Technical progress in materials science and bioprinting has for the past few decades fostered considerable advances in medicine. More recently, the…”
Get full text

Conditioned media from mesenchymal stromal cells restore sodium transport and preserve epithelial permeability in an in vitro model of acute alveolar injury by Goolaerts, Arnaud, Pellan-Randrianarison, Nadia, Larghero, Jérôme, Vanneaux, Valérie, Uzunhan, Yurdagül, Gille, Thomas, Dard, Nicolas, Planès, Carole, Matthay, Michael A, Clerici, Christine

“…Mesenchymal stromal cells (MSCs) or their media (MSC-M) were reported to reverse acute lung injury (ALI)-induced decrease of alveolar fluid clearance. To…”
Get more information

Improved functionality of hepatic spheroids cultured in acoustic levitation compared to existing 2D and 3D models by Rabiet, Lucile, Jeger-Madiot, Nathan, García, Duván Rojas, Tosca, Lucie, Tachdjian, Gérard, Kellouche, Sabrina, Agniel, Rémy, Larghero, Jérôme, Aider, Jean-Luc, Arakelian, Lousineh

“…Hepatic spheroids are of high interest in basic research, drug discovery and cell therapy. Existing methods for spheroid culture present advantages and…”
Get full text

Endothelial CD34 expression and regulation of immune cell response in-vitro by Arakelian, Lousineh, Lion, Julien, Churlaud, Guillaume, Bargui, Rezlene, Thierry, Briac, Mutabazi, Evelyne, Bruneval, Patrick, Alberdi, Antonio José, Doliger, Christelle, Veyssiere, Maëva, Larghero, Jérôme, Mooney, Nuala

“…Endothelial cells cover the lining of different blood vessels and lymph nodes, and have major functions including the transport of blood, vessel homeostasis,…”
Get full text

Transfusion independence and HMGA2 activation after gene therapy of human β-thalassaemia by Cavazzana-Calvo, Marina, Payen, Emmanuel, Negre, Olivier, Wang, Gary, Hehir, Kathleen, Fusil, Floriane, Down, Julian, Denaro, Maria, Brady, Troy, Westerman, Karen, Cavallesco, Resy, Gillet-Legrand, Beatrix, Caccavelli, Laure, Sgarra, Riccardo, Maouche-Chrétien, Leila, Bernaudin, Françoise, Girot, Robert, Dorazio, Ronald, Mulder, Geert-Jan, Polack, Axel, Bank, Arthur, Soulier, Jean, Larghero, Jérôme, Kabbara, Nabil, Dalle, Bruno, Gourmel, Bernard, Socie, Gérard, Chrétien, Stany, Cartier, Nathalie, Aubourg, Patrick, Fischer, Alain, Cornetta, Kenneth, Galacteros, Frédéric, Beuzard, Yves, Gluckman, Eliane, Bushman, Frederick, Hacein-Bey-Abina, Salima, Leboulch, Philippe

“…Gene therapy success Blood disorders caused by abnormal β-globin — β-thalassaemia and sickle cell disease — are the most prevalent inherited disorders…”
Get full text

Autologous Hematopoietic Stem Cell Transplantation vs Intravenous Pulse Cyclophosphamide in Diffuse Cutaneous Systemic Sclerosis: A Randomized Clinical Trial by van Laar, Jacob M, Farge, Dominique, Sont, Jacob K, Naraghi, Kamran, Marjanovic, Zora, Larghero, Jérôme, Schuerwegh, Annemie J, Marijt, Erik W. A, Vonk, Madelon C, Schattenberg, Anton V, Matucci-Cerinic, Marco, Voskuyl, Alexandre E, van de Loosdrecht, Arjan A, Daikeler, Thomas, Kötter, Ina, Schmalzing, Marc, Martin, Thierry, Lioure, Bruno, Weiner, Stefan M, Kreuter, Alexander, Deligny, Christophe, Durand, Jean-Marc, Emery, Paul, Machold, Klaus P, Sarrot-Reynauld, Francoise, Warnatz, Klaus, Adoue, Daniel F. P, Constans, Joël, Tony, Hans-Peter, Del Papa, Nicoletta, Fassas, Athanasios, Himsel, Andrea, Launay, David, Lo Monaco, Andrea, Philippe, Pierre, Quéré, Isabelle, Rich, Éric, Westhovens, Rene, Griffiths, Bridget, Saccardi, Riccardo, van den Hoogen, Frank H, Fibbe, Willem E, Socié, Gérard, Gratwohl, Alois, Tyndall, Alan

“…IMPORTANCE: High-dose immunosuppressive therapy and autologous hematopoietic stem cell transplantation (HSCT) have shown efficacy in systemic sclerosis in…”
Get full text

Mesenchymal stem cells reduce hypoxia-induced apoptosis in alveolar epithelial cells by modulating HIF and ROS hypoxic signaling by Bernard, Olivier, Jeny, Florence, Uzunhan, Yurdagül, Dondi, Elisabetta, Terfous, Rahma, Label, Rabab, Sutton, Angela, Larghero, Jérôme, Vanneaux, Valérie, Nunes, Hilario, Boncoeur, Emilie, Planès, Carole, Dard, Nicolas

“…Distal lung diseases, such as pulmonary fibrosis or acute lung injury, are commonly associated with local alveolar hypoxia that may be deleterious through the…”
Get more information

Acoustic levitation as a tool for cell‐driven self‐organization of human cell spheroids during long‐term 3D culture by Rabiet, Lucile, Arakelian, Lousineh, Jeger‐Madiot, Nathan, García, Duván Rojas, Larghero, Jérôme, Aider, Jean‐Luc

“…Acoustic levitation, which allows contactless manipulation of micro‐objects with ultrasounds, is a promising technique for spheroids formation and culture…”
Get full text

Treatment of COVID-19-associated ARDS with mesenchymal stromal cells: a multicenter randomized double-blind trial by Monsel, Antoine, Hauw-Berlemont, Caroline, Mebarki, Miryam, Heming, Nicholas, Mayaux, Julien, Nguekap Tchoumba, Otriv, Diehl, Jean-Luc, Demoule, Alexandre, Annane, Djillali, Marois, Clémence, Demeret, Sophie, Weiss, Emmanuel, Voiriot, Guillaume, Fartoukh, Muriel, Constantin, Jean-Michel, Mégarbane, Bruno, Plantefève, Gaëtan, Malard-Castagnet, Stéphanie, Burrel, Sonia, Rosenzwajg, Michelle, Tchitchek, Nicolas, Boucher-Pillet, Hélène, Churlaud, Guillaume, Cras, Audrey, Maheux, Camille, Pezzana, Chloé, Diallo, Mamadou Hassimiou, Ropers, Jacques, Menasché, Philippe, Larghero, Jérôme

“…Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2)-induced acute respiratory distress syndrome (ARDS) causes high mortality. Umbilical cord-derived…”
Get full text

Nanofibrous clinical-grade collagen scaffolds seeded with human cardiomyocytes induces cardiac remodeling in dilated cardiomyopathy by Joanne, Pierre, Kitsara, Maria, Boitard, Solène-Emmanuelle, Naemetalla, Hany, Vanneaux, Valérie, Pernot, Mathieu, Larghero, Jérôme, Forest, Patricia, Chen, Yong, Menasché, Philippe, Agbulut, Onnik

“…Abstract Limited data are available on the effects of stem cells in non-ischemic dilated cardiomyopathy (DCM). Since the diffuse nature of the disease calls…”
Get full text

Cardiovascular Progenitor-Derived Extracellular Vesicles Recapitulate the Beneficial Effects of their Parent Cells in the Treatment of Chronic Heart Failure by Kervadec, Anaïs, Bellamy, Valérie, Harane, Nadia El, Arakélian, Lousineh, Vanneaux, Valérie, Cacciapuoti, Isabelle, Nemetalla, Hany, Périer, Marie-Cécile, Toeg, Hadi D, Richart, Adèle, Lemitre, Mathilde, Yin, Min, Loyer, Xavier, Larghero, Jérôme, Hagège, Albert, Ruel, Marc, Boulanger, Chantal M, Silvestre, Jean-Sébastien, Menasché, Philippe, Renault, Nisa KE

“…Background Cell-based therapies are being explored as a therapeutic option for patients with chronic heart failure following myocardial infarction…”
Get full text

Long-term functional benefits of human embryonic stem cell-derived cardiac progenitors embedded into a fibrin scaffold by Bellamy, Valérie, MSc, Vanneaux, Valérie, MD, PhD, Bel, Alain, MD, Nemetalla, Hany, MD, Emmanuelle Boitard, Solène, MSc, Farouz, Yohan, PhD, Joanne, Pierre, PhD, Perier, Marie-Cécile, MD, Robidel, Estelle, Mandet, Chantal, Hagège, Albert, MD, PhD, Bruneval, Patrick, MD, PhD, Larghero, Jérôme, MD, PhD, Agbulut, Onnik, PhD, Menasché, Philippe, MD, PhD

“…Background Cardiac-committed cells and biomimetic scaffolds independently improve the therapeutic efficacy of stem cells. In this study we tested the long-term…”
Get full text