Search Results - "LARCHE, Mark"

Obituary: Anthony Barrington Kay (1939‐2020) by Larché, Mark

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Legends of allergy/immunology: A. Barry Kay by Larché, Mark

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Mechanisms of peptide immunotherapy in allergic airways disease by Larche, Mark

“…Allergen immunotherapy with whole proteins is clinically efficacious but requires a protracted treatment period because of frequent allergic adverse events. A…”
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Regulatory T cells in allergy and asthma by Larché, Mark

“…Allergic diseases including asthma have risen considerably in prevalence in the last 50 years. A concomitant rise in autoimmune disease suggests a defect in…”
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Comparison of house dust mite sensitization profiles in allergic adults from Canada, Europe, South Africa and USA by Muddaluru, Varun, Valenta, Rudolf, Vrtala, Susanne, Schlederer, Thomas, Hindley, James, Hickey, Pascal, Larché, Mark, Tonti, Elena

“…Background Sensitization to house dust mite (HDM) is a leading cause of allergic rhinitis and asthma. Despite more than 30 HDM‐derived allergens having been…”
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Immunoregulation by targeting T cells in the treatment of allergy and asthma by Larche, Mark

“…T-cell responses to allergens are crucial in determining the choice between health and disease. Th2 responses drive synthesis of IgE and the recruitment,…”
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One hundred and ten years of Allergen Immunotherapy: A journey from empiric observation to evidence by Pfaar, Oliver, Bousquet, Jean, Durham, Stephen R., Kleine‐Tebbe, Jörg, Larché, Mark, Roberts, Graham, Shamji, Mohamed H., Gerth van Wijk, Roy

“…One hundred and ten years after Noon's first clinical report of the subcutaneous application of allergen extracts, allergen immunotherapy (AIT) has evolved as…”
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Modulation of CRTh2 expression on allergen‐specific T cells following peptide immunotherapy by Rudulier, Christopher D., Tonti, Elena, James, Eddie, Kwok, William W., Larché, Mark

“…Background Allergen immunotherapy using synthetic peptide T‐cell epitopes (Cat‐PAD) from the major cat allergen Fel d 1 has been shown, in allergen exposure…”
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T cell–mediated autoimmunity in immune thrombocytopenia by Vrbensky, John R., Nazy, Ishac, Clare, Rumi, Larché, Mark, Arnold, Donald M.

“…Immune thrombocytopenia (ITP) is an autoimmune disorder characterized by a low platelet count and an increased risk of bleeding. In addition to anti‐platelet…”
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The effect of rituximab on vaccine responses in patients with immune thrombocytopenia by Nazi, Ishac, Kelton, John G., Larché, Mark, Snider, Denis P., Heddle, Nancy M., Crowther, Mark A., Cook, Richard J., Tinmouth, Alan T., Mangel, Joy, Arnold, Donald M.

“…B-cell depletion may impair vaccine responses and increase infection risk in patients with immune thrombocytopenia (ITP). We investigated the effects of…”
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T cell epitope-based allergy vaccines by Larché, Mark

“…Specific immunotherapy (SIT) with extracts containing intact allergen molecules is clinically efficacious, but associated with frequent adverse events related…”
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Immunological changes in peripheral blood following nasal allergen challenge in subjects with allergic rhinitis pre‐ and post‐peptide immunotherapy: An open‐label clinical study by Kim, Young Woong, Tonti, Elena, Hickey, Pascal, Ellis, Anne K., Neighbour, Helen, Larché, Mark, Tebbutt, Scott J.

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Phase 1 trial supports safety and mechanism of action of peptide immunotherapy for peanut allergy by Voskamp, Astrid L., Khosa, Sugandhika, Phan, Tracy, DeBerg, Hannah A., Bingham, Judy, Hew, Mark, Smith, William, Abramovitch, Jodie, Rolland, Jennifer M., Moyle, Matthew, Nadeau, Kari C., Lack, Gideon, Larché, Mark, Wambre, Erik, O'Hehir, Robyn E., Hickey, Pascal, Prickett, Sara R.

“…Background Food allergy is a leading cause of anaphylaxis worldwide. Allergen‐specific immunotherapy is the only treatment shown to modify the natural history…”
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Nasal allergen challenge and environmental exposure chamber challenge: A randomized trial comparing clinical and biological responses to cat allergen by Larson, David, Patel, Piyush, Salapatek, Anne Marie, Couroux, Peter, Whitehouse, Don, Pina, Adela, Johnson, Jacqueline L., Sever, Michelle L., Sanda, Srinath, Poyser, Julian, Allio, Theresa, Scadding, Guy W., Qin, Tielin, Shamji, Mohamed H., Kwok, William W., James, Eddie A., French, Deanna, Lelic, Alina, Larché, Mark, Altman, Matthew C., Togias, Alkis, Durham, Stephen R.

“…The direct-instillation nasal allergen challenge (NAC) and the environmental exposure chamber (EEC) are 2 methods of conducting controlled allergen…”
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Induction of bystander tolerance and immune deviation after Fel d 1 peptide immunotherapy by Moldaver, Daniel M., Bharhani, Mantej S., Rudulier, Christopher D., Wattie, Jennifer, Inman, Mark D., Larché, Mark

“…Treatment of patients with cat allergy with peptides derived from Fel d 1 (the major cat allergen) ameliorated symptoms of cat allergy in phase 2 clinical…”
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Increased cytotoxic potential of CD8+ T cells in immune thrombocytopenia by Vrbensky, John R., Arnold, Donald M., Kelton, John G., Smith, James W., Jaffer, Anushka M., Larché, Mark, Clare, Rumi, Ivetic, Nikola, Nazy, Ishac

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Concepts and perspectives on peptide-based immunotherapy in allergy by Tonti, Elena, Larché, Mark

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The role of T lymphocytes in the pathogenesis of asthma by Larché, Mark, Robinson, Douglas S., Kay, A.Barry

“…Continuing Medical Education examination CONTINUING MEDICAL EDUCATION ARTICLECredit can now be obtained, free for a limited time, by reading the following…”
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Peptide immunotherapy in allergic asthma generates IL-10-dependent immunological tolerance associated with linked epitope suppression by Campbell, John D, Buckland, Karen F, McMillan, Sarah J, Kearley, Jennifer, Oldfield, William L G, Stern, Lawrence J, Grönlund, Hans, van Hage, Marianne, Reynolds, Catherine J, Boyton, Rosemary J, Cobbold, Stephen P, Kay, A Barry, Altmann, Daniel M, Lloyd, Clare M, Larché, Mark

“…Treatment of patients with allergic asthma using low doses of peptides containing T cell epitopes from Fel d 1, the major cat allergen, reduces allergic…”
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Natural regulatory T cells in isolated early responders compared with dual responders with allergic asthma by Kinoshita, Takashi, MD, Baatjes, Adrian, MSc, Smith, Steven G., PhD, Dua, Benny, MSc, Watson, Richard, BSc, Kawayama, Tomotaka, MD, Larche, Mark, PhD, Gauvreau, Gail M., PhD, O’Byrne, Paul M., MD, FRCPI

“…Background Natural regulatory T (Treg) cells are implicated in the regulation of the inflammatory response in patients with allergic asthma. Objectives We…”
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