Search Results - "LARBI, Anis"

Markers of T Cell Senescence in Humans by Xu, Weili, Larbi, Anis

“…Many countries are facing the aging of their population, and many more will face a similar obstacle in the near future, which could be a burden to many…”
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From Genesis to Old Age: Exploring the Immune System One Cell at a Time with Flow Cytometry by Larbi, Anis

“…The immune system is a highly complex and tightly regulated system that plays a crucial role in protecting the body against external threats, such as…”
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The integration of inflammaging in age-related diseases by Fulop, Tamas, Witkowski, Jacek M., Olivieri, Fabiola, Larbi, Anis

“…Aging is characterized by a morpho-functional adaptation, variably affecting major physiological systems, depending on a complex interaction between genetic,…”
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Two distinct interstitial macrophage populations coexist across tissues in specific subtissular niches by Chakarov, Svetoslav, Lim, Hwee Ying, Tan, Leonard, Lim, Sheau Yng, See, Peter, Lum, Josephine, Zhang, Xiao-Meng, Foo, Shihui, Nakamizo, Satoshi, Duan, Kaibo, Kong, Wan Ting, Gentek, Rebecca, Balachander, Akhila, Carbajo, Daniel, Bleriot, Camille, Malleret, Benoit, Tam, John Kit Chung, Baig, Sonia, Shabeer, Muhammad, Toh, Sue-Anne Ee Shiow, Schlitzer, Andreas, Larbi, Anis, Marichal, Thomas, Malissen, Bernard, Chen, Jinmiao, Poidinger, Michael, Kabashima, Kenji, Bajenoff, Marc, Ng, Lai Guan, Angeli, Veronique, Ginhoux, Florent

“…Macrophages are a heterogeneous cell population involved in tissue homeostasis, inflammation, and various pathologies. Although the major tissue-resident…”
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The untwining of immunosenescence and aging by Xu, Weili, Wong, Glenn, Hwang, You Yi, Larbi, Anis

“…From a holistic point of view, aging results from the cumulative erosion of the various systems. Among these, the immune system is interconnected to the rest…”
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Plasmacytoid dendritic cells develop from Ly6D+ lymphoid progenitors distinct from the myeloid lineage by Dress, Regine J., Dutertre, Charles-Antoine, Giladi, Amir, Schlitzer, Andreas, Low, Ivy, Shadan, Nurhidaya Binte, Tay, Alicia, Lum, Josephine, Kairi, Muhammad Faris Bin Mohd, Hwang, You Yi, Becht, Etienne, Cheng, Yang, Chevrier, Marion, Larbi, Anis, Newell, Evan W., Amit, Ido, Chen, Jinmiao, Ginhoux, Florent

“…Dendritic cells (DC) are currently classified as conventional DCs (cDCs) and plasmacytoid DCs (pDCs). Through a combination of single-cell transcriptomic…”
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Aging of the immune system: Focus on inflammation and vaccination by Pinti, Marcello, Appay, Victor, Campisi, Judith, Frasca, Daniela, Fülöp, Tamas, Sauce, Delphine, Larbi, Anis, Weinberger, Birgit, Cossarizza, Andrea

“…Major advances in preventing, delaying, or curing individual pathologies are responsible for an increasingly long life span in the developed parts of our…”
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RNA-Seq Signatures Normalized by mRNA Abundance Allow Absolute Deconvolution of Human Immune Cell Types by Monaco, Gianni, Lee, Bernett, Xu, Weili, Mustafah, Seri, Hwang, You Yi, Carré, Christophe, Burdin, Nicolas, Visan, Lucian, Ceccarelli, Michele, Poidinger, Michael, Zippelius, Alfred, Pedro de Magalhães, João, Larbi, Anis

“…The molecular characterization of immune subsets is important for designing effective strategies to understand and treat diseases. We characterized 29 immune…”
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Immunosenescence and Inflamm-Aging As Two Sides of the Same Coin: Friends or Foes? by Fulop, Tamas, Larbi, Anis, Dupuis, Gilles, Le Page, Aurélie, Frost, Eric H, Cohen, Alan A, Witkowski, Jacek M, Franceschi, Claudio

“…The immune system is the most important protective physiological system of the organism. It has many connections with other systems and is, in fact, often…”
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flowAI: automatic and interactive anomaly discerning tools for flow cytometry data by Monaco, Gianni, Chen, Hao, Poidinger, Michael, Chen, Jinmiao, de Magalhães, João Pedro, Larbi, Anis

“…Flow cytometry (FCM) is widely used in both clinical and basic research to characterize cell phenotypes and functions. The latest FCM instruments analyze up to…”
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Single-Cell Analysis of Human Mononuclear Phagocytes Reveals Subset-Defining Markers and Identifies Circulating Inflammatory Dendritic Cells by Dutertre, Charles-Antoine, Becht, Etienne, Irac, Sergio Erdal, Khalilnezhad, Ahad, Narang, Vipin, Khalilnezhad, Shabnam, Ng, Pei Y., van den Hoogen, Lucas L., Leong, Jing Yao, Lee, Bernett, Chevrier, Marion, Zhang, Xiao Meng, Yong, Pearly Jean Ai, Koh, Geraldine, Lum, Josephine, Howland, Shanshan Wu, Mok, Esther, Chen, Jinmiao, Larbi, Anis, Tan, Henry Kun Kiaang, Lim, Tony Kiat Hon, Karagianni, Panagiota, Tzioufas, Athanasios G., Malleret, Benoit, Brody, Joshua, Albani, Salvatore, van Roon, Joel, Radstake, Timothy, Newell, Evan W., Ginhoux, Florent

“…Human mononuclear phagocytes comprise phenotypically and functionally overlapping subsets of dendritic cells (DCs) and monocytes, but the extent of their…”
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Identification of cDC1- and cDC2-committed DC progenitors reveals early lineage priming at the common DC progenitor stage in the bone marrow by Schlitzer, Andreas, Sivakamasundari, V, Chen, Jinmiao, Sumatoh, Hermi Rizal Bin, Schreuder, Jaring, Lum, Josephine, Malleret, Benoit, Zhang, Sanqian, Larbi, Anis, Zolezzi, Francesca, Renia, Laurent, Poidinger, Michael, Naik, Shalin, Newell, Evan W, Robson, Paul, Ginhoux, Florent

“…The progenitor stage of commitment toward the conventional dendritic cell subsets and the transcriptional networks that control it remain poorly understood…”
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Sestrins induce natural killer function in senescent-like CD8+ T cells by Pereira, Branca I., De Maeyer, Roel P. H., Covre, Luciana P., Nehar-Belaid, Djamel, Lanna, Alessio, Ward, Sophie, Marches, Radu, Chambers, Emma S., Gomes, Daniel C. O., Riddell, Natalie E., Maini, Mala K., Teixeira, Vitor H., Janes, Samuel M., Gilroy, Derek W., Larbi, Anis, Mabbott, Neil A., Ucar, Duygu, Kuchel, George A., Henson, Sian M., Strid, Jessica, Lee, Jun H., Banchereau, Jacques, Akbar, Arne N.

“…Aging is associated with remodeling of the immune system to enable the maintenance of life-long immunity. In the CD8 + T cell compartment, aging results in the…”
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The pro-inflammatory phenotype of the human non-classical monocyte subset is attributed to senescence by Ong, Siew-Min, Hadadi, Eva, Dang, Truong-Minh, Yeap, Wei-Hseun, Tan, Crystal Tze-Ying, Ng, Tze-Pin, Larbi, Anis, Wong, Siew-Cheng

“…Human primary monocytes comprise a heterogeneous population that can be classified into three subsets based on CD14 and CD16 expression: classical (CD14 high…”
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Role of the peripheral innate immune system in the development of Alzheimer's disease by Le Page, Aurélie, Dupuis, Gilles, Frost, Eric H., Larbi, Anis, Pawelec, Graham, Witkowski, Jacek M., Fulop, Tamas

“…Alzheimer's disease is one of the most devastating neurodegenerative diseases. The exact cause of the disease is still not known although many scientists…”
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Induced-Pluripotent-Stem-Cell-Derived Primitive Macrophages Provide a Platform for Modeling Tissue-Resident Macrophage Differentiation and Function by Takata, Kazuyuki, Kozaki, Tatsuya, Lee, Christopher Zhe Wei, Thion, Morgane Sonia, Otsuka, Masayuki, Lim, Shawn, Utami, Kagistia Hana, Fidan, Kerem, Park, Dong Shin, Malleret, Benoit, Chakarov, Svetoslav, See, Peter, Low, Donovan, Low, Gillian, Garcia-Miralles, Marta, Zeng, Ruizhu, Zhang, Jinqiu, Goh, Chi Ching, Gul, Ahmet, Hubert, Sandra, Lee, Bernett, Chen, Jinmiao, Low, Ivy, Shadan, Nurhidaya Binte, Lum, Josephine, Wei, Tay Seok, Mok, Esther, Kawanishi, Shohei, Kitamura, Yoshihisa, Larbi, Anis, Poidinger, Michael, Renia, Laurent, Ng, Lai Guan, Wolf, Yochai, Jung, Steffen, Önder, Tamer, Newell, Evan, Huber, Tara, Ashihara, Eishi, Garel, Sonia, Pouladi, Mahmoud A., Ginhoux, Florent

“…Tissue macrophages arise during embryogenesis from yolk-sac (YS) progenitors that give rise to primitive YS macrophages. Until recently, it has been impossible…”
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Whole blood immunophenotyping uncovers immature neutrophil-to-VD2 T-cell ratio as an early marker for severe COVID-19 by Carissimo, Guillaume, Xu, Weili, Kwok, Immanuel, Abdad, Mohammad Yazid, Chan, Yi-Hao, Fong, Siew-Wai, Puan, Kia Joo, Lee, Cheryl Yi-Pin, Yeo, Nicholas Kim-Wah, Amrun, Siti Naqiah, Chee, Rhonda Sin-Ling, How, Wilson, Chan, Stephrene, Fan, Bingwen Eugene, Andiappan, Anand Kumar, Lee, Bernett, Rötzschke, Olaf, Young, Barnaby Edward, Leo, Yee-Sin, Lye, David Chien, Renia, Laurent, Ng, Lai Guan, Larbi, Anis, Ng, Lisa FP

“…SARS-CoV-2 is the novel coronavirus responsible for the current COVID-19 pandemic. Severe complications are observed only in a small proportion of infected…”
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Combinatorial Single-Cell Analyses of Granulocyte-Monocyte Progenitor Heterogeneity Reveals an Early Uni-potent Neutrophil Progenitor by Kwok, Immanuel, Becht, Etienne, Xia, Yu, Ng, Melissa, Teh, Ye Chean, Tan, Leonard, Evrard, Maximilien, Li, Jackson L.Y., Tran, Hoa T.N., Tan, Yingrou, Liu, Dehua, Mishra, Archita, Liong, Ka Hang, Leong, Keith, Zhang, Yuning, Olsson, Andre, Mantri, Chinmay Kumar, Shyamsunder, Pavithra, Liu, Zhaoyuan, Piot, Cecile, Dutertre, Charles-Antoine, Cheng, Hui, Bari, Sudipto, Ang, Nicholas, Biswas, Subhra K., Koeffler, H. Philip, Tey, Hong Liang, Larbi, Anis, Su, I-Hsin, Lee, Bernett, St. John, Ashley, Chan, Jerry K.Y., Hwang, William Y.K., Chen, Jinmiao, Salomonis, Nathan, Chong, Shu Zhen, Grimes, H. Leighton, Liu, Bing, Hidalgo, Andrés, Newell, Evan W., Cheng, Tao, Ginhoux, Florent, Ng, Lai Guan

“…Granulocyte-monocyte progenitors (GMPs) have been previously defined for their potential to generate various myeloid progenies such as neutrophils and…”
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Cytomegalovirus and human immunosenescence by Pawelec, Graham, Derhovanessian, Evelyna, Larbi, Anis, Strindhall, Jan, Wikby, Anders

“…‘Immunosenescence’ is an imprecise term used to describe deleterious age‐associated changes to immune parameters observed in all mammals studied so far…”
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Fetal mast cells mediate postnatal allergic responses dependent on maternal IgE by Msallam, Rasha, Balla, Jozef, Rathore, Abhay P S, Kared, Hassen, Malleret, Benoit, Saron, Wilfried A A, Liu, Zhaoyuan, Hang, Jing Wen, Dutertre, Charles Antoine, Larbi, Anis, Chan, Jerry K Y, St John, Ashley L, Ginhoux, Florent

“…Mast cells (MCs) are central effector cells in allergic reactions that are often mediated by immunoglobulin E (IgE). Allergies commonly start at an early age,…”
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