Search Results - "LAPPALAINEN, Jaakko"

Naloxegol for Opioid-Induced Constipation in Patients with Noncancer Pain by Chey, William D, Webster, Lynn, Sostek, Mark, Lappalainen, Jaakko, Barker, Peter N, Tack, Jan

“…In this trial, patients with opioid-induced constipation were treated with naloxegol, an oral, peripherally acting, μ-opioid receptor antagonist. Naloxegol was…”
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The met allele of the BDNF Val66Met polymorphism predicts poor outcome among survivors of aneurysmal subarachnoid hemorrhage by SIIRONEN, Jari, JUVELA, Seppo, KANAREK, Katarzyna, VILKKI, Juhani, HEMESNIEMI, Juha, LAPPALAINEN, Jaakko

“…Brain-derived neurotrophic factor (BDNF) plays a role in neuronal survival, plasticity and neurogenesis. The BDNF gene contains a common Val66Met polymorphism;…”
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Interactive Effects of Sex and 5-HTTLPR on Mood and Impulsivity During Tryptophan Depletion in Healthy People by Walderhaug, Espen, Magnusson, Andres, Neumeister, Alexander, Lappalainen, Jaakko, Lunde, Hilde, Refsum, Helge, Landrø, Nils Inge

“…Background Serotonin (5-HT) plays a central role in mood regulation and impulsivity. We studied whether healthy men and women react differently on mood and…”
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Evaluation of the Effect of Naloxegol on Cardiac Repolarization: A Randomized, Placebo- and Positive-Controlled Crossover Thorough QT/QTc Study in Healthy Volunteers by Gottfridsson, Christer, MD, PhD, Carlson, Glenn, MD, Lappalainen, Jaakko, MD, PhD, Sostek, Mark, MD

“…Abstract Background Opioid-induced constipation (OIC) is a common adverse effect associated with opioid use. Naloxegol is a PEGylated derivative of naloxone in…”
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Brain derived neurotrophic factor (BDNF) gene variants and Alzheimer's disease, affective disorders, posttraumatic stress disorder, schizophrenia, and substance dependence by Zhang, Huiping, Ozbay, Fatih, Lappalainen, Jaakko, Kranzler, Henry R., van Dyck, Christopher H., Charney, Dennis S., Price, Lawrence H., Southwick, Steven, Yang, Bao-Zhu, Rasmussen, Ann, Gelernter, Joel

“…Genetic variation at the locus encoding the brain derived neurotrophic factor (BDNF) has been implicated in some neuropsychiatric disorders such as Alzheimer's…”
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900 Efficacy and Safety of Naloxegol in Patients With Opioid-Induced Constipation: Results From 2 Prospective, Randomized, Controlled Trials by Chey, William D, Webster, Lynn, Sostek, Mark, Lappalainen, Jaakko N, Barker, Peter N, Tack, Jan F

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Smoking and suicidality among adolescent psychiatric patients by Mäkikyrö, Taru H, Hakko, Helinä H, Timonen, Markku J, Lappalainen, Jaakko A.S, Ilomäki, Risto S, Marttunen, Mauri J, Läksy, Kristian, Räsänen, Pirkko K

“…To investigate the relationship between smoking and suicidality among adolescent psychiatric patients in Finland. Data from 157 patients (aged 12–17 years)…”
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Smoking and suicidality Among adolescent psychiatric patients by MÄKIKYRÖ, Taru H, HAKKO, Helinä H, TIMONEN, Markku J, LAPPALAINEN, Jaakko A. S, ILOMÄKI, Risto S, MARTTUNEN, Mauri J, LÄKSY, Kristian, RASANEN, Pirkko K

“…To investigate the relationship between smoking and suicidality among adolescent psychiatric patients in Finland. Data from 157 patients (aged 12-17 years)…”
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Population admixture modulates risk for alcohol dependence by Zuo, Lingjun, Luo, Xingguang, Listman, Jennifer B, Kranzler, Henry R, Wang, Shuang, Anton, Raymond F, Blumberg, Hilary P, Stein, Murray B, Pearlson, Godfrey D, Covault, Jonathan, Charney, Dennis S, van Kammen, Daniel P, Price, Lawrence H, Lappalainen, Jaakko, Cramer, Joyce, Krystal, John H, Gelernter, Joel

“…The admixture of different ancestral populations in America may have important implications for the risk for psychiatric disorders, as it appears to have for…”
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Identification, Expression, and Pharmacology of a Cys23-Ser23 Substitution in the Human 5-HT2C Receptor Gene (HTR2C) by Lappalainen, Jaakko, Zhang, Li, Dean, Michael, Oz, Murat, Ozaki, Norio, Yu, Da-hong, Virkkunen, Matti, Weight, Forrest, Linnoila, Markku, Goldman, David

“…The function of brain serotonin-2C (5-HT2C) receptors, including behavioral and neurochemical responses to 5-HT2C agonist challenge, has been suggested to be…”
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A Naturally Occurring Amino Acid Substitution of the Human Serotonin 5‐HT2A Receptor Influences Amplitude and Timing of Intracellular Calcium Mobilization by Ozaki, Norio, Manji, Husseini, Lubierman, Victoria, Lu, Sha Jia, Lappalainen, Jaakko, Rosenthal, Norman E., Goldman, David

“…: Recently, two naturally occurring amino acid substitutions were identified in the C‐terminal region of the serotonin 5‐HT2A receptor. One of these, His…”
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A phase 2, double-blind, randomized, placebo-controlled, dose-escalation study to evaluate the efficacy, safety, and tolerability of naloxegol in patients with opioid-induced constipation by Webster, Lynn, Dhar, Sunita, Eldon, Michael, Masuoka, Lorianne, Lappalainen, Jaakko, Sostek, Mark

“…Oral naloxegol was well tolerated and increased the frequency of spontaneous bowel movements in patients with opioid-induced constipation without compromising…”
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HTR2C Cys23Ser polymorphism in relation to CSF monoamine metabolite concentrations and DSM-III-R psychiatric diagnoses by Lappalainen, Jaakko, Long, Jeffrey C, Virkkunen, Matti, Ozaki, Norio, Goldman, David, Linnoila, Markku

“…Background: Heritable variation in brain monoaminergic activity has been suggested to lead to interindividual differences in vulnerability to alcoholism, and…”
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Alcohol and mortality after moderate to severe traumatic brain injury: a meta-analysis of observational studies by Raj, Rahul, Mikkonen, Era D, Siironen, Jari, Hernesniemi, Juha, Lappalainen, Jaakko, Skrifvars, Markus B

“…OBJECT Experimental studies have shown numerous neuroprotective properties of alcohol ("ethanol") after TBI, but clinical studies have provided conflicting…”
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Effect of fasedienol (PH94B) pherine nasal spray and steroidal hormones on electrogram responses and autonomic nervous system activity in healthy adult volunteers by Monti, Louis, Hanover, Rita, Salmán, Ester, Baker, Ross A, Lappalainen, Jaakko, Smith, Mark

“…Fasedienol (PH94B) is a pherine compound formulated as a nasal spray that is hypothesized to regulate olfactory-amygdala circuits of fear and anxiety…”
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Acute alcohol intoxication and long-term outcome in patients with traumatic brain injury by Raj, Rahul, Skrifvars, Markus B, Kivisaari, Riku, Hernesniemi, Juha, Lappalainen, Jaakko, Siironen, Jari

“…The effect of blood alcohol concentration (BAC) on outcome after traumatic brain injury (TBI) is controversial. We sought to assess the independent effect of…”
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Association Between Alcoholism and ??-Amino Butyric Acid ??2 Receptor Subtype in a Russian Population by Lappalainen, Jaakko, Krupitsky, Evgeny, Remizov, Mikhail, Pchelina, Sofia, Taraskina, Anastaisa, Zvartau, Edwin, Somberg, Lucia K., Covault, Jonathan, Kranzler, Henry R., Krystal, John H., Gelernter, Joel

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A Multicenter, Double-Blind, Randomized, Placebo-Controlled Phase 3 Trial to Determine the Efficacy and Safety of Ganaxolone as Adjunctive Therapy for Adults with Drug-Resistant Focal-Onset Seizures (P5.237) by Lappalainen, Jaakko, Tsai, Julia, Amerine, William, Patroneva, Albena

“…Abstract only…”
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Efficacy and safety of naloxegol in patients with opioid-induced constipation and laxative-inadequate response by Tack, Jan, Lappalainen, Jaakko, Diva, Ulysses, Tummala, Raj, Sostek, Mark

“…Background Treatment options for patients with opioid-induced constipation (OIC) and inadequate response to laxatives (LIR) are few. Objective Assess the…”
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Pharmacogenetic Randomized Trial for Cocaine Abuse: Disulfiram and Dopamine β-Hydroxylase by Kosten, Thomas R, Wu, Guiying, Huang, Wen, Harding, Mark J, Hamon, Sara C, Lappalainen, Jaakko, Nielsen, David A

“…Background Disulfiram has been an effective cocaine addiction pharmacotherapy, and one of its possible mechanisms of efficacy is through copper chelation and…”
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