Search Results - "LANUSSE, C. E."

Altered drug influx/efflux and enhanced metabolic activity in triclabendazole-resistant liver flukes by Alvarez, L I, Solana, H D, Mottier, M L, Virkel, G L, Fairweather, I, Lanusse, C E

“…Triclabendazole (TCBZ) is a halogenated benzimidazole compound that possesses high activity against immature and adult stages of the liver fluke, Fasciola…”
Get more information

Inhibition of cytochrome P450-mediated metabolism enhances ex vivo susceptibility of Fasciola hepatica to triclabendazole by Devine, C, Brennan, G P, Lanusse, C E, Alvarez, L I, Trudgett, A, Hoey, E, Fairweather, I

“…A study has been carried out to investigate whether the action of triclabendazole (TCBZ) against Fasciola hepatica is altered by inhibition of drug metabolism…”
Get more information

Effect of the metabolic inhibitor, methimazole on the drug susceptibility of a triclabendazole-resistant isolate of Fasciola hepatica by Devine, C, Brennan, G P, Lanusse, C E, Alvarez, L I, Trudgett, A, Hoey, E, Fairweather, I

“…A study has been carried out to investigate whether the action of triclabendazole (TCBZ) is altered in the presence of a metabolic inhibitor. The flavin…”
Get more information

Piperonyl butoxide enhances triclabendazole action against triclabendazole-resistant Fasciola hepatica by Devine, C, Brennan, G P, Lanusse, C E, Alvarez, L I, Trudgett, A, Hoey, E, Fairweather, I

“…A study has been carried out to determine whether the action of triclabendazole (TCBZ) against the liver fluke, Fasciola hepatica is altered by inhibition of…”
Get more information

Inhibition of triclabendazole metabolism in vitro by ketoconazole increases disruption to the tegument of a triclabendazole-resistant isolate of Fasciola hepatica by Devine, C., Brennan, G. P., Lanusse, C. E., Alvarez, L. I., Trudgett, A., Hoey, E., Fairweather, I.

“…A study has been carried out to investigate whether the action of triclabendazole (TCBZ) against Fasciola hepatica is altered by inhibition of drug metabolism…”
Get full text

Transtegumental diffusion of benzimidazole anthelmintics into Moniezia benedeni: correlation with their octanol–water partition coefficients by Mottier, M.L., Alvarez, L.I., Pis, M.A., Lanusse, C.E.

“…The experiments described here report on the correlation between the ex vivo diffusion of different benzimidazole (BZD) anthelmintics into the cestode parasite…”
Get full text

Comparative in vitro characterization of moxidectin and doramectin percutaneous absorption through bovine skin by SALLOVITZ, J. M, NEJAMKIN, P, LIFSCHITZ, A. L, VIRKEL, G. L, IMPERIALE, F. A, LANUSSE, C. E

“…Sallovitz, J. M., Nejamkin, P., Lifschitz, A. L., Virkel, G. L., Imperiale, F. A., Lanusse, C. E. Comparative in vitro characterization of moxidectin and…”
Get full text

Comparative metabolism of albendazole and albendazole sulphoxide by different helminth parasites by SOLANA, H. D, RODRIGUEZ, J. A, LANUSSE, C. E

“…Albendazole (ABZ) is a broad-spectrum benzimidazole anthelmintic widely used in human and veterinary medicine. The aim of the current work was to characterise…”
Get full text

Comparative assessment of the access of albendazole, fenbendazole and triclabendazole to Fasciola hepatica: effect of bile in the incubation medium by Alvarez, L I, Mottier, M L, Lanusse, C E

“…The work reported here describes the comparative ability of albendazole (ABZ), fenbendazole (FBZ) and triclabendazole (TCBZ) to penetrate through the tegument…”
Get more information

Pharmacologic interaction between oxfendazole and triclabendazole: In vitro biotransformation and systemic exposure in sheep by Viviani, P., Lifschitz, A.L., Luque, S.E., Lloberas, M.M., Maté, M.L., Cardozo, P.A., Lanusse, C.E., Virkel, G.L.

“…The aim of the current work was to evaluate a potential pharmacokinetic interaction between the flukicide triclabendazole (TCBZ) and the broad-spectrum…”
Get full text

Assessment of the pharmacological interactions between the nematodicidal fenbendazole and the flukicidal triclabendazole: In vitro studies with bovine liver microsomes and slices by Viviani, P., Lifschitz, A. L., Maté, M. L., García, J. P., Lanusse, C. E., Virkel, G. L.

“…Parasitic diseases have a significant impact on livestock production. Nematodicidal drugs, such as fenbendazole (FBZ) or its oxidized metabolite oxfendazole…”
Get full text

Gaining Insights Into the Pharmacology of Anthelmintics Using Haemonchus contortus as a Model Nematode by Lanusse, C E, Alvarez, L I, Lifschitz, A L

“…Progress made in understanding pharmacokinetic behaviour and pharmacodynamic mechanisms of drug action/resistance has allowed deep insights into the…”
Get more information

Uptake of albendazole and albendazole sulphoxide by Haemonchus contortus and Fasciola hepatica in sheep by Alvarez, L.I, Imperiale, F.A, Sánchez, S.F, Murno, G.A, Lanusse, C.E

“…The pattern of in vivo uptake of albendazole (ABZ) and its major metabolite, ABZ-sulphoxide (ABZSO), by Haemonchus contortus and Fasciola hepatica recovered…”
Get full text

Effects of ivermectin and doramectin faecal residues on the invertebrate colonization of cattle dung by Suarez, V.H, Lifschitz, A.L, Sallovitz, J.M, Lanusse, C.E

“…:  The effects of avermectin [ivermectin (IVM) and doramectin (DRM)] faecal residues on dung colonization and degradation by invertebrates were evaluated…”
Get full text

Potentiation of triclabendazole action in vivo against a triclabendazole-resistant isolate of Fasciola hepatica following its co-administration with the metabolic inhibitor, ketoconazole by Devine, C., Brennan, G.P., Lanusse, C.E., Alvarez, L.I., Trudgett, A., Hoey, E., Fairweather, I.

“…An in vivo study in the laboratory rat model has been carried out to monitor morphological changes in adult Fasciola hepatica over a 4-day period resulting…”
Get full text

Changes to oxfendazole chiral kinetics and anthelmintic efficacy induced by piperonyl butoxide in horses by BRUNI, S. F. SÁNCHEZ, FUSÉ, L. A., MORENO, L., SAUMELL, C. A., ÁLVAREZ, L. I., FIEL, C., McKELLAR, Q. A., LANUSSE, C. E.

“…Summary Reasons for performing the study: The study of novel pharmacological strategies to control parasitism in horses is required since many parasite species…”
Get full text

Enhancement of triclabendazole action in vivo against a triclabendazole-resistant isolate of Fasciola hepatica by co-treatment with ketoconazole by Devine, C., Brennan, G.P., Lanusse, C.E., Alvarez, L.I., Trudgett, A., Hoey, E., Fairweather, I.

“…An in vivo study in the laboratory rat model was carried out to monitor morphological changes in adult Fasciola hepatica over a 4-day period resulting from…”
Get full text

Ex vivo diffusion of albendazole and its sulfoxide metabolite into Ascaris suum and Fasciola hepatica by ALVAREZ, L. I, MOTTIER, M. L, SANCHEZ, S. F, LANUSSE, C. E

“…The current experiments compare the pattern of ex vivo uptake (diffusion) of albendazole (ABZ) and albendazole sulfoxide (ABZSO) by Ascaris suum and Fasciola…”
Get full text

In vivo and ex vivo uptake of albendazole and its sulphoxide metabolite by cestode parasites: relationship with their kinetic behavior in sheep by Alvarez, L.I, Sanchez, S.F, Lanusse, C.E

“…The current experiments correlate the disposition kinetics of albendazole (ABZ) following its intravenous (i.v.) and intraruminal (i.r.) administrations to…”
Get full text

Erratum to: Inhibition of triclabendazole metabolism in vitro by ketoconazole increases disruption to the tegument of a triclabendazole-resistant isolate of Fasciola hepatica by Devine, C., Brennan, G. P., Lanusse, C. E., Alvarez, L. I., Trudgett, A., Hoey, E., Fairweather, I.

“…A study has been carried out to investigate whether the action of triclabendazole (TCBZ) against Fasciola hepatica is altered by inhibition of drug metabolism…”
Get full text