Search Results - "LANTZ, Olivier"

MAIT cells: an historical and evolutionary perspective by Lantz, Olivier, Legoux, François

“…In humans, MAIT cells represent the most abundant T‐cell subset reacting against bacteria. MAIT cells belong to the evolutionarily conserved family of “preset”…”
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MAIT cells, surveyors of a new class of antigen: development and functions by Le Bourhis, Lionel, Mburu, Yvonne K, Lantz, Olivier

“…Highlights ► MAIT cells recognize riboflavin derivatives originating from bacteria. ► Selection by hematopoietic thymic cells induce MAIT cell-specific…”
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A common transcriptomic program acquired in the thymus defines tissue residency of MAIT and NKT subsets by Salou, Marion, Legoux, François, Gilet, Jules, Darbois, Aurélie, du Halgouet, Anastasia, Alonso, Ruby, Richer, Wilfrid, Goubet, Anne-Gaëlle, Daviaud, Céline, Menger, Laurie, Procopio, Emanuele, Premel, Virginie, Lantz, Olivier

“…Mucosal-associated invariant T (MAIT) cells are abundant T cells with unique specificity for microbial metabolites. MAIT conservation along evolution indicates…”
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Mucosal-associated invariant T cells regulate Th1 response in multiple sclerosis by Miyazaki, Yusei, Miyake, Sachiko, Chiba, Asako, Lantz, Olivier, Yamamura, Takashi

“…Mucosal-associated invariant T (MAIT) cells are innate T cells expressing an invariant Vα7.2-Jα33 T-cell antigen receptor α chain and are enriched in…”
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Mucosal-associated invariant T cells promote inflammation and intestinal dysbiosis leading to metabolic dysfunction during obesity by Toubal, Amine, Kiaf, Badr, Beaudoin, Lucie, Cagninacci, Lucie, Rhimi, Moez, Fruchet, Blandine, da Silva, Jennifer, Corbett, Alexandra J., Simoni, Yannick, Lantz, Olivier, Rossjohn, Jamie, McCluskey, James, Lesnik, Philippe, Maguin, Emmanuelle, Lehuen, Agnès

“…Obesity is associated with low-grade chronic inflammation promoting insulin-resistance and diabetes. Gut microbiota dysbiosis is a consequence as well as a…”
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Patient-Specific Circulating Tumor DNA Detection during Neoadjuvant Chemotherapy in Triple-Negative Breast Cancer by Riva, Francesca, Bidard, Francois-Clement, Houy, Alexandre, Saliou, Adrien, Madic, Jordan, Rampanou, Aurore, Hego, Caroline, Milder, Maud, Cottu, Paul, Sablin, Marie-Paule, Vincent-Salomon, Anne, Lantz, Olivier, Stern, Marc-Henri, Proudhon, Charlotte, Pierga, Jean-Yves

“…In nonmetastatic triple-negative breast cancer (TNBC) patients, we investigated whether circulating tumor DNA (ctDNA) detection can reflect the tumor response…”
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Tumor invasion in draining lymph nodes is associated with Treg accumulation in breast cancer patients by Núñez, Nicolas Gonzalo, Tosello Boari, Jimena, Ramos, Rodrigo Nalio, Richer, Wilfrid, Cagnard, Nicolas, Anderfuhren, Cyrill Dimitri, Niborski, Leticia Laura, Bigot, Jeremy, Meseure, Didier, De La Rochere, Philippe, Milder, Maud, Viel, Sophie, Loirat, Delphine, Pérol, Louis, Vincent-Salomon, Anne, Sastre-Garau, Xavier, Burkhard, Becher, Sedlik, Christine, Lantz, Olivier, Amigorena, Sebastian, Piaggio, Eliane

“…Tumor-draining lymph node (TDLN) invasion by metastatic cells in breast cancer correlates with poor prognosis and is associated with local immunosuppression,…”
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MAIT, MR1, microbes and riboflavin: a paradigm for the co-evolution of invariant TCRs and restricting MHCI-like molecules? by Mondot, Stanislas, Boudinot, Pierre, Lantz, Olivier

“…MAIT cells express an invariant TCR that recognizes non-peptidic microbial antigens presented by the non-polymorphic MHCI-like molecule, MR1. We briefly…”
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MAIT cells detect and efficiently lyse bacterially-infected epithelial cells by Le Bourhis, Lionel, Dusseaux, Mathilde, Bohineust, Armelle, Bessoles, Stéphanie, Martin, Emmanuel, Premel, Virginie, Coré, Maxime, Sleurs, David, Serriari, Nacer-Eddine, Treiner, Emmanuel, Hivroz, Claire, Sansonetti, Philippe, Gougeon, Marie-Lise, Soudais, Claire, Lantz, Olivier

“…Mucosal associated invariant T cells (MAIT) are innate T lymphocytes that detect a large variety of bacteria and yeasts. This recognition depends on the…”
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Role of MR1-driven signals and amphiregulin on the recruitment and repair function of MAIT cells during skin wound healing by du Halgouet, Anastasia, Darbois, Aurélie, Alkobtawi, Mansour, Mestdagh, Martin, Alphonse, Aurélia, Premel, Virginie, Yvorra, Thomas, Colombeau, Ludovic, Rodriguez, Raphaël, Zaiss, Dietmar, El Morr, Yara, Bugaut, Hélène, Legoux, François, Perrin, Laetitia, Aractingi, Selim, Golub, Rachel, Lantz, Olivier, Salou, Marion

“…Tissue repair processes maintain proper organ function following mechanical or infection-related damage. In addition to antibacterial properties, mucosal…”
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Dendritic Cell-Derived Exosomes for Cancer Immunotherapy: What's Next? by VIAUD, Sophie, THERY, Clotilde, PLOIX, Stéphanie, TURSZ, Thomas, LAPIERRE, Valérie, LANTZ, Olivier, ZITVOGEL, Laurence, CHAPUT, Nathalie

“…Exosomes are nanovesicles originating from late endosomal compartments and secreted by most living cells in ex vivo cell culture conditions. The interest in…”
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Complementarity and redundancy of IL-22-producing innate lymphoid cells by Rankin, Lucille C, Girard-Madoux, Mathilde J H, Seillet, Cyril, Mielke, Lisa A, Kerdiles, Yann, Fenis, Aurore, Wieduwild, Elisabeth, Putoczki, Tracy, Mondot, Stanislas, Lantz, Olivier, Demon, Dieter, Papenfuss, Anthony T, Smyth, Gordon K, Lamkanfi, Mohamed, Carotta, Sebastian, Renauld, Jean-Christophe, Shi, Wei, Carpentier, Sabrina, Soos, Tim, Arendt, Christopher, Ugolini, Sophie, Huntington, Nicholas D, Belz, Gabrielle T, Vivier, Eric

“…The function of group 3 innate lymphoid cells (ILC3 cells) is still being determined. Vivier and colleagues describe the development of ILC3 subsets and show…”
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MAIT cells launch a rapid, robust and distinct hyperinflammatory response to bacterial superantigens and quickly acquire an anergic phenotype that impedes their cognate antimicrobial function: Defining a novel mechanism of superantigen-induced immunopathology and immunosuppression by Shaler, Christopher R, Choi, Joshua, Rudak, Patrick T, Memarnejadian, Arash, Szabo, Peter A, Tun-Abraham, Mauro E, Rossjohn, Jamie, Corbett, Alexandra J, McCluskey, James, McCormick, John K, Lantz, Olivier, Hernandez-Alejandro, Roberto, Haeryfar, S M Mansour

“…Superantigens (SAgs) are potent exotoxins secreted by Staphylococcus aureus and Streptococcus pyogenes. They target a large fraction of T cell pools to set in…”
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Outlier response to anti-PD1 in uveal melanoma reveals germline MBD4 mutations in hypermutated tumors by Rodrigues, Manuel, Mobuchon, Lenha, Houy, Alexandre, Fiévet, Alice, Gardrat, Sophie, Barnhill, Raymond L., Popova, Tatiana, Servois, Vincent, Rampanou, Aurore, Mouton, Aurore, Dayot, Stéphane, Raynal, Virginie, Galut, Michèle, Putterman, Marc, Tick, Sarah, Cassoux, Nathalie, Roman-Roman, Sergio, Bidard, François-Clément, Lantz, Olivier, Mariani, Pascale, Piperno-Neumann, Sophie, Stern, Marc-Henri

“…Metastatic uveal melanoma is a deadly disease with no proven standard of care. Here we present a metastatic uveal melanoma patient with an exceptional high…”
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The Transcription Factor PLZF Directs the Effector Program of the NKT Cell Lineage by Savage, Adam K., Constantinides, Michael G., Han, Jin, Picard, Damien, Martin, Emmanuel, Li, Bofeng, Lantz, Olivier, Bendelac, Albert

“…The transcriptional control of CD1d-restricted NKT cell development has remained elusive. We report that PLZF (promyelocytic leukemia zinc finger, Zbtb16), a…”
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MAIT cell inhibition promotes liver fibrosis regression via macrophage phenotype reprogramming by Mabire, Morgane, Hegde, Pushpa, Hammoutene, Adel, Wan, Jinghong, Caër, Charles, Sayegh, Rola Al, Cadoux, Mathilde, Allaire, Manon, Weiss, Emmanuel, Thibault-Sogorb, Tristan, Lantz, Olivier, Goodhardt, Michèle, Paradis, Valérie, de la Grange, Pierre, Gilgenkrantz, Hélène, Lotersztajn, Sophie

“…Recent data have shown that liver fibrosis can regress even at later stages of cirrhosis and shifting the immune response from pro-inflammatory towards a…”
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A comprehensive assessment of demographic, environmental, and host genetic associations with gut microbiome diversity in healthy individuals by Scepanovic, Petar, Hodel, Flavia, Mondot, Stanislas, Partula, Valentin, Byrd, Allyson, Hammer, Christian, Alanio, Cécile, Bergstedt, Jacob, Patin, Etienne, Touvier, Mathilde, Lantz, Olivier, Albert, Matthew L, Duffy, Darragh, Quintana-Murci, Lluis, Fellay, Jacques

“…The gut microbiome is an important determinant of human health. Its composition has been shown to be influenced by multiple environmental factors and likely by…”
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In Vitro and In Vivo Analysis of the Gram-Negative Bacteria-Derived Riboflavin Precursor Derivatives Activating Mouse MAIT Cells by Soudais, Claire, Samassa, Fatoumata, Sarkis, Manal, Le Bourhis, Lionel, Bessoles, Stéphanie, Blanot, Didier, Hervé, Mireille, Schmidt, Frédéric, Mengin-Lecreulx, Dominique, Lantz, Olivier

“…Mucosal-associated invariant T (MAIT) cells recognize microbial compounds presented by the MHC-related 1 (MR1) protein. Although riboflavin precursor…”
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Induction of anergic or regulatory tumor-specific CD4+ T cells in the tumor-draining lymph node by Alonso, Ruby, Flament, Héloïse, Lemoine, Sébastien, Sedlik, Christine, Bottasso, Emanuel, Péguillet, Isabel, Prémel, Virginie, Denizeau, Jordan, Salou, Marion, Darbois, Aurélie, Núñez, Nicolás Gonzalo, Salomon, Benoit, Gross, David, Piaggio, Eliane, Lantz, Olivier

“…CD4 + T cell antitumor responses have mostly been studied in transplanted tumors expressing secreted model antigens (Ags), while most mutated proteins in human…”
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Circulating tumor DNA as a non-invasive substitute to metastasis biopsy for tumor genotyping and personalized medicine in a prospective trial across all tumor types by Lebofsky, Ronald, Decraene, Charles, Bernard, Virginie, Kamal, Maud, Blin, Anthony, Leroy, Quentin, Rio Frio, Thomas, Pierron, Gaëlle, Callens, Céline, Bieche, Ivan, Saliou, Adrien, Madic, Jordan, Rouleau, Etienne, Bidard, François-Clément, Lantz, Olivier, Stern, Marc-Henri, Le Tourneau, Christophe, Pierga, Jean-Yves

“…Cell-free tumor DNA (ctDNA) has the potential to enable non-invasive diagnostic tests for personalized medicine in providing similar molecular information as…”
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