Search Results - "LANSBURY, P. T"

Kinetic Stabilization of the α-Synuclein Protofibril by a Dopamine-α-Synuclein Adduct by Conway, Kelly A., Rochet, Jean-Christophe, Bieganski, Robert M., Lansbury, Peter T.

“…The substantia nigra in Parkinson's disease (PD) is depleted of dopaminergic neurons and contains fibrillar Lewy bodies comprising primarily α-synuclein. We…”
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Vesicle Permeabilization by Protofibrillar α-Synuclein:  Implications for the Pathogenesis and Treatment of Parkinson's Disease by Volles, Michael J, Lee, Seung-Jae, Rochet, Jean-Christophe, Shtilerman, Mark D, Ding, Tomas T, Kessler, Jeffrey C, Lansbury, Peter T

“…Fibrillar α-synuclein is a component of the Lewy body, the characteristic neuronal inclusion of the Parkinson's disease (PD) brain. Both α-synuclein mutations…”
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Fibrils Formed in Vitro from α-Synuclein and Two Mutant Forms Linked to Parkinson's Disease are Typical Amyloid by Conway, Kelly A, Harper, James D, Lansbury, Peter T

“…Two missense mutations in the gene encoding α-synuclein have been linked to rare, early-onset forms of Parkinson's disease (PD). These forms of PD, as well as…”
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Seeding "one-dimensional crystallization" of amyloid: a pathogenic mechanism in Alzheimer's disease and scrapie? by Jarrett, J T, Lansbury, Jr, P T

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NACP, A Protein Implicated in Alzheimer's Disease and Learning, Is Natively Unfolded by Weinreb, Paul H, Zhen, Weiguo, Poon, Anna W, Conway, Kelly A, Lansbury, Peter T

“…The “non-Aβ component of Alzheimer's disease amyloid plaque” (NAC) is a minor peptide component of the insoluble fibrillar core of the Alzheimer's disease (AD)…”
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Inhibition of Fibrillization and Accumulation of Prefibrillar Oligomers in Mixtures of Human and Mouse α-Synuclein by Rochet, Jean-Christophe, Conway, Kelly A, Lansbury, Peter T

“…Parkinson's disease (PD) is a neurodegenerative disorder attributed to the loss of dopaminergic neurons from the substantia nigra. Some surviving neurons are…”
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A detergent-insoluble membrane compartment contains A beta in vivo by Lee, S J, Liyanage, U, Bickel, P E, Xia, W, Lansbury, Jr, P T, Kosik, K S

“…Ordered assembly of the amyloid-beta protein (A beta) into amyloid fibrils is a critical step in Alzheimer's disease (AD). To release the amyloidogenic peptide…”
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A Kinetic Model for Amyloid Formation in the Prion Diseases: Importance of Seeding by Come, Jon H., Fraser, Paul E., Lansbury, Peter T.

“…The transmissible spongiform encephalopathies (TSEs) are neurodegenerative diseases characterized by amyloid formation in the brain. The major amyloid protein…”
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Amyloid fibrillogenesis: themes and variations by Rochet, Jean-Christophe, Lansbury, Peter T

“…Recent progress has improved our knowledge of how proteins form amyloid fibrils. Both ‘natively unfolded’ and globular proteins have been shown to initiate…”
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The carboxy terminus of the .beta. amyloid protein is critical for the seeding of amyloid formation: Implications for the pathogenesis of Alzheimer's disease by Jarrett, Joseph T, Berger, Elizabeth P, Lansbury, Peter T

“…Several variants of the beta amyloid protein, differing only at their carboxy terminus (beta 1-39, beta 1-40, beta 1-42, and beta 1-43), have been identified…”
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Accelerated Oligomerization by Parkinson's Disease Linked α-Synuclein Mutants by CONWAY, K. A., LEE, S.-J, ROCHET, J.-C, DING, T. T., HARPER, J. D., WILLIAMSON, R. E., LANSBURY JR, P. T.

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Evolution of Amyloid: What Normal Protein Folding May Tell Us about Fibrillogenesis and Disease by Lansbury, Peter T.

“…Two globular proteins with no homology to the disease-associated proteins or to each other have the ability to form fibrils that resemble those extracted from…”
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Species Specificity in the Cell-Free Conversion of Prion Protein to Protease-Resistant Forms: A Model for the Scrapie Species Barrier by Kocisko, David A., Priola, Suzette A., Raymond, Gregory J., Chesebro, Bruce, Lansbury, Peter T., Caughey, Byron

“…Scrapie is a transmissible neurodegenerative disease that appears to result from an accumulation in the brain of an abnormal protease-resistant isoform of…”
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Is there a cause-and-effect relationship between α -synuclein fibrillization and Parkinson's disease? by Lansbury Jr, Peter T, Goldberg, Matthew S

“…The first gene to be linked to Parkinson's disease encodes the neuronal protein alpha-synuclein. Recent mouse and Drosophila models of Parkinson's disease…”
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Structural neurology: are seeds at the root of neuronal degeneration? by Lansbury, Jr, P T

“…Age-related neurodegenerative diseases form a clinically and neuropathologically diverse group that includes common sporadic diseases such as Alzheimer's…”
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Acceleration of Oligomerization, Not Fibrillization, Is a Shared Property of Both α -Synuclein Mutations Linked to Early-Onset Parkinson's Disease: Implications for Pathogenesis and Therapy by Conway, Kelly A., Lee, Seung-Jae, Rochet, Jean-Christophe, Ding, Tomas T., Williamson, Robin E., Lansbury, Peter T.

“…The Parkinson's disease (PD) substantia nigra is characterized by the presence of Lewy bodies containing fibrillar α -synuclein. Early-onset PD has been linked…”
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Apolipoprotein E is a Kinetic But not as a Thermodynamic Inhibitor of Amyloid Formation: Implications for the Pathogenesis and Treatment of Alzheimer Disease by Evans, Krista C., Berger, Elizabeth P., Cho, Cheon-Gyu, Weisgraber, Karl H., Lansbury, Peter T.

“…The apolipoprotein E4 (APOE4) allele is associated with an early age of onset of the nonfamilial form of Alzheimer disease (AD) and with increased β protein…”
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Molecular assessment of the potential transmissibilities of BSE and scrapie to humans by Caughey, Byron, Raymond, Gregory J, Hope, James, Kocisko, David A, Priola, Suzette A, Raymond, Lynne D, Bossers, Alex, Ironside, James, Will, Robert G, Chen, Shu G, Petersen, Robert B, Gambetti, Pierluigi, Rubenstein, Richard, Smits, Mari A, Lansbury, Peter T

“…More than a million cattle infected with bovine spongiform encephalopathy (BSE) may have entered the human food chain. Fears that BSE might transmit to man…”
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MODELS OF AMYLOID SEEDING IN ALZHEIMER'S DISEASE AND SCRAPIE:Mechanistic Truths and Physiological Consequences of the Time-Dependent Solubility of Amyloid Proteins by Harper, James D, Lansbury, Peter T

“…Ordered protein aggregation in the brain is a hallmark of Alzheimer's disease and scrapie. The disease-specific amyloid fibrils comprise primarily a single…”
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Amyloid Diseases: Abnormal Protein Aggregation in Neurodegeneration by Koo, Edward H., Lansbury, Peter T., Kelly, Jeffery W.

“…Koo et al focus on biophysical studies of protein aggregation in Alzheimer's disease and familial amyloid polyneuropathy. Mechanistic models connecting…”
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