Search Results - "LANGOSCH, D"

Understanding intramembrane proteolysis: from protein dynamics to reaction kinetics by Langosch, D., Scharnagl, C., Steiner, H., Lemberg, M.K.

“…•How intramembrane proteases select their substrates is currently unknown.•Helix-destabilizing amino acids within transmembrane helices often facilitate…”
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The role of transmembrane domains in membrane fusion by Langosch, D, Hofmann, M, Ungermann, C

“…Biological membrane fusion is driven by different types of molecular fusion machines. Most of these proteins are membrane-anchored by single transmembrane…”
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The dimerization motif of the glycophorin A transmembrane segment in membranes: Importance of glycine residues by Brosig, Bettina, Langosch, Dieter

“…The glycophorin A transmembrane segment homodimerizes to a right‐handed pair of α‐helices. Here, we identified the amino acid motif mediating this interaction…”
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Peptide mimics of SNARE transmembrane segments drive membrane fusion depending on their conformational plasticity by Langosch, Dieter, Crane, Jonathan M, Brosig, Bettina, Hellwig, Andrea, Tamm, Lukas K, Reed, Jennifer

“…SNARE proteins are essential for different types of intracellular membrane fusion. Whereas interaction between their cytoplasmic domains is held responsible…”
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The atypical M2 segment of the beta subunit confers picrotoxinin resistance to inhibitory glycine receptor channels by Pribilla, I., Takagi, T., Langosch, D., Bormann, J., Betz, H.

“…Purified preparations of the inhibitory glycine receptor (GlyR) contain alpha and beta subunits, which share homologous primary structures and a common…”
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Secondary structure and distribution of fusogenic LV-peptides in lipid membranes by Ollesch, J., Poschner, B. C., Nikolaus, J., Hofmann, M. W., Herrmann, A., Gerwert, K., Langosch, D.

“…LV-peptides were designed as membrane-spanning low-complexity model structures that mimic fusion protein transmembrane domains. These peptides harbor a…”
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Role of the Vam3p Transmembrane Segment in Homodimerization and SNARE Complex Formation by Roy, R, Peplowska, K, Rohde, J, Ungermann, C, Langosch, D

“…Intracellular membrane fusion in eukaryotic cells is mediated by SNARE (soluble N-ethylmaleimide sensitive factor (NSF) attachment protein receptor) proteins…”
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The 93-kDa glycine receptor-associated protein binds to tubulin by KIRSCH, J, LANGOSCH, D, PRIOR, P, LITTAUER, U. Z, SCHMITT, B, BETZ, H

“…A peripheral membrane protein with a relative molecular mass of 93,000 Da is associated with cytoplasmic domains of the inhibitory glycine receptor of…”
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Primary structure and alternative splice variants of gephyrin, a putative glycine receptor-tubulin linker protein by Prior, P, Schmitt, B, Grenningloh, G, Pribilla, I, Multhaup, G, Beyreuther, K, Maulet, Y, Werner, P, Langosch, D, Kirsch, J

“…A 93 kd polypeptide associated with the mammalian inhibitory glycine receptor (GlyR) is localized at central synapses and binds with high affinity to…”
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Strategies for Prokaryotic Expression of Eukaryotic Membrane Proteins by Laage, Rico, Langosch, Dieter

“…High‐level heterologous expression of integral membrane proteins at full‐length is a useful tool for their structural and functional characterization. Here,…”
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Conserved Quaternary Structure of Ligand-Gated Ion Channels: The Postsynaptic Glycine Receptor is a Pentamer by Langosch, Dieter, Thomas, Leo, Betz, Heinrich

“…The postsynaptic glycine receptor of rat spinal cord is a glycosylated membrane protein that, after affinity purification, contains membrane-spanning subunits…”
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Decreased agonist affinity and chloride conductance of mutant glycine receptors associated with human hereditary hyperekplexia by Langosch, D., Laube, B., Rundström, N., Schmieden, V., Bormann, J., Betz, H.

“…Hereditary hyperekplexia is a dominant neurological disorder associated with point mutations at the channel‐forming segment M2 of the glycine receptor alpha 1…”
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Residues within transmembrane segment M2 determine chloride conductance of glycine receptor homo- and hetero-oligomers by BORMANN, J, RUNDSTRÖM, N, BETZ, H, LANGOSCH, D

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Cyanotriphenylborate: Subtype-Specific Blocker of Glycine Receptor Chloride Channels by Rundstrom, Nils, Schmieden, Volker, Betz, Heinrich, Bormann, Joachim, Langosch, Dieter

“…The inhibitory glycine receptor is a ligandgated ion-channel protein existing in different homo- and heterooligomeric isoforms. Here we show that the chloride…”
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Modulating Hinge Flexibility in the APP Transmembrane Domain Alters γ-Secretase Cleavage by Götz, Alexander, Mylonas, Nadine, Högel, Philipp, Silber, Mara, Heinel, Hannes, Menig, Simon, Vogel, Alexander, Feyrer, Hannes, Huster, Daniel, Luy, Burkhard, Langosch, Dieter, Scharnagl, Christina, Muhle-Goll, Claudia, Kamp, Frits, Steiner, Harald

“…Intramembrane cleavage of the β-amyloid precursor protein C99 substrate by γ-secretase is implicated in Alzheimer’s disease pathogenesis. Biophysical data have…”
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Functions of SNAREs in intracellular membrane fusion and lipid bilayer mixing by Ungermann, Christian, Langosch, Dieter

“…Intracellular membrane fusion occurs with exquisite coordination and specificity. Each fusion event requires three basic components: Rab-GTPases organize the…”
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Isolation and characterization of a second nitrogenase Fe-protein from Azotobacter vinelandii by Hales, B J, Langosch, D J, Case, E E

“…Wild-type Azotobacter vinelandii strain UW was transformed with plasmid pDB12 to produce a species (LS10) unable to synthesize the structural proteins of…”
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Tryptophan Supports Interaction of Transmembrane Helices by Ridder, Anja, Skupjen, Paulina, Unterreitmeier, Stephanie, Langosch, Dieter

“…Interactions of transmembrane helices play an important role in folding and oligomerisation of integral membrane proteins. The interfacial residues of these…”
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Phenylalanine Promotes Interaction of Transmembrane Domains via GxxxG Motifs by Unterreitmeier, Stephanie, Fuchs, Angelika, Schäffler, Teresa, Heym, Roland G., Frishman, Dmitrij, Langosch, Dieter

“…Interactions of transmembrane helices play a crucial role in the folding and oligomerisation of integral membrane proteins. In order to uncover novel sequence…”
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Residues within transmembrane segment M2 determine chloride conductance of glycine receptor homo‐ and hetero‐oligomers by Bormann, J., Rundström, N., Betz, H., Langosch, D.

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