Search Results - "LANGMAN, Michael J"

Phase III Randomized Trial Assessing Rofecoxib in the Adjuvant Setting of Colorectal Cancer: Final Results of the VICTOR Trial by MIDGLEY, Rachel S, MCCONKEY, Christopher C, LANGMAN, Michael J, KERR, David J, JOHNSTONE, Elaine C, DUNN, Janet A, SMITH, Justine L, GRUMETT, Simon A, JULIER, Patrick, IVESON, Claire, YANAGISAWA, Yoko, WARREN, Bryan

“…Laboratory and case-control studies suggest a pivotal role for the cyclooxygenase-2 (COX-2) pathway in colorectal carcinogenesis. The purpose of this study was…”
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Sudden death in patients receiving drugs tending to prolong the QT interval by Jolly, Kate, Gammage, Michael D., Cheng, Kar Keung, Bradburn, Peter, Banting, Miriam V., Langman, Michael J. S.

“…WHAT IS ALREADY KNOWN ABOUT THIS SUBJECT • Drugs slowing electocardiographic QT conduction can cause tachyarrhythmias, torsades de pointes (TdP) and cardiac…”
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Rofecoxib and Cardiovascular Adverse Events in Adjuvant Treatment of Colorectal Cancer by Kerr, David J, Dunn, Janet A, Langman, Michael J, Smith, Justine L, Midgley, Rachel S.J, Stanley, Andrew, Stokes, Joanne C, Julier, Patrick, Iveson, Claire, Duvvuri, Ravi, McConkey, Christopher C

“…In this clinical trial, rofecoxib (25 mg per day) was studied in the prevention of recurrent colorectal cancer. Although the median duration of study treatment…”
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Antihypertensive medication and the risk of acute pancreatitis: The European case-control study on drug-induced acute pancreatitis (EDIP) by Eland, Ingo A., Sundström, Anders, Velo, Giancarlo P., Andersen, Morten, Sturkenboom, Miriam C. J. M., Langman, Michael J. S., Stricker, Bruno H. CH, Wiholm, Beje, FOR THE EDIP STUDY GROUP OF THE EUROPEAN PHARMACOVIGILANCE RESEARCH GROUP

“…Objective. Angiotensin-converting enzyme (ACE) inhibitors and diuretics have been associated with acute pancreatitis. We quantified the risk of acute…”
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Adverse effects of conventional non-steroidal anti-inflammatory drugs on the upper gastrointestinal tract by Langman, Michael J. S.

“…This article reviews the clinical and epidemiological features of conventional non‐steroidal anti‐inflammatory drug (NSAID) related peptic ulcer complications,…”
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Adverse Upper Gastrointestinal Effects of Rofecoxib Compared With NSAIDs by Langman, Michael J, Jensen, Dennis M, Watson, Douglas J, Harper, Sean E, Zhao, Peng-Liang, Quan, Hui, Bolognese, James A, Simon, Thomas J

“…CONTEXT Nonsteroidal anti-inflammatory drug (NSAID)–induced gastrointestinal (GI) toxic effects, such as upper GI tract perforations, symptomatic…”
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Psychotropic medication: curing illness or creating problems? by Jolly, Kate, Langman, Michael J S

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Is Thiosulfate Sulfurtransferase the Colonic Sulfide Oxidase? by Eggo, Margaret C., Warrack, Rhian, Ramasamy, Sundaram, Langman, Michael J., Singh, Sukhdev

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NSAIDs and gastrointestinal cancer prevention by JOLLY, Kate, CHENG, Kar K, LANGMAN, Michael J. S

“…Numerous studies report the relationship between aspirin and other nonsteroidal anti-inflammatories (NSAIDs) and cancer incidence, in particular for colorectal…”
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Loss of Estrogen Inactivation in Colonic Cancer by English, Mark A, Kane, Kate F, Cruickshank, Neil, Langman, Michael J. S, Stewart, Paul M, Hewison, Martin

“…Age and sex differences in the incidence of colonic cancer, together with epidemiological data on patients taking hormone replacement therapy, suggest the…”
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Controversies in COX-2 selective inhibition by SIMON, Lee S, SMOLEN, Josef S, DOUGADOS, Maxime, DUBOIS, Raymond N, FITZGERALD, Garret A, FRISHMAN, W, GARCIA RODRIGUEZ, Luis A, HOCHBERG, Marc C, KALDEN, Joachim R, LAINE, Loren, LANGMAN, Michael J. S, PRESCOTT, Stephen M, ABRAMSON, Steven B, VAN DE PUTTE, Leo B. A, WHELTON, Andrew, WHITE, William B, WILLIAMS, Gordon H, APPEL, Gerald, BOMBARDIER, Claire, BRATER, D. Craig, BREEDVELD, Ferdinand C, BRUNE, Kay, BURMESTER, Gerd R, CROFFORD, Leslie J

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Heparin therapy for ulcerative colitis? Effects and mechanisms by MICHELL, Nicholas P, LALOR, Patricia, LANGMAN, Michael J. S

“…Despite intensive medical treatment with steroids and immunosuppressants, acute colitis is still associated with a colectomy rate of up to 15%. Following the…”
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Rofecoxib and the Risk of Adverse Upper Gastrointestinal Effects—Reply by Langman, Michael J

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Targets of 17β-oestradiol-induced apoptosis in colon cancer cells: a mechanism for the protective effects of hormone replacement therapy? by YAN QIU, LANGMAN, Michael J. S, EGGO, Margaret C

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Protein kinase C delta is not activated by caspase-3 and its inhibition is sufficient to induce apoptosis in the colon cancer line, COLO 205 by Lewis, Aurélia E., Susarla, Radhika, Wong, Benjamin C.Y., Langman, Michael J.S., Eggo, Margaret C.

“…Activation of protein kinase C δ (PKCδ) is believed to be pro-apoptotic. PKCδ is reported to be reduced in colon cancers. Using a colon cancer cell line, COLO…”
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Smoking And Ulcerative Colitis [With Reply] by Kennedy, H. G., Amery, K. V., Logan, R., Langman, Michael J. S.

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Ulcerative colitis and ‘Energy-deficiency’: The HT29 colonic cell line as a model for the effects of sulphide on colonocyte metabolism by Hulin, Sarah J., Singh, Sukhdev, Chapman, Mark A.S., Allan, Arthur, Langman, Michael J., Eggo, Margaret C.

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Protein kinase C inhibition induces DNA fragmentation in COLO 205 cells which is blocked by cysteine protease inhibition but not mediated through caspase-3 by Lewis, Aurélia E, Wong, Benjamin C.Y, Langman, Michael J.S, Eggo, Margaret C

“…Enhancing apoptosis to remove abnormal cells has potential in reversing cancerous processes. Caspase-3 activation generally accompanies apoptosis and its…”
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Targets of 17beta-oestradiol-induced apoptosis in colon cancer cells: a mechanism for the protective effects of hormone replacement therapy? by Qiu, Y, Langman, MJ, Eggo, MC

“…Epidemiological studies show a strong link between postmenopausal hormone replacement therapy and decreased incidence of colorectal cancer. The colon cancer…”
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Apoptosis is induced by 17b-estradiol in COLO 205 cells — possible role of ERB by Qiu, Yan, Waters, Charlotte E., Langman, Michael J., Eggo, Margaret C.

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