Search Results - "LANGE, JENNY"

Pathomechanisms in the neuronal ceroid lipofuscinoses by Nelvagal, Hemanth R., Lange, Jenny, Takahashi, Keigo, Tarczyluk-Wells, Marta A., Cooper, Jonathan D.

“…The neuronal ceroid lipofuscinoses (NCLs) are a group of inherited neurodegenerative lysosomal storage disorders (LSDs), traditionally grouped together based…”
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Cerebral Organoids and Antisense Oligonucleotide Therapeutics: Challenges and Opportunities by Lange, Jenny, Zhou, Haiyan, McTague, Amy

“…The advent of stem cell-derived cerebral organoids has already advanced our understanding of disease mechanisms in neurological diseases. Despite this, many…”
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Glial Dysfunction and Its Contribution to the Pathogenesis of the Neuronal Ceroid Lipofuscinoses by Takahashi, Keigo, Nelvagal, Hemanth R, Lange, Jenny, Cooper, Jonathan D

“…While significant efforts have been made in developing pre-clinical treatments for the neuronal ceroid lipofuscinoses (NCLs), many challenges still remain to…”
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Mislocalization of Nucleocytoplasmic Transport Proteins in Human Huntington's Disease PSC-Derived Striatal Neurons by Lange, Jenny, Wood-Kaczmar, Alison, Ali, Aneesa, Farag, Sahar, Ghosh, Rhia, Parker, Jennifer, Casey, Caroline, Uno, Yumiko, Kunugi, Akiyoshi, Ferretti, Patrizia, Andre, Ralph, Tabrizi, Sarah J

“…Huntington's disease (HD) is an inherited neurodegenerative disorder caused by a CAG repeat expansion in the huntingtin gene ( ). Disease progression is…”
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Compromised astrocyte function and survival negatively impact neurons in infantile neuronal ceroid lipofuscinosis by Lange, Jenny, Haslett, Luke J, Lloyd-Evans, Emyr, Pocock, Jennifer M, Sands, Mark S, Williams, Brenda P, Cooper, Jonathan D

“…The neuronal ceroid lipofuscinoses (NCLs) are the most common cause of childhood dementia and are invariably fatal. Early localized glial activation occurs in…”
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PolyQ length-dependent metabolic alterations and DNA damage drive human astrocyte dysfunction in Huntington’s disease by Lange, Jenny, Gillham, Olivia, Flower, Michael, Ging, Heather, Eaton, Simon, Kapadia, Sneha, Neueder, Andreas, Duchen, Michael R., Ferretti, Patrizia, Tabrizi, Sarah J.

“…Huntington’s Disease (HD) is a neurodegenerative disease caused by a polyglutamine (polyQ) expansion in the Huntingtin gene. Astrocyte dysfunction is known to…”
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Cover Image, Volume 70, Issue 3 by Lange, Jenny, Gillham, Olivia, Alkharji, Reem, Eaton, Simon, Ferrari, Giulia, Madej, Monika, Flower, Michael, Tedesco, Francesco Saverio, Muntoni, Francesco, Ferretti, Patrizia

“…Cover Illustration: Dystrophin, a protein mutated in Duchenne muscular dystrophy, is expressed in human astrocytes differentiated from neural stem cells and…”
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Dystrophin deficiency affects human astrocyte properties and response to damage by Lange, Jenny, Gillham, Olivia, Alkharji, Reem, Eaton, Simon, Ferrari, Giulia, Madej, Monika, Flower, Michael, Tedesco, Francesco Saverio, Muntoni, Francesco, Ferretti, Patrizia

“…In addition to progressive muscular degeneration due to dystrophin mutations, 1/3 of Duchenne muscular dystrophy (DMD) patients present cognitive deficits…”
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Identification of rare non-synonymous variants in SYNE1/CPG2 in bipolar affective disorder by Sharp, Sally Isabel, Lange, Jenny, Kandaswamy, Radhika, Daher, Mazen, Anjorin, Adebayo, Bass, Nicholas James, McQuillin, Andrew

“…Bipolar affective disorder (BPD) is a severe mood disorder with a prevalence of ˜1.5% in the population. The pathogenesis of BPD is poorly understood; however,…”
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The glial contribution to pathogenesis differs between forms of Batten disease: implications for therapy by Cooper, Jonathan D, Lange, Jenny, van Trigt, Laurent, Brooks, Helen, Parviainen, Lotta, Dihanich, Sybille, Anderson, Greg, Williams, Brenda P

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Neuron-glia interactions in infantile neuronal ceroid lipofuscinosis (cln1 disease) by Lange, Jenny

“…The neuronal ceroid lipofuscinoses (NCLs) are the most common cause of childhood dementia and are invariably fatal. Early, localised glial activation occurs in…”
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Identification of rare nonsynonymous variants in SYNE1/CPG2 in bipolar affective disorder by Sharp, Sally I, Lange, Jenny, Kandaswamy, Radhika, Daher, Mazen, Anjorin, Adebayo, Bass, Nicholas J, McQuillin, Andrew

“…BACKGROUNDBipolar affective disorder (BPD) is a severe mood disorder with a prevalence of ∼1.5% in the population. The pathogenesis of BPD is poorly…”
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The Effects of Measures of Language Experience and Language Ability on Segmental Accuracy in Bilingual Children by Goldstein, Brian A, Bunta, Ferenc, Lange, Jenny, Rodriguez, Jenny, Burrows, Lauren

“…Purpose: The present study investigated the effects of selected measures of language experience (parent-reported estimates of frequency of output and language…”
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Collaborative Investigation of Inclusive Early Education Practices by GETTINGER MARIBETH, STOIBER KAREN CALLAN, Lange, Jenny

“…This paper describes the rationale, development, and first-year implementation of Wisconsin's Preschool Action Research and Development Initiative (PARDI)…”
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Collaborative Investigation of Inclusive Early Education Practices: A Blueprint for Teacher-Researcher Partnership by GETTINGER, MARIBETH, STOIBER, KAREN CALLAN, LANGE, JENNY

“…This paper describes the rationale, development, and first-year implementation of Wisconsin's Preschool Action Research and Development Initiative (PARDI)…”
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Out of the Nest: Instructional Strategies to Prepare Young, Exceptional Children for the Mainstream by Lange, Jenny, Comp

“…Designed to help prepare handicapped preschool children for mainstreaming, the manual describes 37 skills and related strategies for teaching those skills. The…”
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