Search Results - "LANGDON, R."

Scaffold Diversity of Exemplified Medicinal Chemistry Space by Langdon, Sarah R, Brown, Nathan, Blagg, Julian

“…The scaffold diversity of 7 representative commercial and proprietary compound libraries is explored for the first time using both Murcko frameworks and…”
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Eclogitization of the Monviso ophiolite (W. Alps) and implications on subduction dynamics by ANGIBOUST, S., LANGDON, R., AGARD, P., WATERS, D., CHOPIN, C.

“…To constrain deep (40–100 km) subduction dynamics, extensive P–T data are provided on the eclogitic Monviso ophiolite derived from the subducted…”
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Bioisosteric Replacement and Scaffold Hopping in Lead Generation and Optimization by Langdon, Sarah R., Ertl, Peter, Brown, Nathan

“…Bioisosteric replacement and scaffold hopping are twin methods used in drug design to improve the synthetic accessibility, potency and drug like properties of…”
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A qualitative study of nurses' perceptions of a behavioural strategies e-learning program to reduce interruptions during medication administration by Johnson, Maree, Levett-Jones, Tracy, Langdon, R., Weidemann, Gabrielle, Manias, Elizabeth, Everett, Bronwyn

“…We sought to evaluate the perceptions of nurses of an e-learning educational program to encourage the use of behavioural strategies—blocking, engaging,…”
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A phase II trial of imatinib (ST1571) in patients with c-kit expressing relapsed small-cell lung cancer: a CALGB and NCCTG study by Dy, G. K., Miller, A. A., Mandrekar, S. J., Aubry, M.-C., Langdon, R. M., Morton, R. F., Schild, S. E., Jett, J. R., Adjei, A. A.

“…Background: The aim of the present study was to evaluate the clinical activity of imatinib mesylate in patients with recurrent and refractory c-kit-expressing…”
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Autism, early psychosis, and social anxiety disorder: understanding the role of social cognition and its relationship to disability in young adults with disorders characterized by social impairments by Pepper, K. L., Demetriou, E. A., Park, S. H., Song, Y. C., Hickie, I. B., Cacciotti-Saija, C., Langdon, R., Piguet, O., Kumfor, F., Thomas, E. E., Guastella, A. J.

“…Impairments in social cognition are believed contribute to disability, particularly for disorders characterized by difficulties in social interaction. There…”
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Extremes of Clinical and Enzymatic Phenotypes in Children With Hyperinsulinism Caused by Glucokinase Activating Mutations by SAYED, Samir, LANGDON, David R, STANLEY, Charles A, ODILI, Stella, PAN CHEN, BUETTGER, Carol, SCHIFFMAN, Alisa B, SUCHI, Mariko, TAUB, Rebecca, GRIMSBY, Joseph, MATSCHINSKY, Franz M

“…Extremes of Clinical and Enzymatic Phenotypes in Children With Hyperinsulinism Caused by Glucokinase Activating Mutations Samir Sayed 1 , David R. Langdon 2 ,…”
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Belief-bias reasoning in non-clinical delusion-prone individuals by Anandakumar, T, Connaughton, E, Coltheart, M, Langdon, R

“…Abstract Background and Objectives It has been proposed that people with delusions have difficulty inhibiting beliefs (i.e., “doxastic inhibition”) so as to…”
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Systematic conservation planning in the face of climate change: bet-hedging on the Columbia Plateau by Schloss, Carrie A, Lawler, Joshua J, Larson, Eric R, Papendick, Hilary L, Case, Michael J, Evans, Daniel M, DeLap, Jack H, Langdon, Jesse G R, Hall, Sonia A, McRae, Brad H

“…Systematic conservation planning efforts typically focus on protecting current patterns of biodiversity. Climate change is poised to shift species…”
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Belief-bias reasoning in non-clinical delusion-prone individuals by Anandakumar, T, Connaughton, E, Coltheart, M, Langdon, R

“…Abstract Background and Objectives It has been proposed that people with delusions have difficulty inhibiting beliefs (i.e., “doxastic inhibition”) so as to…”
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The phenomenology of inner speech: comparison of schizophrenia patients with auditory verbal hallucinations and healthy controls by Langdon, R, Jones, S R, Connaughton, E, Fernyhough, C

“…Despite the popularity of inner-speech theories of auditory verbal hallucinations (AVHs), little is known about the phenomenological qualities of inner speech…”
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Disturbed communication in schizophrenia: the role of poor pragmatics and poor mind-reading by Langdon, R, Coltheart, M, Ward, P B, Catts, S V

“…Disturbed speech in schizophrenia may reflect pragmatic deficits of expressive language. Pragmatic comprehension deficits also occur in schizophrenia. This…”
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Chronic treatment with a glucokinase activator delays the onset of hyperglycaemia and preserves beta cell mass in the Zucker diabetic fatty rat by Futamura, M., Yao, J., Li, X., Bergeron, R., Tran, J.-L., Zycband, E., Woods, J., Zhu, Y., Shao, Q., Maruki-Uchida, H., Goto-Shimazaki, H., Langdon, R. B., Erion, M. D., Eiki, J., Zhou, Y.-P.

“…Aims/hypothesis Glucokinase activators (GKAs) are currently being developed as new therapies for type 2 diabetes and have been shown to enhance beta cell…”
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Scaffold-Focused Virtual Screening: Prospective Application to the Discovery of TTK Inhibitors by Langdon, Sarah R, Westwood, Isaac M, van Montfort, Rob L. M, Brown, Nathan, Blagg, Julian

“…We describe and apply a scaffold-focused virtual screen based upon scaffold trees to the mitotic kinase TTK (MPS1). Using level 1 of the scaffold tree, we…”
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Construction Workers’ Well-Being: What Leads to Depression, Anxiety, and Stress? by Langdon, Rebecca R, Sawang, Sukanlaya

“…AbstractWork-related stress is an important issue in any industry, particularly in construction, in which stressful environments are frequently encountered…”
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Efficacy and safety of initial combination treatment with sitagliptin and pioglitazone-a factorial study by Henry, R. R., Staels, B., Fonseca, V. A., Chou, M. Z., Teng, R., Golm, G. T., Langdon, R. B., Kaufman, K. D., Steinberg, H., Goldstein, B. J.

“…Aim To evaluate the efficacy and safety of initial combination therapy of sitagliptin 100 mg/day coadministered with all marketed doses of pioglitazone in…”
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Treatment preference and recruitment to pediatric RCTs: A systematic review by Beasant, L, Brigden, A, Parslow, R.M, Apperley, H, Keep, T, Northam, A, Wray, C, King, H, Langdon, R, Mills, N, Young, B, Crawley, E

“…Abstract Background Recruitment to pediatric randomised controlled trials (RCTs) can be a challenge, with ethical issues surrounding assent and consent…”
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American Society of Clinical Oncology Clinical practice guidelines for the use of chemotherapy and radiotherapy protectants by HENSLEY, M. L, SCHUCHTER, L. M, NEGRIN, R, SZATROWSKI, T. P, THIGPEN, J. T, VON HOFF, D, WASSERMAN, T. H, WINER, E. P, PFISTER, D. G, LINDLEY, C, MEROPOL, N. J, COHEN, G. I, BRODER, G, GRADISHAR, W. J, GREEN, D. M, LANGDON, R. J, MITCHELL, R. B

“…Because toxicities associated with chemotherapy and radiotherapy can adversely affect short- and long-term patient quality of life, can limit the dose and…”
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Visual perspective-taking and schizotypy: evidence for a simulation-based account of mentalizing in normal adults by Langdon, Robyn, Coltheart, Max

“…Modular theory-of-mind accounts attribute poor mentalizing to disruption of a cognitive module dedicated to computing higher-order representations of primary…”
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Bone loss in the oestrogen-depleted rat is not exacerbated by sitagliptin, either alone or in combination with a thiazolidinedione by Cusick, T., Mu, J., Pennypacker, B. L., Li, Z., Scott, K. R., Shen, X., Fisher, J. E., Langdon, R. B., Kimmel, D. B., Zhang, B. B., Glantschnig, H.

“…Antihyperglycaemic therapy on bone was evaluated in the ovariectomized (OVX), non‐diabetic adult rat. Animals were treated daily for 12 weeks with various…”
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