Search Results - "LANG, Chim C"

Anti-Inflammatory Effects of Metformin Irrespective of Diabetes Status by Cameron, Amy R, Morrison, Vicky L, Levin, Daniel, Mohan, Mohapradeep, Forteath, Calum, Beall, Craig, McNeilly, Alison D, Balfour, David J.K, Savinko, Terhi, Wong, Aaron K.F, Viollet, Benoit, Sakamoto, Kei, Fagerholm, Susanna C, Foretz, Marc, Lang, Chim C, Rena, Graham

“…RATIONALE:The diabetes mellitus drug metformin is under investigation in cardiovascular disease, but the molecular mechanisms underlying possible benefits are…”
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The clinical significance of interleukin‐6 in heart failure: results from the BIOSTAT‐CHF study by Markousis‐Mavrogenis, George, Tromp, Jasper, Ouwerkerk, Wouter, Devalaraja, Matt, Anker, Stefan D., Cleland, John G., Dickstein, Kenneth, Filippatos, Gerasimos S., Harst, Pim, Lang, Chim C., Metra, Marco, Ng, Leong L., Ponikowski, Piotr, Samani, Nilesh J, Zannad, Faiez, Zwinderman, Aeilko H., Hillege, Hans L., Veldhuisen, Dirk J., Kakkar, Rahul, Voors, Adriaan A., Meer, Peter

“…Aims Inflammation is a central process in the pathophysiology of heart failure (HF), but trials targeting tumour necrosis factor (TNF)‐α were largely…”
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Selenium and outcome in heart failure by Bomer, Nils, Grote Beverborg, Niels, Hoes, Martijn F., Streng, Koen W., Vermeer, Mathilde, Dokter, Martin M., IJmker, Jan, Anker, Stefan D., Cleland, John G.F., Hillege, Hans L., Lang, Chim C., Ng, Leong L., Samani, Nilesh J., Tromp, Jasper, Veldhuisen, Dirk J., Touw, Daan J., Voors, Adriaan A., Meer, Peter

“…Aims Severe deficiency of the essential trace element selenium can cause myocardial dysfunction although the mechanism at cellular level is uncertain. Whether,…”
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Effect of high-dose allopurinol on exercise in patients with chronic stable angina: a randomised, placebo controlled crossover trial by Noman, Awsan, MB, Ang, Donald SC, MD, Ogston, Simon, PhD, Lang, Chim C, Prof, Struthers, Allan D, Prof

“…Summary Background Experimental evidence suggests that xanthine oxidase inhibitors can reduce myocardial oxygen consumption for a particular stroke volume. If…”
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Targeting the renin–angiotensin–aldosterone system in heart failure by Lang, Chim C., Struthers, Allan D.

“…The renin–angiotensin–aldosterone system (RAAS) is well established as a therapeutic target in patients with heart failure. Professors Lang and Struthers…”
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Waist‐to‐hip ratio and mortality in heart failure by Streng, Koen W., Voors, Adriaan A., Hillege, Hans L., Anker, Stefan D., Cleland, John G., Dickstein, Kenneth, Filippatos, Gerasimos, Metra, Marco, Ng, Leong L., Ponikowski, Piotr, Samani, Nilesh J., van Veldhuisen, Dirk J., Zwinderman, Aeilko H., Zannad, Faiez, Damman, Kevin, van der Meer, Peter, Lang, Chim C.

“…Aims A higher body mass index (BMI) is associated with better survival in heart failure (HF) patients, also known as the obesity paradox. However, BMI does not…”
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Impact of Renin-Angiotensin System Blockade Therapy on Outcome in Aortic Stenosis by Nadir, M. Adnan, MBBS, Wei, Li, MPH, PhD, Elder, Douglas H.J., MBChB, Libianto, Renata, MBBS, Lim, Tiong K., MD, Pauriah, Maheshwar, MBChB, Pringle, Stuart D., MD, Doney, Alex D., PhD, Choy, Anna-Maria, MD, Struthers, Allan D., MD, Lang, Chim C., MD

“…Objectives The purpose of this study was to investigate the impact of renin-angiotensin system blockade therapy on outcomes in aortic stenosis (AS). Background…”
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Allopurinol Reduces Left Ventricular Mass in Patients With Type 2 Diabetes and Left Ventricular Hypertrophy by Szwejkowski, Benjamin R., MBChB, Gandy, Stephen J., PhD, Rekhraj, Sushma, MBChB, Houston, John G., MD, Lang, Chim C., MD, Morris, Andrew D., MD, George, Jacob, MD, Struthers, Allan D., MD

“…Objectives This study sought to ascertain whether high-dose allopurinol causes regression of left ventricular mass (LVM) in patients with type 2 diabetes…”
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High-Dose Allopurinol Reduces Left Ventricular Mass in Patients With Ischemic Heart Disease by Rekhraj, Sushma, MBChB, Gandy, Stephen J., PhD, Szwejkowski, Benjamin R., MBChB, Nadir, M. Adnan, MD, Noman, Awsan, MBChB, Houston, J. Graeme, MD, MA, Lang, Chim C., MD, George, Jacob, MD, Struthers, Allan D., MD

“…Objectives This study sought to ascertain if high-dose allopurinol regresses left ventricular mass (LVM) in patients with ischemic heart disease (IHD)…”
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The effects of the cardiac myosin activator, omecamtiv mecarbil, on cardiac function in systolic heart failure: a double-blind, placebo-controlled, crossover, dose-ranging phase 2 trial by Cleland, John GF, Prof, Teerlink, John R, Prof, Senior, Roxy, Prof, Nifontov, Evgeny M, Prof, Mc Murray, John JV, Prof, Lang, Chim C, Prof, Tsyrlin, Vitaly A, Prof, Greenberg, Barry H, Prof, Mayet, Jamil, MD, Francis, Darrel P, MD, Shaburishvili, Tamaz, MD, Monaghan, Mark, PhD, Saltzberg, Mitchell, MD, Neyses, Ludwig, Prof, Wasserman, Scott M, MD, Lee, Jacqueline H, Saikali, Khalil G, PhD, Clarke, Cyril P, MBBS, Goldman, Jonathan H, MD, Wolff, Andrew A, MD, Malik, Fady I, MD

“…Summary Background Many patients with heart failure remain symptomatic and have a poor prognosis despite existing treatments. Decreases in myocardial…”
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Obesity and the risk of myocardial infarction in 27 000 participants from 52 countries: a case-control study by Yusuf, Salim, Hawken, Steven, Ôunpuu, Stephanie, Bautista, Leonelo, Franzosi, Maria Grazia, Commerford, Patrick, Lang, Chim C, Rumboldt, Zvonko, Onen, Churchill L, Lisheng, Liu, Tanomsup, Supachai, Wangai, Paul, Razak, Fahad, Sharma, Arya M, Anand, Sonia S

“…Obesity is a major risk factor for cardiovascular disease, but the most predictive measure for different ethnic populations is not clear. We aimed to assess…”
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Heart failure treatment up‐titration and outcome and age: an analysis of BIOSTAT‐CHF by Mordi, Ify R., Ouwerkerk, Wouter, Anker, Stefan D., Cleland, John G., Dickstein, Kenneth, Metra, Marco, Ng, Leong L., Samani, Nilesh J., Veldhuisen, Dirk J., Zannad, Faiez, Voors, Adriaan A., Lang, Chim C.

“…Aims Several studies have shown that older patients with heart failure with reduced ejection fraction (HFrEF) are undertreated. The aim of this study was to…”
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Blood-based and Imaging Biomarkers of Atherosclerosis by Ali, Kashan, Lang, Chim C, Huang, Jeffrey T J, Choy, Anna-Maria

“…Atherosclerosis is the main cause of arterial thrombosis, causing acute occlusive cardiovascular syndromes. Numerous risk prediction models have been…”
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Left Ventricular Hypertrophy in Diabetic Cardiomyopathy: A Target for Intervention by Mohan, Mohapradeep, Dihoum, Adel, Mordi, Ify R, Choy, Anna-Maria, Rena, Graham, Lang, Chim C

“…Heart failure is an important manifestation of diabetic heart disease. Before the development of symptomatic heart failure, as much as 50% of patients with…”
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AMP-activated protein kinase pathway: a potential therapeutic target in cardiometabolic disease by Wong, Aaron K F, Howie, Jacqueline, Petrie, John R, Lang, Chim C

“…AMPK (AMP-activated protein kinase) is a heterotrimetric enzyme that is expressed in many tissues, including the heart and vasculature, and plays a central…”
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Mechanistic Insights Into the Therapeutic Use of High-Dose Allopurinol in Angina Pectoris by Rajendra, Narasimharajapura S., MD, Ireland, Sheila, RGN, RM, George, Jacob, MD, Belch, Jill J.F., MD, Lang, Chim C., MD, Struthers, Allan D., MD

“…Objectives The aim of this study was to evaluate the effect of high-dose allopurinol on vascular oxidative stress (OS) and endothelial function in subjects…”
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COVID-19-Associated Cardiovascular Complications by Lee, Clement C. E., Ali, Kashan, Connell, David, Mordi, Ify R., George, Jacob, Lang, Elizabeth MSL, Lang, Chim C.

“…Coronavirus disease 2019 (COVID-19) has been reported to cause cardiovascular complications such as myocardial injury, thromboembolic events, arrhythmia, and…”
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A heart failure phenotype stratified model for predicting 1-year mortality in patients admitted with acute heart failure: results from an individual participant data meta-analysis of four prospective European cohorts by Chen, Yuntao, Voors, Adriaan A, Jaarsma, Tiny, Lang, Chim C, Sama, Iziah E, Akkerhuis, K Martijn, Boersma, Eric, Hillege, Hans L, Postmus, Douwe

“…Prognostic models developed in general cohorts with a mixture of heart failure (HF) phenotypes, though more widely applicable, are also likely to yield larger…”
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Dapagliflozin, inflammation and left ventricular remodelling in patients with type 2 diabetes and left ventricular hypertrophy by Dihoum, Adel, Brown, Alexander Jm, McCrimmon, Rory J, Lang, Chim C, Mordi, Ify R

“…Sodium-glucose co-transporter 2 (SGLT2) inhibitors have beneficial effects in heart failure (HF), including reverse remodelling, but the mechanisms by which…”
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Relationship between peripheral and coronary function using laser Doppler imaging and transthoracic echocardiography by Khan, Faisel, Patterson, Dean, Belch, Jill J F, Hirata, Kumiko, Lang, Chim C

“…Vascular dysfunction in the coronary and peripheral circulations is an early prognostic marker of future cardiovascular events. Measurements of coronary and…”
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