Search Results - "LANDREE, Leslie E"

AMPK in the brain: its roles in energy balance and neuroprotection by Ronnett, Gabriele V, Ramamurthy, Santosh, Kleman, Amy M, Landree, Leslie E, Aja, Susan

“…Adenosine monophosphate-activated protein kinase (AMPK) senses metabolic stress and integrates diverse physiological signals to restore energy balance…”
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Pharmacological Inhibition of AMP-activated Protein Kinase Provides Neuroprotection in Stroke by McCullough, Louise D., Zeng, Zhiyuan, Li, Hong, Landree, Leslie E., McFadden, Jill, Ronnett, Gabriele V.

“…The restoration of energy balance during ischemia is critical to cellular survival; however, relatively little is known concerning the regulation of neuronal…”
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C75, a Fatty Acid Synthase Inhibitor, Reduces Food Intake via Hypothalamic AMP-activated Protein Kinase by Kim, Eun-Kyoung, Miller, Ian, Aja, Susan, Landree, Leslie E, Pinn, Michael, McFadden, Jill, Kuhajda, Francis P, Moran, Timothy H, Ronnett, Gabriele V

“…Energy homeostasis and feeding are regulated by the central nervous system. C75, a fatty acid synthase (FAS) inhibitor, causes weight loss and anorexia,…”
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Fatty acid synthase inhibition activates AMP-activated protein kinase in SKOV3 human ovarian cancer cells by WEIBO ZHOU, WAN FANG HAN, RONNETT, Gabriele V, TOWNSEND, Craig A, KUHAJDA, Francis P, LANDREE, Leslie E, THUPARI, Jagan N, PINN, Michael L, BILILIGN, Tsion, EUN KYOUNG KIM, VADLAMUDI, Aravinda, MEDGHALCHI, Susan M, EL MESKINI, Rajaa

“…Fatty acid synthase (FAS), the enzyme responsible for the de novo synthesis of fatty acids, is highly expressed in ovarian cancers and most common human…”
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C75 Increases Peripheral Energy Utilization and Fatty Acid Oxidation in Diet-Induced Obesity by Thupari, Jagan N., Landree, Leslie E., Ronnett, Gabriele V., Kuhajda, Francis P.

“…C75, a known inhibitor of fatty acid synthase is postulated to cause significant weight loss through decreased hypothalamic neuropeptide Y (NPY) production…”
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Physiological glucose is critical for optimized neuronal viability and AMPK responsiveness in vitro by Kleman, Amy M., Yuan, Jason Y., Aja, Susan, Ronnett, Gabriele V., Landree, Leslie E.

“…Understanding the mechanisms that govern neuronal responses to oxidative and metabolic stress is essential for therapeutic intervention. In vitro modeling is…”
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Pharmacological glycerol-3-phosphate acyltransferase inhibition decreases food intake and adiposity and increases insulin sensitivity in diet-induced obesity by Kuhajda, Francis P, Aja, Susan, Tu, Yajun, Han, Wan Fang, Medghalchi, Susan M, El Meskini, Rajaa, Landree, Leslie E, Peterson, Jonathan M, Daniels, Khadija, Wong, Kody, Wydysh, Edward A, Townsend, Craig A, Ronnett, Gabriele V

“…Storage of excess calories as triglycerides is central to obesity and its associated disorders. Glycerol-3-phosphate acyltransferases (GPATs) catalyze the…”
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Fatty Acid Metabolism, the Central Nervous System, and Feeding by Ronnett, Gabriele V., Kleman, Amy M., Kim, Eun‐Kyoung, Landree, Leslie E., Tu, Yajun

“…A potential role for fatty acid metabolism in the regulation of energy balance in the brain or in the periphery has been considered only recently. Fatty acid…”
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C75, a Fatty Acid Synthase Inhibitor, Modulates AMP-activated Protein Kinase to Alter Neuronal Energy Metabolism by Landree, Leslie E, Hanlon, Andrea L, Strong, David W, Rumbaugh, Gavin, Miller, Ian M, Thupari, Jagan N, Connolly, Erin C, Huganir, Richard L, Richardson, Christine, Witters, Lee A, Kuhajda, Francis P, Ronnett, Gabriele V

“…C75, a synthetic inhibitor of fatty acid synthase (FAS), is hypothesized to alter the metabolism of neurons in the hypothalamus that regulate feeding behavior…”
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Expression of FAS within hypothalamic neurons: a model for decreased food intake after C75 treatment by Kim, Eun-Kyoung, Miller, Ian, Landree, Leslie E, Borisy-Rudin, Felice F, Brown, Pierre, Tihan, Tarik, Townsend, Craig A, Witters, Lee A, Moran, Timothy H, Kuhajda, Francis P, Ronnett, Gabriele V

“…We previously demonstrated that C75, a specific and potent inhibitor of fatty acid synthase (FAS), reduced food intake and decreased body weight in mice. In…”
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The connections between C75 and obesity drug-target pathways by Kuhajda, Francis P., Landree, Leslie E., Ronnett, Gabriele V.

“…Obesity and its attendant disorders, such as Type II diabetes, have reached epidemic proportions in the USA, and their prevalence is increasing globally. C75…”
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Fatty acid metabolism as a target for obesity treatment by Ronnett, Gabriele V., Kim, Eun-Kyoung, Landree, Leslie E., Tu, Yajun

“…Although metabolites and energy balance have long been known to play roles in the regulation of food intake, the potential role of fatty acid metabolism in…”
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Pharmacological stimulation of brain carnitine palmitoyl-transferase-1 decreases food intake and body weight by Aja, Susan, Landree, Leslie E, Kleman, Amy M, Medghalchi, Susan M, Vadlamudi, Aravinda, McFadden, Jill M, Aplasca, Andrea, Hyun, Jayson, Plummer, Erica, Daniels, Khadija, Kemm, Matthew, Townsend, Craig A, Thupari, Jagan N, Kuhajda, Francis P, Moran, Timothy H, Ronnett, Gabriele V

“…Inhibition of brain carnitine palmitoyl-transferase-1 (CPT-1) is reported to decrease food intake and body weight in rats. Yet, the fatty acid synthase (FAS)…”
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