Search Results - "LANDAY, Alan L"

Impact of aging on immunity in the context of COVID-19, HIV, and tuberculosis by Grifoni, Alba, Alonzi, Tonino, Alter, Galit, Noonan, Douglas McClain, Landay, Alan L, Albini, Adriana, Goletti, Delia

“…Knowledge of aging biology needs to be expanded due to the continuously growing number of elderly people worldwide. Aging induces changes that affect all…”
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Inside Out: HIV, the Gut Microbiome, and the Mucosal Immune System by Liu, Jay, Williams, Brett, Frank, Daniel, Dillon, Stephanie M, Wilson, Cara C, Landay, Alan L

“…The components of the human gut microbiome have been found to influence a broad array of pathologic conditions ranging from heart disease to diabetes and even…”
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Wnt signaling in bone, kidney, intestine, and adipose tissue and interorgan interaction in aging by Chen, Di, Xie, Rong, Shu, Bing, Landay, Alan L., Wei, Changli, Reiser, Jochen, Spagnoli, Anna, Torquati, Alfonso, Forsyth, Christopher B., Keshavarzian, Ali, Sumner, D. Rick

“…Over the last two decades, it has become increasingly apparent that Wnt signaling plays a critical role in development and adult tissue homeostasis in multiple…”
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Regulation of Intestinal Immune Responses through TLR Activation: Implications for Pro- and Prebiotics by de Kivit, Sander, Tobin, Mary C, Forsyth, Christopher B, Keshavarzian, Ali, Landay, Alan L

“…The intestinal mucosa is constantly facing a high load of antigens including bacterial antigens derived from the microbiota and food. Despite this, the immune…”
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Time to Viral Rebound After Interruption of Modern Antiretroviral Therapies by Li, Jonathan Z, Aga, Evgenia, Bosch, Ronald J, Pilkinton, Mark, Kroon, Eugène, MacLaren, Lynsay, Keefer, Michael, Fox, Lawrence, Barr, Liz, Acosta, Edward, Ananworanich, Jintanat, Coombs, Robert, Mellors, John W, Landay, Alan L, Macatangay, Bernard, Deeks, Steven, Gandhi, Rajesh T, Smith, Davey M

“…Abstract Background Development of human immunodeficiency virus (HIV) remission strategies requires precise information on time to HIV rebound after treatment…”
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The Hitchhiker Guide to CD4 + T-Cell Depletion in Lentiviral Infection. A Critical Review of the Dynamics of the CD4 + T Cells in SIV and HIV Infection by Le Hingrat, Quentin, Sereti, Irini, Landay, Alan L, Pandrea, Ivona, Apetrei, Cristian

“…CD4 T-cell depletion is pathognomonic for AIDS in both HIV and simian immunodeficiency virus (SIV) infections. It occurs early, is massive at mucosal sites,…”
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Glycogen Levels in Undiluted Genital Fluid and Their Relationship to Vaginal pH, Estrogen, and Progesterone by Mirmonsef, Paria, Hotton, Anna L, Gilbert, Douglas, Gioia, Casey J, Maric, Danijela, Hope, Thomas J, Landay, Alan L, Spear, Gregory T

“…Colonization of the female lower genital tract with Lactobacillus provides protection against STIs and adverse pregnancy outcomes. Growth of genital…”
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Alterations in circulating immunoregulatory proteins discriminate poor CD4 T lymphocyte trajectories in people with HIV on suppressive antiretroviral therapy by Moar, Preeti, Bowler, Scott, Landay, Alan L, Gianella, Sara, Ndhlovu, Lishomwa C, Premeaux, Thomas A

“…Despite the success in the management of HIV with antiretroviral therapy (ART), people with HIV (PWH) have a heightened state of immune activation and…”
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Serum Immune Activation Markers Are Persistently Increased in Patients with HIV Infection after 6 Years of Antiretroviral Therapy despite Suppression of Viral Replication and Reconstitution of CD4+ T Cells by French, Martyn A., King, Martin S., Tschampa, Jean M., da Silva, Barbara A., Landay, Alan L.

“…The effect of long-term antiretroviral therapy on serum immune activation markers was assessed in a cohort of 63 patients before and after 6 years of boosted…”
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Induction of HIF-1α by HIV-1 Infection in CD4 + T Cells Promotes Viral Replication and Drives Extracellular Vesicle-Mediated Inflammation by Duette, Gabriel, Pereyra Gerber, Pehuen, Rubione, Julia, Perez, Paula S, Landay, Alan L, Crowe, Suzanne M, Liao, Zhaohao, Witwer, Kenneth W, Holgado, María Pía, Salido, Jimena, Geffner, Jorge, Sued, Omar, Palmer, Clovis S, Ostrowski, Matias

“…Chronic immune activation and inflammation are hallmarks of HIV-1 infection and a major cause of serious non-AIDS events in HIV-1-infected individuals on…”
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HIV and comorbidities – the importance of gut inflammation and the kynurenine pathway by MacCann, Rachel, Landay, Alan L., Mallon, Patrick W.G.

“…The purpose of this article is to review alterations in microbiota composition, diversity, and functional features in the context of chronic inflammation and…”
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Combined protein and transcript single-cell RNA sequencing in human peripheral blood mononuclear cells by Vallejo, Jenifer, Saigusa, Ryosuke, Gulati, Rishab, Armstrong Suthahar, Sujit Silas, Suryawanshi, Vasantika, Alimadadi, Ahmad, Durant, Christopher P, Ghosheh, Yanal, Roy, Payel, Ehinger, Erik, Pattarabanjird, Tanyaporn, Hanna, David B, Landay, Alan L, Tracy, Russell P, Lazar, Jason M, Mack, Wendy J, Weber, Kathleen M, Adimora, Adaora A, Hodis, Howard N, Tien, Phyllis C, Ofotokun, Igho, Heath, Sonya L, Shemesh, Avishai, McNamara, Coleen A, Lanier, Lewis L, Hedrick, Catherine C, Kaplan, Robert C, Ley, Klaus

“…Cryopreserved peripheral blood mononuclear cells (PBMCs) are frequently collected and provide disease- and treatment-relevant data in clinical studies. Here,…”
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HIV infection and cardiovascular disease have both shared and distinct monocyte gene expression features: Women's Interagency HIV study by Lin, Juan, Ehinger, Erik, Hanna, David B, Qi, Qibin, Wang, Tao, Ghosheh, Yanal, Mueller, Karin, Anastos, Kathryn, Lazar, Jason M, Mack, Wendy J, Tien, Phyllis C, Berman, Joan W, Cohen, Mardge H, Ofotokun, Igho, Gange, Stephen, Liu, Chenglong, Heath, Sonya L, Tracy, Russell P, Hodis, Howard N, Landay, Alan L, Ley, Klaus, Kaplan, Robert C

“…Persistent inflammation contributes to the development of cardiovascular disease (CVD) as an HIV-associated comorbidity. Innate immune cells such as monocytes…”
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Editorial: Advances in T Cell Therapeutic Vaccines for HIV by Macatangay, Bernard J C, Landay, Alan L, Garcia, Felipe, Rinaldo, Charles R

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Age-associated changes in monocyte and innate immune activation markers occur more rapidly in HIV infected women by Martin, Genevieve E, Gouillou, Maelenn, Hearps, Anna C, Angelovich, Thomas A, Cheng, Allen C, Lynch, Fiona, Cheng, Wan-Jung, Paukovics, Geza, Palmer, Clovis S, Novak, Richard M, Jaworowski, Anthony, Landay, Alan L, Crowe, Suzanne M

“…Aging is associated with immune dysfunction and the related development of conditions with an inflammatory pathogenesis. Some of these immune changes are also…”
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Upregulation of IL-32 Isoforms in Virologically Suppressed HIV-Infected Individuals: Potential Role in Persistent Inflammation and Transcription From Stable HIV-1 Reservoirs by Zaidan, Sarah M, Leyre, Louise, Bunet, Rémi, Larouche-Anctil, Etienne, Turcotte, Isabelle, Sylla, Mohamed, Chamberland, Annie, Chartrand-Lefebvre, Carl, Ancuta, Petronela, Routy, Jean-Pierre, Baril, Jean-Guy, Trottier, Benoit, MacPherson, Paul, Trottier, Sylvie, Harris, Marianne, Walmsley, Sharon, Conway, Brian, Wong, Alexander, Thomas, Réjean, Kaplan, Robert C, Landay, Alan L, Durand, Madeleine, Chomont, Nicolas, Tremblay, Cécile L, El-Far, Mohamed

“…BACKGROUND:Human IL-32 is a polyfunctional cytokine that was initially reported to inhibit HIV-1 infection. However, recent data suggest that IL-32 may enhance…”
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Upregulated IL-32 Expression And Reduced Gut Short Chain Fatty Acid Caproic Acid in People Living With HIV With Subclinical Atherosclerosis by El-Far, Mohamed, Durand, Madeleine, Turcotte, Isabelle, Larouche-Anctil, Etienne, Sylla, Mohamed, Zaidan, Sarah, Chartrand-Lefebvre, Carl, Bunet, Rémi, Ramani, Hardik, Sadouni, Manel, Boldeanu, Irina, Chamberland, Annie, Lesage, Sylvie, Baril, Jean-Guy, Trottier, Benoit, Thomas, Réjean, Gonzalez, Emmanuel, Filali-Mouhim, Ali, Goulet, Jean-Philippe, Martinson, Jeffrey A, Kassaye, Seble, Karim, Roksana, Kizer, Jorge R, French, Audrey L, Gange, Stephen J, Ancuta, Petronela, Routy, Jean-Pierre, Hanna, David B, Kaplan, Robert C, Chomont, Nicolas, Landay, Alan L, Tremblay, Cécile L

“…Despite the success of antiretroviral therapy (ART), people living with HIV (PLWH) are still at higher risk for cardiovascular diseases (CVDs) that are…”
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Multisite Comparison of High-Sensitivity Multiplex Cytokine Assays by Breen, Elizabeth Crabb, Reynolds, Sandra M, Cox, Christopher, Jacobson, Lisa P, Magpantay, Larry, Mulder, Candice B, Dibben, Oliver, Margolick, Joseph B, Bream, Jay H, Sambrano, Elise, Martínez-Maza, Otoniel, Sinclair, Elizabeth, Borrow, Persephone, Landay, Alan L, Rinaldo, Charles R, Norris, Philip J

“…Classifications Services CVI Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit…”
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A low T regulatory cell response may contribute to both viral control and generalized immune activation in HIV controllers by Hunt, Peter W, Landay, Alan L, Sinclair, Elizabeth, Martinson, Jeffrey A, Hatano, Hiroyu, Emu, Brinda, Norris, Philip J, Busch, Michael P, Martin, Jeffrey N, Brooks, Cicely, McCune, Joseph M, Deeks, Steven G

“…HIV-infected individuals maintaining undetectable viremia in the absence of therapy (HIV controllers) often maintain high HIV-specific T cell responses, which…”
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Phospholipid Metabolism Is Associated with Time to HIV Rebound upon Treatment Interruption by Giron, Leila B, Papasavvas, Emmanouil, Yin, Xiangfan, Goldman, Aaron R, Tang, Hsin-Yao, Palmer, Clovis S, Landay, Alan L, Li, Jonathan Z, Koethe, John R, Mounzer, Karam, Kostman, Jay R, Liu, Qin, Montaner, Luis J, Abdel-Mohsen, Mohamed

“…Lipids are biologically active molecules involved in a variety of cellular processes and immunological functions, including inflammation. It was recently shown…”
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