Search Results - "LANDAUER, MICHAEL"

History and development of radiation-protective agents by Weiss, Joseph F., Landauer, Michael R.

“…Purpose: The search for ideal protective agents for use in a variety of radiation scenarios has continued for more than six decades. This review evaluates…”
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Mechanism and therapeutic window of a genistein nanosuspension to protect against hematopoietic-acute radiation syndrome by Landauer, Michael R, Harvey, Adam J, Kaytor, Michael D, Day, Regina M

“…Abstract There are no FDA-approved drugs that can be administered prior to ionizing radiation exposure to prevent hematopoietic–acute radiation syndrome…”
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Delta-tocotrienol suppresses radiation-induced microRNA-30 and protects mice and human CD34+ cells from radiation injury by Li, Xiang Hong, Ha, Cam T, Fu, Dadin, Landauer, Michael R, Ghosh, Sanchita P, Xiao, Mang

“…We reported that microRNA-30c (miR-30c) plays a key role in radiation-induced human cell damage through an apoptotic pathway. Herein we further evaluated…”
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Protection against ionizing radiation by antioxidant nutrients and phytochemicals by Weiss, Joseph F., Landauer, Michael R.

“…The potential of antioxidants to reduce the cellular damage induced by ionizing radiation has been studied in animal models for more than 50 years. The…”
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Genistein Nanoparticles Protect Mouse Hematopoietic System and Prevent Proinflammatory Factors after Gamma Irradiation by Ha, Cam T., Li, Xiang-Hong, Fu, Dadin, Xiao, Mang, Landauer, Michael R.

“…Previous studies demonstrated that genistein protects mice from radiation-induced bone marrow failure. To overcome genistein's extremely low water solubility,…”
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The interaction of dietary isoflavones and estradiol replacement on behavior and brain-derived neurotrophic factor in the ovariectomized rat by Russell, Ashley L., Grimes, Jamie Moran, Larco, Darwin O., Cruthirds, Danette F., Westerfield, Joanna, Wooten, Lawren, Keil, Margaret, Weiser, Michael J., Landauer, Michael R., Handa, Robert J., Wu, T. John

“…•E2 administration resulted in anxiogenic behaviors when dietary isoflavones were present.•E2 administration resulted in anxiolytic and anti-depressive like…”
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Accelerated senescence in skin in a murine model of radiation-induced multi-organ injury by McCart, Elizabeth A, Thangapazham, Rajesh L, Lombardini, Eric D, Mog, Steven R, Panganiban, Ronald Allan M, Dickson, Kelley M, Mansur, Rihab A, Nagy, Vitaly, Kim, Sung-Yop, Selwyn, Reed, Landauer, Michael R, Darling, Thomas N, Day, Regina M

“…Abstract Accidental high-dose radiation exposures can lead to multi-organ injuries, including radiation dermatitis. The types of cellular damage leading to…”
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Genistein Protects Against Biomarkers of Delayed Lung Sequelae in Mice Surviving High-Dose Total Body Irradiation by Day, Regina M, Barshishat-Kupper, Michal, Mog, Steven R, McCart, Elizabeth A, Prasanna, P G S, Davis, Thomas A, Landauer, Michael R

“…The effects of genistein on 30-day survival and delayed lung injury were examined in C57BL/6J female mice. A single subcutaneous injection of vehicle (PEG-400)…”
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Delta-Tocotrienol Protects Mice from Radiation-Induced Gastrointestinal Injury by Li, Xiang Hong, Ghosh, Sanchita P., Ha, Cam T., Fu, Dadin, Elliott, Thomas B., Bolduc, David L., Villa, Vilmar, Whitnall, Mark H., Landauer, Michael R., Xiao, Mang

“…We recently demonstrated that natural delta-tocotrienol (DT3) significantly enhanced survival in total-body irradiated (TBI) mice, and protected mouse bone…”
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Timing of captopril administration determines radiation protection or radiation sensitization in a murine model of total body irradiation by Davis, Thomas A, Landauer, Michael R, Mog, Steven R, Barshishat-Kupper, Michal, Zins, Stephen R, Amare, Mihret F, Day, Regina M

“…Objective Angiotensin II (Ang II), a potent vasoconstrictor, affects the growth and development of hematopoietic cells. Mixed findings have been reported for…”
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Genistein induces radioprotection by hematopoietic stem cell quiescence by Davis, Thomas A., Mungunsukh, Ognoon, Zins, Stephen, Day, Regina M., Landauer, Michael R.

“…Purpose: In this study we addressed whether genistein-induced radioprotection in mice is associated with alterations of the cell cycle of hematopoietic stem…”
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Screening for ADHD-Related Symptoms in Preschoolers Should Be Considered-Results From a Representative Sample of 5-Year-Olds From a German Metropolitan Region by Mechler, Konstantin, Krömer, Thomas, Landauer, Michael, Dittmann, Ralf W, Häge, Alexander

“…Early assessment and intervention are crucial to alleviate symptoms and prevent long-term negative outcomes in children suffering from…”
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Effects of genistein administration on cytokine induction in whole-body gamma irradiated mice by Singh, Vijay K., Grace, Marcy B., Parekh, Vaishali I., Whitnall, Mark H., Landauer, Michael R.

“…The development of an effective pharmacological countermeasure is needed to reduce the morbidity and mortality in military and civilian populations associated…”
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Subcutaneous administration of genistein prior to lethal irradiation supports multilineage, hematopoietic progenitor cell recovery and survival by Davis, Thomas A., Clarke, Tara K., Mog, Steven R., Landauer, Michael R.

“…Purpose: Genistein, a non-toxic isoflavone from soybeans, has immunomodulating and radioprotective properties. In this study we investigated the mechanism for…”
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Captopril modulates hypoxia-inducible factors and erythropoietin responses in a murine model of total body irradiation by Barshishat-Kupper, Michal, Mungunsukh, Ognoon, Tipton, Ashlee J, McCart, Elizabeth A, Panganiban, Ronald A.M, Davis, Thomas A, Landauer, Michael R, Day, Regina M

“…Objective Our laboratory reported that the angiotensin converting enzyme inhibitor captopril improves erythroid recovery from total body irradiation (TBI) in…”
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Antibacterial activity of the soy isoflavone genistein by Hong, Hyunki, Landauer, Michael R., Foriska, Mark A., Ledney, G. David

“…Genistein, a radioprotective soy isoflavone and protein kinase inhibitor, blocks the invasion of pathogenic bacteria in mammalian epithelial cells. The purpose…”
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Genistein treatment protects mice from ionizing radiation injury by Landauer, Michael R., Srinivasan, Venkataraman, Seed, Thomas M.

“…The radioprotective and behavioral effects of an acute administration of the isoflavone genistein (4′,5,7‐trihydroxyflavone) were investigated in adult CD2F1…”
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Protein Oxidation in the Lungs of C57BL/6J Mice Following X-Irradiation by Barshishat-Kupper, Michal, McCart, Elizabeth A, Freedy, James G, Tipton, Ashlee J, Nagy, Vitaly, Kim, Sung-Yop, Landauer, Michael R, Mueller, Gregory P, Day, Regina M

“…Damage to normal lung tissue is a limiting factor when ionizing radiation is used in clinical applications. In addition, radiation pneumonitis and fibrosis are…”
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Evaluation of Hydration and Nutritional Gels as Supportive Care after Total-Body Irradiation in Mice (Mus musculus) by Moccia, Krinon D, Olsen, Cara H, Mitchell, Jennifer M, Landauer, Michael R

“…Concern regarding the potential for radiation exposure from accidents or nuclear and radiologic terrorism is increasing. The purpose of this study was to…”
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Response to Moulder et al., “Re: Davis et al., ‘Timing of captopril administration determines radiation protection or radiation sensitization in a murine model of total body irradiation’” by Davis, Thomas A., Ph.D, Landauer, Michael R., Ph.D, Mog, Steven R., D.V.M, Barshishat-Kupper, Michal, Ph.D, Zins, Stephen R., B.S, Amare, Mihret F., B.S, Day, Regina M., Ph.D

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