Search Results - "LANDAU, Nathaniel R"

Intrinsic host restrictions to HIV-1 and mechanisms of viral escape by Simon, Viviana, Bloch, Nicolin, Landau, Nathaniel R

“…HIV devotes a large portion of its coding capacity to counteracting the function of mammalian antiviral proteins. Landau and colleagues discuss the biology of…”
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Resistance of SARS-CoV-2 Omicron BA.1 and BA.2 Variants to Vaccine-Elicited Sera and Therapeutic Monoclonal Antibodies by Zhou, Hao, Dcosta, Belinda M., Landau, Nathaniel R., Tada, Takuya

“…The recent emergence of the Omicron BA.1 and BA.2 variants with heavily mutated spike proteins has posed a challenge to the effectiveness of current vaccines…”
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SAMHD1 restricts the replication of human immunodeficiency virus type 1 by depleting the intracellular pool of deoxynucleoside triphosphates by Lahouassa, Hichem, Daddacha, Waaqo, Hofmann, Henning, Ayinde, Diana, Logue, Eric C, Dragin, Loïc, Bloch, Nicolin, Maudet, Claire, Bertrand, Matthieu, Gramberg, Thomas, Pancino, Gianfranco, Priet, Stéphane, Canard, Bruno, Laguette, Nadine, Benkirane, Monsef, Transy, Catherine, Landau, Nathaniel R, Kim, Baek, Margottin-Goguet, Florence

“…SAMHD1 restricts the infection of dendritic cells by human immunodeficiency virus type 1. Margottin-Goguet and colleagues show that SAMHD1 limits viral DNA…”
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CCR5 is a receptor for Staphylococcus aureus leukotoxin ED by Alonzo III, Francis, Kozhaya, Lina, Rawlings, Stephen A., Reyes-Robles, Tamara, DuMont, Ashley L., Myszka, David G., Landau, Nathaniel R., Unutmaz, Derya, Torres, Victor J.

“…Pore-forming toxins are critical virulence factors for many bacterial pathogens and are central to Staphylococcus aureus- mediated killing of host cells. S…”
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B cell genomics behind cross-neutralization of SARS-CoV-2 variants and SARS-CoV by Scheid, Johannes F., Barnes, Christopher O., Eraslan, Basak, Hudak, Andrew, Keeffe, Jennifer R., Cosimi, Lisa A., Brown, Eric M., Muecksch, Frauke, Weisblum, Yiska, Zhang, Shuting, Delorey, Toni, Woolley, Ann E., Ghantous, Fadi, Park, Sung-Moo, Phillips, Devan, Tusi, Betsabeh, Huey-Tubman, Kathryn E., Cohen, Alexander A., Gnanapragasam, Priyanthi N.P., Rzasa, Kara, Hatziioanno, Theodora, Durney, Michael A., Gu, Xiebin, Tada, Takuya, Landau, Nathaniel R., West, Anthony P., Rozenblatt-Rosen, Orit, Seaman, Michael S., Baden, Lindsey R., Graham, Daniel B., Deguine, Jacques, Bieniasz, Paul D., Regev, Aviv, Hung, Deborah, Bjorkman, Pamela J., Xavier, Ramnik J.

“…Monoclonal antibodies (mAbs) are a focus in vaccine and therapeutic design to counteract severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and its…”
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Convalescent-Phase Sera and Vaccine-Elicited Antibodies Largely Maintain Neutralizing Titer against Global SARS-CoV-2 Variant Spikes by Tada, Takuya, Dcosta, Belinda M, Samanovic, Marie I, Herati, Ramin S, Cornelius, Amber, Zhou, Hao, Vaill, Ada, Kazmierski, Wes, Mulligan, Mark J, Landau, Nathaniel R

“…The increasing prevalence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants with spike protein mutations raises concerns that antibodies…”
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Human Immunodeficiency Virus Type 1 Modified To Package Simian Immunodeficiency Virus Vpx Efficiently Infects Macrophages and Dendritic Cells by SUNSERI, Nicole, O'BRIEN, Meagan, BHARDWAJ, Nina, LANDAU, Nathaniel R

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Honing the T cell response to HIV: Turning off the noise by Landau, Nathaniel R.

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B.1.526 SARS-CoV-2 Variants Identified in New York City are Neutralized by Vaccine-Elicited and Therapeutic Monoclonal Antibodies by Zhou, Hao, Dcosta, Belinda M, Samanovic, Marie I, Mulligan, Mark J, Landau, Nathaniel R, Tada, Takuya

“…DNA sequence analysis recently identified the novel SARS-CoV-2 variant B.1.526 that is spreading at an alarming rate in the New York City area. Two versions of…”
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Neutralization of SARS-CoV-2 Variants by mRNA and Adenoviral Vector Vaccine-Elicited Antibodies by Tada, Takuya, Zhou, Hao, Samanovic, Marie I, Dcosta, Belinda M, Cornelius, Amber, Herati, Ramin S, Mulligan, Mark J, Landau, Nathaniel R

“…The increasing prevalence of SARS-CoV-2 variants has raised concerns regarding possible decreases in vaccine effectiveness. Here, neutralizing antibody titers…”
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Variable susceptibility of intestinal organoid-derived monolayers to SARS-CoV-2 infection by Jang, Kyung Ku, Kaczmarek, Maria E, Dallari, Simone, Chen, Ying-Han, Tada, Takuya, Axelrad, Jordan, Landau, Nathaniel R, Stapleford, Kenneth A, Cadwell, Ken

“…Gastrointestinal effects associated with Coronavirus Disease 2019 (COVID-19) are highly variable for reasons that are not understood. In this study, we used…”
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The Vpx Lentiviral Accessory Protein Targets SAMHD1 for Degradation in the Nucleus by HOFMANN, Henning, LOGUE, Eric C, BLOCH, Nicolin, DADDACHA, Waaqo, POLSKY, Sylvie B, SCHULTZ, Megan L, KIM, Baek, LANDAU, Nathaniel R

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The ACE2-binding Interface of SARS-CoV-2 Spike Inherently Deflects Immune Recognition by Hattori, Takamitsu, Koide, Akiko, Noval, Maria G., Panchenko, Tatyana, Romero, Larizbeth A., Teng, Kai Wen, Tada, Takuya, Landau, Nathaniel R., Stapleford, Kenneth A., Koide, Shohei

“…[Display omitted] •Epitope analysis with a designed receptor-binding domain (RBD) mutant of Spike.•Patient antibodies dominantly bind regions outside the…”
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HIV-1 Vpr function is mediated by interaction with the damage-specific DNA-binding protein DDB1 by Schröfelbauer, Bärbel, Hakata, Yoshiyuki, Landau, Nathaniel R

“…The Vpr accessory protein of HIV-1 induces a response similar to that of DNA damage. In cells expressing Vpr, the DNA damage sensing kinase, ATR, is activated,…”
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Antibody isotype diversity against SARS-CoV-2 is associated with differential serum neutralization capacities by Noval, Maria G., Kaczmarek, Maria E., Koide, Akiko, Rodriguez-Rodriguez, Bruno A., Louie, Ping, Tada, Takuya, Hattori, Takamitsu, Panchenko, Tatyana, Romero, Larizbeth A., Teng, Kai Wen, Bazley, Andrew, de Vries, Maren, Samanovic, Marie I., Weiser, Jeffrey N., Aifantis, Ioannis, Cangiarella, Joan, Mulligan, Mark J., Desvignes, Ludovic, Dittmann, Meike, Landau, Nathaniel R., Aguero-Rosenfeld, Maria, Koide, Shohei, Stapleford, Kenneth A.

“…Understanding antibody responses to SARS-CoV-2 is indispensable for the development of containment measures to overcome the current COVID-19 pandemic. Recent…”
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Restriction of diverse retroviruses by SAMHD1 by Gramberg, Thomas, Kahle, Tanja, Bloch, Nicolin, Wittmann, Sabine, Müllers, Erik, Daddacha, Waaqo, Hofmann, Henning, Kim, Baek, Lindemann, Dirk, Landau, Nathaniel R

“…SAMHD1 is a triphosphohydrolase that restricts the replication of HIV-1 and SIV in myeloid cells. In macrophages and dendritic cells, SAMHD1 restricts virus…”
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Checkpoint inhibitor-expressing lentiviral vaccine suppresses tumor growth in preclinical cancer models by Tada, Takuya, Norton, Thomas D, Leibowitz, Rebecca, Landau, Nathaniel R

“…BackgroundWhile immunotherapy has been highly successful for the treatment of some cancers, for others, the immune response to tumor antigens is weak leading…”
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Partial resistance of SARS-CoV-2 Delta variants to vaccine-elicited antibodies and convalescent sera by Tada, Takuya, Zhou, Hao, Dcosta, Belinda M., Samanovic, Marie I., Mulligan, Mark J., Landau, Nathaniel R.

“…Highly transmissible SARS-CoV-2 variants identified in India and designated B.1.617, Kappa (B.1.617.1), Delta (B.1.617.2), B.1.618, and B.1.36.29 contain spike…”
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Evidence for an Activation Domain at the Amino Terminus of Simian Immunodeficiency Virus Vpx by GRAMBERG, Thomas, SUNSERI, Nicole, LANDAU, Nathaniel R

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APOBEC3A Is a Potent Inhibitor of Adeno-Associated Virus and Retrotransposons by Chen, Hui, Lilley, Caroline E., Yu, Qin, Lee, Darwin V., Chou, Jody, Narvaiza, Iñigo, Landau, Nathaniel R., Weitzman, Matthew D.

“…APOBEC3 proteins constitute a family of cytidine deaminases that provide intracellular resistance to retrovirus replication and transposition of endogenous…”
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