Search Results - "LAMMI, Mikko J"

Selenium-Related Transcriptional Regulation of Gene Expression by Lammi, Mikko J, Qu, Chengjuan

“…The selenium content of the body is known to control the expression levels of numerous genes, both so-called selenoproteins and non-selenoproteins. Selenium is…”
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Comparison of the major cell populations among osteoarthritis, Kashin–Beck disease and healthy chondrocytes by single-cell RNA-seq analysis by Wang, Xi, Ning, Yujie, Zhang, Pan, Poulet, Blandine, Huang, Ruitian, Gong, Yi, Hu, Minhan, Li, Cheng, Zhou, Rong, Lammi, Mikko J., Guo, Xiong

“…Chondrocytes are the key target cells of the cartilage degeneration that occurs in Kashin–Beck disease (KBD) and osteoarthritis (OA). However, the…”
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Challenges in Fabrication of Tissue-Engineered Cartilage with Correct Cellular Colonization and Extracellular Matrix Assembly by Lammi, Mikko J, Piltti, Juha, Prittinen, Juha, Qu, Chengjuan

“…A correct articular cartilage ultrastructure regarding its structural components and cellularity is important for appropriate performance of tissue-engineered…”
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Editorial: Genetic and environmental roles in bone and joint diseases by Lammi, Mikko J, Wang, Xi, Ning, Yujie

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Regulation of Oxygen Tension as a Strategy to Control Chondrocytic Phenotype for Cartilage Tissue Engineering and Regeneration by Lammi, Mikko J, Qu, Chengjuan

“…Cartilage defects and osteoarthritis are health problems which are major burdens on health care systems globally, especially in aging populations. Cartilage is…”
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Effects of long‐term low oxygen tension in human chondrosarcoma cells by Piltti, Juha, Bygdell, Joakim, Qu, Chengjuan, Lammi, Mikko J.

“…The cell‐based therapies could be potential methods to treat damaged cartilage tissues. Instead of native hyaline cartilage, the current therapies generate…”
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Three-Dimensional Osteogenic Differentiation of Bone Marrow Mesenchymal Stem Cells Promotes Matrix Metallopeptidase 13 (MMP13) Expression in Type I Collagen Hydrogels by Oliveros Anerillas, Luis, Kingham, Paul J, Lammi, Mikko J, Wiberg, Mikael, Kelk, Peyman

“…Autologous bone transplantation is the principal method for reconstruction of large bone defects. This technique has limitations, such as donor site…”
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Alterations in the gut microbiota and metabolite profiles of patients with Kashin-Beck disease, an endemic osteoarthritis in China by Wang, Xi, Ning, Yujie, Li, Cheng, Gong, Yi, Huang, Ruitian, Hu, Minhan, Poulet, Blandine, Xu, Ke, Zhao, Guanghui, Zhou, Rong, Lammi, Mikko J., Guo, Xiong

“…Kashin-Beck disease (KBD) is a severe osteochondral disorder that may be driven by the interaction between genetic and environmental factors. We aimed to…”
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Cellular responses to T-2 toxin and/or deoxynivalenol that induce cartilage damage are not specific to chondrocytes by Lei, Yang, Guanghui, Zhao, Xi, Wang, Yingting, Wang, Xialu, Lin, Fangfang, Yu, Goldring, Mary B., Xiong, Guo, Lammi, Mikko J.

“…The relationship between T-2 toxin and deoxynivalenol (DON) and the risk of Kashin-Beck disease is still controversial since it is poorly known about their…”
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Involvement of Yes-Associated Protein 1 Activation in the Matrix Degradation of Human-Induced-Pluripotent-Stem-Cell-Derived Chondrocytes Induced by T-2 Toxin and Deoxynivalenol Alone and in Combination by Liu, Li, Liu, Huan, Meng, Peilin, Zhang, Yanan, Zhang, Feng'e, Jia, Yumeng, Cheng, Bolun, Lammi, Mikko J, Zhang, Feng, Guo, Xiong

“…T-2 toxin and deoxynivalenol (DON) are two prevalent mycotoxins that cause cartilage damage in Kashin-Beck disease (KBD). Cartilage extracellular matrix (ECM)…”
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Comparative analysis of the gut microbiota composition between knee osteoarthritis and Kashin-Beck disease in Northwest China by Ning, Yujie, Hu, Minhan, Gong, Yi, Huang, Ruitian, Xu, Ke, Chen, Sijie, Zhang, Feiyu, Liu, Yanli, Chen, Feihong, Chang, Yanhai, Zhao, Guanghui, Li, Cheng, Zhou, Rong, Lammi, Mikko J, Guo, Xiong, Wang, Xi

“…Osteoarthritis (OA) and Kashin-Beck disease (KBD) both are two severe osteochondral disorders. In this study, we aimed to compare the gut microbiota structure…”
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ATAC-seq reveals the roles of chromatin accessibility in the chondrocytes of Kashin-Beck disease compared with primary osteoarthritis by Wang, Sen, Wang, Yuanji, Li, Xingyu, Yuan, Linlin, Guo, Xiong, Lammi, Mikko J

“…This study aimed to investigate the roles of accessible chromatin in understanding the different pathogeneses between Kashin-Beck disease (KBD) and primary…”
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Chondrogenic differentiation of human pluripotent stem cells in chondrocyte co-culture by Qu, Chengjuan, Puttonen, Katja A., Lindeberg, Heli, Ruponen, Marika, Hovatta, Outi, Koistinaho, Jari, Lammi, Mikko J.

“…Chondrogenic differentiation of human embryonic (hESCs) or induced pluripotent stem cells (hiPSCs) has been achieved in embryoid bodies (EBs) by adding…”
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Dysregulation of Cells Cycle and Apoptosis in Human Induced Pluripotent Stem Cells Chondrocytes Through p53 Pathway by HT-2 Toxin: An in vitro Study by Zhang, Yanan, Liu, Huan, Lin, Xialu, Zhang, Feng’e, Meng, Peilin, Tan, Sijia, Lammi, Mikko J., Guo, Xiong

“…Kashin–Beck disease (KBD) mainly damages growth plate of adolescents and is susceptible to both gene and gene–environmental risk factors. HT-2 toxin, which is…”
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Effects of Articular Cartilage Constituents on Phosphotungstic Acid Enhanced Micro-Computed Tomography by Karhula, Sakari S, Finnilä, Mikko A, Lammi, Mikko J, Ylärinne, Janne H, Kauppinen, Sami, Rieppo, Lassi, Pritzker, Kenneth P H, Nieminen, Heikki J, Saarakkala, Simo

“…Contrast-enhanced micro-computed tomography (CEμCT) with phosphotungstic acid (PTA) has shown potential for detecting collagen distribution of articular…”
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Rho-kinase inhibitor Y-27632 and hypoxia synergistically enhance chondrocytic phenotype and modify S100 protein profiles in human chondrosarcoma cells by Piltti, Juha, Bygdell, Joakim, Fernández-Echevarría, Cecilia, Marcellino, Daniel, Lammi, Mikko J.

“…Articular chondrocytes are slowly dividing cells that tend to lose their cell type-specific phenotype and ability to produce structurally and functionally…”
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Roles of Glycoproteins in the Diagnosis and Differential Diagnosis of Chronic and Latent Keshan Disease by Wang, Sen, Fan, Zheng, Zhou, Bing, Wang, Yingting, Du, Peiru, Tan, Wuhong, Lammi, Mikko J, Guo, Xiong

“…We aimed to explore the roles of glycoproteins in the pathogenesis of chronic and latent Keshan disease (CKD and LKD), and screen the lectins as indicators of…”
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Stress–relaxation of human patellar articular cartilage in unconfined compression: Prediction of mechanical response by tissue composition and structure by Julkunen, Petro, Wilson, Wouter, Jurvelin, Jukka S, Rieppo, Jarno, Qu, Cheng-Juan, Lammi, Mikko J, Korhonen, Rami K

“…Abstract Mechanical properties of articular cartilage are controlled by tissue composition and structure. Cartilage function is sensitively altered during…”
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Behavior of Human Bone Marrow-Derived Mesenchymal Stem Cells on Various Titanium-Based Coatings by Qu, Chengjuan, Kaitainen, Salla, Kröger, Heikki, Lappalainen, Reijo, Lammi, Mikko J

“…The chemical composition and texture of titanium coatings can influence the growth characteristics of the adhered cells. An enhanced proliferation of the human…”
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Genome-wide gene expression analysis suggests an important role of suppressed immunity in pathogenesis of Kashin-Beck disease by Wang, Shuang, Guo, Xiong, Wu, Xiao-ming, Lammi, Mikko J

“…To investigate the differences between the gene expression profiles in peripheral blood mononuclear cells (PBMC) from normal controls and patients with…”
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