Search Results - "LAMMERTSMA, Adriaan A"

Forward to the Past: The Case for Quantitative PET Imaging by Lammertsma, Adriaan A

“…PET was developed in the 1970s as an in vivo method to measure regional pathophysiologic processes. In the 1990s the focus moved to the detection of local…”
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Effect of Plaque Burden and Morphology on Myocardial Blood Flow and Fractional Flow Reserve by Driessen, Roel S., Stuijfzand, Wijnand J., Raijmakers, Pieter G., Danad, Ibrahim, Min, James K., Leipsic, Jonathon A., Ahmadi, Amir, Narula, Jagat, van de Ven, Peter M., Huisman, Marc C., Lammertsma, Adriaan A., van Rossum, Albert C., van Royen, Niels, Knaapen, Paul

“…Atherosclerotic plaque characteristics may affect downstream myocardial perfusion, as well as coronary lesion severity. This study sought to evaluate the…”
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Rapid Decrease in Delivery of Chemotherapy to Tumors after Anti-VEGF Therapy: Implications for Scheduling of Anti-Angiogenic Drugs by Van der Veldt, Astrid A.M., Lubberink, Mark, Bahce, Idris, Walraven, Maudy, de Boer, Michiel P., Greuter, Henri N.J.M., Hendrikse, N. Harry, Eriksson, Jonas, Windhorst, Albert D., Postmus, Pieter E., Verheul, Henk M., Serné, Erik H., Lammertsma, Adriaan A., Smit, Egbert F.

“…Current strategies combining anti-angiogenic drugs with chemotherapy provide clinical benefit in cancer patients. It is assumed that anti-angiogenic drugs,…”
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Microglia Activation in Recent-Onset Schizophrenia: A Quantitative (R) -[11 C]PK11195 Positron Emission Tomography Study by van Berckel, Bart N, Bossong, Matthijs G, Boellaard, Ronald, Kloet, Reina, Schuitemaker, Alie, Caspers, Esther, Luurtsema, Gert, Windhorst, Albert D, Cahn, Wiepke, Lammertsma, Adriaan A, Kahn, René S

“…Background Schizophrenia is a brain disease involving progressive loss of gray matter of unknown cause. Most likely, this loss reflects neuronal damage, which…”
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Continuous thermodilution to assess absolute flow and microvascular resistance: validation in humans using [15O]H2O positron emission tomography by Everaars, Henk, de Waard, Guus A, Schumacher, Stefan P, Zimmermann, Frederik M, Bom, Michiel J, van de Ven, Peter M, Raijmakers, Pieter G, Lammertsma, Adriaan A, Götte, Marco J, van Rossum, Albert C, Kurata, Akira, Marques, Koen M J, Pijls, Nico H J, van Royen, Niels, Knaapen, Paul

“…Abstract Aims Continuous thermodilution is a novel technique to quantify absolute coronary flow and microvascular resistance (MVR). Notably, intracoronary…”
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Prognostic value of [15O]H2O positron emission tomography-derived global and regional myocardial perfusion by Bom, Michiel J, van Diemen, Pepijn A, Driessen, Roel S, Everaars, Henk, Schumacher, Stefan P, Wijmenga, Jan-Thijs, Raijmakers, Pieter G, van de Ven, Peter M, Lammertsma, Adriaan A, van Rossum, Albert C, Knuuti, Juhani, Danad, Ibrahim, Knaapen, Paul

“…Abstract Aims To evaluate the prognostic value of global and regional quantitative [15O]H2O positron emission tomography (PET) perfusion. Methods and results…”
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Blood-brain barrier P-glycoprotein function in Alzheimer's disease by van Assema, Daniëlle M. E., Lubberink, Mark, Bauer, Martin, van der Flier, Wiesje M., Schuit, Robert C., Windhorst, Albert D., Comans, Emile F. I., Hoetjes, Nikie J., Tolboom, Nelleke, Langer, Oliver, Müller, Markus, Scheltens, Philip, Lammertsma, Adriaan A., van Berckel, Bart N. M.

“…A major pathological hallmark of Alzheimer's disease is accumulation of amyloid-β in senile plaques in the brain. Evidence is accumulating that decreased…”
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Evaluation of strategies towards harmonization of FDG PET/CT studies in multicentre trials: comparison of scanner validation phantoms and data analysis procedures by Makris, Nikolaos E., Huisman, Marc C., Kinahan, Paul E., Lammertsma, Adriaan A., Boellaard, Ronald

“…Purpose PET quantification based on standardized uptake values (SUV) is hampered by several factors, in particular by variability in PET acquisition settings…”
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Automatic generation of absolute myocardial blood flow images using [15O]H2O and a clinical PET/CT scanner by Harms, Hendrik J., Knaapen, Paul, de Haan, Stefan, Halbmeijer, Rick, Lammertsma, Adriaan A., Lubberink, Mark

“…Purpose Parametric imaging of absolute myocardial blood flow (MBF) using [ 15 O]H 2 O enables determination of MBF with high spatial resolution. The aim of…”
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Consensus Nomenclature for in vivo Imaging of Reversibly Binding Radioligands by Innis, Robert B, Cunningham, Vincent J, Delforge, Jacques, Fujita, Masahiro, Gjedde, Albert, Gunn, Roger N, Holden, James, Houle, Sylvain, Huang, Sung-Cheng, Ichise, Masanori, Iida, Hidehiro, Ito, Hiroshi, Kimura, Yuichi, Koeppe, Robert A, Knudsen, Gitte M, Knuuti, Juhani, Lammertsma, Adriaan A, Laruelle, Marc, Logan, Jean, Maguire, Ralph Paul, Mintun, Mark A, Morris, Evan D, Parsey, Ramin, Price, Julie C, Slifstein, Mark, Sossi, Vesna, Suhara, Tetsuya, Votaw, John R, Wong, Dean F, Carson, Richard E

“…An international group of experts in pharmacokinetic modeling recommends a consensus nomenclature to describe in vivo molecular imaging of reversibly binding…”
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The P2X7 receptor tracer [11C]SMW139 as an in vivo marker of neuroinflammation in multiple sclerosis: a first-in man study by Hagens, Marloes H. J., Golla, Sandeep S. V., Janssen, Bieneke, Vugts, Danielle J., Beaino, Wissam, Windhorst, Albert D., O’Brien-Brown, James, Kassiou, Michael, Schuit, Robert C., Schwarte, Lothar A., de Vries, Helga E., Killestein, Joep, Barkhof, Frederik, van Berckel, Bart N. M., Lammertsma, Adriaan A.

“…Purpose The novel PET tracer [ 11 C]SMW139 binds with high affinity to the P2X 7 receptor, which is expressed on pro-inflammatory microglia. The purposes of…”
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Parametric imaging of dual-time window [18F]flutemetamol and [18F]florbetaben studies by Heeman, Fiona, Yaqub, Maqsood, Hendriks, Janine, Bader, Ilona, Barkhof, Frederik, Gispert, Juan Domingo, van Berckel, Bart N.M., Lopes Alves, Isadora, Lammertsma, Adriaan A.

“…Optimal pharmacokinetic models for quantifying amyloid beta (Aβ) burden using both [18F]flutemetamol and [18F]florbetaben scans have previously been identified…”
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First in man study of [18F]fluoro-PEG-folate PET: a novel macrophage imaging technique to visualize rheumatoid arthritis by Verweij, Nicki J. F., Yaqub, Maqsood, Bruijnen, Stefan T. G., Pieplenbosch, S., ter Wee, Marieke M., Jansen, Gerrit, Chen, Qingshou, Low, Philip S., Windhorst, Albert D., Lammertsma, Adriaan A., Hoekstra, Otto S., Voskuyl, Alexandre E., van der Laken, Conny J.

“…Non-invasive imaging of arthritis activity in rheumatoid arthritis (RA) patients using macrophage PET holds promise for early diagnosis and therapeutic…”
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Quantification of [18F]DPA-714 Binding in the Human Brain: Initial Studies in Healthy Controls and Alzheimer'S Disease Patients by Golla, Sandeep SV, Boellaard, Ronald, Oikonen, Vesa, Hoffmann, Anja, van Berckel, Bart NM, Windhorst, Albert D, Virta, Jere, Haaparanta-Solin, Merja, Luoto, Pauliina, Savisto, Nina, Solin, Olof, Valencia, Ray, Thiele, Andrea, Eriksson, Jonas, Schuit, Robert C, Lammertsma, Adriaan A, Rinne, Juha O

“…Fluorine-18 labelled N,N-diethyl-2-(2-[4-(2-fluoroethoxy)phenyl]-5,7-dimethylpyrazolo[1,5-α]pyrimidine-3-yl)acetamide ([18F] DPA-714) binds to the 18-kDa…”
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Evaluation of a cumulative SUV-volume histogram method for parameterizing heterogeneous intratumoural FDG uptake in non-small cell lung cancer PET studies by van Velden, Floris H. P., Cheebsumon, Patsuree, Yaqub, Maqsood, Smit, Egbert F., Hoekstra, Otto S., Lammertsma, Adriaan A., Boellaard, Ronald

“…Purpose Standardized uptake values (SUV) are commonly used for quantification of whole-body [ 18 F]fluoro-2-deoxy- D -glucose (FDG) positron emission…”
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Imaging of neuroinflammation in Alzheimer's disease, multiple sclerosis and stroke: Recent developments in positron emission tomography by Janssen, Bieneke, Vugts, Danielle J., Funke, Uta, Molenaar, Ger T., Kruijer, Perry S., van Berckel, Bart N.M., Lammertsma, Adriaan A., Windhorst, Albert D.

“…Neuroinflammation is thought to play a pivotal role in many diseases affecting the brain, including Alzheimer's disease, multiple sclerosis and stroke…”
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Optimization of Supervised Cluster Analysis for Extracting Reference Tissue Input Curves in (R)-[11C]PK11195 Brain PET Studies by Yaqub, Maqsood, van Berckel, Bart NM, Schuitemaker, Alie, Hinz, Rainer, Turkheimer, Federico E, Tomasi, Giampaolo, Lammertsma, Adriaan A, Boellaard, Ronald

“…Performance of two supervised cluster analysis (SVCA) algorithms for extracting reference tissue curves was evaluated to improve quantification of dynamic…”
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Δ9-Tetrahydrocannabinol Induces Dopamine Release in the Human Striatum by Bossong, Matthijs G, van Berckel, Bart NM, Boellaard, Ronald, Zuurman, Lineke, Schuit, Robert C, Windhorst, Albert D, van Gerven, Joop M A, Ramsey, Nick F, Lammertsma, Adriaan A, Kahn, René S

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Microglial activation in Alzheimer's disease: an ( R )-[11 C]PK11195 positron emission tomography study by Schuitemaker, Alie, Kropholler, Marc A, Boellaard, Ronald, van der Flier, Wiesje M, Kloet, Reina W, van der Doef, Thalia F, Knol, Dirk L, Windhorst, Albert D, Luurtsema, Gert, Barkhof, Frederik, Jonker, Cees, Lammertsma, Adriaan A, Scheltens, Philip, van Berckel, Bart N.M

“…Abstract Inflammatory mechanisms, like microglial activation, could be involved in the pathogenesis of Alzheimer's disease (AD). ( R )-[11 C]PK11195…”
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Investigation of image-derived input functions for non-invasive quantification of myelin density using [11C]MeDAS PET by van der Weijden, Chris W.J., van der Hoorn, Anouk, Wang, Yanming, Willemsen, Antoon T.M., Dierckx, Rudi A.J.O., Lammertsma, Adriaan A., de Vries, Erik F.J.

“…Multiple sclerosis (MS) is an inflammatory demyelinating disease. Current treatments are focussed on immune suppression to modulate pathogenic activity that…”
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