Search Results - "LAMB, G. D"

Skeletal Muscle Fatigue: Cellular Mechanisms by Allen, D. G, Lamb, G. D, Westerblad, H

“…School of Medical Sciences and Bosch Institute, University of Sydney, Sydney, New South Wales, and Department of Zoology, La Trobe University, Melbourne,…”
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Impaired calcium release during fatigue by Allen, D. G, Lamb, G. D, Westerblad, H

“…1 School of Medical Sciences and Bosch Institute, University of Sydney; 2 Department of Zoology, La Trobe University, Melbourne, Victoria, Australia; and 3…”
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Ca2+‐dependent proteolysis of junctophilin‐1 and junctophilin‐2 in skeletal and cardiac muscle by Murphy, R. M., Dutka, T. L., Horvath, D., Bell, J. R., Delbridge, L. M., Lamb, G. D.

“…Key points If skeletal muscle fibres are subjected to excessive activation, or stretched whilst contracting, they subsequently display long‐term reductions in…”
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In Situ Study of Model Organic Friction Modifiers Using Liquid Cell AFM; Saturated and Mono-unsaturated Carboxylic Acids by Campen, S., Green, J. H., Lamb, G. D., Spikes, H. A.

“…Fatty acids and their derivatives have been used as model organic friction modifiers for almost a century, but there is still debate as to the nature of the…”
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Effects of carnosine on contractile apparatus Ca²⁺ sensitivity and sarcoplasmic reticulum Ca²⁺ release in human skeletal muscle fibers by Dutka, T L, Lamboley, C R, McKenna, M J, Murphy, R M, Lamb, G D

“…There is considerable interest in potential ergogenic and therapeutic effects of increasing skeletal muscle carnosine content, although its effects on…”
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Acute effects of taurine on sarcoplasmic reticulum Ca2+ accumulation and contractility in human type I and type II skeletal muscle fibers by Dutka, T L, Lamboley, C R, Murphy, R M, Lamb, G D

“…Taurine occurs in high concentrations in muscle and is implicated in numerous physiological processes, yet its effects on many aspects of contractility remain…”
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Ca2+ leakage out of the sarcoplasmic reticulum is increased in type I skeletal muscle fibres in aged humans by Lamboley, C. R., Wyckelsma, V. L., McKenna, M. J., Murphy, R. M., Lamb, G. D.

“…Key points The amount of Ca2+ stored in the sarcoplasmic reticulum (SR) of muscle fibres is decreased in aged individuals, and an important question is whether…”
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Differential effects of peroxynitrite on contractile protein properties in fast- and slow-twitch skeletal muscle fibers of rat by DUTKA, T. L, MOLLICA, J. P, LAMB, G. D

“…Oxidative modification of contractile proteins is thought to be a key factor in muscle weakness observed in many pathophysiological conditions. In particular,…”
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Hydroxyl radical and glutathione interactions alter calcium sensitivity and maximum force of the contractile apparatus in rat skeletal muscle fibres by Murphy, R. M., Dutka, T. L., Lamb, G. D.

“…Studies on intact muscle fibres indicate that reactive oxygen species (ROS) produced during muscle activity, or applied exogenously, can cause decreased force…”
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Effect of 23-day muscle disuse on sarcoplasmic reticulum Ca2+ properties and contractility in human type I and type II skeletal muscle fibers by Lamboley, C R, Wyckelsma, V L, Perry, B D, McKenna, M J, Lamb, G D

“…Inactivity negatively impacts on skeletal muscle function mainly through muscle atrophy. However, recent evidence suggests that the quality of individual…”
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Na+-K+ pumps in the transverse tubular system of skeletal muscle fibers preferentially use ATP from glycolysis by Dutka, T L, Lamb, G D

“…The Na(+)-K(+) pumps in the transverse tubular (T) system of a muscle fiber play a vital role keeping K(+) concentration in the T-system sufficiently low…”
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Effects of oxidation and reduction on contractile function in skeletal muscle fibres of the rat by Lamb, G. D., Posterino, G. S.

“…This study investigated the effects of the oxidants hydrogen peroxide (H 2 O 2 ) and 2,2′-dithiodipyridine (DTDP), and reductants, glutathione (GSH) and…”
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Calcium phosphate precipitation in the sarcoplasmic reticulum reduces action potential-mediated Ca2+ release in mammalian skeletal muscle by Dutka, T L, Cole, L, Lamb, G D

“…During vigorous exercise, Pi concentration levels within the cytoplasm of fast-twitch muscle fibers may reach > or =30 mM. Cytoplasmic Pi may enter the…”
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Reply from T. L. Dutka, J. P. Mollica, G. S. Posterino and G. D. Lamb by Dutka, T. L., Mollica, J. P., Posterino, G. S., Lamb, G. D.

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Effects of oxidation and cytosolic redox conditions on excitation-contraction coupling in rat skeletal muscle by Posterino, G S, Cellini, M A, Lamb, G D

“…In this study the effects of oxidation and reduction on various steps in the excitation-contraction (E-C) coupling sequence was examined in mammalian skeletal…”
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Different Ca2+ releasing action of caffeine and depolarisation in skeletal muscle fibres of the rat by Lamb, G. D., Cellini, M. A., Stephenson, D. G.

“…The relative abilities of caffeine and transverse tubular (T-) system depolarisation to induce Ca 2+ release in mammalian skeletal muscle were compared in…”
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Effect of sarcoplasmic reticulum Ca2+ content on action potential-induced Ca2+ release in rat skeletal muscle fibres by Posterino, G S, Lamb, G D

“…This study examined the relationship between the level of Ca 2+ loading in the sarcoplasmic reticulum (SR) and the amount of Ca 2+ released by an action…”
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Transverse tubular system depolarization reduces tetanic force in rat skeletal muscle fibers by impairing action potential repriming by Dutka, T L, Lamb, G D

“…When muscle fibers are repeatedly stimulated, they may become depolarized and force output decline. Excitation of the transverse tubular system (T-system) is…”
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Twitch and tetanic force responses and longitudinal propagation of action potentials in skinned skeletal muscle fibres of the rat by Posterino, G. S., Lamb, G. D., Stephenson, D. G.

“…Transverse electrical field stimulation (50 V cm −1 , 2 ms duration) of mechanically skinned skeletal muscle fibres of the rat elicited twitch and tetanic…”
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Excitability of the T-tubular system in rat skeletal muscle: roles of K+ and Na+ gradients and Na+–K+ pump activity by Nielsen, O. B., Ørtenblad, N., Lamb, G. D., Stephenson, D. G.

“…Strenuous exercise causes an increase in extracellular [K + ] and intracellular Na + ([Na + ] i ) of working muscles, which may reduce sarcolemma excitability…”
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