Search Results - "LAMB, David C"

Unusual properties of the cytochrome P450 superfamily by Lamb, David C., Waterman, Michael R.

“…During the early years of cytochrome P450 research, a picture of conserved properties arose from studies of mammalian forms of these monooxygenases. They…”
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Structure-Function Analysis of the Essential Mycobacterium tuberculosis P450 Drug Target, CYP121A1 by Padayachee, Tiara, Lamb, David C, Nelson, David R, Syed, Khajamohiddin

“…Cytochrome P450 CYP121A1 is a well-known drug target against , the human pathogen that causes the deadly disease tuberculosis (TB). CYP121A1 is a unique P450…”
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On the occurrence of cytochrome P450 in viruses by Lamb, David C., Follmer, Alec H., Goldstone, Jared V., Nelson, David R., Warrilow, Andrew G., Price, Claire L., True, Marie Y., Kelly, Steven L., Poulos, Thomas L., Stegeman, John J.

“…Genes encoding cytochrome P450 (CYP; P450) enzymes occur widely in the Archaea, Bacteria, and Eukarya, where they play important roles in metabolism of…”
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Vertebrate endocrine disruptors induce sex-reversal in blue mussels by Evensen, K. Garrett, Rusin, Emily, Robinson, William E., Price, Claire L., Kelly, Steven L., Lamb, David C., Goldstone, Jared V., Poynton, Helen C.

“…Mollusks are the second most diverse animal phylum, yet little is known about their endocrinology or how they respond to endocrine disrupting compound (EDC)…”
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Unravelling the role of transient redox partner complexes in P450 electron transfer mechanics by Hargrove, Tatiana Y., Lamb, David C., Smith, Jarrod A., Wawrzak, Zdzislaw, Kelly, Steven L., Lepesheva, Galina I.

“…The molecular evolution of cytochromes P450 and associated redox-driven oxidative catalysis remains a mystery in biology. It is widely believed that sterol…”
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Structure-Function Analysis of the Biotechnologically Important Cytochrome P450 107 (CYP107) Enzyme Family by Padayachee, Tiara, Lamb, David C, Nelson, David R, Syed, Khajamohiddin

“…Cytochrome P450 monooxygenases (CYPs; P450s) are a superfamily of heme-containing enzymes that are recognized for their vast substrate range and oxidative…”
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Orphan cytochrome P450 20a1 CRISPR/Cas9 mutants and neurobehavioral phenotypes in zebrafish by Brun, Nadja R., Salanga, Matthew C., Mora-Zamorano, Francisco X., Lamb, David C., Goldstone, Jared V., Stegeman, John J.

“…Orphan cytochrome P450 (CYP) enzymes are those for which biological substrates and function(s) are unknown. Cytochrome P450 20A1 (CYP20A1) is the last human…”
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Metabolic arsenal of giant viruses: Host hijack or self-use? by Brahim Belhaouari, Djamal, Pires De Souza, Gabriel Augusto, Lamb, David C, Kelly, Steven L, Goldstone, Jared V, Stegeman, John J, Colson, Philippe, La Scola, Bernard, Aherfi, Sarah

“…Viruses generally are defined as lacking the fundamental properties of living organisms in that they do not harbor an energy metabolism system or protein…”
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Cytochrome P450 20A1 in zebrafish: Cloning, regulation and potential involvement in hyperactivity disorders by Lemaire, Benjamin, Kubota, Akira, O'Meara, Conor M., Lamb, David C., Tanguay, Robert L., Goldstone, Jared V., Stegeman, John J.

“…Cytochrome P450 (CYP) enzymes for which there is no functional information are considered “orphan” CYPs. Previous studies showed that CYP20A1, an orphan, is…”
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Azole Binding Properties of Candida albicans Sterol 14-α Demethylase (CaCYP51) by WARRILOW, Andrew G. S, MARTEL, Claire M, PARKER, Josie E, MELO, Nadja, LAMB, David C, NES, W. David, KELLY, Diane E, KELLY, Steven L

“…Classifications Services AAC Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit…”
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Crystal Structure of Albaflavenone Monooxygenase Containing a Moonlighting Terpene Synthase Active Site by Zhao, Bin, Lei, Li, Vassylyev, Dmitry G., Lin, Xin, Cane, David E., Kelly, Steven L., Yuan, Hang, Lamb, David C., Waterman, Michael R.

“…Albaflavenone synthase (CYP170A1) is a monooxygenase catalyzing the final two steps in the biosynthesis of this antibiotic in the soil bacterium, Streptomyces…”
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The First Virally Encoded Cytochrome P450 by LAMB, David C, LI LEI, WARRILOW, Andrew G. S, LEPESHEVA, Galina I, MULLINS, Jonathan G. L, WATERMAN, Michael R, KELLY, Steven L

“…Article Usage Stats Services JVI Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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Characterization of a Virally Encoded Flavodoxin That Can Drive Bacterial Cytochrome P450 Monooxygenase Activity by Lamb, David C, Goldstone, Jared V, Zhao, Bin, Lei, Li, Mullins, Jonathan G L, Allen, Michael J, Kelly, Steven L, Stegeman, John J

“…Flavodoxins are small electron transport proteins that are involved in a myriad of photosynthetic and non-photosynthetic metabolic pathways in Bacteria…”
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Investigating conservation of the albaflavenone biosynthetic pathway and CYP170 bifunctionality in streptomycetes by Moody, Suzy C., Zhao, Bin, Lei, Li, Nelson, David R., Mullins, Jonathan G. L., Waterman, Michael R., Kelly, Steven L., Lamb, David C.

“…Albaflavenone, a tricyclic sesquiterpene antibiotic, is biosynthesized in Streptomyces coelicolor A3(2) by enzymes encoded in a two‐gene operon. Initially,…”
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Cyclization of a Cellular Dipentaenone by Streptomyces coelicolor Cytochrome P450 154A1 without Oxidation/Reduction by Cheng, Qian, Lamb, David C, Kelly, Steven L, Lei, Li, Guengerich, F. Peter

“…We report a comprehensive genetic, metabolomic, and biochemical study on the catalytic properties of Streptomyces coelicolor cytochrome P450 (P450) 154A1,…”
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Structural analysis of cytochrome P450 105N1 involved in the biosynthesis of the zincophore, coelibactin by Zhao, Bin, Moody, Suzy C, Hider, Robert C, Lei, Li, Kelly, Steven L, Waterman, Michael R, Lamb, David C

“…Coelibactin is a putative non-ribosomally synthesized peptide with predicted zincophore activity and which has been implicated in antibiotic regulation in…”
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Binding of Two Flaviolin Substrate Molecules, Oxidative Coupling, and Crystal Structure of Streptomyces coelicolor A3(2) Cytochrome P450 158A2 by Zhao, Bin, Guengerich, F. Peter, Bellamine, Aouatef, Lamb, David C., Izumikawa, Miho, Lei, Li, Podust, Larissa M., Sundaramoorthy, Munirathinam, Kalaitzis, John A., Reddy, L. Manmohan, Kelly, Steven L., Moore, Bradley S., Stec, Donald, Voehler, Markus, Falck, John R., Shimada, Tsutomu, Waterman, Michael R.

“…Cytochrome P450 158A2 (CYP158A2) is encoded within a three-gene operon (sco1206-sco1208) in the prototypic soil bacterium Streptomyces coelicolor A3(2). This…”
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S279 Point Mutations in Candida albicans Sterol 14-α Demethylase (CYP51) Reduce In Vitro Inhibition by Fluconazole by WARRILOW, Andrew G. S, MULLINS, Jonathan G. L, HULL, Claire M, PARKER, Josie E, LAMB, David C, KELLY, Diane E, KELLY, Steven L

“…Classifications Services AAC Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit…”
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Structure-Functional Characterization of Cytochrome P450 Sterol 14α-Demethylase (CYP51B) from Aspergillus fumigatus and Molecular Basis for the Development of Antifungal Drugs by Hargrove, Tatiana Y., Wawrzak, Zdzislaw, Lamb, David C., Guengerich, F. Peter, Lepesheva, Galina I.

“…Aspergillus fumigatus is the opportunistic fungal pathogen that predominantly affects the immunocompromised population and causes 600,000 deaths/year. The…”
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Biosynthesis of the Sesquiterpene Antibiotic Albaflavenone in Streptomyces coelicolor A3(2) by Zhao, Bin, Lin, Xin, Lei, Li, Lamb, David C., Kelly, Steven L., Waterman, Michael R., Cane, David E.

“…Cytochrome P450 170A1 (CYP170A1) is encoded by the sco5223 gene of the Gram-positive, soil-dwelling bacterium Streptomyces coelicolor A3(2) as part of a…”
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