Search Results - "LAMANNA, Joseph C"

Mitochondrial abnormalities in a streptozotocin-induced rat model of sporadic Alzheimer's disease by Correia, Sónia C, Santos, Renato X, Santos, Maria S, Casadesus, Gemma, Lamanna, Joseph C, Perry, George, Smith, Mark A, Moreira, Paula I

“…This study aimed to show that the rat model of sporadic Alzheimer's disease (sAD) generated by the intracerebroventricular (icv) injection of a…”
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Increased cerebral vascularization and decreased water exchange across the blood-brain barrier in aquaporin-4 knockout mice by Zhang, Yifan, Xu, Kui, Liu, Yuchi, Erokwu, Bernadette O, Zhao, Pan, Flask, Chris A, Ramos-Estebanez, Ciro, Farr, George W, LaManna, Joseph C, Boron, Walter F, Yu, Xin

“…Aquaporin-4 (AQP4) plays an important role in regulating water exchange across the blood-brain barrier (BBB) and brain-cerebrospinal fluid interface. Studies…”
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Functionalized Phenylbenzamides Inhibit Aquaporin-4 Reducing Cerebral Edema and Improving Outcome in Two Models of CNS Injury by Farr, George W., Hall, Christopher H., Farr, Susan M., Wade, Ramon, Detzel, Joshua M., Adams, Amielia G., Buch, Jasen M., Beahm, Derek L., Flask, Christopher A., Xu, Kui, LaManna, Joseph C., McGuirk, Paul R., Boron, Walter F., Pelletier, Marc F.

“…Cerebral edema in ischemic stroke can lead to increased intracranial pressure, reduced cerebral blood flow and neuronal death. Unfortunately, current therapies…”
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Neuroprotection in diet-induced ketotic rat brain after focal ischemia by Puchowicz, Michelle A, Zechel, Jennifer L, Valerio, Jose, Emancipator, Douglas S, Xu, Kui, Pundik, Svetlana, LaManna, Joseph C, Lust, W David

“…Neuroprotective properties of ketosis may be related to the upregulation of hypoxia inducible factor (HIF)-1α, a primary constituent associated with hypoxic…”
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Angioplasticity and cerebrovascular remodeling by Lamanna, Joseph C

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Chronic hypoxia and the cerebral circulation by Xu, Kui, LaManna, Joseph C

“…Department of Anatomy, Case Western Reserve University School of Medicine, Cleveland, Ohio Exposure to mild hypoxia elicits a characteristic cerebrovascular…”
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Increased vasopressin transmission from the paraventricular nucleus to the rostral medulla augments cardiorespiratory outflow in chronic intermittent hypoxia-conditioned rats by Kc, Prabha, Balan, Kannan V., Tjoe, Steven S., Martin, Richard J., LaManna, Joseph C., Haxhiu, Musa A., Dick, Thomas E.

“…A co-morbidity of sleep apnoea is hypertension associated with elevated sympathetic nerve activity (SNA) which may result from conditioning to chronic…”
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Optical Methods for the Study of Brain Metabolism In Situ by LaManna, Joseph C

“…From its inception, the International Society of Oxygen Transport to Tissue (ISOTT) included several core members who were intrigued by the possibility of…”
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Hypoxia-inducible factor-1 (HIF-1)-independent microvascular angiogenesis in the aged rat brain by Ndubuizu, Obinna I, Tsipis, Constantinos P, Li, Ang, LaManna, Joseph C

“…Abstract Angiogenesis is a critical component of mammalian brain adaptation to prolonged hypoxia. Hypoxia-induced angiogenesis is mediated by hypoxia-inducible…”
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Hypoxic Regulation of Angiopoietin-2 Expression in Endothelial Cells by Pichiule, Paola, Chavez, Juan C., LaManna, Joseph C.

“…Exposure of endothelial cells to hypoxia-induced angiopoietin-2 (Ang2) expression. The increase in Ang2 mRNA levels occurred by transcriptional regulation and…”
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Structural and functional adaptation to hypoxia in the rat brain by LaManna, Joseph C, Chavez, Juan Carlos, Pichiule, Paola

“…Chronic exposure to a hypoxic environment leads to structural and functional adaptations in the rat brain. One significant adaptation is a decrease in…”
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Activation of Hypoxia-Inducible Factor-1 in the Rat Cerebral Cortex after Transient Global Ischemia: Potential Role of Insulin-Like Growth Factor-1 by Chavez, Juan C, LaManna, Joseph C

“…Hypoxia-inducible factor-1 (HIF-1) is a transcription factor that regulates the adaptive response to hypoxia in mammalian cells. It consists of a regulatory…”
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Kidney EPO expression during chronic hypoxia in aged mice by Benderro, Girriso F, LaManna, Joseph C

“…In order to maintain normal cellular function, mammalian tissue oxygen concentrations must be tightly regulated within a narrow physiological range. The…”
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Effect of chronic continuous or intermittent hypoxia and reoxygenation on cerebral capillary density and myelination by Kanaan, Amjad, Farahani, Reza, Douglas, Robert M, Lamanna, Joseph C, Haddad, Gabriel G

“…Chronic hypoxia, whether continuous (CCH) or intermittent (CIH), occurs in many neonatal pathological conditions, such as bronchopulmonary dysplasia and…”
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Angiopoietin-2 and rat brain capillary remodeling during adaptation and deadaptation to prolonged mild hypoxia by Pichiule, Paola, LaManna, Joseph C

“…Departments of Anatomy and Neurology, Case Western Reserve University, School of Medicine, Cleveland, Ohio 44106 Angiogenesis is a crucial component of rat…”
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Diet-induced ketosis increases capillary density without altered blood flow in rat brain by Puchowicz, Michelle A, Xu, Kui, Sun, Xiaoyan, Ivy, Andre, Emancipator, Doug, LaManna, Joseph C

“…It is recognized that ketone bodies, such as R-beta-hydroxybutyrate (beta-HB) and acetoacetate, are energy sources for the brain. As with glucose metabolism,…”
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Absence of cellular stress in brain after hypoxia induced by arousal from hibernation in Arctic ground squirrels by Ma, Yi Long, Zhu, Xiongwei, Rivera, Patricia M, Tøien, Øivind, Barnes, Brian M, LaManna, Joseph C, Smith, Mark A, Drew, Kelly L

“…Although hypoxia tolerance in heterothermic mammals is well established, it is unclear whether the adaptive significance stems from hypoxia or other cellular…”
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Environmental Enrichment Improved Cognitive Performance in Mice under Normoxia and Hypoxia by Bindra, Sahej, LaManna, Joseph C, Xu, Kui

“…The mammalian brain modulates its microvascular network to accommodate tissue energy demand in a process referred to as angioplasticity. There is an aging…”
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Defining the role of HIF and its downstream mediators in hypoxic-induced cerebral angiogenesis by Sun, Xiaoyan, Tsipis, Constantinos P, Benderro, Girriso F, Xu, Kui, Lamanna, Joseph C

“…Now that some of the basic mechanisms that underlie hypoxia-induced cerebral angiogenesis have been described, it has become clear that the hypoxia-inducible…”
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O2 regulates stem cells through Wnt/β-catenin signalling by Mazumdar, Jolly, O'Brien, W. Timothy, Johnson, Randall S., LaManna, Joseph C., Chavez, Juan C., Klein, Peter S., Simon, M. Celeste

“…Low oxygen levels are observed in the niche of some stem cells. The hypoxic transcription factor HIF-1 directly regulates Wnt signalling to ensure stem cells…”
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