Search Results - "LAM, M. M"

Population genomics of Klebsiella pneumoniae by Wyres, Kelly L., Lam, Margaret M. C., Holt, Kathryn E.

“…Klebsiella pneumoniae is a common cause of antimicrobial-resistant opportunistic infections in hospitalized patients. The species is naturally resistant to…”
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Optimizing Pulsar Timing Array Observational Cadences for Sensitivity to Low-frequency Gravitational-wave Sources by Lam, M. T.

“…Observations of low-frequency gravitational waves (GWs) will require the highest possible timing precision from an array of the most spin-stable pulsars. We…”
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A genomic surveillance framework and genotyping tool for Klebsiella pneumoniae and its related species complex by Lam, Margaret M. C., Wick, Ryan R., Watts, Stephen C., Cerdeira, Louise T., Wyres, Kelly L., Holt, Kathryn E.

“…Klebsiella pneumoniae is a leading cause of antimicrobial-resistant (AMR) healthcare-associated infections, neonatal sepsis and community-acquired liver…”
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Distinct evolutionary dynamics of horizontal gene transfer in drug resistant and virulent clones of Klebsiella pneumoniae by Wyres, Kelly L, Wick, Ryan R, Judd, Louise M, Froumine, Roni, Tokolyi, Alex, Gorrie, Claire L, Lam, Margaret M C, Duchêne, Sebastián, Jenney, Adam, Holt, Kathryn E

“…Klebsiella pneumoniae has emerged as an important cause of two distinct public health threats: multi-drug resistant (MDR) healthcare-associated infections and…”
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Activation mechanism of the calcium-activated chloride channel TMEM16A revealed by cryo-EM by Paulino, Cristina, Kalienkova, Valeria, Lam, Andy K. M., Neldner, Yvonne, Dutzler, Raimund

“…Cryo-electron microscopy mapping of the calcium-activated chloride channel TMEM16A combined with functional experiments reveals that calcium ions interact…”
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SIRT3 Deficiency and Mitochondrial Protein Hyperacetylation Accelerate the Development of the Metabolic Syndrome by Hirschey, Matthew D., Shimazu, Tadahiro, Jing, Enxuan, Grueter, Carrie A., Collins, Amy M., Aouizerat, Bradley, Stančáková, Alena, Goetzman, Eric, Lam, Maggie M., Schwer, Bjoern, Stevens, Robert D., Muehlbauer, Michael J., Kakar, Sanjay, Bass, Nathan M., Kuusisto, Johanna, Laakso, Markku, Alt, Frederick W., Newgard, Christopher B., Farese, Robert V., Kahn, C. Ronald, Verdin, Eric

“…Acetylation is increasingly recognized as an important metabolic regulatory posttranslational protein modification, yet the metabolic consequence of…”
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The Form and Function of PIEZO2 by Szczot, Marcin, Nickolls, Alec R, Lam, Ruby M, Chesler, Alexander T

“…Mechanosensation is the ability to detect dynamic mechanical stimuli (e.g., pressure, stretch, and shear stress) and is essential for a wide variety of…”
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Tracking key virulence loci encoding aerobactin and salmochelin siderophore synthesis in Klebsiella pneumoniae by Lam, Margaret M C, Wyres, Kelly L, Judd, Louise M, Wick, Ryan R, Jenney, Adam, Brisse, Sylvain, Holt, Kathryn E

“…Klebsiella pneumoniae is a recognised agent of multidrug-resistant (MDR) healthcare-associated infections; however, individual strains vary in their virulence…”
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Energization of the Ring Current by Substorms by Sandhu, J. K., Rae, I. J., Freeman, M. P., Forsyth, C., Gkioulidou, M., Reeves, G. D., Spence, H. E., Jackman, C. M., Lam, M. M.

“…The substorm process releases large amounts of energy into the magnetospheric system, although where the energy is transferred to and how it is partitioned…”
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Relativistic Shapiro Delay Measurements of an Extremely Massive Millisecond Pulsar by Cromartie, H T, Fonseca, E, Ransom, S M, Demorest, P B, Arzoumanian, Z, Blumer, H, Brook, P R, DeCesar, M E, Dolch, T, Ellis, J A, Ferdman, R D, Ferrara, E C, Garver-Daniels, N, Gentile, P, Jones, M L, Lam, M T, Lorimer, D R, Lynch, R S, McLaughlin, M A, Ng, C, Nice, D J, Pennucci, T T, Spiewak, R, Stairs, I H, Stovall, K, Swiggum, J K, Zhu, W W

“…Despite its importance to our understanding of physics at supranuclear densities, the equation of state (EoS) of matter deep within neutron stars remains…”
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Mechanism of pore opening in the calcium-activated chloride channel TMEM16A by Lam, Andy K. M., Dutzler, Raimund

“…The anion channel TMEM16A is activated by intracellular Ca 2+ in a highly cooperative process. By combining electrophysiology and autocorrelation analysis, we…”
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Heterogeneity of Psychosis Risk Within Individuals at Clinical High Risk: A Meta-analytical Stratification by Fusar-Poli, Paolo, Cappucciati, Marco, Borgwardt, Stefan, Woods, Scott W, Addington, Jean, Nelson, Barnaby, Nieman, Dorien H, Stahl, Daniel R, Rutigliano, Grazia, Riecher-Rössler, Anita, Simon, Andor E, Mizuno, Masafumi, Lee, Tae Young, Kwon, Jun Soo, Lam, May M L, Perez, Jesus, Keri, Szabolcs, Amminger, Paul, Metzler, Sibylle, Kawohl, Wolfram, Rössler, Wulf, Lee, Jimmy, Labad, Javier, Ziermans, Tim, An, Suk Kyoon, Liu, Chen-Chung, Woodberry, Kristen A, Braham, Amel, Corcoran, Cheryl, McGorry, Patrick, Yung, Alison R, McGuire, Philip K

“…Individuals can be classified as being at clinical high risk (CHR) for psychosis if they meet at least one of the ultra-high-risk (UHR) inclusion criteria…”
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Gating the pore of the calcium-activated chloride channel TMEM16A by Lam, Andy K. M., Rheinberger, Jan, Paulino, Cristina, Dutzler, Raimund

“…The binding of cytoplasmic Ca 2+ to the anion-selective channel TMEM16A triggers a conformational change around its binding site that is coupled to the release…”
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Inexact SARAH algorithm for stochastic optimization by Nguyen, Lam M., Scheinberg, Katya, Takáč, Martin

“…We develop and analyse a variant of the SARAH algorithm, which does not require computation of the exact gradient. Thus this new method can be applied to…”
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EANM procedure guideline for the treatment of liver cancer and liver metastases with intra-arterial radioactive compounds by Weber, M., Lam, M., Chiesa, C., Konijnenberg, M., Cremonesi, M., Flamen, P., Gnesin, S., Bodei, L., Kracmerova, T., Luster, M., Garin, E., Herrmann, K.

“…Primary liver tumours (i.e. hepatocellular carcinoma (HCC) or intrahepatic cholangiocarcinoma (ICC)) are among the most frequent cancers worldwide. However,…”
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Inhibition mechanism of the chloride channel TMEM16A by the pore blocker 1PBC by Lam, Andy K. M., Rutz, Sonja, Dutzler, Raimund

“…TMEM16A, a calcium-activated chloride channel involved in multiple cellular processes, is a proposed target for diseases such as hypertension, asthma, and…”
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Proximal junctional kyphosis and failure—diagnosis, prevention, and treatment by Nguyen, Ngoc-Lam M., Kong, Christopher Y., Hart, Robert A.

“…Technical advancements have enabled the spinal deformity surgeon to correct severe spinal mal-alignment. However, proximal adjacent segment pathology (ASP)…”
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Indigenous and local knowledge in sustainability transformations research: a literature review by Lam, David P. M., Hinz, Elvira, Lang, Daniel J., Tengö, Maria, Wehrden, Henrik von, Martín-López, Berta

“…Scholars, politicians, practitioners, and civil society increasingly call for sustainability transformations to cope with urgent social and environmental…”
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Don’t Turn a Deaf Ear: A Case for Assessing Interactive Listening by Lam, Daniel M K

“…Abstract The reciprocal nature of spoken interaction means that participants constantly alternate between speaker and listener roles. However, listener or…”
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Precision Timing of PSR J0437–4715 with the IAR Observatory and Implications for Low-frequency Gravitational Wave Source Sensitivity by Lam, M. T., Hazboun, J. S.

“…While observations of many high-precision radio pulsars of order ≲1 μ s across the sky are needed for the detection and characterization of a stochastic…”
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