Search Results - "LAIHIA, J"

Topical cis-urocanic acid attenuates oedema and erythema in acute and subacute skin inflammation in the mouse by Laihia, J.K., Taimen, P., Kujari, H., Leino, L.

“…Summary Background  cis‐Urocanic acid (cis‐UCA) is an endogenous immunosuppressive molecule of the epidermis. Objectives  We investigated the effects of…”
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Cis-urocanic acid suppresses UV-B-induced interleukin-6 and -8 secretion and cytotoxicity in human corneal and conjunctival epithelial cells in vitro by Viiri, J, Jauhonen, H M, Kauppinen, A, Ryhänen, T, Paimela, T, Hyttinen, J, Sorri, I, Laihia, J K, Leino, L, Kaarniranta, K

“…Urocanic acid (UCA) is a major ultraviolet (UV)-absorbing endogenous chromophore in the epidermis and is also an efficacious immunosuppressant. The…”
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Effect of cis-urocanic acid on bovine neutrophil generation of reactive oxygen species by Rinaldi, M, Moroni, P, Leino, L, Laihia, J, Paape, M J, Bannerman, D D

“…Neutrophils play a fundamental role in the host innate immune response during mastitis and other bacterial-mediated diseases of cattle. One of the critical…”
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Cis‐urocanic acid inhibits SAPK/JNK signaling pathway in UV‐B exposed human corneal epithelial cells in vitro by PAIMELA, T, JAUHONEN, HM, KAUPPINEN, A, LAIHIA, JK, LEINO, L, SALMINEN, A, KAARNIRANTA, K

“…Purpose Urocanic acid (UCA) is a major endogenous UV‐absorbing chromophore in the epidermis and it is also an efficacious immunosuppressant. The effects of…”
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A review of studies on the effects of ultraviolet irradiation on the resistance to infections: evidence from rodent infection models and verification by experimental and observational human studies by Termorshuizen, F, Garssen, J, Norval, M, Koulu, L, Laihia, J, Leino, L, Jansen, C.T, De Gruijl, F, Gibbs, N.K, De Simone, C, Van Loveren, H

“…Recent studies on the immunosuppressive effects of ultraviolet radiation (UVR) and the related resistance to infections in rodents and humans are presented…”
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4508 POSTER Protodynamic therapy–anovel anti-cancer concept for treatment of urinary bladder carcinoma by Laihia, J, Pylkkänen, L, Laato, M, Boström, P, Leino, L

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Solar-simulating irradiation of the skin of human subjects in vivo produces Langerhans cell responses distinct from irradiation ex vivo and in vitro by Laihia, J. K., Jansen, C. T.

“…: It has been postulated that Langerhans cells (LC) provide tolerogenic signals in the local impairment of cutaneous immune functions and antigen‐specific…”
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Urocanic Acid Binds to GABA but not to Histamine (H1, H2, or H3) Receptors by Laihia, Jarmo K., Jansen, Christer T., Attila, Martti, Tuomisto, Leena, Neuvonen, Kari, Pasanen, Paavo

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Lucigenin and linoleate enhanced chemiluminescent assay for superoxide dismutase activity by Laihia, J K, Jansén, C T, Ahotupa, M

“…The xanthine/xanthine oxidase dependent chemiluminescence was enhanced both by lucigenin and linoleate to create a sensitive, specific, and rapid…”
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Adaptation of the Human Skin by Chronic Solar-simulating UV Irradiation Prevents Ultraviolet-B Irradiation-induced Rise in Serum C–Reactive Protein Levels by Laihia, Jarmo K., Koskinen, Janne O., Waris, Matti E., Jansén, Christer T.

“…Exposure of the skin to UV radiation induces local inflammation. We hypothesized that inflammation induced by erythemal UV-B irradiation could elevate levels…”
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Urocanic acid isomers do not modulate intracellular calcium and cyclic AMP in human natural killer cells by LAIHIA, Jarmo K, UKSILA, Jaakko, TOPPARI, Jorma, JANSEN, Christer T

“…Ultraviolet irradiation influences natural killer cell function both in vitro and in vivo. The postulated ultraviolet photoreceptor in the epidermis, urocanic…”
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Urocanic Acid Concentration and Photoisomerization in Caucasian Skin Phototypes by Snellman, E., Jansén, C T., Laihia, J. K., Milán, T., Koulu, L., Leszczynski, K., Pasanen, P.

“…— To investigate the relationship between erythemal sensitivity of the skin to U V radiation and epidermal urocanic acid (UCA) concentration, 45 healthy…”
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Up-regulation of human epidermal Langerhans' cell B7-1 and B7-2 co-stimulatory molecules in vivo by solar-simulating irradiation by Laihia, J K, Jansen, C T

“…Ultraviolet (UV) radiation impairs cutaneous immune functions and induces antigen-specific tolerance both locally at the irradiated skin site, as well as at…”
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Expression of CD80 (B7/BB-1) and CD28 in human white blood cells treated with urocanic acid by LAIHIA, J. K, UKSILA, J, LUHTALA, M, JANSEN, C. T

“…Urocanic acid (UCA) is formed in the epidermis where it accumulates to be converted from trans- to cis-UCA by ultraviolet (UV) radiation. The two isomers…”
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Comparison of sensitizing protocols for ultraviolet B-induced immunosuppression in C3H mice by Laihia, J K, Jansén, C T

“…To compare previously used protocols for ultraviolet (UV)-induced suppression of contact hypersensitivity in mice, and to develop an optimized protocol for C3H…”
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Urocanic acid photoconversion in relation to erythematogenicity of radiation from different types of phototherapy equipment by Laihia, J K, Jansén, C T

“…The photoisomerization characteristics of urocanic acid (UCA) were studied by using both a narrow-band monochromator and 4 broad-band phototherapy devices. The…”
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Effects of cis- and trans-urocanic acids on the secretion of interleukin-1 beta and tumour necrosis factor-alpha by human peripheral blood monocytes by Laihia, J K, Jansén, C T, Uksila, J, Punnonen, J, Neuvonen, K, Pasanen, P, Ayräs, P

“…In order to investigate the mechanism of urocanic acid (UCA)-mediated immune modulation, we studied the effect of cis- and trans-UCA on interleukin-1 beta and…”
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Three randomised phase I/IIa trials of 5% cis-urocanic acid emulsion cream in healthy adult subjects and in patients with atopic dermatitis by Peltonen, Juha M, Pylkkänen, Liisa, Jansén, Christer T, Volanen, Iina, Lehtinen, Terhi, Laihia, Jarmo K, Leino, Lasse

“…New treatment modalities are needed in atopic dermatitis. We evaluated the pharmacokinetics, safety, tolerability, and efficacy of topical cis-urocanic acid…”
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Cis‐urocanic acid suppresses UV‐B‐induced interleukin‐6 secretion and cytotoxicity in human corneal and conjunctival epithelial cells in vitro by VIIRI, J, JAUHONEN, HM, RYHäNEN, T, PAIMELA, T, SORRI, I, LAIHIA, JK, LEINO, L, SALMINEN, A, KAARNIRANTA, K

“…Purpose Urocanic acid (UCA) is a major UV‐absorbing endogenous chromophore in the epidermis and is also an efficacious immunosuppressant. The anti‐inflammatory…”
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Stereospecific modulation of GABA A receptor function by urocanic acid isomers by Uusi-Oukari, Mikko, Soini, Sanna L., Heikkilä, Jari, Koivisto, Ari, Neuvonen, Kari, Pasanen, Paavo, Sinkkonen, Saku T., Laihia, Jarmo K., Jansén, Christer T., Korpi, Esa R.

“…A deamination product of histidine, urocanic acid, accumulates in the skin of mammals as trans-urocanic acid. Ultraviolet (UV) irradition converts it to the…”
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