Search Results - "LAIDLAW, M"

Prostaglandin D2 : A dominant mediator of aspirin-exacerbated respiratory disease by Cahill, Katherine N., MD, Bensko, Jillian C, Boyce, Joshua A., MD, Laidlaw, Tanya M., MD

“…Background Aspirin desensitization followed by high-dose aspirin therapy is routinely performed for patients with aspirin-exacerbated respiratory disease…”
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Allergic inflammatory memory in human respiratory epithelial progenitor cells by Ordovas-Montanes, Jose, Dwyer, Daniel F., Nyquist, Sarah K., Buchheit, Kathleen M., Vukovic, Marko, Deb, Chaarushena, Wadsworth, Marc H., Hughes, Travis K., Kazer, Samuel W., Yoshimoto, Eri, Cahill, Katherine N., Bhattacharyya, Neil, Katz, Howard R., Berger, Bonnie, Laidlaw, Tanya M., Boyce, Joshua A., Barrett, Nora A., Shalek, Alex K.

“…Barrier tissue dysfunction is a fundamental feature of chronic human inflammatory diseases 1 . Specialized subsets of epithelial cells—including secretory and…”
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TRIM21/Ro52 - Roles in Innate Immunity and Autoimmune Disease by Jones, Esther L, Laidlaw, Stephen M, Dustin, Lynn B

“…TRIM21 (Ro52/SSA1) is an E3 ubiquitin ligase with key roles in immune host defence, signal transduction, and possibly cell cycle regulation. It is also an…”
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Diagnosis and management of NSAID‐Exacerbated Respiratory Disease (N‐ERD)—a EAACI position paper by Kowalski, Marek L., Agache, Ioana, Bavbek, Sevim, Bakirtas, Arzu, Blanca, Miguel, Bochenek, Grażyna, Bonini, Matteo, Heffler, Enrico, Klimek, Ludger, Laidlaw, Tanya M., Mullol, Joaquim, Niżankowska‐Mogilnicka, Ewa, Park, Hae‐Sim, Sanak, Marek, Sanchez‐Borges, Mario, Sanchez‐Garcia, Silvia, Scadding, Glenis, Taniguchi, Masami, Torres, Maria J., White, Andrew A., Wardzyńska, Aleksandra

“…NSAID‐exacerbated respiratory disease (N‐ERD) is a chronic eosinophilic, inflammatory disorder of the respiratory tract occurring in patients with asthma…”
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Identification of lead sources in residential environments: Sydney Australia by Laidlaw, M.A.S., Zahran, S., Pingitore, N., Clague, J., Devlin, G., Taylor, M.P.

“…Interior and exterior dust, soil and paint were analysed at five brick urban Sydney homes over 15 months to evaluate temporal variations and discriminate…”
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Cysteinyl leukotriene receptors, old and new; implications for asthma by Laidlaw, T. M., Boyce, J. A.

“…Summary The cysteinyl leukotrienes (cys‐LTs) are three structurally similar, but functionally distinct lipid mediators of inflammation. The parent cys‐LT,…”
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Ratio of plasma IL-13/TNF- ∝ and CXCL10/CCL17 predicts mepolizumab and omalizumab response in asthma better than eosinophil count or immunoglobulin E level by Akenroye, Ayobami, Nopsopon, Tanawin, Hacker, Jonathan J., Laidlaw, Tanya M.

“…To date, most studies to identify biomarkers associated with response to the anti-interleukin 5 agent, mepolizumab, and to the anti-immunoglobulin E agent,…”
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Cysteinyl leukotriene overproduction in aspirin-exacerbated respiratory disease is driven by platelet-adherent leukocytes by Laidlaw, Tanya M., Kidder, Molly S., Bhattacharyya, Neil, Xing, Wei, Shen, Shiliang, Milne, Ginger L., Castells, Mariana C., Chhay, Heng, Boyce, Joshua A.

“…Cysteinyl leukotriene (cysLT) overproduction is a hallmark of aspirin-exacerbated respiratory disease (AERD), but its mechanism is poorly understood. Because…”
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Aspirin-Exacerbated Respiratory Disease Involves a Cysteinyl Leukotriene-Driven IL-33-Mediated Mast Cell Activation Pathway by Liu, Tao, Kanaoka, Yoshihide, Barrett, Nora A, Feng, Chunli, Garofalo, Denise, Lai, Juying, Buchheit, Kathleen, Bhattacharya, Neil, Laidlaw, Tanya M, Katz, Howard R, Boyce, Joshua A

“…Aspirin-exacerbated respiratory disease (AERD), a severe eosinophilic inflammatory disorder of the airways, involves overproduction of cysteinyl leukotrienes…”
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Unique Effect of Aspirin Therapy on Biomarkers in Aspirin-exacerbated Respiratory Disease. A Prospective Trial by Cahill, Katherine N, Cui, Jing, Kothari, Parul, Murphy, Katherine, Raby, Benjamin A, Singer, Joseph, Israel, Elliot, Boyce, Joshua A, Laidlaw, Tanya M

“…Daily high-dose aspirin therapy benefits many patients with aspirin-exacerbated respiratory disease but provides no benefit for aspirin-tolerant patients with…”
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Prostaglandin E₂ deficiency causes a phenotype of aspirin sensitivity that depends on platelets and cysteinyl leukotrienes by Liu, Tao, Laidlaw, Tanya M, Katz, Howard R, Boyce, Joshua A

“…Aspirin-exacerbated respiratory disease (AERD) is characterized by asthma, tissue eosinophilia, overproduction of cysteinyl leukotrienes (cysLTs), and…”
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Recycling of cell surface membrane proteins from yeast endosomes is regulated by ubiquitinated Ist1 by Laidlaw, Kamilla M E, Calder, Grant, MacDonald, Chris

“…Upon internalization, many surface membrane proteins are recycled back to the plasma membrane. Although these endosomal trafficking pathways control surface…”
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Efficacy and safety of dupilumab in patients with severe chronic rhinosinusitis with nasal polyps (LIBERTY NP SINUS-24 and LIBERTY NP SINUS-52): results from two multicentre, randomised, double-blind, placebo-controlled, parallel-group phase 3 trials by Bachert, Claus, Han, Joseph K, Desrosiers, Martin, Hellings, Peter W, Amin, Nikhil, Lee, Stella E, Mullol, Joaquim, Greos, Leon S, Bosso, John V, Laidlaw, Tanya M, Cervin, Anders U, Maspero, Jorge F, Hopkins, Claire, Olze, Heidi, Canonica, G Walter, Paggiaro, Pierluigi, Cho, Seong H, Fokkens, Wytske J, Fujieda, Shigeharu, Zhang, Mei, Lu, Xin, Fan, Chunpeng, Draikiwicz, Steven, Kamat, Siddhesh A, Khan, Asif, Pirozzi, Gianluca, Patel, Naimish, Graham, Neil M H, Ruddy, Marcella, Staudinger, Heribert, Weinreich, David, Stahl, Neil, Yancopoulos, George D, Mannent, Leda P

“…Patients with chronic rhinosinusitis with nasal polyps (CRSwNP) generally have a high symptom burden and poor health-related quality of life, often requiring…”
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Thymic stromal lymphopoietin controls prostaglandin D2 generation in patients with aspirin-exacerbated respiratory disease by Buchheit, Kathleen M., MD, Cahill, Katherine N., MD, Katz, Howard R., PhD, Murphy, Katherine C., BA, Feng, Chunli, MD, Lee-Sarwar, Kathleen, MD, Lai, Juying, MD, Bhattacharyya, Neil, MD, Israel, Elliot, MD, Boyce, Joshua A., MD, Laidlaw, Tanya M., MD

“…Background Prostaglandin (PG) D2 is the dominant COX product of mast cells and is an effector of aspirin-induced respiratory reactions in patients with…”
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Hypersensitivity reactions to chemotherapy: Outcomes and safety of rapid desensitization in 413 cases by Castells, Mariana C., MD, PhD, Tennant, Nichole M., BA, Sloane, David E., MD, Ida Hsu, F., MD, Barrett, Nora A., MD, Hong, David I., MD, Laidlaw, Tanya M., MD, Legere, Henry J., MD, Nallamshetty, Samridhi N., MD, Palis, Ross I., MD, Rao, Jayanti J., MD, Berlin, Suzanne T., DO, Campos, Susana M., MD, Matulonis, Ursula A., MD

“…Background Hypersensitivity reactions (HSRs) to chemotherapeutic drugs, including mAbs, often require that the provoking medication be discontinued, thus…”
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Plasma tryptase elevation during aspirin-induced reactions in aspirin-exacerbated respiratory disease by Cahill, Katherine N., Murphy, Katherine, Singer, Joseph, Israel, Elliot, Boyce, Joshua A., Laidlaw, Tanya M.

“…Plasma tryptase elevation during aspirin-induced respiratory reactions occurs in 50% of reactions despite CysLT 1 R antagonist prophylaxis and identifies lung…”
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A glucose-starvation response governs endocytic trafficking and eisosomal retention of surface cargoes in budding yeast by Laidlaw, Kamilla M E, Bisinski, Daniel D, Shashkova, Sviatlana, Paine, Katherine M, Veillon, Malaury A, Leake, Mark C, MacDonald, Chris

“…Eukaryotic cells adapt their metabolism to the extracellular environment. Downregulation of surface cargo proteins in response to nutrient stress reduces the…”
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Platelets in patients with aspirin-exacerbated respiratory disease by Laidlaw, Tanya M., MD, Boyce, Joshua A., MD

“…Aspirin-exacerbated respiratory disease (AERD) is a chronic inflammatory disease characterized clinically by the triad of asthma, nasal polyposis, and…”
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Human airway mast cells proliferate and acquire distinct inflammation-driven phenotypes during type 2 inflammation by Dwyer, Daniel F, Ordovas-Montanes, Jose, Allon, Samuel J, Buchheit, Kathleen M, Vukovic, Marko, Derakhshan, Tahereh, Feng, Chunli, Lai, Juying, Hughes, Travis K, Nyquist, Sarah K, Giannetti, Matthew P, Berger, Bonnie, Bhattacharyya, Neil, Roditi, Rachel E, Katz, Howard R, Nawijn, Martijn C, Berg, Marijn, van den Berge, Maarten, Laidlaw, Tanya M, Shalek, Alex K, Barrett, Nora A, Boyce, Joshua A

“…Mast cells (MCs) play a pathobiologic role in type 2 (T2) allergic inflammatory diseases of the airway, including asthma and chronic rhinosinusitis with nasal…”
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Pathomechanisms of AERD-Recent Advances by Lyly, Annina, Laidlaw, Tanya M, Lundberg, Marie

“…The pathomechanisms behind NSAID-exacerbated respiratory disease are complex and still largely unknown. They are presumed to involve genetic predisposition and…”
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