Search Results - "LAGPACAN, Leah L"

Organic cation transporters are determinants of oxaliplatin cytotoxicity by SHUZHONG ZHANG, LOVEJOY, Katherine S, LIPPARD, Stephen J, GIACOMINI, Kathleen M, SHIMA, James E, LAGPACAN, Leah L, YAN SHU, LAPUK, Anna, YING CHEN, KOMORI, Takafumi, GRAY, Joe W, XIN CHEN

“…Although the platinum-based anticancer drugs cisplatin, carboplatin, and oxaliplatin have similar DNA-binding properties, only oxaliplatin is active against…”
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The human organic anion transporter 3 (OAT3; SLC22A8): genetic variation and functional genomics by Erdman, Andrew R, Mangravite, Lara M, Urban, Thomas J, Lagpacan, Leah L, Castro, Richard A, de la Cruz, Melanie, Chan, Wendy, Huang, Conrad C, Johns, Susan J, Kawamoto, Michiko, Stryke, Douglas, Taylor, Travis R, Carlson, Elaine J, Ferrin, Thomas E, Brett, Claire M, Burchard, Esteban G, Giacomini, Kathleen M

“…The human organic anion transporter, OAT3 (SLC22A8), plays a critical role in renal drug elimination, by mediating the entry of a wide variety of organic…”
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Functional genetic diversity in the high-affinity carnitine transporter OCTN2 (SLC22A5) by Urban, Thomas J, Gallagher, Renata C, Brown, Chaline, Castro, Richard A, Lagpacan, Leah L, Brett, Claire M, Taylor, Travis R, Carlson, Elaine J, Ferrin, Thomas E, Burchard, Esteban G, Packman, Seymour, Giacomini, Kathleen M

“…Systemic carnitine deficiency (SCD) is a rare autosomal recessive disease resulting from defects in the OCTN2 (SLC22A5) gene, which encodes the high-affinity…”
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Functional effects of protein sequence polymorphisms in the organic cation/ergothioneine transporter OCTN1 (SLC22A4) by Urban, Thomas J, Yang, Chen, Lagpacan, Leah L, Brown, Chaline, Castro, Richard A, Taylor, Travis R, Huang, Conrad C, Stryke, Douglas, Johns, Susan J, Kawamoto, Michiko, Carlson, Elaine J, Ferrin, Thomas E, Burchard, Esteban G, Giacomini, Kathleen M

“…BACKGROUNDOCTN1 is a multispecific transporter of organic cations and zwitterions, including several clinically important drugs as well as the antioxidant…”
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FUNCTIONAL CHARACTERIZATION AND HAPLOTYPE ANALYSIS OF POLYMORPHISMS IN THE HUMAN EQUILIBRATIVE NUCLEOSIDE TRANSPORTER, ENT2 by OWEN, Ryan P, LAGPACAN, Leah L, TAYLOR, Travis R, DE LA CRUZ, Melanie, HUANG, Conrad C, KAWAMOTO, Michiko, JOHNS, Susan J, STRYKE, Doug, FERRIN, Thomas E, GIACOMINI, Kathleen M

“…The equilibrative nucleoside transporter 2 (ENT2; SLC29A2 ) is a bidirectional transporter that is involved in the disposition of naturally occurring…”
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PharmGKB submission update: V. PMT submissions of genetic variation in SLC22 family transporters by Shu, Yan, Urban, Thomas J, Leabman, Maya K, Fujita, Tomoe, Erdman, Andrew R, Lagpacan, Leah L, Brown, Chaline, Castro, Richard A, Huang, Conrad C, Stryke, Doug, Kawamoto, Michiko, Johns, Susan J, Taylor, Travis R, Chan, Wendy, De La Cruz, Melanie, Carlson, Elaine J, Ferrin, Thomas E, Brett, Claire M, Burchard, Esteban G, Herskowitz, Ira, Kroetz, Deanna L, Giacomini, Kathleen M

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Functional genomics of membrane transporters in human populations by Urban, Thomas J, Sebro, Ronnie, Hurowitz, Evan H, Leabman, Maya K, Badagnani, Ilaria, Lagpacan, Leah L, Risch, Neil, Giacomini, Kathleen M

“…Although considerable progress has been made toward characterizing human DNA sequence variation, there remains a deficiency in information on human phenotypic…”
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Reduced‐function polymorphisms in the high‐affinity carnitine transporter OCTN2 (SLC22A5) by Urban, Thomas J, Brown, Chaline, Castro, Richard A., Lagpacan, Leah L., Taylor, Travis R., Burchard, Esteban G., Packman, Seymour, Giacomini, Kathleen M.

“…Systemic carnitine deficiency (SCD) is a rare autosomal recessive disease resulting from defects in the OCTN2 (SLC22A5) gene, which encodes the high‐affinity…”
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