Search Results - "LAGARDE, Pauline"

Acquisition of cancer stem cell capacities after spontaneous cell fusion by Merle, Candice, Lagarde, Pauline, Lartigue, Lydia, Chibon, Frédéric

“…Cancer stem/Initiating cell (CS/IC) hypothesis argues that CS/ICs are responsible of tumour initiation, drug resistance, metastasis or disease relapse. Their…”
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Validated prediction of clinical outcome in sarcomas and multiple types of cancer on the basis of a gene expression signature related to genome complexity by Lucchesi, Carlo, de Reynies, Aurélien, Brouste, Véronique, Coindre, Jean-Michel, Blay, Jean-Yves, Bui, Binh, Salas, Sébastien, Chibon, Frédéric, Terrier, Philippe, Vince-Ranchère, Dominique, Guillou, Louis, Pérot, Gaëlle, Tirode, Franck, Kauffmann, Audrey, Bonvalot, Sylvie, Aurias, Alain, Collin, Françoise, Leroux, Agnès, Le Cesne, Axel, Lagarde, Pauline

“…A prognostic gene expression signature predicts metastasis in individuals with sarcomas and other tumor types more accurately than existing tools. Sarcomas are…”
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Chromosome Instability Accounts for Reverse Metastatic Outcomes of Pediatric and Adult Synovial Sarcomas by LAGARDE, Pauline, PRZYBYL, Joanna, NEUVILLE, Agnès, COINDRE, Jean-Michel, ITALIANO, Antoine, ORBACH, Daniel, DEBIEC-RYCHTER, Maria, CHIBON, Frédéric, BRULARD, Céline, PEROT, Gaelle, PIERRON, Gaelle, DELATTRE, Olivier, SCIOT, Raf, WOZNIAK, Agnieszka, SCHÖFFSKI, Patrick, TERRIER, Philippe

“…Synovial sarcoma (SS) occurs in both children and adults, although metastatic events are much more common in adults. Whereas the importance of the t(X;18)…”
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MED12 alterations in both human benign and malignant uterine soft tissue tumors by Pérot, Gaëlle, Croce, Sabrina, Ribeiro, Agnès, Lagarde, Pauline, Velasco, Valérie, Neuville, Agnès, Coindre, Jean-Michel, Stoeckle, Eberhard, Floquet, Anne, MacGrogan, Gaëtan, Chibon, Frédéric

“…The relationship between benign uterine leiomyomas and their malignant counterparts, i.e. leiomyosarcomas and smooth muscle tumors of uncertain malignant…”
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Cell fusion enhances energy metabolism of mesenchymal tumor hybrid cells to sustain their proliferation and invasion by Brito, Ariadna, Merle, Candice, Lagarde, Pauline, Faustin, Benjamin, Devin, Anne, Lartigue, Lydia, Chibon, Frederic

“…Abstract Background Cell-to-cell fusion is emerging as a key element of the metastatic process in various cancer types. We recently showed that hybrids made…”
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Mitotic Checkpoints and Chromosome Instability Are Strong Predictors of Clinical Outcome in Gastrointestinal Stromal Tumors by LAGARDE, Pauline, PEROT, Gaëlle, AURIAS, Alain, COINDRE, Jean-Michel, DEBIEC-RYCHTER, Maria, CHIBON, Frédéric, KAUFFMANN, Audrey, BRULARD, Céline, DAPREMONT, Valérie, HOSTEIN, Isabelle, NEUVILLE, Agnes, WOZNIAK, Agnieszka, SCIOT, Raf, SCHÖFFSKI, Patrick

“…The importance of KIT and PDGFRA mutations in the oncogenesis of gastrointestinal stromal tumors (GIST) is well established, but the genetic basis of GIST…”
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Recurrent TRIO Fusion in Nontranslocation-Related Sarcomas by Delespaul, Lucile, Lesluyes, Tom, Pérot, Gaëlle, Brulard, Céline, Lartigue, Lydia, Baud, Jessica, Lagarde, Pauline, Le Guellec, Sophie, Neuville, Agnès, Terrier, Philippe, Vince-Ranchère, Dominique, Schmidt, Susanne, Debant, Anne, Coindre, Jean-Michel, Chibon, Frédéric

“…Despite various differences, nontranslocation-related sarcomas (e.g., comprising undifferentiated pleomorphic sarcoma, leiomyosarcoma, myxofibrosarcoma) are…”
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YAP1 and VGLL3, encoding two cofactors of TEAD transcription factors, are amplified and overexpressed in a subset of soft tissue sarcomas by Hélias-Rodzewicz, Zofia, Pérot, Gaëlle, Chibon, Frédéric, Ferreira, Céline, Lagarde, Pauline, Terrier, Philippe, Coindre, Jean-Michel, Aurias, Alain

“…In a series of 404 adult soft tissue sarcomas, analyzed by array‐CGH, we have observed in approximately 10% of them a genomic amplification of either…”
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Recurrent DMD Deletions Highlight Specific Role of Dp71 Isoform in Soft-Tissue Sarcomas by Mauduit, Olivier, Delcroix, Vanessa, Lesluyes, Tom, Pérot, Gaëlle, Lagarde, Pauline, Lartigue, Lydia, Blay, Jean-Yves, Chibon, Frédéric

“…Soft-tissue sarcomas (STS) are rare tumors whose oncogenesis remains unknown and for which no common therapeutic target has yet been identified. Analysis of…”
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Heterogeneous Mechanisms of Secondary Resistance and Clonal Selection in Sarcoma during Treatment with Nutlin by Laroche, Audrey, Tran-Cong, Kevin, Chaire, Vanessa, Lagarde, Pauline, Hostein, Isabelle, Coindre, Jean-Michel, Chibon, Frederic, Neuville, Agnes, Lesluyes, Tom, Lucchesi, Carlo, Italiano, Antoine

“…Nutlin inhibits TP53-MDM2 interaction and is under investigation in soft-tissue sarcomas (STS) and other malignancies. Molecular mechanisms of secondary…”
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Molecular characterization by array comparative genomic hybridization and DNA sequencing of 194 desmoid tumors by Salas, Sébastien, Chibon, Frederic, Noguchi, Tetsuro, Terrier, Philippe, Ranchere-Vince, Dominique, Lagarde, Pauline, Benard, Jean, Forget, Sébastien, Blanchard, Camille, Dômont, Julien, Bonvalot, Sylvie, Guillou, Louis, Leroux, Agnès, Mechine-Neuville, Agnes, Schöffski, Patrick, Laë, Marik, Collin, Françoise, Verola, Olivier, Carbonnelle, Amelie, Vescovo, Laure, Bui, Binh, Brouste, Véronique, Sobol, Hagay, Aurias, Alain, Coindre, Jean-Michel

“…Desmoid tumors are fibroblastic/myofibroblastic proliferations. Previous studies reported that CTNNB1 mutations were detected in 84% and that mutations of the…”
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Liposomal Irinotecan Shows a Larger Therapeutic Index than Non-liposomal Irinotecan in Patient-Derived Xenograft Models of Pancreatic Cancer by Barbier, Sandrine, Beaufils, Benjamin, de Miguel, Ricardo, Reyre, Melissa, Le Meitour, Yannick, Lortie, Andreanne, de Boisferon, Marc Hillairet, Chaumeron, Sophie, Espirito, Anne, Fossati, Lina, Lagarde, Pauline, Klinz, Stephan, Thiagalingam, Arunthathi, Lezmi, Stéphane, Meyer-Losic, Florence

“…Introduction Liposomal irinotecan promotes controlled sustained release of irinotecan (CPT-11), therefore, we hypothesize that the therapeutic index…”
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Prognostic value of PLAGL1-specific CpG site methylation in soft-tissue sarcomas by Peille, Anne-Lise, Brouste, Veronique, Kauffmann, Audrey, Lagarde, Pauline, Le Morvan, Valerie, Coindre, Jean-Michel, Chibon, Frederic, Bresson-Bepoldin, Laurence

“…Soft tissue sarcomas (STS) are rare, complex tumors with a poor prognosis. The identification of new prognostic biomarkers is needed to improve patient…”
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PRIMA-1MET induces death in soft-tissue sarcomas cell independent of p53 by Grellety, Thomas, Laroche-Clary, Audrey, Chaire, Vanessa, Lagarde, Pauline, Chibon, Frñdñric, Neuville, Agnes, Italiano, Antoine

“…Background The aim of this study was to explore the efficacy and define mechanisms of action of PRIMA-1.sup.MET as a TP53 targeted therapy in soft-tissue…”
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Cell fusion enhances energy metabolism of mesenchymal tumor hybrid cells to sustain their proliferation and invasion by Brito, Ariadna, Merle, Candice, Lagarde, Pauline, Faustin, Benjamin, Devin, Anne, Lartigue, Lydia, Chibon, Frederic

“…Background: Cell-to-cell fusion is emerging as a key element of the metastatic process in various cancer types. We recently showed that hybrids made from the…”
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Intimal Sarcoma Is the Most Frequent Primary Cardiac Sarcoma: Clinicopathologic and Molecular Retrospective Analysis of 100 Primary Cardiac Sarcomas by Neuville, Agnès, Collin, Françoise, Bruneval, Patrick, Parrens, Marie, Thivolet, Françoise, Gomez-Brouchet, Anne, Terrier, Philippe, de Montpreville, Vincent Thomas, Le Gall, François, Hostein, Isabelle, Lagarde, Pauline, Chibon, Frédéric, Coindre, Jean-Michel

“…We report novel molecular and pathologic features of sarcomas involving the heart. Intimal sarcoma appears as the most frequent primary cardiac sarcoma within…”
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Fusion-mediated chromosomal instability promotes aneuploidy patterns that resemble human tumors by Delespaul, Lucile, Merle, Candice, Lesluyes, Tom, Lagarde, Pauline, Le Guellec, Sophie, Pérot, Gaëlle, Baud, Jessica, Carlotti, Martina, Danet, Coralie, Fèvre, Murielle, Rousseau, Benoit, Durrieu, Stéphanie, Teichmann, Martin, Coindre, Jean-Michel, Lartigue, Lydia, Chibon, Frédéric

“…Oncogenesis is considered to result from chromosomal instability, in addition to oncogene and tumor-suppressor alterations. Intermediate to aneuploidy and…”
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Genome remodeling upon mesenchymal tumor cell fusion contributes to tumor progression and metastatic spread by Lartigue, Lydia, Merle, Candice, Lagarde, Pauline, Delespaul, Lucile, Lesluyes, Tom, Le Guellec, Sophie, Pérot, Gaelle, Leroy, Laura, Coindre, Jean-Michel, Chibon, Frédéric

“…Cell fusion in tumor progression mostly refers to the merging of a cancer cell with a cell that has migration and immune escape capabilities such as…”
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PRIMA-1(MET) induces death in soft-tissue sarcomas cell independent of p53 by Grellety, Thomas, Laroche-Clary, Audrey, Chaire, Vanessa, Lagarde, Pauline, Chibon, Frédéric, Neuville, Agnes, Italiano, Antoine

“…The aim of this study was to explore the efficacy and define mechanisms of action of PRIMA-1(MET) as a TP53 targeted therapy in soft-tissue sarcoma (STS)…”
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New insights in sarcoma oncogenesis: a comprehensive analysis of a large series of 160 soft tissue sarcomas with complex genomics by Gibault, Laure, Pérot, Gaëlle, Chibon, Frédéric, Bonnin, Sarah, Lagarde, Pauline, Terrier, Philippe, Coindre, Jean-Michel, Aurias, Alain

“…Adult soft tissue sarcomas (STS) are rare tumours of mesenchymal lineage. Based on cytogenetic and comparative genomic hybridization (CGH) data, they can be…”
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